GlucoCEST Imaging of Neoplastic Tumours

Informazioni relative al progetto

GLINT

ID dell’accordo di sovvenzione: 667510

DOI

10.3030/667510

Progetto chiuso

Data della firma CE 9 Dicembre 2015

Data di avvio 1 Gennaio 2016

Data di completamento 31 Dicembre 2019

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 6 454 612,00

Contributo UE

€ 5 797 799,00

Coordinato da

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (4)

Development and implementation of optimized MR T2 and T1ρ techniques
Development and implementation of optimized MRI CEST sequences based, e.g. on SSFP
Optimised saturation and excitation RF pulses for 3T, 7T, and 9.4T
N-pool Bloch-McConnell simulation software

Documents, reports (19)

Estimate of the coefficients of variation, signal- and contrast-to-noise of both sequences on volunteers
Assessment of in vitro magnetic field dependence properties
Evaluation of response to new anticancer therapy
Assessment of intracellular energy substrate levels upon native and methylated glucose injections
Comparison of GlucoCEST contrast with [18F]FDG uptake
Report on maintenance of website, updating with project news, results, success information
Dependence of detection thresholds on administration ways
Combined optical and MR-based measurements of intracellular glucose concentration
Ethics protocols, informed consents and information sheets for scanning the right number of patients (incl. high field)

Submission to the EC of Ethics protocols, informed consents and information sheets for scanning the right number of patients (incl. high field)

Assessing the intra-/extracellular localisation of 3OMG by measuring pH

OMG by measuring pH

Ethical approval for animal experiments, with personal licenses (incl. translation)

Demonstration of obtaining ethical approval for animal experiments, with personal licenses (incl. translation) to ensure ethical requirements are met.

Technical validation of the GlucoCEST technique in human cancers
Biological validation of the GlucoCEST technique against imaging markers, histopathology and genomics
pK by combined CEST / 13C NMR spectroscopy
Development and testing of new Glucose analogues
Evaluation of response to conventional therapy
Ethics for scanning children and scanning of first paediatric lymphoma patient
Assessment of in vivo pH dependence of GlucoCEST contrast in mouse tumour models using CEST-based agents
Assessment of GlucoCEST effect of 3OMG on a number of tumour models including from breast tumour cell lines DA3, 4T1, and MCF7 and brain metastases of the DA3 tumour cells.

Demonstrators, pilots, prototypes (2)

Scanning of 1st adult patient for head-and-neck tumours and gliomas
Up-to-date steady-state and dynamic MRI sequences for GlucoCEST

Websites, patent fillings, videos etc. (2)

Set up of website

Set up of website to promote GLINT

Biomarker qualification of GlucoCEST

Pubblicazioni

Peer reviewed articles (18)

QUESP and QUEST revisited - fast and accurate quantitative CEST experiments

Autori: Moritz Zaiss, Goran Angelovski, Eleni Demetriou, Michael T. McMahon, Xavier Golay, Klaus Scheffler
Pubblicato in: Magnetic Resonance in Medicine, Numero 79/3, 2018, Pagina/e 1708-1721, ISSN 0740-3194
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrm.26813

Generation of multiparametric MRI maps by using Gd-labelled- RBCs reveals phenotypes and stages of murine prostate cancer

Autori: Ferrauto, Giuseppe; Di Gregorio, Enza; Lanzardo, Stefania; Ciolli, Laura; Iezzi, Manuela; Aime, Silvio
Pubblicato in: Scientific Reports, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-28926-5

EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging

Autori: Longo, Dario Livio; Moustaghfir, Fatima Zzahra; Zerbo, Alexandre; Consolino, Lorena; Anemone, Annasofia; Bracesco, Martina; Aime, Silvio
Pubblicato in: International Journal of Pharmaceutics, 2017, ISSN 0378-5173
Editore: Elsevier BV
DOI: 10.1016/j.ijpharm.2017.04.040

Snapshot-CEST: Optimizing spiral-centric-reordered gradient echo acquisition for fast and robust 3D CEST MRI at 9.4 T

Autori: Moritz Zaiss, Philipp Ehses, Klaus Scheffler
Pubblicato in: NMR in Biomedicine, Numero 31/4, 2018, Pagina/e e3879, ISSN 0952-3480
Editore: John Wiley & Sons Inc.
DOI: 10.1002/nbm.3879

3D gradient echo snapshot CEST MRI with low power saturation for human studies at 3T

Autori: Anagha Deshmane, Moritz Zaiss, Tobias Lindig, Kai Herz, Mark Schuppert, Chirayu Gandhi, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler
Pubblicato in: Magnetic Resonance in Medicine, Numero 81/4, 2019, Pagina/e 2412-2423, ISSN 0740-3194
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27569

Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging

Autori: Francesca Arena, Pietro Irrera, Lorena Consolino, Sonia Colombo Serra, Moritz Zaiss, Dario Livio Longo
Pubblicato in: Journal of Magnetic Resonance, Numero 287, 2018, Pagina/e 1-9, ISSN 1090-7807
Editore: Academic Press
DOI: 10.1016/j.jmr.2017.12.007

CEST imaging at 9.4 T using adjusted adiabatic spin-lock pulses for on- and off-resonant T1⍴-dominated Z-spectrum acquisition

Autori: Kai Herz, Chirayu Gandhi, Mark Schuppert, Anagha Deshmane, Klaus Scheffler, Moritz Zaiss
Pubblicato in: Magnetic Resonance in Medicine, Numero 81/1, 2019, Pagina/e 275-290, ISSN 0740-3194
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27380

Possible artifacts in dynamic CEST MRI due to motion and field alterations

Autori: Moritz Zaiss, Kai Herz, Anagha Deshmane, Mina Kim, Xavier Golay, Tobias Lindig, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler
Pubblicato in: Journal of Magnetic Resonance, Numero 298, 2019, Pagina/e 16-22, ISSN 1090-7807
Editore: Academic Press
DOI: 10.1016/j.jmr.2018.11.002

Chemical exchange saturation transfer MRI contrast in the human brain at 9.4 T

Autori: Moritz Zaiss, Mark Schuppert, Anagha Deshmane, Kai Herz, Philipp Ehses, Lars Füllbier, Tobias Lindig, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler
Pubblicato in: NeuroImage, Numero 179, 2018, Pagina/e 144-155, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2018.06.026

3-O-Methyl-d-glucose mutarotation and proton exchange rates assessed by 13C, 1H NMR and by chemical exchange saturation transfer and spin lock measurements

Autori: Michal Rivlin, Gil Navon
Pubblicato in: Journal of Biomolecular NMR, Numero 72/1-2, 2018, Pagina/e 93-103, ISSN 0925-2738
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10858-018-0209-y

Adaptive denoising for chemical exchange saturation transfer MR imaging

Autori: Johannes Breitling, Anagha Deshmane, Steffen Goerke, Andreas Korzowski, Kai Herz, Mark E. Ladd, Klaus Scheffler, Peter Bachert, Moritz Zaiss
Pubblicato in: NMR in Biomedicine, Numero 32/11, 2019, ISSN 0952-3480
Editore: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4133

Multiple interleaved mode saturation (MIMOSA) for B 1 + inhomogeneity mitigation in chemical exchange saturation transfer

Autori: Andrzej Liebert, Moritz Zaiss, Rene Gumbrecht, Katharina Tkotz, Peter Linz, Benjamin Schmitt, Frederik B. Laun, Arnd Doerfler, Michael Uder, Armin M. Nagel
Pubblicato in: Magnetic Resonance in Medicine, Numero 82/2, 2019, Pagina/e 693-705, ISSN 0740-3194
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27762

Quantification of hydroxyl exchange of D‐Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9.4 Tesla

Autori: Moritz Zaiss, Annasofia Anemone, Steffen Goerke, Dario Livio Longo, Kai Herz, Rolf Pohmann, Silvio Aime, Michal Rivlin, Gil Navon, Xavier Golay, Klaus Scheffler
Pubblicato in: NMR in Biomedicine, 2019, ISSN 0952-3480
Editore: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4113

Molecular imaging of tumors by chemical exchange saturation transfer MRI of glucose analogs

Autori: Michal Rivlin, Gil Navon
Pubblicato in: Quantitative Imaging in Medicine and Surgery, Numero 9/10, 2019, Pagina/e 1731-1746, ISSN 2223-4292
Editore: AME Publishing company
DOI: 10.21037/qims.2019.09.12

Challenges in glucoCEST MR body imaging at 3 Tesla

Autori: Mina Kim, Francisco Torrealdea, Sola Adeleke, Marilena Rega, Vincent Evans, Teresita Beeston, Katerina Soteriou, Stefanie Thust, Aaron Kujawa, Sachi Okuchi, Elizabeth Isaac, Wivijin Piga, Jonathan R. Lambert, Asim Afaq, Eleni Demetriou, Pratik Choudhary, King Kenneth Cheung, Sarita Naik, David Atkinson, Shonit Punwani, Xavier Golay
Pubblicato in: Quantitative Imaging in Medicine and Surgery, Numero 9/10, 2019, Pagina/e 1628-1640, ISSN 2223-4292
Editore: AME Publishing Company
DOI: 10.21037/qims.2019.10.05

Assessment of a clinically feasible Bayesian fitting algorithm using a simplified description of Chemical Exchange Saturation Transfer (CEST) imaging

Autori: Aaron Kujawa, Mina Kim, Eleni Demetriou, Annasofia Anemone, Dario Livio Longo, Moritz Zaiss, Xavier Golay
Pubblicato in: Journal of Magnetic Resonance, Numero 300, 2019, Pagina/e 120-134, ISSN 1090-7807
Editore: Academic Press
DOI: 10.1016/j.jmr.2019.01.006

CEST MRI of 3-O-methyl-D-glucose on different breast cancer models

Autori: Michal Rivlin, Gil Navon
Pubblicato in: Magnetic Resonance in Medicine, 2017, ISSN 0740-3194
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrm.26752

In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging

Autori: Annasofia Anemone, Lorena Consolino, Laura Conti, Francesca Reineri, Federica Cavallo, Silvio Aime, Dario Longo
Pubblicato in: International Journal of Oncology, 2017, ISSN 1019-6439
Editore: Demetrios A. Spandidos Ed. & Pub.
DOI: 10.3892/ijo.2017.4029

Conference proceedings (5)

Principal Process Analysis of dynamic GlucoCEST MRI data

Autori: Casagranda, Stefano; Pizzolato, Marco; Torrealdea, Francisco; Golay, Xavier; Boutelier, Timothé
Pubblicato in: ISMRM 2018, Numero 1, 2018
Editore: Archives ouvertes HAL

Bayesian fitting of Chemical Exchange Saturation Transfer (CEST) imaging data with an analytical model for multiple CEST pools

Autori: Aaron Kujawa , Eleni Demetriou , Mina Kim , Moritz Zaiss , Xavier Golay
Pubblicato in: ISMRM 2019, 2019
Editore: International Society for Magnetic Resonance in Medicine

Fluid suppression in CEST imaging affects predominantly IDH-mutant 1p/19q retained gliomas with T2-FLAIR mismatch

Autori: S. Casagranda, L. Mancini, G. Gautier, P. Peter, B. Lopez, S. Brandner, E. De Vita, X. Golay, and S. Bisdas
Pubblicato in: ISMRM 2020, 2020
Editore: International Society for Magnetic Resonance in Medicine

Glioma staging with CEST asymmetry curves and amides/amines ratio

Autori: L.Mancini, S. Casagranda, F. Torrealdea, M.Rega, E. De Vita, B. Lopez, S. Brandner, B. Schmitt, P. Liebig, E. Sanverdi, X. Golay, S. Bisdas
Pubblicato in: ISRM 2020, 2020
Editore: International Society for Magnetic Resonance in Medicine

Translating pH-sensitive PROgressive saturation for Quantifying Exchange using Saturation Times (PRO-QUEST) MRI to a 3T Clinical Scanner

Autori: Mina Kim , Marco Battiston , Eleni Demetriou , Aaron Kujawa , Torben Schneider , Vincent Evans , Sachi Okuchi , David Atkinson , Claudia Wheeler-Kingshott , Xavier Golay
Pubblicato in: ISMRM 2019, 2019
Editore: International Society for Magnetic Resonance in Medicine

Non-peer reviewed articles (1)

T1ρ‐based dynamic glucose‐enhanced (DGEρ) MRI at 3 T: method development and early clinical experience in the human brain

Autori: Kai Herz, Tobias Lindig, Anagha Deshmane, Jens Schittenhelm, Marco Skardelly, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler, Moritz Zaiss
Pubblicato in: Magnetic Resonance in Medicine, Numero 82/5, 2019, Pagina/e 1832-1847, ISSN 0740-3194
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27857

Diritti di proprietà intellettuale

Patent (3)

METHOD AND APPARATUS FOR PROCESSING MAGNETIC RESONANCE DATA USING MACHINE LEARNING

Numero candidatura/pubblicazione: 18 191698
Data: 2018-08-30
Candidato/i: MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

GLUCOSE ANALOGS FOR DIAGNOSIS OF DISEASE STATES

Numero candidatura/pubblicazione: EP 15732449
Data: 2015-03-26
Candidato/i: TEL AVIV UNIVERSITY

Methods and means for imaging

Numero candidatura/pubblicazione: GB 1705653.2
Data: 2017-04-07
Candidato/i: UNIVERSITY COLLEGE LONDON