GlucoCEST Imaging of Neoplastic Tumours

Livrables

Development and implementation of optimized MR T2 and T1ρ techniques
Development and implementation of optimized MRI CEST sequences based, e.g. on SSFP
Optimised saturation and excitation RF pulses for 3T, 7T, and 9.4T
N-pool Bloch-McConnell simulation software

Estimate of the coefficients of variation, signal- and contrast-to-noise of both sequences on volunteers
Assessment of in vitro magnetic field dependence properties
Evaluation of response to new anticancer therapy
Assessment of intracellular energy substrate levels upon native and methylated glucose injections
Comparison of GlucoCEST contrast with [18F]FDG uptake
Report on maintenance of website, updating with project news, results, success information
Dependence of detection thresholds on administration ways
Combined optical and MR-based measurements of intracellular glucose concentration
Ethics protocols, informed consents and information sheets for scanning the right number of patients (incl. high field)

Submission to the EC of Ethics protocols, informed consents and information sheets for scanning the right number of patients (incl. high field)

Assessing the intra-/extracellular localisation of 3OMG by measuring pH

OMG by measuring pH

Ethical approval for animal experiments, with personal licenses (incl. translation)

Demonstration of obtaining ethical approval for animal experiments, with personal licenses (incl. translation) to ensure ethical requirements are met.

Technical validation of the GlucoCEST technique in human cancers
Biological validation of the GlucoCEST technique against imaging markers, histopathology and genomics
pK by combined CEST / 13C NMR spectroscopy
Development and testing of new Glucose analogues
Evaluation of response to conventional therapy
Ethics for scanning children and scanning of first paediatric lymphoma patient
Assessment of in vivo pH dependence of GlucoCEST contrast in mouse tumour models using CEST-based agents
Assessment of GlucoCEST effect of 3OMG on a number of tumour models including from breast tumour cell lines DA3, 4T1, and MCF7 and brain metastases of the DA3 tumour cells.

Scanning of 1st adult patient for head-and-neck tumours and gliomas
Up-to-date steady-state and dynamic MRI sequences for GlucoCEST

Set up of website

Set up of website to promote GLINT

Biomarker qualification of GlucoCEST

Publications

QUESP and QUEST revisited - fast and accurate quantitative CEST experiments

Auteurs: Moritz Zaiss, Goran Angelovski, Eleni Demetriou, Michael T. McMahon, Xavier Golay, Klaus Scheffler
Publié dans: Magnetic Resonance in Medicine, Numéro 79/3, 2018, Page(s) 1708-1721, ISSN 0740-3194
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/mrm.26813

Generation of multiparametric MRI maps by using Gd-labelled- RBCs reveals phenotypes and stages of murine prostate cancer

Auteurs: Ferrauto, Giuseppe; Di Gregorio, Enza; Lanzardo, Stefania; Ciolli, Laura; Iezzi, Manuela; Aime, Silvio
Publié dans: Scientific Reports, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-28926-5

EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging

Auteurs: Longo, Dario Livio; Moustaghfir, Fatima Zzahra; Zerbo, Alexandre; Consolino, Lorena; Anemone, Annasofia; Bracesco, Martina; Aime, Silvio
Publié dans: International Journal of Pharmaceutics, 2017, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2017.04.040

Snapshot-CEST: Optimizing spiral-centric-reordered gradient echo acquisition for fast and robust 3D CEST MRI at 9.4 T

Auteurs: Moritz Zaiss, Philipp Ehses, Klaus Scheffler
Publié dans: NMR in Biomedicine, Numéro 31/4, 2018, Page(s) e3879, ISSN 0952-3480
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/nbm.3879

3D gradient echo snapshot CEST MRI with low power saturation for human studies at 3T

Auteurs: Anagha Deshmane, Moritz Zaiss, Tobias Lindig, Kai Herz, Mark Schuppert, Chirayu Gandhi, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler
Publié dans: Magnetic Resonance in Medicine, Numéro 81/4, 2019, Page(s) 2412-2423, ISSN 0740-3194
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27569

Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging

Auteurs: Francesca Arena, Pietro Irrera, Lorena Consolino, Sonia Colombo Serra, Moritz Zaiss, Dario Livio Longo
Publié dans: Journal of Magnetic Resonance, Numéro 287, 2018, Page(s) 1-9, ISSN 1090-7807
Éditeur: Academic Press
DOI: 10.1016/j.jmr.2017.12.007

CEST imaging at 9.4 T using adjusted adiabatic spin-lock pulses for on- and off-resonant T1⍴-dominated Z-spectrum acquisition

Auteurs: Kai Herz, Chirayu Gandhi, Mark Schuppert, Anagha Deshmane, Klaus Scheffler, Moritz Zaiss
Publié dans: Magnetic Resonance in Medicine, Numéro 81/1, 2019, Page(s) 275-290, ISSN 0740-3194
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27380

Possible artifacts in dynamic CEST MRI due to motion and field alterations

Auteurs: Moritz Zaiss, Kai Herz, Anagha Deshmane, Mina Kim, Xavier Golay, Tobias Lindig, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler
Publié dans: Journal of Magnetic Resonance, Numéro 298, 2019, Page(s) 16-22, ISSN 1090-7807
Éditeur: Academic Press
DOI: 10.1016/j.jmr.2018.11.002

Chemical exchange saturation transfer MRI contrast in the human brain at 9.4 T

Auteurs: Moritz Zaiss, Mark Schuppert, Anagha Deshmane, Kai Herz, Philipp Ehses, Lars Füllbier, Tobias Lindig, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler
Publié dans: NeuroImage, Numéro 179, 2018, Page(s) 144-155, ISSN 1053-8119
Éditeur: Academic Press
DOI: 10.1016/j.neuroimage.2018.06.026

3-O-Methyl-d-glucose mutarotation and proton exchange rates assessed by 13C, 1H NMR and by chemical exchange saturation transfer and spin lock measurements

Auteurs: Michal Rivlin, Gil Navon
Publié dans: Journal of Biomolecular NMR, Numéro 72/1-2, 2018, Page(s) 93-103, ISSN 0925-2738
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10858-018-0209-y

Adaptive denoising for chemical exchange saturation transfer MR imaging

Auteurs: Johannes Breitling, Anagha Deshmane, Steffen Goerke, Andreas Korzowski, Kai Herz, Mark E. Ladd, Klaus Scheffler, Peter Bachert, Moritz Zaiss
Publié dans: NMR in Biomedicine, Numéro 32/11, 2019, ISSN 0952-3480
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4133

Multiple interleaved mode saturation (MIMOSA) for B 1 + inhomogeneity mitigation in chemical exchange saturation transfer

Auteurs: Andrzej Liebert, Moritz Zaiss, Rene Gumbrecht, Katharina Tkotz, Peter Linz, Benjamin Schmitt, Frederik B. Laun, Arnd Doerfler, Michael Uder, Armin M. Nagel
Publié dans: Magnetic Resonance in Medicine, Numéro 82/2, 2019, Page(s) 693-705, ISSN 0740-3194
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27762

Quantification of hydroxyl exchange of D‐Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9.4 Tesla

Auteurs: Moritz Zaiss, Annasofia Anemone, Steffen Goerke, Dario Livio Longo, Kai Herz, Rolf Pohmann, Silvio Aime, Michal Rivlin, Gil Navon, Xavier Golay, Klaus Scheffler
Publié dans: NMR in Biomedicine, 2019, ISSN 0952-3480
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4113

Molecular imaging of tumors by chemical exchange saturation transfer MRI of glucose analogs

Auteurs: Michal Rivlin, Gil Navon
Publié dans: Quantitative Imaging in Medicine and Surgery, Numéro 9/10, 2019, Page(s) 1731-1746, ISSN 2223-4292
Éditeur: AME Publishing company
DOI: 10.21037/qims.2019.09.12

Challenges in glucoCEST MR body imaging at 3 Tesla

Auteurs: Mina Kim, Francisco Torrealdea, Sola Adeleke, Marilena Rega, Vincent Evans, Teresita Beeston, Katerina Soteriou, Stefanie Thust, Aaron Kujawa, Sachi Okuchi, Elizabeth Isaac, Wivijin Piga, Jonathan R. Lambert, Asim Afaq, Eleni Demetriou, Pratik Choudhary, King Kenneth Cheung, Sarita Naik, David Atkinson, Shonit Punwani, Xavier Golay
Publié dans: Quantitative Imaging in Medicine and Surgery, Numéro 9/10, 2019, Page(s) 1628-1640, ISSN 2223-4292
Éditeur: AME Publishing Company
DOI: 10.21037/qims.2019.10.05

Assessment of a clinically feasible Bayesian fitting algorithm using a simplified description of Chemical Exchange Saturation Transfer (CEST) imaging

Auteurs: Aaron Kujawa, Mina Kim, Eleni Demetriou, Annasofia Anemone, Dario Livio Longo, Moritz Zaiss, Xavier Golay
Publié dans: Journal of Magnetic Resonance, Numéro 300, 2019, Page(s) 120-134, ISSN 1090-7807
Éditeur: Academic Press
DOI: 10.1016/j.jmr.2019.01.006

CEST MRI of 3-O-methyl-D-glucose on different breast cancer models

Auteurs: Michal Rivlin, Gil Navon
Publié dans: Magnetic Resonance in Medicine, 2017, ISSN 0740-3194
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/mrm.26752

In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging

Auteurs: Annasofia Anemone, Lorena Consolino, Laura Conti, Francesca Reineri, Federica Cavallo, Silvio Aime, Dario Longo
Publié dans: International Journal of Oncology, 2017, ISSN 1019-6439
Éditeur: Demetrios A. Spandidos Ed. & Pub.
DOI: 10.3892/ijo.2017.4029

Principal Process Analysis of dynamic GlucoCEST MRI data

Auteurs: Casagranda, Stefano; Pizzolato, Marco; Torrealdea, Francisco; Golay, Xavier; Boutelier, Timothé
Publié dans: ISMRM 2018, Numéro 1, 2018
Éditeur: Archives ouvertes HAL

Bayesian fitting of Chemical Exchange Saturation Transfer (CEST) imaging data with an analytical model for multiple CEST pools

Auteurs: Aaron Kujawa , Eleni Demetriou , Mina Kim , Moritz Zaiss , Xavier Golay
Publié dans: ISMRM 2019, 2019
Éditeur: International Society for Magnetic Resonance in Medicine

Fluid suppression in CEST imaging affects predominantly IDH-mutant 1p/19q retained gliomas with T2-FLAIR mismatch

Auteurs: S. Casagranda, L. Mancini, G. Gautier, P. Peter, B. Lopez, S. Brandner, E. De Vita, X. Golay, and S. Bisdas
Publié dans: ISMRM 2020, 2020
Éditeur: International Society for Magnetic Resonance in Medicine

Glioma staging with CEST asymmetry curves and amides/amines ratio

Auteurs: L.Mancini, S. Casagranda, F. Torrealdea, M.Rega, E. De Vita, B. Lopez, S. Brandner, B. Schmitt, P. Liebig, E. Sanverdi, X. Golay, S. Bisdas
Publié dans: ISRM 2020, 2020
Éditeur: International Society for Magnetic Resonance in Medicine

Translating pH-sensitive PROgressive saturation for Quantifying Exchange using Saturation Times (PRO-QUEST) MRI to a 3T Clinical Scanner

Auteurs: Mina Kim , Marco Battiston , Eleni Demetriou , Aaron Kujawa , Torben Schneider , Vincent Evans , Sachi Okuchi , David Atkinson , Claudia Wheeler-Kingshott , Xavier Golay
Publié dans: ISMRM 2019, 2019
Éditeur: International Society for Magnetic Resonance in Medicine

T1ρ‐based dynamic glucose‐enhanced (DGEρ) MRI at 3 T: method development and early clinical experience in the human brain

Auteurs: Kai Herz, Tobias Lindig, Anagha Deshmane, Jens Schittenhelm, Marco Skardelly, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler, Moritz Zaiss
Publié dans: Magnetic Resonance in Medicine, Numéro 82/5, 2019, Page(s) 1832-1847, ISSN 0740-3194
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27857

Droits de propriété intellectuelle

METHOD AND APPARATUS FOR PROCESSING MAGNETIC RESONANCE DATA USING MACHINE LEARNING

Numéro de demande/publication: 18 191698
Date: 2018-08-30

GLUCOSE ANALOGS FOR DIAGNOSIS OF DISEASE STATES

Numéro de demande/publication: EP 15732449
Date: 2015-03-26

Methods and means for imaging

Numéro de demande/publication: GB 1705653.2
Date: 2017-04-07

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