Systems Medicine of Mitochondrial Parkinson’s Disease

Informations projet

SysMedPD

N° de convention de subvention: 668738

DOI

10.3030/668738

Projet clôturé

Date de signature de la CE 1 Decembre 2015

Date de début 1 Decembre 2015

Date de fin 30 Novembre 2020

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 5 999 990,00

Contribution de l’UE

€ 5 999 990,00

Coordonné par

UNIVERSITEIT LEIDEN
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Demonstrators, pilots, prototypes (5)

Miniaturised metabolomics platform including storage device for sample transport
Computational model of brain metabolism

Computational model of brain metabolism (lead partner: UL-Fleming)

Complete mitochondrial molecular network reconstruction

Complete mitochondrial molecular network reconstruction (lead partner: UL-Balling)

Metabolomics platform for mitochondrial dysfunction
Draft mitochondrial molecular network reconstruction

Draft mitochondrial molecular network reconstruction (lead partner: UL-Balling)

Documents, reports (4)

Successful differentiation of dopaminergic neurons from iPSCs and subsequent transplantation into NOD SCID mice

Successful differentiation of dopaminergic neurons from iPSCs and subsequent transplantation into NOD SCID mice (lead partner: UL-Schwamborn)

Successful neurochemical analysis performed in transplanted SCID mice and correlation to phenotype progression investigated
Open access summary report
Characterisation of in vivo amperometric sensors and microdialysis in the striatum of mice

Other (1)

SysMedPD audio-visual material

Websites, patent fillings, videos etc. (1)

External project website

Publications

Peer reviewed articles (28)

Passive controlled flow for Parkinson's disease neuronal cell culture in 3D microfluidic devices

Auteurs: Javier Jarazo; Khalid I. W. Kane; Ronan M. T. Fleming; Ronan M. T. Fleming; Jens Christian Schwamborn; Edinson Lucumi Moreno
Publié dans: Organs-on-a-Chip, Numéro 2, 2020, ISSN 2666-1020
Éditeur: Elsevier
DOI: 10.1016/j.ooc.2020.100005

Personalized whole‐body models integrate metabolism, physiology, and the gut microbiome

Auteurs: Ines Thiele, Swagatika Sahoo, Almut Heinken, Johannes Hertel, Laurent Heirendt, Maike K Aurich, Ronan MT Fleming
Publié dans: Molecular Systems Biology, Numéro 16/5, 2020, ISSN 1744-4292
Éditeur: Nature Publishing Group
DOI: 10.15252/msb.20198982

Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism

Auteurs: Max Borsche, Inke R König, Sylvie Delcambre, Simona Petrucci, Alexander Balck, Norbert Brüggemann, Alexander Zimprich, Kobi Wasner, Sandro L Pereira, Micol Avenali, Christian Deuschle, Katja Badanjak, Jenny Ghelfi, Thomas Gasser, Meike Kasten, Philip Rosenstiel, Katja Lohmann, Kathrin Brockmann, Enza Maria Valente, Richard J Youle, Anne Grünewald, Christine Klein
Publié dans: Brain, Numéro 143, 2020, Page(s) 3041-3051, ISSN 0006-8950
Éditeur: Oxford University Press
DOI: 10.1093/brain/awaa246

Mitochondria and Parkinson’s Disease: Clinical, Molecular, and Translational Aspects

Auteurs: Max Borsche, Sandro L. Pereira, Christine Klein, Anne Grünewald
Publié dans: Journal of Parkinson's Disease, Numéro 11/1, 2021, Page(s) 45-60, ISSN 1877-7171
Éditeur: IOS Press
DOI: 10.3233/jpd-201981

Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy

Auteurs: Vasudev Kantae, Elke H. J. Krekels, Michiel J. Van Esdonk, Peter Lindenburg, Amy C. Harms, Catherijne A. J. Knibbe, Piet H. Van der Graaf, Thomas Hankemeier
Publié dans: Metabolomics, Numéro 13/1, 2017, ISSN 1573-3882
Éditeur: Springer Verlag
DOI: 10.1007/s11306-016-1143-1

MetaboTools: A Comprehensive Toolbox for Analysis of Genome-Scale Metabolic Models

Auteurs: Maike K. Aurich, Ronan M. T. Fleming, Ines Thiele
Publié dans: Frontiers in Physiology, Numéro 7, 2016, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2016.00327

High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform

Auteurs: Nienke R. Wevers, Remko van Vught, Karlijn J. Wilschut, Arnaud Nicolas, Chiwan Chiang, Henriette L. Lanz, Sebastiaan J. Trietsch, Jos Joore, Paul Vulto
Publié dans: Scientific Reports, Numéro 6/1, 2016, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep38856

Real-Time Amperometric Recording of Extracellular H2O2 in the Brain of Immunocompromised Mice: An In Vitro, Ex Vivo and In Vivo Characterisation Study

Auteurs: Caroline H. Reid, Niall J. Finnerty
Publié dans: Sensors, Numéro 17/7, 2017, Page(s) 1596, ISSN 1424-8220
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s17071596

Embryonic development of selectively vulnerable neurons in Parkinson’s disease

Auteurs: Miguel A. P. Oliveira, Rudi Balling, Marten P. Smidt, Ronan M. T. Fleming
Publié dans: npj Parkinson's Disease, Numéro 3/1, 2017, ISSN 2373-8057
Éditeur: Nature publishing group
DOI: 10.1038/s41531-017-0022-4

96 perfusable blood vessels to study vascular permeability in vitro

Auteurs: V. van Duinen, A. van den Heuvel, S. J. Trietsch, H. L. Lanz, J. M van Gils, A. J. van Zonneveld, P. Vulto, T. Hankemeier
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-017-14716-y

Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0

Auteurs: Laurent Heirendt, Sylvain Arreckx, Thomas Pfau, Sebastián N. Mendoza, Anne Richelle, Almut Heinken, Hulda S. Haraldsdóttir, Jacek Wachowiak, Sarah M. Keating, Vanja Vlasov, Stefania Magnusdóttir, Chiam Yu Ng, German Preciat, Alise Žagare, Siu H. J. Chan, Maike K. Aurich, Catherine M. Clancy, Jennifer Modamio, John T. Sauls, Alberto Noronha, Aarash Bordbar, Benjamin Cousins, Diana C. El Assal,
Publié dans: Nature Protocols, Numéro 14/3, 2019, Page(s) 639-702, ISSN 1754-2189
Éditeur: Nature Publishing Group
DOI: 10.1038/s41596-018-0098-2

3D Cultures of Parkinson's Disease-Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing

Auteurs: Silvia Bolognin, Marie Fossépré, Xiaobing Qing, Javier Jarazo, Janez Ščančar, Edinson Lucumi Moreno, Sarah L. Nickels, Kobi Wasner, Nassima Ouzren, Jonas Walter, Anne Grünewald, Enrico Glaab, Luis Salamanca, Ronan M. T. Fleming, Paul M. A. Antony, Jens C. Schwamborn
Publié dans: Advanced Science, Numéro 6/1, 2019, Page(s) 1800927, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.201800927

FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling

Auteurs: Jonathan Arias-Fuenzalida, Javier Jarazo, Xiaobing Qing, Jonas Walter, Gemma Gomez-Giro, Sarah Louise Nickels, Holm Zaehres, Hans Robert Schöler, Jens Christian Schwamborn
Publié dans: Stem Cell Reports, Numéro 9/5, 2017, Page(s) 1423-1431, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2017.08.026

Comparative evaluation of atom mapping algorithms for balanced metabolic reactions: application to Recon 3D

Auteurs: German A. Preciat Gonzalez, Lemmer R. P. El Assal, Alberto Noronha, Ines Thiele, Hulda S. Haraldsdóttir, Ronan M. T. Fleming
Publié dans: Journal of Cheminformatics, Numéro 9/1, 2017, ISSN 1758-2946
Éditeur: Chemistry Central
DOI: 10.1186/s13321-017-0223-1

Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32

Auteurs: Laura Gonzalez-Cano, Ingeborg Menzl, Johan Tisserand, Sarah Nicklas, Jens C. Schwamborn
Publié dans: Molecular Neurobiology, Numéro 55/4, 2018, Page(s) 3490-3498, ISSN 0893-7648
Éditeur: Humana Press, Inc.
DOI: 10.1007/s12035-017-0570-y

ReconMap: an interactive visualization of human metabolism

Auteurs: Alberto Noronha, Anna Dröfn Daníelsdóttir, Piotr Gawron, Freyr Jóhannsson, Soffía Jónsdóttir, Sindri Jarlsson, Jón Pétur Gunnarsson, Sigurður Brynjólfsson, Reinhard Schneider, Ines Thiele, Ronan M. T. Fleming
Publié dans: Bioinformatics, 2017, Page(s) btw667, ISSN 1367-4803
Éditeur: Oxford University Press
DOI: 10.1093/bioinformatics/btw667

Guidelines for Fluorescent Guided Biallelic HDR Targeting Selection With PiggyBac System Removal for Gene Editing

Auteurs: Javier Jarazo, Xiaobing Qing, Jens C. Schwamborn
Publié dans: Frontiers in Genetics, Numéro 10, 2019, ISSN 1664-8021
Éditeur: Frontiers Media
DOI: 10.3389/fgene.2019.00190

Automated microfluidic cell culture of stem cell derived dopaminergic neurons

Auteurs: Khalid I. W. Kane, Edinson Lucumi Moreno, Siham Hachi, Moriz Walter, Javier Jarazo, Miguel A. P. Oliveira, Thomas Hankemeier, Paul Vulto, Jens C. Schwamborn, Martin Thoma, Ronan M. T. Fleming
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-34828-3

Modeling Parkinson’s disease in midbrain-like organoids

Auteurs: Lisa M. Smits, Lydia Reinhardt, Peter Reinhardt, Michael Glatza, Anna S. Monzel, Nancy Stanslowsky, Marcelo D. Rosato-Siri, Alessandra Zanon, Paul M. Antony, Jessica Bellmann, Sarah M. Nicklas, Kathrin Hemmer, Xiaobing Qing, Emanuel Berger, Norman Kalmbach, Marc Ehrlich, Silvia Bolognin, Andrew A. Hicks, Florian Wegner, Jared L. Sterneckert, Jens C. Schwamborn
Publié dans: npj Parkinson's Disease, Numéro 5/1, 2019, ISSN 2373-8057
Éditeur: Nature Research
DOI: 10.1038/s41531-019-0078-4

LC–MS/MS analysis of the central energy and carbon metabolites in biological samples following derivatization by dimethylaminophenacyl bromide

Auteurs: Cornelius C.W. Willacey, Martijn Naaktgeboren, Edinson Lucumi Moreno, Agnieszka B. Wegrzyn, Daan van der Es, Naama Karu, Ronan M.T. Fleming, Amy C. Harms, Thomas Hankemeier
Publié dans: Journal of Chromatography A, Numéro 1608, 2019, Page(s) 460413, ISSN 0021-9673
Éditeur: Elsevier BV
DOI: 10.1016/j.chroma.2019.460413

Chaperone-mediated autophagy as a therapeutic target for Parkinson disease

Auteurs: Philip Campbell, Huw Morris, Anthony Schapira
Publié dans: Expert Opinion on Therapeutic Targets, Numéro 22/10, 2018, Page(s) 823-832, ISSN 1472-8222
Éditeur: Ashley Publications Ltd.
DOI: 10.1080/14728222.2018.1517156

Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients

Auteurs: Sarah Louise Nickels, Jonas Walter, Silvia Bolognin, Deborah Gérard, Christian Jaeger, Xiaobing Qing, Johan Tisserand, Javier Jarazo, Kathrin Hemmer, Amy Harms, Rashi Halder, Philippe Lucarelli, Emanuel Berger, Paul M.A. Antony, Enrico Glaab, Thomas Hankemeier, Christine Klein, Thomas Sauter, Lasse Sinkkonen, Jens Christian Schwamborn
Publié dans: Parkinsonism & Related Disorders, Numéro 67, 2019, Page(s) 48-55, ISSN 1353-8020
Éditeur: Elsevier BV
DOI: 10.1016/j.parkreldis.2019.09.018

An electrochemical investigation into the effects of local and systemic administrations of sodium nitroprusside in brain extracellular fluid of mice

Auteurs: Caroline H. Reid, Niall J. Finnerty
Publié dans: Bioelectrochemistry, Numéro 132, 2020, Page(s) 107441, ISSN 1567-5394
Éditeur: Elsevier BV
DOI: 10.1016/j.bioelechem.2019.107441

Recon3D enables a three-dimensional view of gene variation in human metabolism

Auteurs: Elizabeth Brunk, Swagatika Sahoo, Daniel C Zielinski, Ali Altunkaya, Andreas Dräger, Nathan Mih, Francesco Gatto, Avlant Nilsson, German Andres Preciat Gonzalez, Maike Kathrin Aurich, Andreas Prlić, Anand Sastry, Anna D Danielsdottir, Almut Heinken, Alberto Noronha, Peter W Rose, Stephen K Burley, Ronan M T Fleming, Jens Nielsen, Ines Thiele, Bernhard O Palsson
Publié dans: Nature Biotechnology, Numéro 36/3, 2018, Page(s) 272-281, ISSN 1087-0156
Éditeur: Nature Publishing Group
DOI: 10.1038/nbt.4072

Long Term Amperometric Recordings in the Brain Extracellular Fluid of Freely Moving Immunocompromised NOD SCID Mice

Auteurs: Caroline Reid, Niall Finnerty
Publié dans: Sensors, Numéro 17/3, 2017, Page(s) 419, ISSN 1424-8220
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s17020419

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

Auteurs: Anna S. Monzel, Lisa M. Smits, Kathrin Hemmer, Siham Hachi, Edinson Lucumi Moreno, Thea van Wuellen, Javier Jarazo, Jonas Walter, Inga Brüggemann, Ibrahim Boussaad, Emanuel Berger, Ronan M.T. Fleming, Silvia Bolognin, Jens C. Schwamborn
Publié dans: Stem Cell Reports, Numéro 8/5, 2017, Page(s) 1144-1154, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2017.03.010

Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE2 biosynthesis by sonlicromanol’s metabolite KH176m

Auteurs: X. Jiang, H. Renkema, B. Pennings, S. Pecheritsyna, J. C. Schoeman, T. Hankemeier, J. Smeitink, J. Beyrath
Publié dans: Scientific Reports, Numéro 11/1, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-79466-w

Parkin Deficiency Appears Not to Be Associated with Cardiac Damage in Parkinson's Disease

Auteurs: Michaela Trilck‐Winkler, Max Borsche, Inke R. König, Alexander Balck, Insa Lenz, Meike Kasten, Katja Lohmann, Kathrin Brockmann, Enza Maria Valente, Christine Klein, Norbert Brüggemann, Philip Seibler
Publié dans: Movement Disorders, Numéro 36/1, 2021, Page(s) 271-273, ISSN 0885-3185
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/mds.28422

Thesis and dissertations (3)

Selective vulnerability in Parkinson's disease: contributions from neuronal connectivity, lineage and functional identity

Auteurs: Oliveira, Miguel
Publié dans: 2017
Éditeur: University of Luxembourg

The Parkinson’s Disease Associated Pink1-Parkin Pathway In Pathology And Development

Auteurs: Jarazo, Javier
Publié dans: 2018
Éditeur: University of Luxembourg

Neurochemical Monitoring in a Humanised Murine Model of Parkinson's disease using Amperometry and Microdialysis

Auteurs: Caroline Reid
Publié dans: 2019
Éditeur: Maynooth University

Other (3)

In Vivo Phenotyping Of Parkinson-Specific Stem Cells Reveals Increased a-Synuclein Levels But No Spreading

Auteurs: Schwamborn, Jens; Hemmer, Kathrin; Smits, Lisa; Bolognin, Silvia
Publié dans: 2017
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/140178

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids

Auteurs: Lisa M. Smits, Stefano Magni, Kamil Grzyb, Paul MA. Antony, Rejko Krüger, Alexander Skupin, Silvia Bolognin, Jens C. Schwamborn
Publié dans: 2019
Éditeur: Bioarxiv
DOI: 10.1101/589598

Parkinson’s disease phenotypes in patient specific brain organoids are improved by HP-β-CD treatment.

Auteurs: Javier Jarazo, Kyriaki Barmpa, Isabel Rosety, Lisa M. Smits, Jonathan Arias-Fuenzalida, Jonas Walter, Gemma Gomez-Giro, Anna S. Monzel, Xiaobing Qing, Gerald Cruciani, Ibrahim Boussaad, Christian Jäger, Aleksandar Rakovic, Emanuel Berger, Silvia Bolognin, Paul M. A. Antony, Christine Klein, Rejko Krüger, Philip Seibler, Jens C. Schwamborn
Publié dans: 2019
Éditeur: Bioarxiv
DOI: 10.1101/813089

Non-peer reviewed articles (1)

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality

Auteurs: Jonas Walter, Silvia Bolognin, Paul M.A. Antony, Sarah L. Nickels, Suresh K. Poovathingal, Luis Salamanca, Stefano Magni, Rita Perfeito, Fredrik Hoel, Xiaobing Qing, Javier Jarazo, Jonathan Arias-Fuenzalida, Tomasz Ignac, Anna S. Monzel, Laura Gonzalez-Cano, Luis Pereira de Almeida, Alexander Skupin, Karl J. Tronstad, Jens C. Schwamborn
Publié dans: Stem Cell Reports, Numéro 12/5, 2019, Page(s) 878-889, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2019.03.004