Systems Medicine of Mitochondrial Parkinson’s Disease

Información del proyecto

SysMedPD

Identificador del acuerdo de subvención: 668738

DOI

10.3030/668738

Proyecto cerrado

Fecha de la firma de la CE 1 Diciembre 2015

Fecha de inicio 1 Diciembre 2015

Fecha de finalización 30 Noviembre 2020

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 5 999 990,00

Aportación de la UE

€ 5 999 990,00

Coordinado por

UNIVERSITEIT LEIDEN
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Demonstrators, pilots, prototypes (5)

Miniaturised metabolomics platform including storage device for sample transport
Computational model of brain metabolism

Computational model of brain metabolism (lead partner: UL-Fleming)

Complete mitochondrial molecular network reconstruction

Complete mitochondrial molecular network reconstruction (lead partner: UL-Balling)

Metabolomics platform for mitochondrial dysfunction
Draft mitochondrial molecular network reconstruction

Draft mitochondrial molecular network reconstruction (lead partner: UL-Balling)

Documents, reports (4)

Successful differentiation of dopaminergic neurons from iPSCs and subsequent transplantation into NOD SCID mice

Successful differentiation of dopaminergic neurons from iPSCs and subsequent transplantation into NOD SCID mice (lead partner: UL-Schwamborn)

Successful neurochemical analysis performed in transplanted SCID mice and correlation to phenotype progression investigated
Open access summary report
Characterisation of in vivo amperometric sensors and microdialysis in the striatum of mice

Other (1)

SysMedPD audio-visual material

Websites, patent fillings, videos etc. (1)

External project website

Publicaciones

Peer reviewed articles (28)

Passive controlled flow for Parkinson's disease neuronal cell culture in 3D microfluidic devices

Autores: Javier Jarazo; Khalid I. W. Kane; Ronan M. T. Fleming; Ronan M. T. Fleming; Jens Christian Schwamborn; Edinson Lucumi Moreno
Publicado en: Organs-on-a-Chip, Edición 2, 2020, ISSN 2666-1020
Editor: Elsevier
DOI: 10.1016/j.ooc.2020.100005

Personalized whole‐body models integrate metabolism, physiology, and the gut microbiome

Autores: Ines Thiele, Swagatika Sahoo, Almut Heinken, Johannes Hertel, Laurent Heirendt, Maike K Aurich, Ronan MT Fleming
Publicado en: Molecular Systems Biology, Edición 16/5, 2020, ISSN 1744-4292
Editor: Nature Publishing Group
DOI: 10.15252/msb.20198982

Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism

Autores: Max Borsche, Inke R König, Sylvie Delcambre, Simona Petrucci, Alexander Balck, Norbert Brüggemann, Alexander Zimprich, Kobi Wasner, Sandro L Pereira, Micol Avenali, Christian Deuschle, Katja Badanjak, Jenny Ghelfi, Thomas Gasser, Meike Kasten, Philip Rosenstiel, Katja Lohmann, Kathrin Brockmann, Enza Maria Valente, Richard J Youle, Anne Grünewald, Christine Klein
Publicado en: Brain, Edición 143, 2020, Página(s) 3041-3051, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awaa246

Mitochondria and Parkinson’s Disease: Clinical, Molecular, and Translational Aspects

Autores: Max Borsche, Sandro L. Pereira, Christine Klein, Anne Grünewald
Publicado en: Journal of Parkinson's Disease, Edición 11/1, 2021, Página(s) 45-60, ISSN 1877-7171
Editor: IOS Press
DOI: 10.3233/jpd-201981

Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy

Autores: Vasudev Kantae, Elke H. J. Krekels, Michiel J. Van Esdonk, Peter Lindenburg, Amy C. Harms, Catherijne A. J. Knibbe, Piet H. Van der Graaf, Thomas Hankemeier
Publicado en: Metabolomics, Edición 13/1, 2017, ISSN 1573-3882
Editor: Springer Verlag
DOI: 10.1007/s11306-016-1143-1

MetaboTools: A Comprehensive Toolbox for Analysis of Genome-Scale Metabolic Models

Autores: Maike K. Aurich, Ronan M. T. Fleming, Ines Thiele
Publicado en: Frontiers in Physiology, Edición 7, 2016, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2016.00327

High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform

Autores: Nienke R. Wevers, Remko van Vught, Karlijn J. Wilschut, Arnaud Nicolas, Chiwan Chiang, Henriette L. Lanz, Sebastiaan J. Trietsch, Jos Joore, Paul Vulto
Publicado en: Scientific Reports, Edición 6/1, 2016, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep38856

Real-Time Amperometric Recording of Extracellular H2O2 in the Brain of Immunocompromised Mice: An In Vitro, Ex Vivo and In Vivo Characterisation Study

Autores: Caroline H. Reid, Niall J. Finnerty
Publicado en: Sensors, Edición 17/7, 2017, Página(s) 1596, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s17071596

Embryonic development of selectively vulnerable neurons in Parkinson’s disease

Autores: Miguel A. P. Oliveira, Rudi Balling, Marten P. Smidt, Ronan M. T. Fleming
Publicado en: npj Parkinson's Disease, Edición 3/1, 2017, ISSN 2373-8057
Editor: Nature publishing group
DOI: 10.1038/s41531-017-0022-4

96 perfusable blood vessels to study vascular permeability in vitro

Autores: V. van Duinen, A. van den Heuvel, S. J. Trietsch, H. L. Lanz, J. M van Gils, A. J. van Zonneveld, P. Vulto, T. Hankemeier
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-14716-y

Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0

Autores: Laurent Heirendt, Sylvain Arreckx, Thomas Pfau, Sebastián N. Mendoza, Anne Richelle, Almut Heinken, Hulda S. Haraldsdóttir, Jacek Wachowiak, Sarah M. Keating, Vanja Vlasov, Stefania Magnusdóttir, Chiam Yu Ng, German Preciat, Alise Žagare, Siu H. J. Chan, Maike K. Aurich, Catherine M. Clancy, Jennifer Modamio, John T. Sauls, Alberto Noronha, Aarash Bordbar, Benjamin Cousins, Diana C. El Assal,
Publicado en: Nature Protocols, Edición 14/3, 2019, Página(s) 639-702, ISSN 1754-2189
Editor: Nature Publishing Group
DOI: 10.1038/s41596-018-0098-2

3D Cultures of Parkinson's Disease-Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing

Autores: Silvia Bolognin, Marie Fossépré, Xiaobing Qing, Javier Jarazo, Janez Ščančar, Edinson Lucumi Moreno, Sarah L. Nickels, Kobi Wasner, Nassima Ouzren, Jonas Walter, Anne Grünewald, Enrico Glaab, Luis Salamanca, Ronan M. T. Fleming, Paul M. A. Antony, Jens C. Schwamborn
Publicado en: Advanced Science, Edición 6/1, 2019, Página(s) 1800927, ISSN 2198-3844
Editor: Wiley
DOI: 10.1002/advs.201800927

FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling

Autores: Jonathan Arias-Fuenzalida, Javier Jarazo, Xiaobing Qing, Jonas Walter, Gemma Gomez-Giro, Sarah Louise Nickels, Holm Zaehres, Hans Robert Schöler, Jens Christian Schwamborn
Publicado en: Stem Cell Reports, Edición 9/5, 2017, Página(s) 1423-1431, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2017.08.026

Comparative evaluation of atom mapping algorithms for balanced metabolic reactions: application to Recon 3D

Autores: German A. Preciat Gonzalez, Lemmer R. P. El Assal, Alberto Noronha, Ines Thiele, Hulda S. Haraldsdóttir, Ronan M. T. Fleming
Publicado en: Journal of Cheminformatics, Edición 9/1, 2017, ISSN 1758-2946
Editor: Chemistry Central
DOI: 10.1186/s13321-017-0223-1

Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32

Autores: Laura Gonzalez-Cano, Ingeborg Menzl, Johan Tisserand, Sarah Nicklas, Jens C. Schwamborn
Publicado en: Molecular Neurobiology, Edición 55/4, 2018, Página(s) 3490-3498, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-017-0570-y

ReconMap: an interactive visualization of human metabolism

Autores: Alberto Noronha, Anna Dröfn Daníelsdóttir, Piotr Gawron, Freyr Jóhannsson, Soffía Jónsdóttir, Sindri Jarlsson, Jón Pétur Gunnarsson, Sigurður Brynjólfsson, Reinhard Schneider, Ines Thiele, Ronan M. T. Fleming
Publicado en: Bioinformatics, 2017, Página(s) btw667, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btw667

Guidelines for Fluorescent Guided Biallelic HDR Targeting Selection With PiggyBac System Removal for Gene Editing

Autores: Javier Jarazo, Xiaobing Qing, Jens C. Schwamborn
Publicado en: Frontiers in Genetics, Edición 10, 2019, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2019.00190

Automated microfluidic cell culture of stem cell derived dopaminergic neurons

Autores: Khalid I. W. Kane, Edinson Lucumi Moreno, Siham Hachi, Moriz Walter, Javier Jarazo, Miguel A. P. Oliveira, Thomas Hankemeier, Paul Vulto, Jens C. Schwamborn, Martin Thoma, Ronan M. T. Fleming
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-34828-3

Modeling Parkinson’s disease in midbrain-like organoids

Autores: Lisa M. Smits, Lydia Reinhardt, Peter Reinhardt, Michael Glatza, Anna S. Monzel, Nancy Stanslowsky, Marcelo D. Rosato-Siri, Alessandra Zanon, Paul M. Antony, Jessica Bellmann, Sarah M. Nicklas, Kathrin Hemmer, Xiaobing Qing, Emanuel Berger, Norman Kalmbach, Marc Ehrlich, Silvia Bolognin, Andrew A. Hicks, Florian Wegner, Jared L. Sterneckert, Jens C. Schwamborn
Publicado en: npj Parkinson's Disease, Edición 5/1, 2019, ISSN 2373-8057
Editor: Nature Research
DOI: 10.1038/s41531-019-0078-4

LC–MS/MS analysis of the central energy and carbon metabolites in biological samples following derivatization by dimethylaminophenacyl bromide

Autores: Cornelius C.W. Willacey, Martijn Naaktgeboren, Edinson Lucumi Moreno, Agnieszka B. Wegrzyn, Daan van der Es, Naama Karu, Ronan M.T. Fleming, Amy C. Harms, Thomas Hankemeier
Publicado en: Journal of Chromatography A, Edición 1608, 2019, Página(s) 460413, ISSN 0021-9673
Editor: Elsevier BV
DOI: 10.1016/j.chroma.2019.460413

Chaperone-mediated autophagy as a therapeutic target for Parkinson disease

Autores: Philip Campbell, Huw Morris, Anthony Schapira
Publicado en: Expert Opinion on Therapeutic Targets, Edición 22/10, 2018, Página(s) 823-832, ISSN 1472-8222
Editor: Ashley Publications Ltd.
DOI: 10.1080/14728222.2018.1517156

Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients

Autores: Sarah Louise Nickels, Jonas Walter, Silvia Bolognin, Deborah Gérard, Christian Jaeger, Xiaobing Qing, Johan Tisserand, Javier Jarazo, Kathrin Hemmer, Amy Harms, Rashi Halder, Philippe Lucarelli, Emanuel Berger, Paul M.A. Antony, Enrico Glaab, Thomas Hankemeier, Christine Klein, Thomas Sauter, Lasse Sinkkonen, Jens Christian Schwamborn
Publicado en: Parkinsonism & Related Disorders, Edición 67, 2019, Página(s) 48-55, ISSN 1353-8020
Editor: Elsevier BV
DOI: 10.1016/j.parkreldis.2019.09.018

An electrochemical investigation into the effects of local and systemic administrations of sodium nitroprusside in brain extracellular fluid of mice

Autores: Caroline H. Reid, Niall J. Finnerty
Publicado en: Bioelectrochemistry, Edición 132, 2020, Página(s) 107441, ISSN 1567-5394
Editor: Elsevier BV
DOI: 10.1016/j.bioelechem.2019.107441

Recon3D enables a three-dimensional view of gene variation in human metabolism

Autores: Elizabeth Brunk, Swagatika Sahoo, Daniel C Zielinski, Ali Altunkaya, Andreas Dräger, Nathan Mih, Francesco Gatto, Avlant Nilsson, German Andres Preciat Gonzalez, Maike Kathrin Aurich, Andreas Prlić, Anand Sastry, Anna D Danielsdottir, Almut Heinken, Alberto Noronha, Peter W Rose, Stephen K Burley, Ronan M T Fleming, Jens Nielsen, Ines Thiele, Bernhard O Palsson
Publicado en: Nature Biotechnology, Edición 36/3, 2018, Página(s) 272-281, ISSN 1087-0156
Editor: Nature Publishing Group
DOI: 10.1038/nbt.4072

Long Term Amperometric Recordings in the Brain Extracellular Fluid of Freely Moving Immunocompromised NOD SCID Mice

Autores: Caroline Reid, Niall Finnerty
Publicado en: Sensors, Edición 17/3, 2017, Página(s) 419, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s17020419

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

Autores: Anna S. Monzel, Lisa M. Smits, Kathrin Hemmer, Siham Hachi, Edinson Lucumi Moreno, Thea van Wuellen, Javier Jarazo, Jonas Walter, Inga Brüggemann, Ibrahim Boussaad, Emanuel Berger, Ronan M.T. Fleming, Silvia Bolognin, Jens C. Schwamborn
Publicado en: Stem Cell Reports, Edición 8/5, 2017, Página(s) 1144-1154, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2017.03.010

Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE2 biosynthesis by sonlicromanol’s metabolite KH176m

Autores: X. Jiang, H. Renkema, B. Pennings, S. Pecheritsyna, J. C. Schoeman, T. Hankemeier, J. Smeitink, J. Beyrath
Publicado en: Scientific Reports, Edición 11/1, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-79466-w

Parkin Deficiency Appears Not to Be Associated with Cardiac Damage in Parkinson's Disease

Autores: Michaela Trilck‐Winkler, Max Borsche, Inke R. König, Alexander Balck, Insa Lenz, Meike Kasten, Katja Lohmann, Kathrin Brockmann, Enza Maria Valente, Christine Klein, Norbert Brüggemann, Philip Seibler
Publicado en: Movement Disorders, Edición 36/1, 2021, Página(s) 271-273, ISSN 0885-3185
Editor: John Wiley & Sons Inc.
DOI: 10.1002/mds.28422

Thesis and dissertations (3)

Selective vulnerability in Parkinson's disease: contributions from neuronal connectivity, lineage and functional identity

Autores: Oliveira, Miguel
Publicado en: 2017
Editor: University of Luxembourg

The Parkinson’s Disease Associated Pink1-Parkin Pathway In Pathology And Development

Autores: Jarazo, Javier
Publicado en: 2018
Editor: University of Luxembourg

Neurochemical Monitoring in a Humanised Murine Model of Parkinson's disease using Amperometry and Microdialysis

Autores: Caroline Reid
Publicado en: 2019
Editor: Maynooth University

Other (3)

In Vivo Phenotyping Of Parkinson-Specific Stem Cells Reveals Increased a-Synuclein Levels But No Spreading

Autores: Schwamborn, Jens; Hemmer, Kathrin; Smits, Lisa; Bolognin, Silvia
Publicado en: 2017
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/140178

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids

Autores: Lisa M. Smits, Stefano Magni, Kamil Grzyb, Paul MA. Antony, Rejko Krüger, Alexander Skupin, Silvia Bolognin, Jens C. Schwamborn
Publicado en: 2019
Editor: Bioarxiv
DOI: 10.1101/589598

Parkinson’s disease phenotypes in patient specific brain organoids are improved by HP-β-CD treatment.

Autores: Javier Jarazo, Kyriaki Barmpa, Isabel Rosety, Lisa M. Smits, Jonathan Arias-Fuenzalida, Jonas Walter, Gemma Gomez-Giro, Anna S. Monzel, Xiaobing Qing, Gerald Cruciani, Ibrahim Boussaad, Christian Jäger, Aleksandar Rakovic, Emanuel Berger, Silvia Bolognin, Paul M. A. Antony, Christine Klein, Rejko Krüger, Philip Seibler, Jens C. Schwamborn
Publicado en: 2019
Editor: Bioarxiv
DOI: 10.1101/813089

Non-peer reviewed articles (1)

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality

Autores: Jonas Walter, Silvia Bolognin, Paul M.A. Antony, Sarah L. Nickels, Suresh K. Poovathingal, Luis Salamanca, Stefano Magni, Rita Perfeito, Fredrik Hoel, Xiaobing Qing, Javier Jarazo, Jonathan Arias-Fuenzalida, Tomasz Ignac, Anna S. Monzel, Laura Gonzalez-Cano, Luis Pereira de Almeida, Alexander Skupin, Karl J. Tronstad, Jens C. Schwamborn
Publicado en: Stem Cell Reports, Edición 12/5, 2019, Página(s) 878-889, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2019.03.004