New therapies for uveal melanoma

Resultado final

European guidelines for UM patient management and dissemination status

Our goal is also to work on European guidelines for UM patient management based on what is available alreday thourgh the UK guidelines They will include any additional data or recommendations from the UM Cure 2020 project and rely on the expertise of clinicians from the four European referral centres involved in the project Our objective is indeed to make those Europeanwide and applicable to any caregiver who could have to manage and treat a UM patientAt M60 these guidelines will be provided with a description of their dissemination status

Kick-off meeting

At M2 after the kick-off meeting for the project, a report will be produced which will include the detailed agenda and the minutes of the meeting, as a record of the efficient launch of the project.

Establishing a collection of approx. 200 metastatic UM samples

Our objective would be to reach approx 200 metastatic UM samples collected along the project with matched primary tissue and blood sample whenever possible At M60 at the end of the project we will produce a report on what we have been able to achieve through the concerted action of the reference centres involved and on what these biosamples have been partly used for in the frame of the project

Release of main UM Cure 2020 communication tools

The main communication tools for the project, namely the website, social media platforms and UM Cure 2020 Consent Card, will be set-up at project start, for a release at M4. A report at M4 will describe such tools and confirm their availability.

Agreement on minimum dataset for all currently banked UM biosamples

The aim of this deliverable is to share the information currently collected for UM patients and samples across the reference centres, in order to agree on a common minimal set of data that should be available for all UM samples. This precedes the harmonisation efforts among centres which is absolutely necessary to build the common virtual biobank. The common minimal set will be represented by an Excel file with one column per field to be included in the database, and an attached report with description of the work.

Status of prospective collection and use of collected biosamples

D1.3 will consist in a report on the status at M36 of recruitment of prospective UM biosamples under the project. In addition, the status of overall samples available through the network will be included, together with a summary of how these biosamples have been used so far for WP3 and WP4.

Publicaciones

The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases

Autores: Maria Luisa Cayuela, Kathleen B. M. Claes, Miguel Godinho Ferreira, Catarina Martins Henriques, Fredericus van Eeden, Máté Varga, Jeroen Vierstraete, Maria Caterina Mione
Publicado en: Frontiers in Cell and Developmental Biology, Edición 6, 2019, ISSN 2296-634X
Editor: Frontiers Media SA
DOI: 10.3389/fcell.2018.00178

Preclinical Evaluation of Trabectedin in Combination With Targeted Inhibitors for Treatment of Metastatic Uveal Melanoma

Autores: Kseniya Glinkina; Fariba Nemati; Amina F. A. S. Teunisse; Maria Chiara Gelmi; Vesnie Etienne; Muriel J. Kuipers; Samar Alsafadi; Martine J. Jager; Didier Decaudin; Aart G. Jochemsen
Publicado en: Investigative Ophthalmology & Visual Science, 2022, ISSN 0146-0404
Editor: Association for Research in Vision and Ophthalmology
DOI: 10.1167/iovs.63.13.14

Splicing patterns in SF3B1 mutated uveal melanoma generate shared immunogenic tumor-specific neo-epitopes

Autores: Jeremy Bigot, Ana I Lalanne, Francesca Lucibello, Paul Gueguen, Alexandre Houy, Stephane Dayot, Olivier Ganier, Jules Gilet, Jimena Tosello, Fariba Nemati, Gaelle Pierron, Joshua J Waterfall, Raymond Barnhill, Sophie Gardrat, Sophie Piperno-Neumann, Tatiana Popova, Vanessa Masson, Damarys Loew, Pascale Mariani, Nathalie Cassoux, Sebastian Amigorena, Manuel Rodrigues, Samar Alsafadi, Marc-Henri Ste
Publicado en: Cancer Discovery, 2021, Página(s) candisc.0555.2020, ISSN 2159-8274
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0555

Different Pigmentation Risk Loci for High-Risk Monosomy 3 and Low-Risk Disomy 3 Uveal Melanomas

Autores: Lenha Mobuchon, Anne-Céline Derrien, Alexandre Houy, Thibault Verrier, Gaëlle Pierron, Nathalie Cassoux, Maud Milder, Jean-François Deleuze, Anne Boland, Ghislaine Scelo, Géraldine Cancel-Tassin, Olivier Cussenot, Manuel Rodrigues, Josselin Noirel, Mitchell J Machiela, Marc-Henri Stern
Publicado en: JNCI: Journal of the National Cancer Institute, 2021, ISSN 0027-8874
Editor: Oxford University Press
DOI: 10.1093/jnci/djab167

Novel Treatments of Uveal Melanoma Identified with a Synthetic Lethal CRISPR/Cas9 Screen

Autores: Kseniya Glinkina; Arwin Groenewoud; Amina F. A. S. Teunisse; B. Ewa Snaar-Jagalska; Aart G. Jochemsen
Publicado en: Cancers; Volume 14; Edición 13; Pages: 3186, Edición 1, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14133186

Sunglasses to hide behind may also prevent melanoma of the eyes

Autores: Nathalie Dhomen, Piyushkumar A. Mundra, Richard Marais
Publicado en: British Journal of Cancer, 2021, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-021-01343-8

Ortho- and Ectopic Zebrafish Xeno-Engraftment of Ocular Melanoma to Recapitulate Primary Tumor and Experimental Metastasis Development

Autores: Arwin Groenewoud, Jie Yin, B. Ewa Snaar-Jagalska
Publicado en: Journal of Visualized Experiments, Edición 175, 2021, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/62356

Genetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in lung adenocarcinoma and other cancers

Autores: Samar Alsafadi, Stephane Dayot, Malcy Tarin, Alexandre Houy, Dorine Bellanger, Michele Cornella, Michel Wassef, Joshua J. Waterfall, Erik Lehnert, Sergio Roman-Roman, Marc-Henri Stern, Tatiana Popova
Publicado en: Oncogene, Edición 40/1, 2021, Página(s) 85-96, ISSN 0950-9232
Editor: Nature Publishing Group
DOI: 10.1038/s41388-020-01507-5

Quantification of DNA methylation independent of sodium bisulfite conversion using methylation‐sensitive restriction enzymes and digital PCR

Autores: Rogier J. Nell, Debby Steenderen, Nino V. Menger, Thomas J. Weitering, Mieke Versluis, Pieter A. Velden
Publicado en: Human Mutation, Edición 41/12, 2020, Página(s) 2205-2216, ISSN 1059-7794
Editor: John Wiley & Sons Inc.
DOI: 10.1002/humu.24111

Functional and conformational impact of cancer-associated SF3B1 mutations depends on the position and the charge of amino acid substitution

Autores: Christine Canbezdi, Malcy Tarin, Alexandre Houy, Dorine Bellanger, Tatiana Popova, Marc-Henri Stern, Sergio Roman-Roman, Samar Alsafadi
Publicado en: Computational and Structural Biotechnology Journal, Edición 19, 2021, Página(s) 1361-1370, ISSN 2001-0370
Editor: Elsevier
DOI: 10.1016/j.csbj.2021.02.012

Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma

Autores: Rogier J. Nell, Nino V. Menger, Mieke Versluis, Gregorius P. M. Luyten, Robert M. Verdijk, Michele C. Madigan, Martine J. Jager, Pieter A. van der Velden
Publicado en: BMC Cancer, Edición 21/1, 2021, ISSN 1471-2407
Editor: BioMed Central
DOI: 10.1186/s12885-021-07865-x

Iris Colour and the Risk of Developing Uveal Melanoma

Autores: Laurien E. Houtzagers, Annemijn P. A. Wierenga, Aleid A. M. Ruys, Gregorius P. M. Luyten, Martine J. Jager
Publicado en: International Journal of Molecular Sciences, Edición 21/19, 2020, Página(s) 7172, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21197172

Ultraviolet radiation drives mutations in a subset of mucosal melanomas

Autores: Piyushkumar A. Mundra, Nathalie Dhomen, Manuel Rodrigues, Lauge Hjorth Mikkelsen, Nathalie Cassoux, Kelly Brooks, Sara Valpione, Jorge S. Reis-Filho, Steffen Heegaard, Marc-Henri Stern, Sergio Roman-Roman, Richard Marais
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-20432-5

Genetic prognostication in uveal melanoma

Autores: Mehmet Dogrusöz, Martine J. Jager
Publicado en: Acta Ophthalmologica, 2017, ISSN 1755-375X
Editor: Wiley-Blackwell
DOI: 10.1111/aos.13580

Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors

Autores: Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Alice Fiévet, Sophie Gardrat, Raymond L. Barnhill, Tatiana Popova, Vincent Servois, Aurore Rampanou, Aurore Mouton, Stéphane Dayot, Virginie Raynal, Michèle Galut, Marc Putterman, Sarah Tick, Nathalie Cassoux, Sergio Roman-Roman, François-Clément Bidard, Olivier Lantz, Pascale Mariani, Sophie Piperno-Neumann, Marc-Henri Stern
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-04322-5

Digital PCR-Based T-cell Quantification–Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma

Autores: Mark J. de Lange, Rogier J. Nell, Rajshri N. Lalai, Mieke Versluis, Ekaterina S. Jordanova, Gre P.M. Luyten, Martine J. Jager, Sjoerd H. van der Burg, Willem H. Zoutman, Thorbald van Hall, Pieter A. van der Velden
Publicado en: Molecular Cancer Research, 2018, ISSN 1541-7786
Editor: American Association for Cancer Research
DOI: 10.1158/1541-7786.MCR-18-0114

Calcitriol and Calcidiol Can Sensitize Melanoma Cells to Low–LET Proton Beam Irradiation

Autores: Ewa Podgorska, Agnieszka Drzal, Zenon Matuszak, Jan Swakon, Andrzej Slominski, Martyna Elas, Krystyna Urbanska
Publicado en: International Journal of Molecular Sciences, Edición 19/8, 2018, Página(s) 2236, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19082236

New Therapeutic Approach for Targeting Hippo Signalling Pathway

Autores: Leticia Dominguez-Berrocal, Erica Cirri, Xiguang Zhang, Laura Andrini, Gustavo H. Marin, Sophie Lebel-Binay, Angelita Rebollo
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-41404-w

Evolutionary routes in metastatic uveal melanomas depend on MBD4 alterations.

Autores: Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Samar Alsafadi, Sylvain Baulande, Odette Mariani, Benjamin Marande, Khadija Ait Rais, Monique K. Van der Kooij, Ellen H.W. Kapiteijn, Sieta Gassama, Sophie Gardrat, Raymond Barnhill, Vincent Servois, Rémi Dendale, Marc Putterman, Sarah Tick, Sophie Piperno-Neumann, Nathalie Cassoux, Gaelle Pierron, Joshua J Waterfall, Sergio Roman-Roman, Pascale M
Publicado en: Clinical Cancer Research, 2019, Página(s) clincanres.1215.2019, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-19-1215

Ischemia Is Related to Tumour Genetics in Uveal Melanoma

Autores: Niels J. Brouwer, Annemijn P. A. Wierenga, Gülçin Gezgin, Marina Marinkovic, Gregorius P. M. Luyten, Wilma G. M. Kroes, Mieke Versluis, Pieter A. van der Velden, Robert M. Verdijk, Martine J. Jager
Publicado en: Cancers, Edición 11/7, 2019, Página(s) 1004, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11071004

Tumour Angiogenesis in Uveal Melanoma Is Related to Genetic Evolution

Autores: Niels J. Brouwer, Gülçin Gezgin, Annemijn P.A. Wierenga, Inge H.G. Bronkhorst, Marina Marinkovic, Gregorius P.M. Luyten, Mieke Versluis, Wilma G.M. Kroes, Pieter A. van der Velden, Robert M. Verdijk, Martine J. Jager
Publicado en: Cancers, Edición 11/7, 2019, Página(s) 979, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11070979

Emerging Therapeutic Opportunities Based on Current Knowledge of Uveal Melanoma Biology

Autores: Raquel Vivet-Noguer, Malcy Tarin, Sergio Roman-Roman, Samar Alsafadi
Publicado en: Cancers, Edición 11/7, 2019, Página(s) 1019, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11071019

So Close, yet so Far: Discrepancies between Uveal and Other Melanomas. A Position Paper from UM Cure 2020

Autores: Manuel Rodrigues, Leanne de Koning, Sarah Coupland, Aart Jochemsen, Richard Marais, Marc-Henri Stern, André Valente, Raymond Barnhill, Nathalie Cassoux, Andrew Evans, Iain Galloway, Martine Jager, Ellen Kapiteijn, Bozena Romanowska-Dixon, Bettina Ryll, Sergio Roman-Roman, Sophie Piperno-Neumann
Publicado en: Cancers, Edición 11/7, 2019, Página(s) 1032, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11071032

HLA Expression in Uveal Melanoma: An Indicator of Malignancy and a Modifiable Immunological Target

Autores: Souri, Wierenga, Mulder, Jochemsen, Jager
Publicado en: Cancers, Edición 11/8, 2019, Página(s) 1132, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11081132

Loss of BAP1 Is Associated with Upregulation of the NFkB Pathway and Increased HLA Class I Expression in Uveal Melanoma

Autores: Zahra Souri, Annemijn P. A. Wierenga, Christiaan van Weeghel, Pieter A. van der Velden, Wilma G. M. Kroes, Gregorius P. M. Luyten, Sjoerd H. van der Burg, Aart G. Jochemsen, Martine J. Jager
Publicado en: Cancers, Edición 11/8, 2019, Página(s) 1102, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11081102

Differential Expression of DNA Repair Genes in Prognostically-Favorable versus Unfavorable Uveal Melanoma

Autores: Mehmet Dogrusöz, Andrea Ruschel Trasel, Jinfeng Cao, Selҫuk Ҫolak, Sake I. van Pelt, Wilma G. M. Kroes, Amina F. A. S. Teunisse, Samar Alsafadi, Sjoerd G. van Duinen, Gregorius P. M. Luyten, Pieter A. van der Velden, Adriana Amaro, Ulrich Pfeffer, Aart G. Jochemsen, Martine J. Jager
Publicado en: Cancers, Edición 11/8, 2019, Página(s) 1104, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11081104

Do GNAQ and GNA11 Differentially Affect Inflammation and HLA Expression in Uveal Melanoma?

Autores: Christiaan van Weeghel, Annemijn P. A. Wierenga, Mieke Versluis, Thorbald van Hall, Pieter A. van der Velden, Wilma G. M. Kroes, Ulrich Pfeffer, Gregorius P. M. Luyten, Martine J. Jager
Publicado en: Cancers, Edición 11/8, 2019, Página(s) 1127, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11081127

Soluble HLA in the Aqueous Humour of Uveal Melanoma Is Associated with Unfavourable Tumour Characteristics

Autores: Annemijn P. A. Wierenga, Gülçin Gezgin, Els van Beelen, Michael Eikmans, Marijke Spruyt-Gerritse, Niels J. Brouwer, Mieke Versluis, Robert M. Verdijk, Sjoerd G. van Duinen, Marina Marinkovic, Gregorius P. M. Luyten, Martine J. Jager
Publicado en: Cancers, Edición 11/8, 2019, Página(s) 1202, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11081202

Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model

Autores: Francesca Precazzini, Michael Pancher, Pamela Gatto, Ada Tushe, Valentina Adami, Viviana Anelli, Maria Caterina Mione
Publicado en: Developmental Biology, 2019, ISSN 0012-1606
Editor: Academic Press
DOI: 10.1016/j.ydbio.2019.04.005

Aqueous Humor Biomarkers Identify Three Prognostic Groups in Uveal Melanoma

Autores: Annemijn P. A. Wierenga, Jinfeng Cao, Henk Mouthaan, Christiaan van Weeghel, Robert M. Verdijk, Sjoerd G. van Duinen, Wilma G. M. Kroes, Mehmet Dogrusöz, Marina Marinkovic, Sjoerd S. H. van der Burg, Gregorius P. M. Luyten, Martine J. Jager
Publicado en: Investigative Opthalmology & Visual Science, Edición 60/14, 2019, Página(s) 4740, ISSN 1552-5783
Editor: The Association for Research in Vision and Ophthalmology (ARVO)
DOI: 10.1167/iovs.19-28309

Preclinical evaluation of drug combinations identifies co-inhibition of Bcl-2/XL/W and MDM2 as a potential therapy in uveal melanoma

Autores: Didier Decaudin, Estelle Frisch Dit Leitz, Fariba Nemati, Malcy Tarin, Adnan Naguez, Mohamed Zerara, Benjamin Marande, Raquel Vivet-Noguer, Ensar Halilovic, Claire Fabre, Aart Jochemsen, Sergio Roman-Roman, Samar Alsafadi
Publicado en: European Journal of Cancer, Edición 126, 2020, Página(s) 93-103, ISSN 0959-8049
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2019.12.012

Uveal melanoma

Autores: Martine J. Jager, Carol L. Shields, Colleen M. Cebulla, Mohamed H. Abdel-Rahman, Hans E. Grossniklaus, Marc-Henri Stern, Richard D. Carvajal, Rubens N. Belfort, Renbing Jia, Jerry A. Shields, Bertil E. Damato
Publicado en: Nature Reviews Disease Primers, Edición 6/1, 2020, ISSN 2056-676X
Editor: Nature Research
DOI: 10.1038/s41572-020-0158-0

A GWAS in uveal melanoma identifies risk polymorphisms in the CLPTM1L locus

Autores: Lenha Mobuchon, Aude Battistella, Claire Bardel, Ghislaine Scelo, Alexia Renoud, Alexandre Houy, Nathalie Cassoux, Maud Milder, Géraldine Cancel-Tassin, Olivier Cussenot, Olivier Delattre, Céline Besse, Anne Boland, Jean-François Deleuze, David G. Cox, Marc-Henri Stern
Publicado en: npj Genomic Medicine, Edición 2/1, 2017, ISSN 2056-7944
Editor: Macmillan Publishers Limited, part of Springer Nature
DOI: 10.1038/s41525-017-0008-5

Genetic evolution of uveal melanoma guides the development of an inflammatory microenvironment

Autores: Gülçin Gezgin, Mehmet Dogrusöz, T. Huibertus van Essen, Wilhelmina G. M. Kroes, Gregorius P. M. Luyten, Pieter A. van der Velden, Vonn Walter, Robert M. Verdijk, Thorbald van Hall, Sjoerd H. van der Burg, Martine J. Jager
Publicado en: Cancer Immunology, Immunotherapy, Edición 66/7, 2017, Página(s) 903-912, ISSN 0340-7004
Editor: Springer Verlag
DOI: 10.1007/s00262-017-1991-1

The Prognostic Value of AJCC Staging in Uveal Melanoma Is Enhanced by Adding Chromosome 3 and 8q Status

Autores: Mehmet Dogrusöz, Mette Bagger, Sjoerd G. van Duinen, Wilma G. Kroes, Claudia A. L. Ruivenkamp, Stefan Böhringer, Klaus Kaae Andersen, Gregorius P. M. Luyten, Jens F. Kiilgaard, Martine J. Jager
Publicado en: Investigative Opthalmology & Visual Science, Edición 58/2, 2017, Página(s) 833, ISSN 1552-5783
Editor: Association for Research in Vision and Ophthalmology (ARVO)
DOI: 10.1167/iovs.16-20212

UM Cure 2020 - A consortium of European experts in uveal melanoma to identify new therapies for patients with metastatic disease

Autores: S. Coupland, H. Kalirai, M. Jager, A.G. Jochemsen, P.A. van der Velden, B.E. Snaar-Jagalska, N. Dhomen, R. Marais, B. Romanowska Dixon, M. Elas, M.C. Mione, A. Valente, B. Ryll, R. Ruijtenbeek, A. Prestat, H. Hafsi, R. Barnhill, N. Cassoux, D. Decaudin, O. Lantz, S. Piperno-Neumann, M.H. Stern, S. Roman-Roman
Publicado en: Acta Ophthalmologica, Edición 94, 2016, ISSN 1755-375X
Editor: Wiley-Blackwell
DOI: 10.1111/j.1755-3768.2016.0418

UM Cure 2020 − A consortium of European experts in uveal melanoma to identify new therapies for patients with metastatic disease

Autores: N. Dhomen, R. Marais, M.J. Jager, Snaar-Jagalska, S. Coupland, B. Romanowska-Dixon, M.C. Mione, A. Valente, B. Ryll, R. Ruijtenbeek, A. Prestat, E. Vinolo, S. Roman-Roman
Publicado en: European Journal of Cancer, Edición 61, 2016, Página(s) S204-S205, ISSN 0959-8049
Editor: Pergamon Press Ltd.
DOI: 10.1016/S0959-8049(16)61722-7

Zebrafish in Translational Cancer Research: Insight into Leukemia, Melanoma, Glioma and Endocrine Tumor Biology

Autores: Aurora Irene Idilli, Francesca Precazzini, Maria Caterina Mione and Viviana Anelli
Publicado en: Genes, Edición 8/9, 2017, Página(s) 236, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes8090236

Germline MBD4 Mutations and Predisposition to Uveal Melanoma

Autores: Anne-Céline Derrien, Manuel Rodrigues, Alexandre Eeckhoutte, Stéphane Dayot, Alexandre Houy, Lenha Mobuchon, Sophie Gardrat, Delphine Lequin, Stelly Ballet, Gaëlle Pierron, Samar Alsafadi, Odette Mariani, Ahmed El-Marjou, Alexandre Matet, Chrystelle Colas, Nathalie Cassoux, Marc-Henri Stern
Publicado en: JNCI: Journal of the National Cancer Institute, 2020, ISSN 0027-8874
Editor: Oxford University Press
DOI: 10.1093/jnci/djaa047

Immune Checkpoint Inhibitors in Uveal and Conjunctival Melanoma

Autores: Annemijn P.A. Wierenga, Jinfeng Cao, Gregorius P.M. Luyten, Martine J. Jager
Publicado en: International Ophthalmology Clinics, Edición 59/2, 2019, Página(s) 53-63, ISSN 0020-8167
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/iio.0000000000000263

Interplay between TERT promoter mutations and methylation culminates in chromatin accessibility and TERT expression

Autores: Catarina Salgado, Celine Roelse, Rogier Nell, Nelleke Gruis, Remco van Doorn, Pieter van der Velden
Publicado en: PLOS ONE, Edición 15/4, 2020, Página(s) e0231418, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0231418

A novel circulating tumour cell-derived xenograft (CDX) model to investigate uveal melanoma metastasis

Autores: Katharina Mahal, Rebecca Lee, Pablo Garcia-Martinez, Matthew Smith, Nathalie Dhomen, Richard Marais
Publicado en: 1st Joint EACR-MRS Conference Seed and Soil: In Vivo Models of Metastasis, 2017, Página(s) 75-76
Editor: EACR

UM Cure 2020 - A Consortium of European experts in Uveal Melanoma to identify new therapies for patients with metastatic disease

Autores: M.J. Jager, N. Cassoux, B.E. Snaar-Jagalska, S.E. Coupland, R. Marais, B. Romanowska-Dixon, M.C. Mione, A. Valente, B. Ryll, R. Ruijtenbeek, A. Prestat, E. Vinolo, S. Roman-Roman
Publicado en: ISOO 2017 - 18th International Society of Ocular Oncology Biennial Conference, 2017
Editor: International Society of Ocular Oncology

Generation and characterization of zebrafish models of Uveal Melanoma

Autores: Viviana Anelli, Francesca Precazzini, Marina Mione
Publicado en: 1st Italian Zebrafish Meeting, 2-3 February 2017, 2017
Editor: Universita degli studi di Padova

Modeling uveal melanoma using zebrafish to predict suitable therapeutic strategies

Autores: Viviana Anelli, Francesca Precazzini, Marina Mione
Publicado en: EACR-AACR-SIC Special Conference 2017: The Challenges of Optimizing Immuno- and Targeted Therapies: From Cancer Biology to the Clinic, 2017
Editor: European Cancer Organisaton (ECCO)

UM Cure 2020: A Consortium of European experts in Uveal. Melanoma

Autores: Helen Kalirai
Publicado en: OcuMel UK 2016 Annual Conference, 2016, Página(s) https://ocumeluk.org/wp-content/uploads/2016/10/Kalirai.pdf
Editor: OcuMel UK

UM Cure 2020: New therapies for uveal melanoma

Autores: Sergio Roman-Roman, Marc-Henri Stern, Samar Alsafadi, Martine J. Jager, Mehmet Dogrusöz, Sarah E. Coupland, Maria Caterina Mione, Viviana Anelli, Francesca Precazzini, Lenha Mobuchon, Fariba Nemati, Didier Decaudin, Manuel Rodrigues, Olivier Lantz, Raymond Barnhill, Sophie Piperno-Neumann, Nathalie Cassoux, Laurence Desjardins, Gulçin Gezgin, Annemijn Wierenga, Aart J. Jochemsen, Kseniya A. Glin
Publicado en: Impact, Edición 2018/2, 2018, Página(s) 15-17, ISSN 2398-7073
Editor: Science Impact Ltd
DOI: 10.21820/23987073.2018.2.15

Rôle du gène MBD4 dans un phénotype hypermutateur et dans la tumorigenèse

Autores: Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Anne-Céline Derrien, Alice Fiévet, Marc-Henri Stern
Publicado en: médecine/sciences, Edición 34/11, 2018, Página(s) 925-927, ISSN 0767-0974
Editor: Editions E D K
DOI: 10.1051/medsci/2018226

Le mélanome uvéal

Autores: Samar Alsafadi, Lenha Mobuchon, Manuel Rodrigues, Marc-Henri Stern
Publicado en: médecine/sciences, Edición 34/2, 2018, Página(s) 155-160, ISSN 0767-0974
Editor: Editions E D K
DOI: 10.1051/medsci/20183402013

Ocular Oncology

Autores: Bozena Romanowska-Dixon, Martine J. Jager, Sarah E. Coupland
Publicado en: 2020, ISBN 978-83-200-5955-7
Editor: PZWL

Usage of Droplet Digital PCR (ddPCR) Assays for T Cell Quantification in Cancer

Autores: Willem H. Zoutman, Rogier J. Nell, Pieter A. van der Velden
Publicado en: Cancer Immunosurveillance - Methods and Protocols, Edición 1884, 2019, Página(s) 1-14, ISBN 978-1-4939-8884-6
Editor: Springer New York
DOI: 10.1007/978-1-4939-8885-3_1

Patient-derived zebrafish xenograft models reveal ferroptosis as a fatal and druggable weakness in metastatic uveal melanoma

Autores: Arwin Groenewoud, Jie Yin, Maria Chiara Gelmi, Samar Alsafadi, Fariba Nemati, Didier Decaudin, Sergio Roman-Roman, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Martine J. Jager, Ewa Snaar-Jagalska
Publicado en: BioRXiv, 2021
Editor: Cold Spring Harbor Laboratory

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