GlucoCEST Imaging of Neoplastic Tumours

Informacje na temat projektu

GLINT

Identyfikator umowy o grant: 667510

DOI

10.3030/667510

Projekt został zamknięty

Data podpisania przez KE 9 Grudnia 2015

Data rozpoczęcia 1 Stycznia 2016

Data zakończenia 31 Grudnia 2019

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 6 454 612,00

Wkład UE

€ 5 797 799,00

Koordynowany przez

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Other (4)

Development and implementation of optimized MR T2 and T1ρ techniques
Development and implementation of optimized MRI CEST sequences based, e.g. on SSFP
Optimised saturation and excitation RF pulses for 3T, 7T, and 9.4T
N-pool Bloch-McConnell simulation software

Documents, reports (19)

Estimate of the coefficients of variation, signal- and contrast-to-noise of both sequences on volunteers
Assessment of in vitro magnetic field dependence properties
Evaluation of response to new anticancer therapy
Assessment of intracellular energy substrate levels upon native and methylated glucose injections
Comparison of GlucoCEST contrast with [18F]FDG uptake
Report on maintenance of website, updating with project news, results, success information
Dependence of detection thresholds on administration ways
Combined optical and MR-based measurements of intracellular glucose concentration
Ethics protocols, informed consents and information sheets for scanning the right number of patients (incl. high field)

Submission to the EC of Ethics protocols, informed consents and information sheets for scanning the right number of patients (incl. high field)

Assessing the intra-/extracellular localisation of 3OMG by measuring pH

OMG by measuring pH

Ethical approval for animal experiments, with personal licenses (incl. translation)

Demonstration of obtaining ethical approval for animal experiments, with personal licenses (incl. translation) to ensure ethical requirements are met.

Technical validation of the GlucoCEST technique in human cancers
Biological validation of the GlucoCEST technique against imaging markers, histopathology and genomics
pK by combined CEST / 13C NMR spectroscopy
Development and testing of new Glucose analogues
Evaluation of response to conventional therapy
Ethics for scanning children and scanning of first paediatric lymphoma patient
Assessment of in vivo pH dependence of GlucoCEST contrast in mouse tumour models using CEST-based agents
Assessment of GlucoCEST effect of 3OMG on a number of tumour models including from breast tumour cell lines DA3, 4T1, and MCF7 and brain metastases of the DA3 tumour cells.

Demonstrators, pilots, prototypes (2)

Scanning of 1st adult patient for head-and-neck tumours and gliomas
Up-to-date steady-state and dynamic MRI sequences for GlucoCEST

Websites, patent fillings, videos etc. (2)

Set up of website

Set up of website to promote GLINT

Biomarker qualification of GlucoCEST

Publikacje

Peer reviewed articles (18)

QUESP and QUEST revisited - fast and accurate quantitative CEST experiments

Autorzy: Moritz Zaiss, Goran Angelovski, Eleni Demetriou, Michael T. McMahon, Xavier Golay, Klaus Scheffler
Opublikowane w: Magnetic Resonance in Medicine, Numer 79/3, 2018, Strona(/y) 1708-1721, ISSN 0740-3194
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/mrm.26813

Generation of multiparametric MRI maps by using Gd-labelled- RBCs reveals phenotypes and stages of murine prostate cancer

Autorzy: Ferrauto, Giuseppe; Di Gregorio, Enza; Lanzardo, Stefania; Ciolli, Laura; Iezzi, Manuela; Aime, Silvio
Opublikowane w: Scientific Reports, 2018, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-018-28926-5

EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging

Autorzy: Longo, Dario Livio; Moustaghfir, Fatima Zzahra; Zerbo, Alexandre; Consolino, Lorena; Anemone, Annasofia; Bracesco, Martina; Aime, Silvio
Opublikowane w: International Journal of Pharmaceutics, 2017, ISSN 0378-5173
Wydawca: Elsevier BV
DOI: 10.1016/j.ijpharm.2017.04.040

Snapshot-CEST: Optimizing spiral-centric-reordered gradient echo acquisition for fast and robust 3D CEST MRI at 9.4 T

Autorzy: Moritz Zaiss, Philipp Ehses, Klaus Scheffler
Opublikowane w: NMR in Biomedicine, Numer 31/4, 2018, Strona(/y) e3879, ISSN 0952-3480
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/nbm.3879

3D gradient echo snapshot CEST MRI with low power saturation for human studies at 3T

Autorzy: Anagha Deshmane, Moritz Zaiss, Tobias Lindig, Kai Herz, Mark Schuppert, Chirayu Gandhi, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler
Opublikowane w: Magnetic Resonance in Medicine, Numer 81/4, 2019, Strona(/y) 2412-2423, ISSN 0740-3194
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27569

Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging

Autorzy: Francesca Arena, Pietro Irrera, Lorena Consolino, Sonia Colombo Serra, Moritz Zaiss, Dario Livio Longo
Opublikowane w: Journal of Magnetic Resonance, Numer 287, 2018, Strona(/y) 1-9, ISSN 1090-7807
Wydawca: Academic Press
DOI: 10.1016/j.jmr.2017.12.007

CEST imaging at 9.4 T using adjusted adiabatic spin-lock pulses for on- and off-resonant T1⍴-dominated Z-spectrum acquisition

Autorzy: Kai Herz, Chirayu Gandhi, Mark Schuppert, Anagha Deshmane, Klaus Scheffler, Moritz Zaiss
Opublikowane w: Magnetic Resonance in Medicine, Numer 81/1, 2019, Strona(/y) 275-290, ISSN 0740-3194
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27380

Possible artifacts in dynamic CEST MRI due to motion and field alterations

Autorzy: Moritz Zaiss, Kai Herz, Anagha Deshmane, Mina Kim, Xavier Golay, Tobias Lindig, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler
Opublikowane w: Journal of Magnetic Resonance, Numer 298, 2019, Strona(/y) 16-22, ISSN 1090-7807
Wydawca: Academic Press
DOI: 10.1016/j.jmr.2018.11.002

Chemical exchange saturation transfer MRI contrast in the human brain at 9.4 T

Autorzy: Moritz Zaiss, Mark Schuppert, Anagha Deshmane, Kai Herz, Philipp Ehses, Lars Füllbier, Tobias Lindig, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler
Opublikowane w: NeuroImage, Numer 179, 2018, Strona(/y) 144-155, ISSN 1053-8119
Wydawca: Academic Press
DOI: 10.1016/j.neuroimage.2018.06.026

3-O-Methyl-d-glucose mutarotation and proton exchange rates assessed by 13C, 1H NMR and by chemical exchange saturation transfer and spin lock measurements

Autorzy: Michal Rivlin, Gil Navon
Opublikowane w: Journal of Biomolecular NMR, Numer 72/1-2, 2018, Strona(/y) 93-103, ISSN 0925-2738
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10858-018-0209-y

Adaptive denoising for chemical exchange saturation transfer MR imaging

Autorzy: Johannes Breitling, Anagha Deshmane, Steffen Goerke, Andreas Korzowski, Kai Herz, Mark E. Ladd, Klaus Scheffler, Peter Bachert, Moritz Zaiss
Opublikowane w: NMR in Biomedicine, Numer 32/11, 2019, ISSN 0952-3480
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4133

Multiple interleaved mode saturation (MIMOSA) for B 1 + inhomogeneity mitigation in chemical exchange saturation transfer

Autorzy: Andrzej Liebert, Moritz Zaiss, Rene Gumbrecht, Katharina Tkotz, Peter Linz, Benjamin Schmitt, Frederik B. Laun, Arnd Doerfler, Michael Uder, Armin M. Nagel
Opublikowane w: Magnetic Resonance in Medicine, Numer 82/2, 2019, Strona(/y) 693-705, ISSN 0740-3194
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27762

Quantification of hydroxyl exchange of D‐Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9.4 Tesla

Autorzy: Moritz Zaiss, Annasofia Anemone, Steffen Goerke, Dario Livio Longo, Kai Herz, Rolf Pohmann, Silvio Aime, Michal Rivlin, Gil Navon, Xavier Golay, Klaus Scheffler
Opublikowane w: NMR in Biomedicine, 2019, ISSN 0952-3480
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4113

Molecular imaging of tumors by chemical exchange saturation transfer MRI of glucose analogs

Autorzy: Michal Rivlin, Gil Navon
Opublikowane w: Quantitative Imaging in Medicine and Surgery, Numer 9/10, 2019, Strona(/y) 1731-1746, ISSN 2223-4292
Wydawca: AME Publishing company
DOI: 10.21037/qims.2019.09.12

Challenges in glucoCEST MR body imaging at 3 Tesla

Autorzy: Mina Kim, Francisco Torrealdea, Sola Adeleke, Marilena Rega, Vincent Evans, Teresita Beeston, Katerina Soteriou, Stefanie Thust, Aaron Kujawa, Sachi Okuchi, Elizabeth Isaac, Wivijin Piga, Jonathan R. Lambert, Asim Afaq, Eleni Demetriou, Pratik Choudhary, King Kenneth Cheung, Sarita Naik, David Atkinson, Shonit Punwani, Xavier Golay
Opublikowane w: Quantitative Imaging in Medicine and Surgery, Numer 9/10, 2019, Strona(/y) 1628-1640, ISSN 2223-4292
Wydawca: AME Publishing Company
DOI: 10.21037/qims.2019.10.05

Assessment of a clinically feasible Bayesian fitting algorithm using a simplified description of Chemical Exchange Saturation Transfer (CEST) imaging

Autorzy: Aaron Kujawa, Mina Kim, Eleni Demetriou, Annasofia Anemone, Dario Livio Longo, Moritz Zaiss, Xavier Golay
Opublikowane w: Journal of Magnetic Resonance, Numer 300, 2019, Strona(/y) 120-134, ISSN 1090-7807
Wydawca: Academic Press
DOI: 10.1016/j.jmr.2019.01.006

CEST MRI of 3-O-methyl-D-glucose on different breast cancer models

Autorzy: Michal Rivlin, Gil Navon
Opublikowane w: Magnetic Resonance in Medicine, 2017, ISSN 0740-3194
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/mrm.26752

In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging

Autorzy: Annasofia Anemone, Lorena Consolino, Laura Conti, Francesca Reineri, Federica Cavallo, Silvio Aime, Dario Longo
Opublikowane w: International Journal of Oncology, 2017, ISSN 1019-6439
Wydawca: Demetrios A. Spandidos Ed. & Pub.
DOI: 10.3892/ijo.2017.4029

Conference proceedings (5)

Principal Process Analysis of dynamic GlucoCEST MRI data

Autorzy: Casagranda, Stefano; Pizzolato, Marco; Torrealdea, Francisco; Golay, Xavier; Boutelier, Timothé
Opublikowane w: ISMRM 2018, Numer 1, 2018
Wydawca: Archives ouvertes HAL

Bayesian fitting of Chemical Exchange Saturation Transfer (CEST) imaging data with an analytical model for multiple CEST pools

Autorzy: Aaron Kujawa , Eleni Demetriou , Mina Kim , Moritz Zaiss , Xavier Golay
Opublikowane w: ISMRM 2019, 2019
Wydawca: International Society for Magnetic Resonance in Medicine

Fluid suppression in CEST imaging affects predominantly IDH-mutant 1p/19q retained gliomas with T2-FLAIR mismatch

Autorzy: S. Casagranda, L. Mancini, G. Gautier, P. Peter, B. Lopez, S. Brandner, E. De Vita, X. Golay, and S. Bisdas
Opublikowane w: ISMRM 2020, 2020
Wydawca: International Society for Magnetic Resonance in Medicine

Glioma staging with CEST asymmetry curves and amides/amines ratio

Autorzy: L.Mancini, S. Casagranda, F. Torrealdea, M.Rega, E. De Vita, B. Lopez, S. Brandner, B. Schmitt, P. Liebig, E. Sanverdi, X. Golay, S. Bisdas
Opublikowane w: ISRM 2020, 2020
Wydawca: International Society for Magnetic Resonance in Medicine

Translating pH-sensitive PROgressive saturation for Quantifying Exchange using Saturation Times (PRO-QUEST) MRI to a 3T Clinical Scanner

Autorzy: Mina Kim , Marco Battiston , Eleni Demetriou , Aaron Kujawa , Torben Schneider , Vincent Evans , Sachi Okuchi , David Atkinson , Claudia Wheeler-Kingshott , Xavier Golay
Opublikowane w: ISMRM 2019, 2019
Wydawca: International Society for Magnetic Resonance in Medicine

Non-peer reviewed articles (1)

T1ρ‐based dynamic glucose‐enhanced (DGEρ) MRI at 3 T: method development and early clinical experience in the human brain

Autorzy: Kai Herz, Tobias Lindig, Anagha Deshmane, Jens Schittenhelm, Marco Skardelly, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler, Moritz Zaiss
Opublikowane w: Magnetic Resonance in Medicine, Numer 82/5, 2019, Strona(/y) 1832-1847, ISSN 0740-3194
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27857

Prawa własności intelektualnej

Patent (3)

METHOD AND APPARATUS FOR PROCESSING MAGNETIC RESONANCE DATA USING MACHINE LEARNING

Numer wniosku/publikacji: 18 191698
Data: 2018-08-30
Wnioskodawca/wnioskodawcy: MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

GLUCOSE ANALOGS FOR DIAGNOSIS OF DISEASE STATES

Numer wniosku/publikacji: EP 15732449
Data: 2015-03-26
Wnioskodawca/wnioskodawcy: TEL AVIV UNIVERSITY

Methods and means for imaging

Numer wniosku/publikacji: GB 1705653.2
Data: 2017-04-07
Wnioskodawca/wnioskodawcy: UNIVERSITY COLLEGE LONDON