New therapies for uveal melanoma

Livrables

European guidelines for UM patient management and dissemination status

Our goal is also to work on European guidelines for UM patient management based on what is available alreday thourgh the UK guidelines They will include any additional data or recommendations from the UM Cure 2020 project and rely on the expertise of clinicians from the four European referral centres involved in the project Our objective is indeed to make those Europeanwide and applicable to any caregiver who could have to manage and treat a UM patientAt M60 these guidelines will be provided with a description of their dissemination status

Kick-off meeting

At M2 after the kick-off meeting for the project, a report will be produced which will include the detailed agenda and the minutes of the meeting, as a record of the efficient launch of the project.

Establishing a collection of approx. 200 metastatic UM samples

Our objective would be to reach approx 200 metastatic UM samples collected along the project with matched primary tissue and blood sample whenever possible At M60 at the end of the project we will produce a report on what we have been able to achieve through the concerted action of the reference centres involved and on what these biosamples have been partly used for in the frame of the project

Release of main UM Cure 2020 communication tools

The main communication tools for the project, namely the website, social media platforms and UM Cure 2020 Consent Card, will be set-up at project start, for a release at M4. A report at M4 will describe such tools and confirm their availability.

Agreement on minimum dataset for all currently banked UM biosamples

The aim of this deliverable is to share the information currently collected for UM patients and samples across the reference centres, in order to agree on a common minimal set of data that should be available for all UM samples. This precedes the harmonisation efforts among centres which is absolutely necessary to build the common virtual biobank. The common minimal set will be represented by an Excel file with one column per field to be included in the database, and an attached report with description of the work.

Status of prospective collection and use of collected biosamples

D1.3 will consist in a report on the status at M36 of recruitment of prospective UM biosamples under the project. In addition, the status of overall samples available through the network will be included, together with a summary of how these biosamples have been used so far for WP3 and WP4.

Publications

The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases

Auteurs: Maria Luisa Cayuela, Kathleen B. M. Claes, Miguel Godinho Ferreira, Catarina Martins Henriques, Fredericus van Eeden, Máté Varga, Jeroen Vierstraete, Maria Caterina Mione
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 6, 2019, ISSN 2296-634X
Éditeur: Frontiers Media SA
DOI: 10.3389/fcell.2018.00178

Preclinical Evaluation of Trabectedin in Combination With Targeted Inhibitors for Treatment of Metastatic Uveal Melanoma

Auteurs: Kseniya Glinkina; Fariba Nemati; Amina F. A. S. Teunisse; Maria Chiara Gelmi; Vesnie Etienne; Muriel J. Kuipers; Samar Alsafadi; Martine J. Jager; Didier Decaudin; Aart G. Jochemsen
Publié dans: Investigative Ophthalmology & Visual Science, 2022, ISSN 0146-0404
Éditeur: Association for Research in Vision and Ophthalmology
DOI: 10.1167/iovs.63.13.14

Splicing patterns in SF3B1 mutated uveal melanoma generate shared immunogenic tumor-specific neo-epitopes

Auteurs: Jeremy Bigot, Ana I Lalanne, Francesca Lucibello, Paul Gueguen, Alexandre Houy, Stephane Dayot, Olivier Ganier, Jules Gilet, Jimena Tosello, Fariba Nemati, Gaelle Pierron, Joshua J Waterfall, Raymond Barnhill, Sophie Gardrat, Sophie Piperno-Neumann, Tatiana Popova, Vanessa Masson, Damarys Loew, Pascale Mariani, Nathalie Cassoux, Sebastian Amigorena, Manuel Rodrigues, Samar Alsafadi, Marc-Henri Ste
Publié dans: Cancer Discovery, 2021, Page(s) candisc.0555.2020, ISSN 2159-8274
Éditeur: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0555

Different Pigmentation Risk Loci for High-Risk Monosomy 3 and Low-Risk Disomy 3 Uveal Melanomas

Auteurs: Lenha Mobuchon, Anne-Céline Derrien, Alexandre Houy, Thibault Verrier, Gaëlle Pierron, Nathalie Cassoux, Maud Milder, Jean-François Deleuze, Anne Boland, Ghislaine Scelo, Géraldine Cancel-Tassin, Olivier Cussenot, Manuel Rodrigues, Josselin Noirel, Mitchell J Machiela, Marc-Henri Stern
Publié dans: JNCI: Journal of the National Cancer Institute, 2021, ISSN 0027-8874
Éditeur: Oxford University Press
DOI: 10.1093/jnci/djab167

Novel Treatments of Uveal Melanoma Identified with a Synthetic Lethal CRISPR/Cas9 Screen

Auteurs: Kseniya Glinkina; Arwin Groenewoud; Amina F. A. S. Teunisse; B. Ewa Snaar-Jagalska; Aart G. Jochemsen
Publié dans: Cancers; Volume 14; Numéro 13; Pages: 3186, Numéro 1, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14133186

Sunglasses to hide behind may also prevent melanoma of the eyes

Auteurs: Nathalie Dhomen, Piyushkumar A. Mundra, Richard Marais
Publié dans: British Journal of Cancer, 2021, ISSN 0007-0920
Éditeur: Nature Publishing Group
DOI: 10.1038/s41416-021-01343-8

Ortho- and Ectopic Zebrafish Xeno-Engraftment of Ocular Melanoma to Recapitulate Primary Tumor and Experimental Metastasis Development

Auteurs: Arwin Groenewoud, Jie Yin, B. Ewa Snaar-Jagalska
Publié dans: Journal of Visualized Experiments, Numéro 175, 2021, ISSN 1940-087X
Éditeur: MYJoVE Corporation
DOI: 10.3791/62356

Genetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in lung adenocarcinoma and other cancers

Auteurs: Samar Alsafadi, Stephane Dayot, Malcy Tarin, Alexandre Houy, Dorine Bellanger, Michele Cornella, Michel Wassef, Joshua J. Waterfall, Erik Lehnert, Sergio Roman-Roman, Marc-Henri Stern, Tatiana Popova
Publié dans: Oncogene, Numéro 40/1, 2021, Page(s) 85-96, ISSN 0950-9232
Éditeur: Nature Publishing Group
DOI: 10.1038/s41388-020-01507-5

Quantification of DNA methylation independent of sodium bisulfite conversion using methylation‐sensitive restriction enzymes and digital PCR

Auteurs: Rogier J. Nell, Debby Steenderen, Nino V. Menger, Thomas J. Weitering, Mieke Versluis, Pieter A. Velden
Publié dans: Human Mutation, Numéro 41/12, 2020, Page(s) 2205-2216, ISSN 1059-7794
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/humu.24111

Functional and conformational impact of cancer-associated SF3B1 mutations depends on the position and the charge of amino acid substitution

Auteurs: Christine Canbezdi, Malcy Tarin, Alexandre Houy, Dorine Bellanger, Tatiana Popova, Marc-Henri Stern, Sergio Roman-Roman, Samar Alsafadi
Publié dans: Computational and Structural Biotechnology Journal, Numéro 19, 2021, Page(s) 1361-1370, ISSN 2001-0370
Éditeur: Elsevier
DOI: 10.1016/j.csbj.2021.02.012

Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma

Auteurs: Rogier J. Nell, Nino V. Menger, Mieke Versluis, Gregorius P. M. Luyten, Robert M. Verdijk, Michele C. Madigan, Martine J. Jager, Pieter A. van der Velden
Publié dans: BMC Cancer, Numéro 21/1, 2021, ISSN 1471-2407
Éditeur: BioMed Central
DOI: 10.1186/s12885-021-07865-x

Iris Colour and the Risk of Developing Uveal Melanoma

Auteurs: Laurien E. Houtzagers, Annemijn P. A. Wierenga, Aleid A. M. Ruys, Gregorius P. M. Luyten, Martine J. Jager
Publié dans: International Journal of Molecular Sciences, Numéro 21/19, 2020, Page(s) 7172, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21197172

Ultraviolet radiation drives mutations in a subset of mucosal melanomas

Auteurs: Piyushkumar A. Mundra, Nathalie Dhomen, Manuel Rodrigues, Lauge Hjorth Mikkelsen, Nathalie Cassoux, Kelly Brooks, Sara Valpione, Jorge S. Reis-Filho, Steffen Heegaard, Marc-Henri Stern, Sergio Roman-Roman, Richard Marais
Publié dans: Nature Communications, Numéro 12/1, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-20432-5

Genetic prognostication in uveal melanoma

Auteurs: Mehmet Dogrusöz, Martine J. Jager
Publié dans: Acta Ophthalmologica, 2017, ISSN 1755-375X
Éditeur: Wiley-Blackwell
DOI: 10.1111/aos.13580

Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors

Auteurs: Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Alice Fiévet, Sophie Gardrat, Raymond L. Barnhill, Tatiana Popova, Vincent Servois, Aurore Rampanou, Aurore Mouton, Stéphane Dayot, Virginie Raynal, Michèle Galut, Marc Putterman, Sarah Tick, Nathalie Cassoux, Sergio Roman-Roman, François-Clément Bidard, Olivier Lantz, Pascale Mariani, Sophie Piperno-Neumann, Marc-Henri Stern
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-04322-5

Digital PCR-Based T-cell Quantification–Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma

Auteurs: Mark J. de Lange, Rogier J. Nell, Rajshri N. Lalai, Mieke Versluis, Ekaterina S. Jordanova, Gre P.M. Luyten, Martine J. Jager, Sjoerd H. van der Burg, Willem H. Zoutman, Thorbald van Hall, Pieter A. van der Velden
Publié dans: Molecular Cancer Research, 2018, ISSN 1541-7786
Éditeur: American Association for Cancer Research
DOI: 10.1158/1541-7786.MCR-18-0114

Calcitriol and Calcidiol Can Sensitize Melanoma Cells to Low–LET Proton Beam Irradiation

Auteurs: Ewa Podgorska, Agnieszka Drzal, Zenon Matuszak, Jan Swakon, Andrzej Slominski, Martyna Elas, Krystyna Urbanska
Publié dans: International Journal of Molecular Sciences, Numéro 19/8, 2018, Page(s) 2236, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19082236

New Therapeutic Approach for Targeting Hippo Signalling Pathway

Auteurs: Leticia Dominguez-Berrocal, Erica Cirri, Xiguang Zhang, Laura Andrini, Gustavo H. Marin, Sophie Lebel-Binay, Angelita Rebollo
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-41404-w

Evolutionary routes in metastatic uveal melanomas depend on MBD4 alterations.

Auteurs: Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Samar Alsafadi, Sylvain Baulande, Odette Mariani, Benjamin Marande, Khadija Ait Rais, Monique K. Van der Kooij, Ellen H.W. Kapiteijn, Sieta Gassama, Sophie Gardrat, Raymond Barnhill, Vincent Servois, Rémi Dendale, Marc Putterman, Sarah Tick, Sophie Piperno-Neumann, Nathalie Cassoux, Gaelle Pierron, Joshua J Waterfall, Sergio Roman-Roman, Pascale M
Publié dans: Clinical Cancer Research, 2019, Page(s) clincanres.1215.2019, ISSN 1078-0432
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-19-1215

Ischemia Is Related to Tumour Genetics in Uveal Melanoma

Auteurs: Niels J. Brouwer, Annemijn P. A. Wierenga, Gülçin Gezgin, Marina Marinkovic, Gregorius P. M. Luyten, Wilma G. M. Kroes, Mieke Versluis, Pieter A. van der Velden, Robert M. Verdijk, Martine J. Jager
Publié dans: Cancers, Numéro 11/7, 2019, Page(s) 1004, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11071004

Tumour Angiogenesis in Uveal Melanoma Is Related to Genetic Evolution

Auteurs: Niels J. Brouwer, Gülçin Gezgin, Annemijn P.A. Wierenga, Inge H.G. Bronkhorst, Marina Marinkovic, Gregorius P.M. Luyten, Mieke Versluis, Wilma G.M. Kroes, Pieter A. van der Velden, Robert M. Verdijk, Martine J. Jager
Publié dans: Cancers, Numéro 11/7, 2019, Page(s) 979, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11070979

Emerging Therapeutic Opportunities Based on Current Knowledge of Uveal Melanoma Biology

Auteurs: Raquel Vivet-Noguer, Malcy Tarin, Sergio Roman-Roman, Samar Alsafadi
Publié dans: Cancers, Numéro 11/7, 2019, Page(s) 1019, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11071019

So Close, yet so Far: Discrepancies between Uveal and Other Melanomas. A Position Paper from UM Cure 2020

Auteurs: Manuel Rodrigues, Leanne de Koning, Sarah Coupland, Aart Jochemsen, Richard Marais, Marc-Henri Stern, André Valente, Raymond Barnhill, Nathalie Cassoux, Andrew Evans, Iain Galloway, Martine Jager, Ellen Kapiteijn, Bozena Romanowska-Dixon, Bettina Ryll, Sergio Roman-Roman, Sophie Piperno-Neumann
Publié dans: Cancers, Numéro 11/7, 2019, Page(s) 1032, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11071032

HLA Expression in Uveal Melanoma: An Indicator of Malignancy and a Modifiable Immunological Target

Auteurs: Souri, Wierenga, Mulder, Jochemsen, Jager
Publié dans: Cancers, Numéro 11/8, 2019, Page(s) 1132, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11081132

Loss of BAP1 Is Associated with Upregulation of the NFkB Pathway and Increased HLA Class I Expression in Uveal Melanoma

Auteurs: Zahra Souri, Annemijn P. A. Wierenga, Christiaan van Weeghel, Pieter A. van der Velden, Wilma G. M. Kroes, Gregorius P. M. Luyten, Sjoerd H. van der Burg, Aart G. Jochemsen, Martine J. Jager
Publié dans: Cancers, Numéro 11/8, 2019, Page(s) 1102, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11081102

Differential Expression of DNA Repair Genes in Prognostically-Favorable versus Unfavorable Uveal Melanoma

Auteurs: Mehmet Dogrusöz, Andrea Ruschel Trasel, Jinfeng Cao, Selҫuk Ҫolak, Sake I. van Pelt, Wilma G. M. Kroes, Amina F. A. S. Teunisse, Samar Alsafadi, Sjoerd G. van Duinen, Gregorius P. M. Luyten, Pieter A. van der Velden, Adriana Amaro, Ulrich Pfeffer, Aart G. Jochemsen, Martine J. Jager
Publié dans: Cancers, Numéro 11/8, 2019, Page(s) 1104, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11081104

Do GNAQ and GNA11 Differentially Affect Inflammation and HLA Expression in Uveal Melanoma?

Auteurs: Christiaan van Weeghel, Annemijn P. A. Wierenga, Mieke Versluis, Thorbald van Hall, Pieter A. van der Velden, Wilma G. M. Kroes, Ulrich Pfeffer, Gregorius P. M. Luyten, Martine J. Jager
Publié dans: Cancers, Numéro 11/8, 2019, Page(s) 1127, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11081127

Soluble HLA in the Aqueous Humour of Uveal Melanoma Is Associated with Unfavourable Tumour Characteristics

Auteurs: Annemijn P. A. Wierenga, Gülçin Gezgin, Els van Beelen, Michael Eikmans, Marijke Spruyt-Gerritse, Niels J. Brouwer, Mieke Versluis, Robert M. Verdijk, Sjoerd G. van Duinen, Marina Marinkovic, Gregorius P. M. Luyten, Martine J. Jager
Publié dans: Cancers, Numéro 11/8, 2019, Page(s) 1202, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11081202

Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model

Auteurs: Francesca Precazzini, Michael Pancher, Pamela Gatto, Ada Tushe, Valentina Adami, Viviana Anelli, Maria Caterina Mione
Publié dans: Developmental Biology, 2019, ISSN 0012-1606
Éditeur: Academic Press
DOI: 10.1016/j.ydbio.2019.04.005

Aqueous Humor Biomarkers Identify Three Prognostic Groups in Uveal Melanoma

Auteurs: Annemijn P. A. Wierenga, Jinfeng Cao, Henk Mouthaan, Christiaan van Weeghel, Robert M. Verdijk, Sjoerd G. van Duinen, Wilma G. M. Kroes, Mehmet Dogrusöz, Marina Marinkovic, Sjoerd S. H. van der Burg, Gregorius P. M. Luyten, Martine J. Jager
Publié dans: Investigative Opthalmology & Visual Science, Numéro 60/14, 2019, Page(s) 4740, ISSN 1552-5783
Éditeur: The Association for Research in Vision and Ophthalmology (ARVO)
DOI: 10.1167/iovs.19-28309

Preclinical evaluation of drug combinations identifies co-inhibition of Bcl-2/XL/W and MDM2 as a potential therapy in uveal melanoma

Auteurs: Didier Decaudin, Estelle Frisch Dit Leitz, Fariba Nemati, Malcy Tarin, Adnan Naguez, Mohamed Zerara, Benjamin Marande, Raquel Vivet-Noguer, Ensar Halilovic, Claire Fabre, Aart Jochemsen, Sergio Roman-Roman, Samar Alsafadi
Publié dans: European Journal of Cancer, Numéro 126, 2020, Page(s) 93-103, ISSN 0959-8049
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2019.12.012

Uveal melanoma

Auteurs: Martine J. Jager, Carol L. Shields, Colleen M. Cebulla, Mohamed H. Abdel-Rahman, Hans E. Grossniklaus, Marc-Henri Stern, Richard D. Carvajal, Rubens N. Belfort, Renbing Jia, Jerry A. Shields, Bertil E. Damato
Publié dans: Nature Reviews Disease Primers, Numéro 6/1, 2020, ISSN 2056-676X
Éditeur: Nature Research
DOI: 10.1038/s41572-020-0158-0

A GWAS in uveal melanoma identifies risk polymorphisms in the CLPTM1L locus

Auteurs: Lenha Mobuchon, Aude Battistella, Claire Bardel, Ghislaine Scelo, Alexia Renoud, Alexandre Houy, Nathalie Cassoux, Maud Milder, Géraldine Cancel-Tassin, Olivier Cussenot, Olivier Delattre, Céline Besse, Anne Boland, Jean-François Deleuze, David G. Cox, Marc-Henri Stern
Publié dans: npj Genomic Medicine, Numéro 2/1, 2017, ISSN 2056-7944
Éditeur: Macmillan Publishers Limited, part of Springer Nature
DOI: 10.1038/s41525-017-0008-5

Genetic evolution of uveal melanoma guides the development of an inflammatory microenvironment

Auteurs: Gülçin Gezgin, Mehmet Dogrusöz, T. Huibertus van Essen, Wilhelmina G. M. Kroes, Gregorius P. M. Luyten, Pieter A. van der Velden, Vonn Walter, Robert M. Verdijk, Thorbald van Hall, Sjoerd H. van der Burg, Martine J. Jager
Publié dans: Cancer Immunology, Immunotherapy, Numéro 66/7, 2017, Page(s) 903-912, ISSN 0340-7004
Éditeur: Springer Verlag
DOI: 10.1007/s00262-017-1991-1

The Prognostic Value of AJCC Staging in Uveal Melanoma Is Enhanced by Adding Chromosome 3 and 8q Status

Auteurs: Mehmet Dogrusöz, Mette Bagger, Sjoerd G. van Duinen, Wilma G. Kroes, Claudia A. L. Ruivenkamp, Stefan Böhringer, Klaus Kaae Andersen, Gregorius P. M. Luyten, Jens F. Kiilgaard, Martine J. Jager
Publié dans: Investigative Opthalmology & Visual Science, Numéro 58/2, 2017, Page(s) 833, ISSN 1552-5783
Éditeur: Association for Research in Vision and Ophthalmology (ARVO)
DOI: 10.1167/iovs.16-20212

UM Cure 2020 - A consortium of European experts in uveal melanoma to identify new therapies for patients with metastatic disease

Auteurs: S. Coupland, H. Kalirai, M. Jager, A.G. Jochemsen, P.A. van der Velden, B.E. Snaar-Jagalska, N. Dhomen, R. Marais, B. Romanowska Dixon, M. Elas, M.C. Mione, A. Valente, B. Ryll, R. Ruijtenbeek, A. Prestat, H. Hafsi, R. Barnhill, N. Cassoux, D. Decaudin, O. Lantz, S. Piperno-Neumann, M.H. Stern, S. Roman-Roman
Publié dans: Acta Ophthalmologica, Numéro 94, 2016, ISSN 1755-375X
Éditeur: Wiley-Blackwell
DOI: 10.1111/j.1755-3768.2016.0418

UM Cure 2020 − A consortium of European experts in uveal melanoma to identify new therapies for patients with metastatic disease

Auteurs: N. Dhomen, R. Marais, M.J. Jager, Snaar-Jagalska, S. Coupland, B. Romanowska-Dixon, M.C. Mione, A. Valente, B. Ryll, R. Ruijtenbeek, A. Prestat, E. Vinolo, S. Roman-Roman
Publié dans: European Journal of Cancer, Numéro 61, 2016, Page(s) S204-S205, ISSN 0959-8049
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/S0959-8049(16)61722-7

Zebrafish in Translational Cancer Research: Insight into Leukemia, Melanoma, Glioma and Endocrine Tumor Biology

Auteurs: Aurora Irene Idilli, Francesca Precazzini, Maria Caterina Mione and Viviana Anelli
Publié dans: Genes, Numéro 8/9, 2017, Page(s) 236, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes8090236

Germline MBD4 Mutations and Predisposition to Uveal Melanoma

Auteurs: Anne-Céline Derrien, Manuel Rodrigues, Alexandre Eeckhoutte, Stéphane Dayot, Alexandre Houy, Lenha Mobuchon, Sophie Gardrat, Delphine Lequin, Stelly Ballet, Gaëlle Pierron, Samar Alsafadi, Odette Mariani, Ahmed El-Marjou, Alexandre Matet, Chrystelle Colas, Nathalie Cassoux, Marc-Henri Stern
Publié dans: JNCI: Journal of the National Cancer Institute, 2020, ISSN 0027-8874
Éditeur: Oxford University Press
DOI: 10.1093/jnci/djaa047

Immune Checkpoint Inhibitors in Uveal and Conjunctival Melanoma

Auteurs: Annemijn P.A. Wierenga, Jinfeng Cao, Gregorius P.M. Luyten, Martine J. Jager
Publié dans: International Ophthalmology Clinics, Numéro 59/2, 2019, Page(s) 53-63, ISSN 0020-8167
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/iio.0000000000000263

Interplay between TERT promoter mutations and methylation culminates in chromatin accessibility and TERT expression

Auteurs: Catarina Salgado, Celine Roelse, Rogier Nell, Nelleke Gruis, Remco van Doorn, Pieter van der Velden
Publié dans: PLOS ONE, Numéro 15/4, 2020, Page(s) e0231418, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0231418

A novel circulating tumour cell-derived xenograft (CDX) model to investigate uveal melanoma metastasis

Auteurs: Katharina Mahal, Rebecca Lee, Pablo Garcia-Martinez, Matthew Smith, Nathalie Dhomen, Richard Marais
Publié dans: 1st Joint EACR-MRS Conference Seed and Soil: In Vivo Models of Metastasis, 2017, Page(s) 75-76
Éditeur: EACR

UM Cure 2020 - A Consortium of European experts in Uveal Melanoma to identify new therapies for patients with metastatic disease

Auteurs: M.J. Jager, N. Cassoux, B.E. Snaar-Jagalska, S.E. Coupland, R. Marais, B. Romanowska-Dixon, M.C. Mione, A. Valente, B. Ryll, R. Ruijtenbeek, A. Prestat, E. Vinolo, S. Roman-Roman
Publié dans: ISOO 2017 - 18th International Society of Ocular Oncology Biennial Conference, 2017
Éditeur: International Society of Ocular Oncology

Generation and characterization of zebrafish models of Uveal Melanoma

Auteurs: Viviana Anelli, Francesca Precazzini, Marina Mione
Publié dans: 1st Italian Zebrafish Meeting, 2-3 February 2017, 2017
Éditeur: Universita degli studi di Padova

Modeling uveal melanoma using zebrafish to predict suitable therapeutic strategies

Auteurs: Viviana Anelli, Francesca Precazzini, Marina Mione
Publié dans: EACR-AACR-SIC Special Conference 2017: The Challenges of Optimizing Immuno- and Targeted Therapies: From Cancer Biology to the Clinic, 2017
Éditeur: European Cancer Organisaton (ECCO)

UM Cure 2020: A Consortium of European experts in Uveal. Melanoma

Auteurs: Helen Kalirai
Publié dans: OcuMel UK 2016 Annual Conference, 2016, Page(s) https://ocumeluk.org/wp-content/uploads/2016/10/Kalirai.pdf
Éditeur: OcuMel UK

UM Cure 2020: New therapies for uveal melanoma

Auteurs: Sergio Roman-Roman, Marc-Henri Stern, Samar Alsafadi, Martine J. Jager, Mehmet Dogrusöz, Sarah E. Coupland, Maria Caterina Mione, Viviana Anelli, Francesca Precazzini, Lenha Mobuchon, Fariba Nemati, Didier Decaudin, Manuel Rodrigues, Olivier Lantz, Raymond Barnhill, Sophie Piperno-Neumann, Nathalie Cassoux, Laurence Desjardins, Gulçin Gezgin, Annemijn Wierenga, Aart J. Jochemsen, Kseniya A. Glin
Publié dans: Impact, Numéro 2018/2, 2018, Page(s) 15-17, ISSN 2398-7073
Éditeur: Science Impact Ltd
DOI: 10.21820/23987073.2018.2.15

Rôle du gène MBD4 dans un phénotype hypermutateur et dans la tumorigenèse

Auteurs: Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Anne-Céline Derrien, Alice Fiévet, Marc-Henri Stern
Publié dans: médecine/sciences, Numéro 34/11, 2018, Page(s) 925-927, ISSN 0767-0974
Éditeur: Editions E D K
DOI: 10.1051/medsci/2018226

Le mélanome uvéal

Auteurs: Samar Alsafadi, Lenha Mobuchon, Manuel Rodrigues, Marc-Henri Stern
Publié dans: médecine/sciences, Numéro 34/2, 2018, Page(s) 155-160, ISSN 0767-0974
Éditeur: Editions E D K
DOI: 10.1051/medsci/20183402013

Ocular Oncology

Auteurs: Bozena Romanowska-Dixon, Martine J. Jager, Sarah E. Coupland
Publié dans: 2020, ISBN 978-83-200-5955-7
Éditeur: PZWL

Usage of Droplet Digital PCR (ddPCR) Assays for T Cell Quantification in Cancer

Auteurs: Willem H. Zoutman, Rogier J. Nell, Pieter A. van der Velden
Publié dans: Cancer Immunosurveillance - Methods and Protocols, Numéro 1884, 2019, Page(s) 1-14, ISBN 978-1-4939-8884-6
Éditeur: Springer New York
DOI: 10.1007/978-1-4939-8885-3_1

Patient-derived zebrafish xenograft models reveal ferroptosis as a fatal and druggable weakness in metastatic uveal melanoma

Auteurs: Arwin Groenewoud, Jie Yin, Maria Chiara Gelmi, Samar Alsafadi, Fariba Nemati, Didier Decaudin, Sergio Roman-Roman, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Martine J. Jager, Ewa Snaar-Jagalska
Publié dans: BioRXiv, 2021
Éditeur: Cold Spring Harbor Laboratory

Recherche de données OpenAIRE...

Livrables

Publications

Partager cette page

Télécharger