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Advanced Regenerative and REStorative Therapies to combat corneal BLINDNESS

Objective

Over 30 million Europeans are blind or visually impaired, leading to reduced quality of life and a tremendous loss of productivity in society. Corneal blindness is the second largest cause of blindness globally and while treatable, millions remain unnecessarily blind due to issues of access to transplantable tissue, lack of standardized treatments, and the lag in translating new regenerative medicine therapies to the clinic. The objective of ARREST BLINDNESS is therefore to develop and validate new regenerative-based therapies addressing a spectrum of blinding disorders of the cornea. These conditions either have no effective current treatments, depend on a scarce supply of donor tissue, or non-standardized methods are hindering validation of promising regenerative treatments. To achieve our objective, we will implant GMP-fabricated collagen-based bioengineered scaffolds to replace or regenerate the corneal stroma in cases of stromal thinning, scarring, dystrophy or trauma; deliver therapeutic epithelial stem and endothelial cells to the cornea to restore its transparency; deliver regenerative factors to promote neural growth and function; and actively maintain corneal immune privilege in high-risk situations by targeted therapeutic approaches to regress blood and lymphatic vessels. We will additionally develop advanced methods to image and monitor therapy throughout the cycle from GMP-compliant cell and scaffold preparation through the pre- and intra-operative stages, to postoperative follow-up and evaluation. After proof-of-concept and preclinical validation of key enabling components, these technologies will be used by one or several partners in preclinical models and in phase I/II human clinical studies. ARREST BLINDNESS directly addresses the translation of regenerative medicine, bio-artificial organs, tissue engineered scaffolds, and advanced cell and gene therapies into clinical use and will help to alleviate the worldwide problem of corneal blindness.

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2015-two-stage

Coordinator

LINKOPINGS UNIVERSITET
Net EU contribution
€ 1 623 175,00
Address
Campus Valla
581 83 Linkoping
Sweden

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Region
Östra Sverige Östra Mellansverige Östergötlands län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (14)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

OSTERGOTLANDS LANS LANDSTING

Participation ended

Sweden
Net EU contribution
€ 0,00
Address
Larsgatan 49b
581 91 Linkoping

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Region
Östra Sverige Östra Mellansverige Östergötlands län
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
AEON ASTRON EUROPE B.V.
Netherlands
Net EU contribution
€ 277 075,00
Address
J.h. Oortweg 19
2333 CH Leiden

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
NETHERLANDS INSTITUTE FOR INNOVATIVE OCULAR SURGERY
Netherlands
Net EU contribution
€ 622 582,50
Address
Laan Op Zuid 88
3071AA Rotterdam

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITAIR ZIEKENHUIS ANTWERPEN
Belgium
Net EU contribution
€ 738 065,00
Address
Drie Eikenstraat 655
2650 Edegem

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Region
Vlaams Gewest Prov. Antwerpen Arr. Antwerpen
Activity type
Research Organisations
Non-EU contribution
€ 0,00
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
Net EU contribution
€ 1 122 407,50
Address
Kerpener Strasse 62
50937 Koeln

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Region
Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Spain
Net EU contribution
€ 397 656,25
Address
Avenida De La Universidad S-n
03202 Elche

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Region
Este Comunitat Valenciana Alicante/Alacant
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AARHUS UNIVERSITET
Denmark
Net EU contribution
€ 237 165,00
Address
Nordre Ringgade 1
8000 Aarhus C

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Region
Danmark Midtjylland Østjylland
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG
Austria
Net EU contribution
€ 142 800,00
Non-EU contribution
€ 0,00
LINKOCARE LIFE SCIENCES AB
Sweden
Net EU contribution
€ 321 278,75
Address
Mjardevi Science Park, Teknikringen 10, Plan 3
58330 Linkoping

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Östra Sverige Östra Mellansverige Östergötlands län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
HAAG STREIT SURGICAL GMBH & CO KG
Germany
Net EU contribution
€ 233 097,50
Address
Rosengarten 10
22880 Wedel

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Region
Schleswig-Holstein Schleswig-Holstein Pinneberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

MEDIZINISCHES LASERZENTRUM LUBECK GMBH
Germany
Net EU contribution
€ 48 125,00
Address
Peter Monnik Weg 4
23562 Lubeck

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Schleswig-Holstein Schleswig-Holstein Lübeck, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00
NOVALIQ GMBH
Germany
Net EU contribution
€ 149 250,00
Address
Im Neuenheimer Feld 515
69120 Heidelberg

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
GENE SIGNAL INTERNATIONAL SA

Participation ended

Switzerland
Net EU contribution
€ 0,00
Address
Parc Scientifique Epfl - Pse A
1015 Lausanne

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 36 875,00
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Net EU contribution
€ 80 500,00
Address
Albinusdreef 2
2333 ZA Leiden

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00