Common mechanisms and pathways in Stroke and Alzheimer's disease.

Livrables

Web application to compute and present results in a simple way for a broad audience

Online application to compute and present results of a risk assessment of AD in stroke patients in a simple way for a broad audience of clinicians and the general public

WP3 Midterm recruitment report

Overview of recruited subjects, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment

WP4 Report on status of posting results in the study registry(s)

Report on the status of the result posting including timelines when final posting of results is scheduled

WP3 Report on status of posting results in the study registry(s)

Report on the status of the result posting including timelines when final posting of results is scheduled

WP4 Midterm recruitment report

Overview of recruited subjects, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment

Report on knowledge and innovation management

Detailed report on knowledge and innovation management for CoSTREAM results and achievements

Publications

Circulating Metabolites Differentiate Acute Ischemic Stroke from Stroke Mimics

Auteurs: Steffen Tiedt, Stefan Brandmaier, Hanna Kollmeier, Marco Duering, Anna Artati, Jerzy Adamski, Matthias Klein, Thomas Liebig, Lesca M. Holdt, Daniel Teupser, Rui Wang‐Sattler, Edzard Schwedhelm, Christian Gieger, Martin Dichgans
Publié dans: Annals of Neurology, Numéro 88/4, 2020, Page(s) 736-746, ISSN 0364-5134
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ana.25859

Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank

Auteurs: Rainer Malik, Marios K. Georgakis, Julia Neitzel, Kristiina Rannikmäe, Michael Ewers, Sudha Seshadri, Cathie L.M. Sudlow, Martin Dichgans
Publié dans: Alzheimer's & Dementia, 2021, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1002/alz.12320

Can active life mitigate the impact of diabetes on dementia and brain aging?

Auteurs: Anna Marseglia, Alexander Darin‐Mattsson, Grégoria Kalpouzos, Giulia Grande, Laura Fratiglioni, Serhiy Dekhtyar, Weili Xu
Publié dans: Alzheimer's & Dementia, Numéro 16/11, 2020, Page(s) 1534-1543, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1002/alz.12142

Shared risk and protective factors between Alzheimer's disease and ischemic stroke: A population‐based longitudinal study

Auteurs: Rui Wang, Chengxuan Qiu, Christina S. Dintica, Ying Shang, Amaia Calderón Larrañaga, Hui‐Xin Wang, Weili Xu
Publié dans: Alzheimer's & Dementia, Numéro 17/2, 2021, Page(s) 191-204, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1002/alz.12203

Relationship between gut microbiota and circulating metabolites in population-based cohorts

Auteurs: Dina Vojinovic, Djawad Radjabzadeh, Alexander Kurilshikov, Najaf Amin, Cisca Wijmenga, Lude Franke, M. Arfan Ikram, Andre G. Uitterlinden, Alexandra Zhernakova, Jingyuan Fu, Robert Kraaij, Cornelia M. van Duijn
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-13721-1

Herpes simplex virus 1 and the risk of dementia: a population-based study

Auteurs: Meghan J. Murphy, Lana Fani, M. Kamran Ikram, Mohsen Ghanbari, M. Arfan Ikram
Publié dans: Scientific Reports, Numéro 11/1, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-87963-9

Impaired olfaction is associated with cognitive decline and neurodegeneration in the brain

Auteurs: Christina S. Dintica, Anna Marseglia, Debora Rizzuto, Rui Wang, Janina Seubert, Konstantinos Arfanakis, David A. Bennett, Weili Xu
Publié dans: Neurology, Numéro 92/7, 2019, Page(s) e700-e709, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000006919

Genetically determined blood pressure, antihypertensive drug classes, and risk of stroke subtypes

Auteurs: Marios K. Georgakis, Dipender Gill, Alastair J.S. Webb, Evangelos Evangelou, Paul Elliott, Cathie L.M. Sudlow, Abbas Dehghan, Rainer Malik, Ioanna Tzoulaki, Martin Dichgans
Publié dans: Neurology, Numéro 95/4, 2020, Page(s) e353-e361, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000009814

Relationship Between Blood Pressure and Incident Cardiovascular Disease: Linear and Nonlinear Mendelian Randomization Analyses

Auteurs: Rainer Malik, Marios K. Georgakis, Marijana Vujkovic, Scott M. Damrauer, Paul Elliott, Ville Karhunen, Alice Giontella, Cristiano Fava, Jacklyn N. Hellwege, Megan M. Shuey, Todd L. Edwards, Tormod Rogne, Bjørn O. Åsvold, Ben M. Brumpton, Stephen Burgess, Martin Dichgans, Dipender Gill
Publié dans: Hypertension, Numéro 77/6, 2021, Page(s) 2004-2013, ISSN 0194-911X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.120.16534

RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke

Auteurs: Steffen Tiedt, Matthias Prestel, Rainer Malik, Nicola Schieferdecker, Marco Duering, Veronika Kautzky, Ivelina Stoycheva, Julia Böck, Bernd H. Northoff, Matthias Klein, Franziska Dorn, Knut Krohn, Daniel Teupser, Arthur Liesz, Nikolaus Plesnila, Lesca Miriam Holdt, Martin Dichgans
Publié dans: Circulation Research, Numéro 121/8, 2017, Page(s) 970-980, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.117.311572

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2 : A genome‐wide association study in over 12,000 non‐demented participants

Auteurs: Vincent Damotte, Sven J. Lee, Vincent Chouraki, Benjamin Grenier‐Boley, Jeannette Simino, Hieab Adams, Giuseppe Tosto, Charles White, Natalie Terzikhan, Carlos Cruchaga, Maria J. Knol, Shuo Li, Susanna Schraen, Megan L. Grove, Claudia Satizabal, Najaf Amin, Claudine Berr, Steven Younkin, Rebecca F. Gottesman, Luc Buée, Alexa Beiser, David S. Knopman, Andre Uitterlinden, Charles DeCarli, Jan Bre
Publié dans: Alzheimer's & Dementia, 2021, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1002/alz.12333

Modifiable Lifestyle Factors and Risk of Stroke

Auteurs: Eric L. Harshfield, Marios K. Georgakis, Rainer Malik, Martin Dichgans, Hugh S. Markus
Publié dans: Stroke, Numéro 52/3, 2021, Page(s) 931-936, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.120.031710

Association of life‐course depression with the risk of dementia in late life: A nationwide twin study

Auteurs: Wenzhe Yang, Xuerui Li, Kuan‐Yu Pan, Rongrong Yang, Ruixue Song, Xiuying Qi, Nancy L. Pedersen, Weili Xu
Publié dans: Alzheimer's & Dementia, 2021, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1002/alz.12303

The genetic architecture of the human cerebral cortex

Auteurs: KATRINA L. GRASBY, NEDA JAHANSHAD, JODIE N. PAINTER, LUCÍA COLODRO-CONDE, JANITA BRALTEN, DERREK P. HIBAR, PENELOPE A. LIND, FABRIZIO PIZZAGALLI, CHRISTOPHER R. K. CHING, MARY AGNES B. MCMAHON, NATALIA SHATOKHINA, LEO C. P. ZSEMBIK, SOPHIA I. THOMOPOULOS, ALYSSA H. ZHU, LACHLAN T. STRIKE, INGRID AGARTZ, SAUD ALHUSAINI, MARCIO A. A. ALMEIDA, DAG ALNÆS, INGE K. AMLIEN, MICAEL ANDERSSON, TYLER ARD,
Publié dans: Science, 2020, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.aay6690

Integration of demographics, genetics, imaging and metabolomics data to identify Alzheimer’s disease patients

Auteurs: Vincent Damotte, Guillemette Marot, Aline Meirhaeghe, Philippe Amouyel, Céline Bellenguez, Vincent Chouraki
Publié dans: Alzheimer's & Dementia, Numéro 16/S4, 2020, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1002/alz.042659

Patterns of Mitochondrial TSPO Binding in Cerebral Small Vessel Disease: An in vivo PET Study With Neuropathological Comparison

Auteurs: Paul Wright, Mattia Veronese, Ndabezinhle Mazibuko, Federico E. Turkheimer, Eugenii A. Rabiner, Clive G. Ballard, Steven C. R. Williams, Avinash Kumar Hari Narayanan, Bahiya Osrah, Ricky Williams, Tiago R. Marques, Oliver D. Howes, Federico Roncaroli, Michael J. O'Sullivan
Publié dans: Frontiers in Neurology, Numéro 11, 2020, ISSN 1664-2295
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.541377

Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities

Auteurs: Nicola J. Armstrong, Karen A. Mather, Muralidharan Sargurupremraj, Maria J. Knol, Rainer Malik, Claudia L. Satizabal, Lisa R. Yanek, Wei Wen, Vilmundur G. Gudnason, Nicole D. Dueker, Lloyd T. Elliott, Edith Hofer, Joshua Bis, Neda Jahanshad, Shuo Li, Mark A. Logue, Michelle Luciano, Markus Scholz, Albert V. Smith, Stella Trompet, Dina Vojinovic, Rui Xia, Fidel Alfaro-Almagro, David Ames, Najaf Ami
Publié dans: Stroke, Numéro 51/7, 2020, Page(s) 2111-2121, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.119.027544

Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer’s disease etiopathogenesis

Auteurs: Laura Madrid, Sonia Moreno-Grau, Shahzad Ahmad, Antonio González-Pérez, Itziar de Rojas, Rui Xia, Pamela V. Martino Adami, Pablo García-González, Luca Kleineidam, Qiong Yang, Vincent Damotte, Joshua C. Bis, Fuensanta Noguera-Perea, Céline Bellenguez, Xueqiu Jian, Juan Marín-Muñoz, Benjamin Grenier-Boley, Adela Orellana, M. Arfan Ikram, Philippe Amouyel, Claudia L. Satizabal, Luis Miguel Rea
Publié dans: Aging, Numéro 13/7, 2021, Page(s) 9277-9329, ISSN 1945-4589
Éditeur: Medline
DOI: 10.18632/aging.202950

A Key Role for Subiculum-Fornix Connectivity in Recollection in Older Age

Auteurs: Naomi Hartopp, Paul Wright, Nicola J. Ray, Tavia E. Evans, Claudia Metzler-Baddeley, John P. Aggleton, Michael J. O’Sullivan
Publié dans: Frontiers in Systems Neuroscience, Numéro 12, 2019, ISSN 1662-5137
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnsys.2018.00070

Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol

Auteurs: Marios K Georgakis, Rainer Malik, Christopher D Anderson, Klaus G Parhofer, Jemma C Hopewell, Martin Dichgans
Publié dans: Brain, Numéro 143/2, 2020, Page(s) 597-610, ISSN 0006-8950
Éditeur: Oxford University Press
DOI: 10.1093/brain/awz413

Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms

Auteurs: Steven A. Lubitz, Owen E. Parsons, Christopher D. Anderson, Emelia J. Benjamin, Rainer Malik, Lu-Chen Weng, Martin Dichgans, Cathie L. Sudlow, Peter M. Rothwell, Jonathan Rosand, Patrick T. Ellinor, Hugh S. Markus, Matthew Traylor
Publié dans: Stroke, Numéro 48/6, 2017, Page(s) 1451-1456, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.116.016198

Association of Circulating Monocyte Chemoattractant Protein–1 Levels With Cardiovascular Mortality

Auteurs: Marios K. Georgakis, James A. de Lemos, Colby Ayers, Biqi Wang, Harry Björkbacka, Tiberiu A. Pana, Barbara Thorand, Caroline Sun, Lana Fani, Rainer Malik, Josée Dupuis, Gunnar Engström, Marju Orho-Melander, Olle Melander, S. Matthijs Boekholdt, Astrid Zierer, Mohamed A. Elhadad, Wolfgang Koenig, Christian Herder, Ron C. Hoogeveen, Maryam Kavousi, Christie M. Ballantyne, Annette Peters, Phyo K.
Publié dans: JAMA Cardiology, Numéro 6/5, 2021, Page(s) 587, ISSN 2380-6583
Éditeur: JAMA
DOI: 10.1001/jamacardio.2020.5392

Deep learning‐guided joint attenuation and scatter correction in multitracer neuroimaging studies

Auteurs: Hossein Arabi, Karin Bortolin, Nathalie Ginovart, Valentina Garibotto, Habib Zaidi
Publié dans: Human Brain Mapping, Numéro 41/13, 2020, Page(s) 3667-3679, ISSN 1065-9471
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/hbm.25039

Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke

Auteurs: Dina Vojinovic, Marita Kalaoja, Stella Trompet, Krista Fischer, Martin J. Shipley, Shuo Li, Aki S. Havulinna, Markus Perola, Veikko Salomaa, Qiong Yang, Naveed Sattar, Pekka Jousilahti, Najaf Amin, Claudia L. Satizabal, Nele Taba, Behnam Sabayan, Ramachandran S. Vasan, M. Arfan Ikram, David J. Stott, Mika Ala-Korpela, J. Wouter Jukema, Sudha Seshadri, Johannes Kettunen, Mika Kivimaki, Tonu Esko, C
Publié dans: Neurology, Numéro 96/8, 2021, Page(s) e1110-e1123, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000011236

Dose–response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus

Auteurs: Stephen Burgess, Rainer Malik, Bowen Liu, Amy M. Mason, Marios K. Georgakis, Martin Dichgans, Dipender Gill
Publié dans: Diabetologia, Numéro 64/4, 2021, Page(s) 845-849, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-020-05377-0

Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke

Auteurs: Chia-Ling Phuah, Tushar Dave, Rainer Malik, Miriam R Raffeld, Alison M Ayres, Joshua N Goldstein, Anand Viswanathan, Steven M Greenberg, Jeremiasz M Jagiella, Björn M Hansen, Bo Norrving, Jordi Jimenez-Conde, Jaume Roquer, Alexander Pichler, Christian Enzinger, Joan Montaner, Israel Fernandez-Cadenas, Arne Lindgren, Agnieszka Slowik, Reinhold Schmidt, Alessandro Biffi, Natalia Rost, Carl D Langef
Publié dans: Brain, Numéro 140/10, 2017, Page(s) 2663-2672, ISSN 0006-8950
Éditeur: Oxford University Press
DOI: 10.1093/brain/awx220

Genetically Predicted Blood Pressure Across the Lifespan

Auteurs: Marios K. Georgakis, Dipender Gill, Rainer Malik, Athanase D. Protogerou, Alastair J.S. Webb, Martin Dichgans
Publié dans: Hypertension, Numéro 76/3, 2020, Page(s) 953-961, ISSN 0194-911X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.120.15136

A high-throughput, ultrafast, and online three-phase electro-extraction method for analysis of trace level pharmaceuticals

Auteurs: Yupeng He, Paul Miggiels, Bert Wouters, Nicolas Drouin, Faisa Guled, Thomas Hankemeier, Petrus W. Lindenburg
Publié dans: Analytica Chimica Acta, Numéro 1149, 2021, Page(s) 338204, ISSN 0003-2670
Éditeur: Elsevier BV
DOI: 10.1016/j.aca.2021.338204

Association of lifespan cognitive reserve indicator with the risk of mild cognitive impairment and its progression to dementia

Auteurs: Hui Xu, Rongrong Yang, Christina Dintica, Xiuying Qi, Ruixue Song, David A Bennett, Weili Xu
Publié dans: Alzheimer's & Dementia, Numéro 16/6, 2020, Page(s) 873-882, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1002/alz.12085

Prevalence, Severity, and Clinical Management of Brain Incidental Findings in Healthy Young Adults: MRi-Share Cross-Sectional Study

Auteurs: Aïcha Soumaré, Naka Beguedou, Alexandre Laurent, Bruno Brochet, Constance Bordes, Sandy Mournet, Emmanuel Mellet, Edwige Pereira, Clothilde Pollet, Morgane Lachaize, Marie Mougin, Ami Tsuchida, Hugues Loiseau, Thomas Tourdias, Christophe Tzourio, Bernard Mazoyer, Stéphanie Debette
Publié dans: Frontiers in Neurology, Numéro 12, 2021, ISSN 1664-2295
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fneur.2021.675244

Plasma Brain-Derived Neurotropic Factor Levels Are Associated with Aging and Smoking But Not with Future Dementia in the Rotterdam Study

Auteurs: Sara Galle, Silvan Licher, Maarten Milders, Jan Berend Deijen, Erik Scherder, Madeleine Drent, Arfan Ikram, Cornelia M. van Duijn
Publié dans: Journal of Alzheimer's Disease, Numéro 80/3, 2021, Page(s) 1139-1149, ISSN 1387-2877
Éditeur: IOS Press
DOI: 10.3233/jad-200371

Cardiometabolic traits mediating the effect of education on osteoarthritis risk: a Mendelian randomization study

Auteurs: D. Gill, V. Karhunen, R. Malik, M. Dichgans, N. Sofat
Publié dans: Osteoarthritis and Cartilage, Numéro 29/3, 2021, Page(s) 365-371, ISSN 1063-4584
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2020.12.015

Circulating metabolites are associated with brain atrophy and white matter hyperintensities

Auteurs: Francisca A. Leeuw, Hata Karamujić‐Čomić, Betty M. Tijms, Carel F.W. Peeters, Maartje I. Kester, Philip Scheltens, Shahzad Ahmad, Dina Vojinovic, Hieab H.H. Adams, Thomas Hankemeier, Daniel Bos, Aad Lugt, Meike W. Vernooij, M. Arfan Ikram, Najaf Amin, Frederik Barkhof, Charlotte E. Teunissen, Cornelia M. Duijn, Wiesje M. Flier
Publié dans: Alzheimer's & Dementia, Numéro 17/2, 2021, Page(s) 205-214, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1002/alz.12180

The role of Apolipoprotein E epsilon4 in the association between psychosocial working conditions and dementia

Auteurs: Kuan-Yu Pan, Weili Xu, Francesca Mangialasche, Giulia Grande, Laura Fratiglioni, Hui-Xin Wang
Publié dans: Aging, Numéro 12/4, 2020, Page(s) 3730-3746, ISSN 1945-4589
Éditeur: Impact Journals
DOI: 10.18632/aging.102843

Twenty-seven-year time trends in dementia incidence in Europe and the United States

Auteurs: Frank J. Wolters, Lori B. Chibnik, Reem Waziry, Roy Anderson, Claudine Berr, Alexa Beiser, Joshua C. Bis, Deborah Blacker, Daniel Bos, Carol Brayne, Jean-François Dartigues, Sirwan K.L. Darweesh, Kendra L. Davis-Plourde, Frank de Wolf, Stephanie Debette, Carole Dufouil, Myriam Fornage, Jaap Goudsmit, Leslie Grasset, Vilmundur Gudnason, Christoforos Hadjichrysanthou, Catherine Helmer, M. Arfan Ikr
Publié dans: Neurology, Numéro 95/5, 2020, Page(s) e519-e531, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000010022

Cerebral Perfusion and the Risk of Dementia

Auteurs: Frank J. Wolters, Hazel I. Zonneveld, Albert Hofman, Aad van der Lugt, Peter J. Koudstaal, Meike W. Vernooij, M. Arfan Ikram
Publié dans: Circulation, Numéro 136/8, 2017, Page(s) 719-728, ISSN 0009-7322
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.117.027448

Circulating biomarkers of immunity and inflammation, risk of Alzheimer’s disease, and hippocampal volume: a Mendelian randomization study

Auteurs: Lana Fani, Marios K. Georgakis, M. Arfan Ikram, M. Kamran Ikram, Rainer Malik, Martin Dichgans
Publié dans: Translational Psychiatry, Numéro 11/1, 2021, ISSN 2158-3188
Éditeur: Nature Publishing Group
DOI: 10.1038/s41398-021-01400-z

Mendelian randomization for studying the effects of perturbing drug targets

Auteurs: Dipender Gill, Marios K. Georgakis, Venexia M. Walker, A. Floriaan Schmidt, Apostolos Gkatzionis, Daniel F. Freitag, Chris Finan, Aroon D. Hingorani, Joanna M.M. Howson, Stephen Burgess, Daniel I. Swerdlow, George Davey Smith, Michael V. Holmes, Martin Dichgans, Robert A Scott, Jie Zheng, Bruce M. Psaty, Neil M. Davies
Publié dans: Wellcome Open Research, Numéro 6, 2021, Page(s) 16, ISSN 2398-502X
Éditeur: F1000 Research
DOI: 10.12688/wellcomeopenres.16544.2

Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226)

Auteurs: Matthew Traylor, Daniel J. Tozer, Iain D. Croall, Danuta M. Lisiecka Ford, Abiodun Olubunmi Olorunda, Giorgio Boncoraglio, Martin Dichgans, Robin Lemmens, Jonathan Rosand, Natalia S. Rost, Peter M. Rothwell, Cathie L.M. Sudlow, Vincent Thijs, Loes Rutten-Jacobs, Hugh S. Markus
Publié dans: Neurology, Numéro 92/8, 2019, Page(s) e749-e757, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/WNL.0000000000006952

Associations Between Cardiovascular Risk, Structural Brain Changes, and Cognitive Decline

Auteurs: Ruixue Song, Hui Xu, Christina S. Dintica, Kuan-Yu Pan, Xiuying Qi, Aron S. Buchman, David A. Bennett, Weili Xu
Publié dans: Journal of the American College of Cardiology, Numéro 75/20, 2020, Page(s) 2525-2534, ISSN 0735-1097
Éditeur: Elsevier BV
DOI: 10.1016/j.jacc.2020.03.053

Cerebrovascular Disease Knowledge Portal

Auteurs: Katherine M. Crawford, Cristina Gallego-Fabrega, Christina Kourkoulis, Laura Miyares, Sandro Marini, Jason Flannick, Noel P. Burtt, Marcin von Grotthuss, Benjamin Alexander, Maria C. Costanzo, Neil H. Vaishnav, Rainer Malik, Jennifer L. Hall, Michael Chong, Jonathan Rosand, Guido J. Falcone
Publié dans: Stroke, Numéro 49/2, 2018, Page(s) 470-475, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.117.018922

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Auteurs: Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten-Jacobs, Anne-Katrin Giese, Sander W. van der Laan, Solveig Gretarsdottir, Christopher D. Anderson, Michael Chong, Hieab H. H. Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M. Bartz, Oscar R. Benavente, Steve Bevan, Giorgio B. Boncoraglio, Robert D. Brown, Ad
Publié dans: Nature Genetics, Numéro 50/4, 2018, Page(s) 524-537, ISSN 1061-4036
Éditeur: Nature Publishing Group
DOI: 10.1038/s41588-018-0058-3

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia

Auteurs: Loes C.A. Rutten-Jacobs, Daniel J. Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S. Markus, Matthew Traylor
Publié dans: Stroke, Numéro 49/6, 2018, Page(s) 1340-1347, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/STROKEAHA.118.020811

Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia

Auteurs: Tavia E. Evans, Hieab H.H. Adams, Silvan Licher, Frank J. Wolters, Aad van der Lugt, M. Kamran Ikram, Michael J. O'Sullivan, Meike W. Vernooij, M. Arfan Ikram
Publié dans: NeuroImage, Numéro 178, 2018, Page(s) 129-135, ISSN 1053-8119
Éditeur: Academic Press
DOI: 10.1016/j.neuroimage.2018.05.041

THE IMPACT OF NUTRIENT PATTERNS ON COGNITIVE DECLINE AMONG SWEDISH OLDER ADULTS: A POPULATION-BASED LONGITUDINAL STUDY

Auteurs: Federica Prinelli, Debora Rizzuto, Behnaz Shakersain, Ingegerd Johansson, Fulvio Daniele Adorni, Massimo Musicco, Laura Fratiglioni, Weili Xu
Publié dans: Alzheimer's & Dementia, Numéro 14/7, 2018, Page(s) P973-P975, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1016/j.jalz.2018.06.1308

The Nordic Prudent Diet Reduces Risk of Cognitive Decline in the Swedish Older Adults: A Population-Based Cohort Study

Auteurs: Behnaz Shakersain, Debora Rizzuto, Susanna Larsson, Gerd Faxén-Irving, Laura Fratiglioni, Wei-Li Xu
Publié dans: Nutrients, Numéro 10/2, 2018, Page(s) 229, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu10020229

Challenges and opportunities in stroke genetics

Auteurs: Rainer Malik, Martin Dichgans
Publié dans: Cardiovascular Research, 2018, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvy068

COL4A2 is associated with lacunar ischemic stroke and deep ICH: meta-analyses among 21,500 cases and 40,600 controls

Auteurs: Rannikmäe, K.; Sivakumaran, V.; Millar, H.; Malik, R.; Anderson, C.D.; Chong, M.; Dave, T.; Falcone, G.J.; Fernandez-Cadenas, I.; Jimenez-Conde, J.; Lindgren, A.; Montaner, J.; O'Donnell, M.; Paré, G.; Radmanesh, F.; Rost, N.S.; Slowik, A.; Söderholm, M.; Traylor, M.; Pulit, S.L.; Seshadri, S.; Worrall, B.B.; Woo, D.; Markus, H.S.; Mitchell, B.D.; Dichgans, M.; Rosand, J.; Sudlow, CLM; Stroke G
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Publié dans: European Journal of Epidemiology, Numéro 32/10, 2017, Page(s) 931-938, ISSN 0393-2990
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A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

Auteurs: Claudia Tamar Silva, Irina V. Zorkoltseva, Maartje N. Niemeijer, Marten E. van den Berg, Najaf Amin, Ayşe Demirkan, Elisa van Leeuwen, Adriana I. Iglesias, Laura B. Piñeros-Hernández, Carlos M. Restrepo, Jan A. Kors, Anatoly V. Kirichenko, Rob Willemsen, Ben A. Oostra, Bruno H. Stricker, André G. Uitterlinden, Tatiana I. Axenovich, Cornelia M. van Duijn, Aaron Isaacs
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Prediabetes and diabetes accelerate cognitive decline and predict microvascular lesions: A population-based cohort study

Auteurs: Anna Marseglia, Laura Fratiglioni, Grégoria Kalpouzos, Rui Wang, Lars Bäckman, Weili Xu
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Does Treating Vascular Risk Factors Prevent Dementia and Alzheimer’s Disease? A Systematic Review and Meta-Analysis

Auteurs: Susanna C. Larsson, Hugh S. Markus
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Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts

Auteurs: Juho Tynkkynen, Vincent Chouraki, Sven J. van der Lee, Jussi Hernesniemi, Qiong Yang, Shuo Li, Alexa Beiser, Martin G. Larson, Katri Sääksjärvi, Martin J. Shipley, Archana Singh-Manoux, Robert E. Gerszten, Thomas J. Wang, Aki S. Havulinna, Peter Würtz, Krista Fischer, Ayse Demirkan, M. Arfan Ikram, Najaf Amin, Terho Lehtimäki, Mika Kähönen, Markus Perola, Andres Metspalu, Antti J. Kangas, P
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A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport

Auteurs: Nienke R. Wevers, Dhanesh G. Kasi, Taylor Gray, Karlijn J. Wilschut, Benjamin Smith, Remko van Vught, Fumitaka Shimizu, Yasuteru Sano, Takashi Kanda, Graham Marsh, Sebastiaan J. Trietsch, Paul Vulto, Henriëtte L. Lanz, Birgit Obermeier
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Serum neurofilament light

Auteurs: Steffen Tiedt, Marco Duering, Christian Barro, Asli Gizem Kaya, Julia Boeck, Felix J. Bode, Matthias Klein, Franziska Dorn, Benno Gesierich, Lars Kellert, Birgit Ertl-Wagner, Michael W. Goertler, Gabor C. Petzold, Jens Kuhle, Frank A. Wollenweber, Nils Peters, Martin Dichgans
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Tooth loss is associated with accelerated cognitive decline and volumetric brain differences: a population-based study

Auteurs: Christina S. Dintica, Debora Rizzuto, Anna Marseglia, Grégoria Kalpouzos, Anna-Karin Welmer, Inger Wårdh, Lars Bäckman, Weili Xu
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Quantitative profiling of endocannabinoids and related N -acylethanolamines in human CSF using nano LC-MS/MS

Auteurs: Vasudev Kantae, Shinji Ogino, Marek Noga, Amy C. Harms, Robin M. van Dongen, Gerrit L. J. Onderwater, Arn M. J. M. van den Maagdenberg, Gisela M. Terwindt, Mario van der Stelt, Michel D. Ferrari, Thomas Hankemeier
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Von Willebrand factor and ADAMTS13 activity in relation to risk of dementia: a population-based study

Auteurs: Frank J. Wolters, Johan Boender, Paul S. de Vries, Michelle A. Sonneveld, Peter J. Koudstaal, Moniek P. de Maat, Oscar H. Franco, M. Kamran Ikram, Frank W. Leebeek, M. Arfan Ikram
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Blood-based metabolic signatures in Alzheimer's disease

Auteurs: Francisca A. de Leeuw, Carel F.W. Peeters, Maartje I. Kester, Amy C. Harms, Eduard A. Struys, Thomas Hankemeier, Herman W.T. van Vlijmen, Sven J. van der Lee, Cornelia M. van Duijn, Philip Scheltens, Ayşe Demirkan, Mark A. van de Wiel, Wiesje M. van der Flier, Charlotte E. Teunissen
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Role of Non-Coding RNAs in Stroke

Auteurs: Steffen Tiedt, Martin Dichgans
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Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury

Auteurs: Stéphanie Debette, Sabrina Schilling, Marie-Gabrielle Duperron, Susanna C. Larsson, Hugh S. Markus
Publié dans: JAMA Neurology, Numéro 76/1, 2019, Page(s) 81, ISSN 2168-6149
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Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults: A Randomized Controlled Trial

Auteurs: Anna Marseglia, Weili Xu, Laura Fratiglioni, Cristina Fabbri, Agnes A. M. Berendsen, Agata Bialecka-Debek, Amy Jennings, Rachel Gillings, Nathalie Meunier, Elodie Caumon, Susan Fairweather-Tait, Barbara Pietruszka, Lisette C. P. G. M. De Groot, Aurelia Santoro, Claudio Franceschi
Publié dans: Frontiers in Physiology, Numéro 9, 2018, ISSN 1664-042X
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An Active Lifestyle Reinforces the Effect of a Healthy Diet on Cognitive Function: A Population-Based Longitudinal Study

Auteurs: Behnaz Shakersain, Debora Rizzuto, Hui-Xin Wang, Gerd Faxén-Irving, Federica Prinelli, Laura Fratiglioni, Weili Xu
Publié dans: Nutrients, Numéro 10/9, 2018, Page(s) 1297, ISSN 2072-6643
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Life expectancy with and without dementia: a population-based study of dementia burden and preventive potential

Auteurs: Frank J Wolters, Liselotte M Tinga, Klodian Dhana, Peter J Koudstaal, Albert Hofman, Daniel Bos, Oscar H Franco, M Arfan Ikram
Publié dans: American Journal of Epidemiology, 2018, ISSN 0002-9262
Éditeur: Oxford University Press
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MRI load of cerebral microvascular lesions and neurodegeneration, cognitive decline, and dementia

Auteurs: Rui Wang, Anna Laveskog, Erika J. Laukka, Grégoria Kalpouzos, Lars Bäckman, Laura Fratiglioni, Chengxuan Qiu
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Disentangling the biological pathways involved in early features of Alzheimer's disease in the Rotterdam Study

Auteurs: Shahzad Ahmad, Christian Bannister, Sven J. van der Lee, Dina Vojinovic, Hieab H.H. Adams, Alfredo Ramirez, Valentina Escott-Price, Rebecca Sims, Emily Baker, Julie Williams, Peter Holmans, Meike W. Vernooij, M. Arfan Ikram, Najaf Amin, Cornelia M. van Duijn
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Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

Auteurs: Sven J. van der Lee, Charlotte E. Teunissen, René Pool, Martin J. Shipley, Alexander Teumer, Vincent Chouraki, Debora Melo van Lent, Juho Tynkkynen, Krista Fischer, Jussi Hernesniemi, Toomas Haller, Archana Singh-Manoux, Aswin Verhoeven, Gonneke Willemsen, Francisca A. de Leeuw, Holger Wagner, Jenny van Dongen, Johannes Hertel, Kathrin Budde, Ko Willems van Dijk, Leonie Weinhold, M. Arfan Ikram,
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Metabolic profiling of intra- and extracranial carotid artery atherosclerosis

Auteurs: Dina Vojinovic, Sven J. van der Lee, Cornelia M. van Duijn, Meike W. Vernooij, Maryam Kavousi, Najaf Amin, Ayşe Demirkan, M. Arfan Ikram, Aad van der Lugt, Daniel Bos
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Vascular Cognitive Impairment

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Helicobacter pylori and the risk of dementia: A population-based study

Auteurs: Lana Fani, Frank J. Wolters, M. Kamran Ikram, Marco J. Bruno, Albert Hofman, Peter J. Koudstaal, Sarwa Darwish Murad, M. Arfan Ikram
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IMPAIRED OLFACTORY FUNCTION IS ASSOCIATED WITH ACCELERATED COGNITIVE DECLINE AND NEURODEGENERATION IN THE BRAIN

Auteurs: Christina S. Dintica, Anna Marseglia, Debora Rizzuto, Rui Wang, Janina Seubert, David A. Bennett, Weili Xu
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Modifiable pathways in Alzheimer’s disease: Mendelian randomisation analysis

Auteurs: Susanna C Larsson, Matthew Traylor, Rainer Malik, Martin Dichgans, Stephen Burgess, Hugh S Markus
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Mixed brain lesions mediate the association between cardiovascular risk burden and cognitive decline in old age: A population-based study

Auteurs: Rui Wang, Laura Fratiglioni, Grégoria Kalpouzos, Martin Lövdén, Erika J. Laukka, Lena Bronge, Lars-Olof Wahlund, Lars Bäckman, Chengxuan Qiu
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High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform

Auteurs: Nienke R. Wevers, Remko van Vught, Karlijn J. Wilschut, Arnaud Nicolas, Chiwan Chiang, Henriette L. Lanz, Sebastiaan J. Trietsch, Jos Joore, Paul Vulto
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Higher Education Is Associated with a Lower Risk of Dementia after a Stroke or TIA. The Rotterdam Study

Auteurs: Saira Saeed Mirza, Marileen L.P. Portegies, Frank J. Wolters, Albert Hofman, Peter J. Koudstaal, Henning Tiemeier, M. Arfan Ikram
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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Auteurs: Rebecca Sims, Sven J van der Lee, Adam C Naj, Céline Bellenguez, Nandini Badarinarayan, Johanna Jakobsdottir, Brian W Kunkle, Anne Boland, Rachel Raybould, Joshua C Bis, Eden R Martin, Benjamin Grenier-Boley, Stefanie Heilmann-Heimbach, Vincent Chouraki, Amanda B Kuzma, Kristel Sleegers, Maria Vronskaya, Agustin Ruiz, Robert R Graham, Robert Olaso, Per Hoffmann, Megan L Grove, Badri N Vardarajan,
Publié dans: Nature Genetics, 2017, ISSN 1061-4036
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Cognitive Trajectories of Older Adults With Prediabetes and Diabetes: A Population-Based Cohort Study

Auteurs: Anna Marseglia, Anna K. Dahl Aslan, Laura Fratiglioni, Giola Santoni, Nancy L. Pedersen, Weili Xu
Publié dans: The Journals of Gerontology: Series A, 2017, ISSN 1079-5006
Éditeur: Gerontological Society of America
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Association of Lifespan Cognitive Reserve Indicator With Dementia Risk in the Presence of Brain Pathologies

Auteurs: Hui Xu, Rongrong Yang, Xiuying Qi, Christina Dintica, Ruixue Song, David A. Bennett, Weili Xu
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High dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage

Auteurs: Marie-Gabrielle Duperron, Christophe Tzourio, Sabrina Schilling, Yi-Cheng Zhu, Aïcha Soumaré, Bernard Mazoyer, Stéphanie Debette
Publié dans: Neurobiology of Aging, Numéro 84, 2019, Page(s) 158-165, ISSN 0197-4580
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Genetically Determined Levels of Circulating Cytokines and Risk of Stroke

Auteurs: Marios K. Georgakis, Dipender Gill, Kristiina Rannikmäe, Matthew Traylor, Christopher D. Anderson, Jin-Moo Lee, Yoichiro Kamatani, Jemma C. Hopewell, Bradford B. Worrall, Jürgen Bernhagen, Cathie L. M. Sudlow, Rainer Malik, Martin Dichgans
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Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

Auteurs: Yiyi Ma, Gyungah R. Jun, Xiaoling Zhang, Jaeyoon Chung, Adam C. Naj, Yuning Chen, Celine Bellenguez, Kara Hamilton-Nelson, Eden R. Martin, Brian W. Kunkle, Joshua C. Bis, Stéphanie Debette, Anita L. DeStefano, Myriam Fornage, Gaël Nicolas, Cornelia van Duijn, David A. Bennett, Philip L. De Jager, Richard Mayeux, Jonathan L Haines, Margaret A. Pericak-Vance, Sudha Seshadri, Jean-Charles Lambert,
Publié dans: JAMA Neurology, Numéro 76/9, 2019, Page(s) 1099, ISSN 2168-6149
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Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes

Auteurs: Marios K. Georgakis, Rainer Malik, Dipender Gill, Nora Franceschini, Cathie L. M. Sudlow, Martin Dichgans, Sara Lindstrom, Lu Wang, Erin N. Smith, William Gordon, Astrid van Hylckama Vlieg, Mariza de Andrade, Jennifer A. Brody, Jack W. Pattee, Jeffrey Haessler, Ben M. Brumpton, Daniel I. Chasman, Pierre Suchon, Ming-Huei Chen, Constance Turman, Marine Germain, Kerri L. Wiggins, James MacDonald, Si
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Vascular Cognitive Impairment and Dementia

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Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

Auteurs: Gad Abraham, Rainer Malik, Ekaterina Yonova-Doing, Agus Salim, Tingting Wang, John Danesh, Adam S. Butterworth, Joanna M. M. Howson, Michael Inouye, Martin Dichgans
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An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

Auteurs: Jun Liu, Elena Carnero-Montoro, Jenny van Dongen, Samantha Lent, Ivana Nedeljkovic, Symen Ligthart, Pei-Chien Tsai, Tiphaine C. Martin, Pooja R. Mandaviya, Rick Jansen, Marjolein J. Peters, Liesbeth Duijts, Vincent W. V. Jaddoe, Henning Tiemeier, Janine F. Felix, Gonneke Willemsen, Eco J. C. de Geus, Audrey Y. Chu, Daniel Levy, Shih-Jen Hwang, Jan Bressler, Rahul Gondalia, Elias L. Salfati, Christ
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Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke

Auteurs: Marios K. Georgakis, Rainer Malik, Harry Björkbacka, Tiberiu Alexandru Pana, Serkalem Demissie, Colby Ayers, Mohamed A. Elhadad, Myriam Fornage, Alexa S. Beiser, Emelia J. Benjamin, S. Matthijs Boekholdt, Gunnar Engström, Christian Herder, Ron C. Hoogeveen, Wolfgang Koenig, Olle Melander, Marju Orho-Melander, Alexandru Schiopu, Martin Söderholm, Nick Wareham, Christie M. Ballantyne, Annette Pet
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Psychosocial working conditions, trajectories of disability, and the mediating role of cognitive decline and chronic diseases: A population-based cohort study

Auteurs: Kuan-Yu Pan, Weili Xu, Francesca Mangialasche, Rui Wang, Serhiy Dekhtyar, Amaia Calderón-Larrañaga, Laura Fratiglioni, Hui-Xin Wang
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Working Life Psychosocial Conditions in Relation to Late-Life Cognitive Decline: A Population-Based Cohort Study

Auteurs: Kuan-Yu Pan, Weili Xu, Francesca Mangialasche, Serhiy Dekhtyar, Laura Fratiglioni, Hui-Xin Wang
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Novel technologies for metabolomics: More for less

Auteurs: Paul Miggiels, Bert Wouters, Gerard J.P. van Westen, Anne-Charlotte Dubbelman, Thomas Hankemeier
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The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1

Auteurs: Matthias Prestel, Caroline Prell-Schicker, Tom Webb, Rainer Malik, Barbara Lindner, Natalie Ziesch, Monika Rex-Haffner, Simone Röh, Thanatip Viturawong, Manuel Lehm, Michal Mokry, Hester den Ruijter, Saskia Haitjema, Yaw Asare, Flavia Söllner, Maryam Ghaderi Najafabadi, Rédouane Aherrahrou, Mete Civelek, Nilesh J. Samani, Matthias Mann, Christof Haffner, Martin Dichgans
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Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

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Leisure activity and social integration mitigate the risk of dementia related to cardiometabolic diseases: A population‐based longitudinal study

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WMH and long-term outcomes in ischemic stroke

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Global Brain Perfusion and the Risk of Transient Ischemic Attack and Ischemic Stroke: The Rotterdam Study

Auteurs: Lana Fani, Daniel Bos, Unal Mutlu, Marileen L.P. Portegies, Hazel I. Zonneveld, Peter J. Koudstaal, Meike W. Vernooij, M. Arfan Ikram, M. Kamran Ikram
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Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy

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The role of haematological traits in risk of ischaemic stroke and its subtypes

Auteurs: Eric L Harshfield, Matthew C Sims, Matthew Traylor, Willem H Ouwehand, Hugh S Markus
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Natural history of prediabetes in older adults from a population‐based longitudinal study

Auteurs: Y. Shang, A. Marseglia, L. Fratiglioni, A.‐K. Welmer, R. Wang, H.‐X. Wang, W. Xu
Publié dans: Journal of Internal Medicine, Numéro 286/3, 2019, Page(s) 326-340, ISSN 0954-6820
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/joim.12920

A prospective study of serum metabolites and risk of ischemic stroke

Auteurs: Daokun Sun, Steffen Tiedt, Bing Yu, Xueqiu Jian, Rebecca F. Gottesman, Thomas H. Mosley, Eric Boerwinkle, Martin Dichgans, Myriam Fornage
Publié dans: Neurology, Numéro 92/16, 2019, Page(s) e1890-e1898, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000007279

Telomere Length and the Risk of Alzheimer’s Disease: The Rotterdam Study

Auteurs: Lana Fani, Saima Hilal, Sanaz Sedaghat, Linda Broer, Silvan Licher, Pascal P. Arp, Joyce B.J. van Meurs, M. Kamran Ikram, M. Arfan Ikram
Publié dans: Journal of Alzheimer's Disease, Numéro 73/2, 2020, Page(s) 707-714, ISSN 1387-2877
Éditeur: IOS Press
DOI: 10.3233/jad-190759

Type 2 diabetes in midlife and risk of cerebrovascular disease in late life: a prospective nested case−control study in a nationwide Swedish twin cohort

Auteurs: Rongrong Yang, Nancy L. Pedersen, Cuiping Bao, Weige Xu, Hui Xu, Ruixue Song, Xiuying Qi, Weili Xu
Publié dans: Diabetologia, Numéro 62/8, 2019, Page(s) 1403-1411, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-019-4892-3

Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study

Auteurs: Kimberly D. van der Willik, Lana Fani, Dimitris Rizopoulos, Silvan Licher, Jesse Fest, Sanne B. Schagen, M. Kamran Ikram, M. Arfan Ikram
Publié dans: Journal of Neuroinflammation, Numéro 16/1, 2019, ISSN 1742-2094
Éditeur: BioMed Central
DOI: 10.1186/s12974-019-1454-z

Genetic risk of dementia mitigated by cognitive reserve: A cohort study

Auteurs: Serhiy Dekhtyar, Anna Marseglia, Weili Xu, Alexander Darin‐Mattsson, Hui‐Xin Wang, Laura Fratiglioni
Publié dans: Annals of Neurology, 2019, ISSN 0364-5134
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ana.25501

Homocysteine and small vessel stroke: A mendelian randomization analysis

Auteurs: Susanna C. Larsson, Matthew Traylor, Hugh S. Markus
Publié dans: Annals of Neurology, Numéro 85/4, 2019, Page(s) 495-501, ISSN 0364-5134
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ana.25440

Vitamin D Status and Risk of Stroke

Auteurs: Brian P. Berghout, Lana Fani, Alis Heshmatollah, Peter J. Koudstaal, M. Arfan Ikram, M. Carola Zillikens, M. Kamran Ikram
Publié dans: Stroke, Numéro 50/9, 2019, Page(s) 2293-2298, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.119.025449

Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects

Auteurs: Aniket Mishra, Ganesh Chauhan, Marie-Helene Violleau, Dina Vojinovic, Xueqiu Jian, Joshua C Bis, Shuo Li, Yasaman Saba, Benjamin Grenier-Boley, Qiong Yang, Traci M Bartz, Edith Hofer, Aïcha Soumaré, Fen Peng, Marie-Gabrielle Duperron, Mario Foglio, Thomas H Mosley, Reinhold Schmidt, Bruce M Psaty, Lenore J Launer, Eric Boerwinkle, Yicheng Zhu, Bernard Mazoyer, Mark Lathrop, Celine Bellenguez, Co
Publié dans: Brain, Numéro 142/4, 2019, Page(s) 1009-1023, ISSN 0006-8950
Éditeur: Oxford University Press
DOI: 10.1093/brain/awz024

Participating in Mental, Social, and Physical Leisure Activities and Having a Rich Social Network Reduce the Incidence of Diabetes-Related Dementia in a Cohort of Swedish Older Adults

Auteurs: Anna Marseglia, Hui-Xin Wang, Debora Rizzuto, Laura Fratiglioni, Weili Xu
Publié dans: Diabetes Care, Numéro 42/2, 2019, Page(s) 232-239, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.2337/dc18-1428

Influence of Genetic Variation in PDE3A on Endothelial Function and Stroke

Auteurs: Matthew Traylor, Ali Amin Al Olama, Leo-Pekka Lyytikäinen, Sandro Marini, Jaeyoon Chung, Rainer Malik, Martin Dichgans, Mika Kähönen, Terho Lehtimäki, Christopher D. Anderson, Olli T. Raitakari, Hugh S. Markus
Publié dans: Hypertension, Numéro 75/2, 2020, Page(s) 365-371, ISSN 0194-911X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.119.13513

Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

Auteurs: Gerrit L.J. Onderwater, Lannie Ligthart, Mariska Bot, Ayse Demirkan, Jingyuan Fu, Carla J.H. van der Kallen, Lisanne S. Vijfhuizen, René Pool, Jun Liu, Floris H.M. Vanmolkot, Marian Beekman, Ke-xin Wen, Najaf Amin, Carisha S. Thesing, Judith A. Pijpers, Dennis A. Kies, Ronald Zielman, Irene de Boer, Marleen M.J. van Greevenbroek, Ilja C.W. Arts, Yuri Milaneschi, Miranda T. Schram, Pieter C. Dagne
Publié dans: Neurology, Numéro 92/16, 2019, Page(s) e1899-e1911, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000007313

A healthy lifestyle mitigates the risk of heart disease related to type 2 diabetes: a prospective nested case–control study in a nationwide Swedish twin cohort

Auteurs: Rongrong Yang, Hui Xu, Nancy L. Pedersen, Xuerui Li, Jing Yu, Cuiping Bao, Xiuying Qi, Weili Xu
Publié dans: Diabetologia, Numéro 64/3, 2021, Page(s) 530-539, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-020-05324-z

Individual changes in anthropometric measures after age 60 years: a 15-year longitudinal population-based study

Auteurs: Jie Guo, Ying Shang, Laura Fratiglioni, Kristina Johnell, Anna-Karin Welmer, Anna Marseglia, Weili Xu
Publié dans: Age and Ageing, 2021, ISSN 0002-0729
Éditeur: Oxford University Press
DOI: 10.1093/ageing/afab045

Association of Cardiovascular Risk Burden With Risk and Progression of Disability: Mediating Role of Cardiovascular Disease and Cognitive Decline

Auteurs: Kaiwang Cui, Ruixue Song, Hui Xu, Ying Shang, Xiuying Qi, Aron S. Buchman, David A. Bennett, Weili Xu
Publié dans: Journal of the American Heart Association, Numéro 9/18, 2020, ISSN 2047-9980
Éditeur: Wiley-Blackwell
DOI: 10.1161/jaha.120.017346

The association of innate and adaptive immunity, subclinical atherosclerosis, and cardiovascular disease in the Rotterdam Study: A prospective cohort study

Auteurs: Lana Fani, Kimberly D. van der Willik, Daniel Bos, Maarten J. G. Leening, Peter J. Koudstaal, Dimitris Rizopoulos, Rikje Ruiter, Bruno H. C. Stricker, Maryam Kavousi, M. Arfan Ikram, M. Kamran Ikram
Publié dans: PLOS Medicine, Numéro 17/5, 2020, Page(s) e1003115, ISSN 1549-1676
Éditeur: PLOS
DOI: 10.1371/journal.pmed.1003115

Association of diabetes with stroke and post‐stroke dementia: A population‐based cohort study

Auteurs: Ying Shang, Laura Fratiglioni, Anna Marseglia, Anna Plym, Anna‐Karin Welmer, Hui‐Xin Wang, Rui Wang, Weili Xu
Publié dans: Alzheimer's & Dementia, Numéro 16/7, 2020, Page(s) 1003-1012, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1002/alz.12101

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Auteurs: Mark K. Bakker, Rick A. A. van der Spek, Wouter van Rheenen, Sandrine Morel, Romain Bourcier, Isabel C. Hostettler, Varinder S. Alg, Kristel R. van Eijk, Masaru Koido, Masato Akiyama, Chikashi Terao, Koichi Matsuda, Robin G. Walters, Kuang Lin, Liming Li, Iona Y. Millwood, Zhengming Chen, Guy A. Rouleau, Sirui Zhou, Kristiina Rannikmäe, Cathie L. M. Sudlow, Henry Houlden, Leonard H. van den Berg,
Publié dans: Nature Genetics, Numéro 52/12, 2020, Page(s) 1303-1313, ISSN 1061-4036
Éditeur: Nature Publishing Group
DOI: 10.1038/s41588-020-00725-7

Association of common genetic variants with brain microbleeds

Auteurs: Maria J. Knol, Dongwei Lu, Matthew Traylor, Hieab H.H. Adams, José Rafael J. Romero, Albert V. Smith, Myriam Fornage, Edith Hofer, Junfeng Liu, Isabel C. Hostettler, Michelle Luciano, Stella Trompet, Anne-Katrin Giese, Saima Hilal, Erik B. van den Akker, Dina Vojinovic, Shuo Li, Sigurdur Sigurdsson, Sven J. van der Lee, Clifford R. Jack, Duncan Wilson, Pinar Yilmaz, Claudia L. Satizabal, David C.
Publié dans: Neurology, Numéro 95/24, 2020, Page(s) e3331-e3343, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000010852

Neurofilament light chain predicts future dementia risk in cerebral small vessel disease

Auteurs: Marco Egle, Laurence Loubiere, Aleksandra Maceski, Jens Kuhle, Nils Peters, Hugh S Markus
Publié dans: Journal of Neurology, Neurosurgery & Psychiatry, Numéro 92/6, 2021, Page(s) 582-589, ISSN 0022-3050
Éditeur: BMJ Publishing Group
DOI: 10.1136/jnnp-2020-325681

Association of low birth weight with cardiometabolic diseases in Swedish twins: a population-based cohort study

Auteurs: Xuerui Li, Rongrong Yang, Wenzhe Yang, Hui Xu, Ruixue Song, Xiuying Qi, Weili Xu
Publié dans: BMJ Open, Numéro 11/6, 2021, Page(s) e048030, ISSN 2044-6055
Éditeur: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-048030

In‐vivo imaging of locus coeruleus integrity at ultra‐high field: A feasibility study

Auteurs: Michela Pievani, Ileana O Jelescu, Joao Jorge, Olivier Reynaud, Paulina Andryszak, Valentina Garibotto, Jorge Jovicich, Giovanni B Frisoni
Publié dans: Alzheimer's & Dementia, Numéro 16/S4, 2020, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1002/alz.040835

Microstructural changes in the reward system are associated with post-stroke depression

Auteurs: Lena K.L. Oestreich, Paul Wright, Michael J. O'Sullivan
Publié dans: NeuroImage: Clinical, Numéro 28, 2020, Page(s) 102360, ISSN 2213-1582
Éditeur: Elsevier BV
DOI: 10.1016/j.nicl.2020.102360

Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk: Mendelian Randomization Analysis

Auteurs: Dipender Gill, Marios K. Georgakis, Verena Zuber, Ville Karhunen, Stephen Burgess, Rainer Malik, Martin Dichgans
Publié dans: Journal of the American Heart Association, Numéro 9/14, 2020, ISSN 2047-9980
Éditeur: Wiley-Blackwell
DOI: 10.1161/jaha.120.016773

Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects

Auteurs: Dipender Gill, Marios K. Georgakis, Fotios Koskeridis, Lan Jiang, Qiping Feng, Wei-Qi Wei, Evropi Theodoratou, Paul Elliott, Joshua C. Denny, Rainer Malik, Evangelos Evangelou, Abbas Dehghan, Martin Dichgans, Ioanna Tzoulaki
Publié dans: Circulation, Numéro 140/4, 2019, Page(s) 270-279, ISSN 0009-7322
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.118.038814

Sleep, 24-h activity rhythms, and plasma markers of neurodegenerative disease

Auteurs: Thom S. Lysen, M. Arfan Ikram, Mohsen Ghanbari, Annemarie I. Luik
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-77830-4

Immunity and amyloid beta, total tau and neurofilament light chain: Findings from a community‐based cohort study

Auteurs: Lana Fani, Shahzad Ahmad, M. Kamran Ikram, Mohsen Ghanbari, M. Arfan Ikram
Publié dans: Alzheimer's & Dementia, Numéro 17/3, 2021, Page(s) 446-456, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1002/alz.12212

ESO Guideline on covert cerebral small vessel disease

Auteurs: Joanna M Wardlaw, Stephanie Debette, Hanna Jokinen, Frank-Erik De Leeuw, Leonardo Pantoni, Hugues Chabriat, Julie Staals, Fergus Doubal, Salvatore Rudilosso, Sebastian Eppinger, Sabrina Schilling, Raffaele Ornello, Christian Enzinger, Charlotte Cordonnier, Martin Taylor-Rowan, Arne G Lindgren
Publié dans: European Stroke Journal, Numéro 6/2, 2021, Page(s) CXI-CLXII, ISSN 2396-9873
Éditeur: SAGE Publishing
DOI: 10.1177/23969873211012132

The relation of poor mastication with cognition and dementia risk: a population-based longitudinal study

Auteurs: Christina S. Dintica, Anna Marseglia, Inger Wårdh, Per Stjernfeldt Elgestad, Debora Rizzuto, Ying Shang, Weili Xu, Nancy L. Pedersen
Publié dans: Aging, Numéro 12/9, 2020, Page(s) 8536-8548, ISSN 1945-4589
Éditeur: Medline
DOI: 10.18632/aging.103156

Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease

Auteurs: Marios K. Georgakis, Eric L. Harshfield, Rainer Malik, Nora Franceschini, Claudia Langenberg, Nicholas J. Wareham, Hugh S. Markus, Martin Dichgans
Publié dans: Neurology, Numéro 96/13, 2021, Page(s) e1732-e1742, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000011555

Microfluidic models of the neurovascular unit

Auteurs: Nienke R Wevers
Publié dans: 2021, ISBN 978-94-6419-210-0
Éditeur: Vrije Universiteit Amsterdam

Genome-Wide Meta-Analysis of Late-Onset Alzheimer’s Disease Using Rare Variant Imputation in 65,602 Subjects Identifies Novel Rare Variant Locus NCK2: The International Genomics of Alzheimer’s Project (IGAP)

Auteurs: Adam C. Naj, Ganna Leonenko, Xueqiu Jian, Benjamin Grenier-Boley, Maria Carolina Dalmasso, Celine Bellenguez, Jin Sha, Yi Zhao, Sven J. van der Lee, Rebecca Sims, Vincent Chouraki, Joshua C. Bis, Brian W. Kunkle, Peter Holmans, Yuk Yee Leung, John J. Farrell, Alessandra Chesi, Hung-Hsin Chen, Badri Vardarajan, Penelope Benchek, Sandral Barral, Chien-Yueh Lee, Pavel Kuksa, Jacob Haut, Edward B. Lee
Publié dans: medRxiv, 2021
Éditeur: medRxiv
DOI: 10.1101/2021.03.14.21253553

Whole-exome sequencing in 16,511 individuals reveals a role of the HTRA1 protease and its substrate EGFL8 in brain white matter hyperintensities

Auteurs: Rainer Malik, Nathalie Beaufort, Simon Frerich, Benno Gesierich, Marios K Georgakis, Kristiina Rannikmäe, Amy C Ferguson, Christof Haffner, Matthew Traylor, Michael Ehrmann, Cathie LM Sudlow, Martin Dichgans
Publié dans: medRxiv, 2021
Éditeur: medRxiv
DOI: 10.1101/2021.03.26.21253954

Genetic study of circulating cytokines offers insight into the determinants, cascades and effects of systemic inflammation

Auteurs: Ville Karhunen, Dipender Gill, Rainer Malik, Mark J. Ponsford, Ari Ahola-Olli, Areti Papadopoulou, Saranya Palaniswamy, Shivaprakash Jagalur Mutt, Sylvain Sebert, Minna Männikkö, Juha Auvinen, Juha Veijola, Karl-Heinz Herzig, Markku Timonen, Sirkka Keinänen-Kiukaanniemi, Martin Dichgans, Marko Salmi, Sirpa Jalkanen, Terho Lehtimäki, Veikko Salomaa, Olli Raitakari, Simon A Jones, Konstantinos K
Publié dans: medRxiv, 2020
Éditeur: medRxiv
DOI: 10.1101/2020.10.26.20219477

Monocyte-chemoattractant protein-1 Levels in Human Atherosclerosis Associate with Plaque Vulnerability

Auteurs: Marios K. Georgakis, Sander W. van der Laan, Yaw Asare, Joost M. Mekke, Saskia Haitjema, Arjan H. Schoneveld, Dominique P.V. de Kleijn, Gert J. de Borst, Gerard Pasterkamp, Martin Dichgans
Publié dans: medRxiv, 2020
Éditeur: medRxiv
DOI: 10.1101/2020.09.04.20187955

Ischemic Heart Disease and Cognitive Prognosis in the First Year after Stroke

Auteurs: Michael J O’Sullivan, Paul Wright
Publié dans: medRxiv, 2020
Éditeur: medRxiv
DOI: 10.1101/2020.05.18.20106088

Vascular Territory, White Matter Connections and the Neuroanatomical Basis of Memory Impairment after Stroke

Auteurs: Paul Wright, Michael J. O’Sullivan
Publié dans: medRxiv, 2013
Éditeur: medRxiv
DOI: 10.1101/19012385

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

Auteurs: Edith Hofer, Gennady V Roshchupkin, Hieab Adams, Maria Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola Armstrong, Claudia Satizabal, Manon Bernard, Joshua Bis, Nathan Gillespie, Michelle Luciano, Aniket Mishra, Markus Scholz, View ORCID ProfileAlexander Teumer, Rui Xia, Xueqiu Jian, Thomas Mosley, Yasaman Saba, Lukas Pirpamer, Stephan Seiler, James Becker, Owen Carmichael, Jerome
Publié dans: bioRxiv, 2018
Éditeur: bioRxiv
DOI: 10.1101/409649

Planar cell polarity pathway and development of the human visual cortex

Auteurs: Jean Shin, Shaojie Ma, Edith Hofer, Yash Patel, Gennady Roshchupkin, Andre M Sousa, Xueqiu Jian, Rebecca Gottesmann, Thomas H Mosley, Myriam Fornage, Yasaman Saba, Lukas Pirpamer, Reinhold Schmidt, Helena Schmidt, Bernard Mazoyer, Amaia Carrion-Castillo, Joshua Bis, Shuo Li, Qiong Yang, Michelle Luciano, Sherif Karama, Lindsay Lewis, Mark Bastin, Matthew A Harris, Ian Deary, Joanna M Wardlaw, Mark
Publié dans: bioRxiv, 2018
Éditeur: bioRxiv
DOI: 10.1101/404558

Meta-analysis of genetic association with diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing

Auteurs: Brian W. Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C. Bis, Adam C. Naj, Anne Boland, Maria Vronskaya, Sven J van der Lee, Alex Amlie-Wolf, Celine Bellenguez, Aura Frizatti, Vincent Chouraki, Alzheimer's Disease Genetics Consortium (ADGC), European Alzheimer's Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environm
Publié dans: bioRxiv, 2018
Éditeur: bioRxiv
DOI: 10.1101/294629

Identification of hippocampal volume as a mediator of the association between APOE4 and dementia

Auteurs: Sixtine Brenek, Stéphanie Debette, Sophie Auriacombe, Philippe Amouyel, Vincent Chouraki, Aline Meirhaeghe, Vincent Damotte
Publié dans: medRxiv, 2020
Éditeur: medRxiv
DOI: 10.1101/2020.12.04.20242461

KL-VS heterozygosity is associated with reduced tau accumulation and lower memory impairment in Alzheimer’s disease

Auteurs: Julia Neitzel, Nicolai Franzmeier, Anna Rubinski, Martin Dichgans, Matthias Brendel, Rainer Malik, Michael Ewers, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Publié dans: medRxiv, 2020
Éditeur: medRxiv
DOI: 10.1101/2020.07.29.20164434

Metabolomic profiling in small vessel disease identifies multiple associations with disease severity

Auteurs: Eric L. Harshfield, Caroline J. Sands, Anil M. Tuladhar, Frank-Erik de Leeuw, Matthew R. Lewis, Hugh S. Markus
Publié dans: medRxiv, 2021
Éditeur: medRxiv
DOI: 10.1101/2021.05.13.21257190

New insights on the genetic etiology of Alzheimer’s and related dementia

Auteurs: Céline Bellenguez, Fahri Küçükali, Iris Jansen, Victor Andrade, Sonia Moreno-Grau, Najaf Amin, Adam C. Naj, Benjamin Grenier-Boley, Rafael Campos-Martin, Peter A. Holmans, Anne Boland, Luca Kleineidam, Vincent Damotte, Sven J. van der Lee, Teemu Kuulasmaa, Qiong Yang, Itziar de Rojas, Joshua C. Bis, Amber Yaqub, Ivana Prokic, Marcos R Costa, Julien Chapuis, Shahzad Ahmad, Vilmantas Giedraitis,
Publié dans: medRxiv, 2020
Éditeur: medRxiv
DOI: 10.1101/2020.10.01.20200659

In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer’s disease phases

Auteurs: Daniela Perani, Arianna Sala, Silvia Paola Caminiti, Luca Presotto, Andrea Pilotto, Claudio Liguori, Agostino Chiaravalloti, Valentina Garibotto, Giovanni Battista Frisoni, Marcello D’Amelio, Barbara Paghera, Orazio Schillaci, Nicola Mercuri, Alessandro Padovani
Publié dans: Alzheimer's Research and Therapy, 2021, ISSN 1758-9193
Éditeur: BioMed Central
DOI: 10.21203/rs.3.rs-212818/v1

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