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Common mechanisms and pathways in Stroke and Alzheimer's disease.

Objetivo

Common mechanisms and pathways in Stroke and Alzheimer's disease.
It has long been recognized that stroke and (Alzheimer’s Disease) AD often co-occur and have an overlapping pathogenesis. As such, these two diseases are not considered fellow travelers, but rather partners in crime. This multidisciplinary consortium includes epidemiologists, geneticists, radiologists, neurologists with a longstanding track-record on the etiology of stroke and AD.
This project aims to improve our understanding of the co-occurrence of stroke and AD. An essential concept of our proposal is that stroke and AD are sequential diseases that have overlapping pathyphysiological mechanisms in addition to shared risk factors. We will particularly focus on these common mechanisms and disentangle when and how these mechanisms diverge into causing either stroke, or AD, or both. Another important concept is that mechanisms under study will not only include the known pathways of ischemic vasculopathy and CAA, but we will explore and unravel novel mechanisms linking stroke and AD. We will do so by exploiting our vast international network in order to link various big datasets and by incorporating novel analytical strategies with emerging technologies in the field of genomics, metabolomics, and brain MR-imaging.

Convocatoria de propuestas

H2020-PHC-2015-two-stage
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Coordinador

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Dirección
Dr Molewaterplein 40
3015 GD Rotterdam
Países Bajos
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 1 098 750

Participantes (10)

KING'S COLLEGE LONDON
United Kingdom
Aportación de la UE
€ 476 228,75
Dirección
Strand
WC2R 2LS London
Tipo de actividad
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Aportación de la UE
€ 509 946,25
Dirección
Trinity Lane The Old Schools
CB2 1TN Cambridge
Tipo de actividad
Higher or Secondary Education Establishments
EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG
Austria
Aportación de la UE
€ 323 750
Dirección
Am Gestade 1
1010 Wien
Tipo de actividad
Research Organisations
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Alemania
Aportación de la UE
€ 510 000
Dirección
Geschwister Scholl Platz 1
80539 Muenchen
Tipo de actividad
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Suecia
Aportación de la UE
€ 256 250
Dirección
Nobels Vag 5
17177 Stockholm
Tipo de actividad
Higher or Secondary Education Establishments
MIMETAS BV
Países Bajos
Aportación de la UE
€ 509 625
Dirección
De Limes 7
2342 DH Oegstgeest
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT PASTEUR DE LILLE FONDATION
Francia
Aportación de la UE
€ 324 875
Dirección
Rue Du Professeur Calmette 1
59019 Lille
Tipo de actividad
Research Organisations
UNIVERSITEIT LEIDEN
Países Bajos
Aportación de la UE
€ 409 510
Dirección
Rapenburg 70
2311 EZ Leiden
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSITE DE GENEVE
Suiza
Aportación de la UE
€ 0
Dirección
Rue Du General Dufour 24
1211 Geneve
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSITE DE BORDEAUX
Francia
Aportación de la UE
€ 171 250
Dirección
Place Pey Berland 35
33000 Bordeaux
Tipo de actividad
Higher or Secondary Education Establishments