Systems Medicine of Mitochondrial Parkinson’s Disease

Informazioni relative al progetto

SysMedPD

ID dell’accordo di sovvenzione: 668738

DOI

10.3030/668738

Progetto chiuso

Data della firma CE 1 Dicembre 2015

Data di avvio 1 Dicembre 2015

Data di completamento 30 Novembre 2020

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 5 999 990,00

Contributo UE

€ 5 999 990,00

Coordinato da

UNIVERSITEIT LEIDEN
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Demonstrators, pilots, prototypes (5)

Miniaturised metabolomics platform including storage device for sample transport
Computational model of brain metabolism

Computational model of brain metabolism (lead partner: UL-Fleming)

Complete mitochondrial molecular network reconstruction

Complete mitochondrial molecular network reconstruction (lead partner: UL-Balling)

Metabolomics platform for mitochondrial dysfunction
Draft mitochondrial molecular network reconstruction

Draft mitochondrial molecular network reconstruction (lead partner: UL-Balling)

Documents, reports (4)

Successful differentiation of dopaminergic neurons from iPSCs and subsequent transplantation into NOD SCID mice

Successful differentiation of dopaminergic neurons from iPSCs and subsequent transplantation into NOD SCID mice (lead partner: UL-Schwamborn)

Successful neurochemical analysis performed in transplanted SCID mice and correlation to phenotype progression investigated
Open access summary report
Characterisation of in vivo amperometric sensors and microdialysis in the striatum of mice

Other (1)

SysMedPD audio-visual material

Websites, patent fillings, videos etc. (1)

External project website

Pubblicazioni

Peer reviewed articles (28)

Passive controlled flow for Parkinson's disease neuronal cell culture in 3D microfluidic devices

Autori: Javier Jarazo; Khalid I. W. Kane; Ronan M. T. Fleming; Ronan M. T. Fleming; Jens Christian Schwamborn; Edinson Lucumi Moreno
Pubblicato in: Organs-on-a-Chip, Numero 2, 2020, ISSN 2666-1020
Editore: Elsevier
DOI: 10.1016/j.ooc.2020.100005

Personalized whole‐body models integrate metabolism, physiology, and the gut microbiome

Autori: Ines Thiele, Swagatika Sahoo, Almut Heinken, Johannes Hertel, Laurent Heirendt, Maike K Aurich, Ronan MT Fleming
Pubblicato in: Molecular Systems Biology, Numero 16/5, 2020, ISSN 1744-4292
Editore: Nature Publishing Group
DOI: 10.15252/msb.20198982

Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism

Autori: Max Borsche, Inke R König, Sylvie Delcambre, Simona Petrucci, Alexander Balck, Norbert Brüggemann, Alexander Zimprich, Kobi Wasner, Sandro L Pereira, Micol Avenali, Christian Deuschle, Katja Badanjak, Jenny Ghelfi, Thomas Gasser, Meike Kasten, Philip Rosenstiel, Katja Lohmann, Kathrin Brockmann, Enza Maria Valente, Richard J Youle, Anne Grünewald, Christine Klein
Pubblicato in: Brain, Numero 143, 2020, Pagina/e 3041-3051, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awaa246

Mitochondria and Parkinson’s Disease: Clinical, Molecular, and Translational Aspects

Autori: Max Borsche, Sandro L. Pereira, Christine Klein, Anne Grünewald
Pubblicato in: Journal of Parkinson's Disease, Numero 11/1, 2021, Pagina/e 45-60, ISSN 1877-7171
Editore: IOS Press
DOI: 10.3233/jpd-201981

Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy

Autori: Vasudev Kantae, Elke H. J. Krekels, Michiel J. Van Esdonk, Peter Lindenburg, Amy C. Harms, Catherijne A. J. Knibbe, Piet H. Van der Graaf, Thomas Hankemeier
Pubblicato in: Metabolomics, Numero 13/1, 2017, ISSN 1573-3882
Editore: Springer Verlag
DOI: 10.1007/s11306-016-1143-1

MetaboTools: A Comprehensive Toolbox for Analysis of Genome-Scale Metabolic Models

Autori: Maike K. Aurich, Ronan M. T. Fleming, Ines Thiele
Pubblicato in: Frontiers in Physiology, Numero 7, 2016, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2016.00327

High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform

Autori: Nienke R. Wevers, Remko van Vught, Karlijn J. Wilschut, Arnaud Nicolas, Chiwan Chiang, Henriette L. Lanz, Sebastiaan J. Trietsch, Jos Joore, Paul Vulto
Pubblicato in: Scientific Reports, Numero 6/1, 2016, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep38856

Real-Time Amperometric Recording of Extracellular H2O2 in the Brain of Immunocompromised Mice: An In Vitro, Ex Vivo and In Vivo Characterisation Study

Autori: Caroline H. Reid, Niall J. Finnerty
Pubblicato in: Sensors, Numero 17/7, 2017, Pagina/e 1596, ISSN 1424-8220
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s17071596

Embryonic development of selectively vulnerable neurons in Parkinson’s disease

Autori: Miguel A. P. Oliveira, Rudi Balling, Marten P. Smidt, Ronan M. T. Fleming
Pubblicato in: npj Parkinson's Disease, Numero 3/1, 2017, ISSN 2373-8057
Editore: Nature publishing group
DOI: 10.1038/s41531-017-0022-4

96 perfusable blood vessels to study vascular permeability in vitro

Autori: V. van Duinen, A. van den Heuvel, S. J. Trietsch, H. L. Lanz, J. M van Gils, A. J. van Zonneveld, P. Vulto, T. Hankemeier
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-14716-y

Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0

Autori: Laurent Heirendt, Sylvain Arreckx, Thomas Pfau, Sebastián N. Mendoza, Anne Richelle, Almut Heinken, Hulda S. Haraldsdóttir, Jacek Wachowiak, Sarah M. Keating, Vanja Vlasov, Stefania Magnusdóttir, Chiam Yu Ng, German Preciat, Alise Žagare, Siu H. J. Chan, Maike K. Aurich, Catherine M. Clancy, Jennifer Modamio, John T. Sauls, Alberto Noronha, Aarash Bordbar, Benjamin Cousins, Diana C. El Assal,
Pubblicato in: Nature Protocols, Numero 14/3, 2019, Pagina/e 639-702, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/s41596-018-0098-2

3D Cultures of Parkinson's Disease-Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing

Autori: Silvia Bolognin, Marie Fossépré, Xiaobing Qing, Javier Jarazo, Janez Ščančar, Edinson Lucumi Moreno, Sarah L. Nickels, Kobi Wasner, Nassima Ouzren, Jonas Walter, Anne Grünewald, Enrico Glaab, Luis Salamanca, Ronan M. T. Fleming, Paul M. A. Antony, Jens C. Schwamborn
Pubblicato in: Advanced Science, Numero 6/1, 2019, Pagina/e 1800927, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.201800927

FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling

Autori: Jonathan Arias-Fuenzalida, Javier Jarazo, Xiaobing Qing, Jonas Walter, Gemma Gomez-Giro, Sarah Louise Nickels, Holm Zaehres, Hans Robert Schöler, Jens Christian Schwamborn
Pubblicato in: Stem Cell Reports, Numero 9/5, 2017, Pagina/e 1423-1431, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2017.08.026

Comparative evaluation of atom mapping algorithms for balanced metabolic reactions: application to Recon 3D

Autori: German A. Preciat Gonzalez, Lemmer R. P. El Assal, Alberto Noronha, Ines Thiele, Hulda S. Haraldsdóttir, Ronan M. T. Fleming
Pubblicato in: Journal of Cheminformatics, Numero 9/1, 2017, ISSN 1758-2946
Editore: Chemistry Central
DOI: 10.1186/s13321-017-0223-1

Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32

Autori: Laura Gonzalez-Cano, Ingeborg Menzl, Johan Tisserand, Sarah Nicklas, Jens C. Schwamborn
Pubblicato in: Molecular Neurobiology, Numero 55/4, 2018, Pagina/e 3490-3498, ISSN 0893-7648
Editore: Humana Press, Inc.
DOI: 10.1007/s12035-017-0570-y

ReconMap: an interactive visualization of human metabolism

Autori: Alberto Noronha, Anna Dröfn Daníelsdóttir, Piotr Gawron, Freyr Jóhannsson, Soffía Jónsdóttir, Sindri Jarlsson, Jón Pétur Gunnarsson, Sigurður Brynjólfsson, Reinhard Schneider, Ines Thiele, Ronan M. T. Fleming
Pubblicato in: Bioinformatics, 2017, Pagina/e btw667, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btw667

Guidelines for Fluorescent Guided Biallelic HDR Targeting Selection With PiggyBac System Removal for Gene Editing

Autori: Javier Jarazo, Xiaobing Qing, Jens C. Schwamborn
Pubblicato in: Frontiers in Genetics, Numero 10, 2019, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2019.00190

Automated microfluidic cell culture of stem cell derived dopaminergic neurons

Autori: Khalid I. W. Kane, Edinson Lucumi Moreno, Siham Hachi, Moriz Walter, Javier Jarazo, Miguel A. P. Oliveira, Thomas Hankemeier, Paul Vulto, Jens C. Schwamborn, Martin Thoma, Ronan M. T. Fleming
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-34828-3

Modeling Parkinson’s disease in midbrain-like organoids

Autori: Lisa M. Smits, Lydia Reinhardt, Peter Reinhardt, Michael Glatza, Anna S. Monzel, Nancy Stanslowsky, Marcelo D. Rosato-Siri, Alessandra Zanon, Paul M. Antony, Jessica Bellmann, Sarah M. Nicklas, Kathrin Hemmer, Xiaobing Qing, Emanuel Berger, Norman Kalmbach, Marc Ehrlich, Silvia Bolognin, Andrew A. Hicks, Florian Wegner, Jared L. Sterneckert, Jens C. Schwamborn
Pubblicato in: npj Parkinson's Disease, Numero 5/1, 2019, ISSN 2373-8057
Editore: Nature Research
DOI: 10.1038/s41531-019-0078-4

LC–MS/MS analysis of the central energy and carbon metabolites in biological samples following derivatization by dimethylaminophenacyl bromide

Autori: Cornelius C.W. Willacey, Martijn Naaktgeboren, Edinson Lucumi Moreno, Agnieszka B. Wegrzyn, Daan van der Es, Naama Karu, Ronan M.T. Fleming, Amy C. Harms, Thomas Hankemeier
Pubblicato in: Journal of Chromatography A, Numero 1608, 2019, Pagina/e 460413, ISSN 0021-9673
Editore: Elsevier BV
DOI: 10.1016/j.chroma.2019.460413

Chaperone-mediated autophagy as a therapeutic target for Parkinson disease

Autori: Philip Campbell, Huw Morris, Anthony Schapira
Pubblicato in: Expert Opinion on Therapeutic Targets, Numero 22/10, 2018, Pagina/e 823-832, ISSN 1472-8222
Editore: Ashley Publications Ltd.
DOI: 10.1080/14728222.2018.1517156

Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients

Autori: Sarah Louise Nickels, Jonas Walter, Silvia Bolognin, Deborah Gérard, Christian Jaeger, Xiaobing Qing, Johan Tisserand, Javier Jarazo, Kathrin Hemmer, Amy Harms, Rashi Halder, Philippe Lucarelli, Emanuel Berger, Paul M.A. Antony, Enrico Glaab, Thomas Hankemeier, Christine Klein, Thomas Sauter, Lasse Sinkkonen, Jens Christian Schwamborn
Pubblicato in: Parkinsonism & Related Disorders, Numero 67, 2019, Pagina/e 48-55, ISSN 1353-8020
Editore: Elsevier BV
DOI: 10.1016/j.parkreldis.2019.09.018

An electrochemical investigation into the effects of local and systemic administrations of sodium nitroprusside in brain extracellular fluid of mice

Autori: Caroline H. Reid, Niall J. Finnerty
Pubblicato in: Bioelectrochemistry, Numero 132, 2020, Pagina/e 107441, ISSN 1567-5394
Editore: Elsevier BV
DOI: 10.1016/j.bioelechem.2019.107441

Recon3D enables a three-dimensional view of gene variation in human metabolism

Autori: Elizabeth Brunk, Swagatika Sahoo, Daniel C Zielinski, Ali Altunkaya, Andreas Dräger, Nathan Mih, Francesco Gatto, Avlant Nilsson, German Andres Preciat Gonzalez, Maike Kathrin Aurich, Andreas Prlić, Anand Sastry, Anna D Danielsdottir, Almut Heinken, Alberto Noronha, Peter W Rose, Stephen K Burley, Ronan M T Fleming, Jens Nielsen, Ines Thiele, Bernhard O Palsson
Pubblicato in: Nature Biotechnology, Numero 36/3, 2018, Pagina/e 272-281, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/nbt.4072

Long Term Amperometric Recordings in the Brain Extracellular Fluid of Freely Moving Immunocompromised NOD SCID Mice

Autori: Caroline Reid, Niall Finnerty
Pubblicato in: Sensors, Numero 17/3, 2017, Pagina/e 419, ISSN 1424-8220
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s17020419

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

Autori: Anna S. Monzel, Lisa M. Smits, Kathrin Hemmer, Siham Hachi, Edinson Lucumi Moreno, Thea van Wuellen, Javier Jarazo, Jonas Walter, Inga Brüggemann, Ibrahim Boussaad, Emanuel Berger, Ronan M.T. Fleming, Silvia Bolognin, Jens C. Schwamborn
Pubblicato in: Stem Cell Reports, Numero 8/5, 2017, Pagina/e 1144-1154, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2017.03.010

Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE2 biosynthesis by sonlicromanol’s metabolite KH176m

Autori: X. Jiang, H. Renkema, B. Pennings, S. Pecheritsyna, J. C. Schoeman, T. Hankemeier, J. Smeitink, J. Beyrath
Pubblicato in: Scientific Reports, Numero 11/1, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-79466-w

Parkin Deficiency Appears Not to Be Associated with Cardiac Damage in Parkinson's Disease

Autori: Michaela Trilck‐Winkler, Max Borsche, Inke R. König, Alexander Balck, Insa Lenz, Meike Kasten, Katja Lohmann, Kathrin Brockmann, Enza Maria Valente, Christine Klein, Norbert Brüggemann, Philip Seibler
Pubblicato in: Movement Disorders, Numero 36/1, 2021, Pagina/e 271-273, ISSN 0885-3185
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mds.28422

Thesis and dissertations (3)

Selective vulnerability in Parkinson's disease: contributions from neuronal connectivity, lineage and functional identity

Autori: Oliveira, Miguel
Pubblicato in: 2017
Editore: University of Luxembourg

The Parkinson’s Disease Associated Pink1-Parkin Pathway In Pathology And Development

Autori: Jarazo, Javier
Pubblicato in: 2018
Editore: University of Luxembourg

Neurochemical Monitoring in a Humanised Murine Model of Parkinson's disease using Amperometry and Microdialysis

Autori: Caroline Reid
Pubblicato in: 2019
Editore: Maynooth University

Other (3)

In Vivo Phenotyping Of Parkinson-Specific Stem Cells Reveals Increased a-Synuclein Levels But No Spreading

Autori: Schwamborn, Jens; Hemmer, Kathrin; Smits, Lisa; Bolognin, Silvia
Pubblicato in: 2017
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/140178

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids

Autori: Lisa M. Smits, Stefano Magni, Kamil Grzyb, Paul MA. Antony, Rejko Krüger, Alexander Skupin, Silvia Bolognin, Jens C. Schwamborn
Pubblicato in: 2019
Editore: Bioarxiv
DOI: 10.1101/589598

Parkinson’s disease phenotypes in patient specific brain organoids are improved by HP-β-CD treatment.

Autori: Javier Jarazo, Kyriaki Barmpa, Isabel Rosety, Lisa M. Smits, Jonathan Arias-Fuenzalida, Jonas Walter, Gemma Gomez-Giro, Anna S. Monzel, Xiaobing Qing, Gerald Cruciani, Ibrahim Boussaad, Christian Jäger, Aleksandar Rakovic, Emanuel Berger, Silvia Bolognin, Paul M. A. Antony, Christine Klein, Rejko Krüger, Philip Seibler, Jens C. Schwamborn
Pubblicato in: 2019
Editore: Bioarxiv
DOI: 10.1101/813089

Non-peer reviewed articles (1)

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality

Autori: Jonas Walter, Silvia Bolognin, Paul M.A. Antony, Sarah L. Nickels, Suresh K. Poovathingal, Luis Salamanca, Stefano Magni, Rita Perfeito, Fredrik Hoel, Xiaobing Qing, Javier Jarazo, Jonathan Arias-Fuenzalida, Tomasz Ignac, Anna S. Monzel, Laura Gonzalez-Cano, Luis Pereira de Almeida, Alexander Skupin, Karl J. Tronstad, Jens C. Schwamborn
Pubblicato in: Stem Cell Reports, Numero 12/5, 2019, Pagina/e 878-889, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2019.03.004