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PERSONALIZED ENGINE FOR CANCER INTEGRATIVE STUDY AND EVALUATION

Objective

Despite of their great promise, high-throughput technologies in cancer research have often failed to translate to major therapeutic advances in the clinic. One challenge has been tumour heterogeneity, where multiple competing subclones coexist within a single tumour. Genomic heterogeneity renders it difficult to identify all driving molecular alterations, and thus results in therapies that only target subsets of aggressive tumour cells. Another challenge lies in the integration of multiple types of molecular data into mathematical disease models that can make actionable clinical statements.

We aim to develop predictive computational technology that can exploit molecular and clinical data to improve our understanding of disease mechanisms and to inform clinicians about optimized strategies for therapeutic intervention. We propose to focus on prostate cancer, a leading cause of cancer death amongst men in Europe, but also prone to over-treatment. Our approach combines the exploitation of genomic, transcriptomic, proteomic, and clinical data in primary and metastatic tumours, prospective cohorts of well characterized prostate cancer patients, drug screenings in cell lines, and the use of the Watson technology, a last generation cognitive computer developed at IBM.

The translational objective of this study is to develop technology for identifying disease mechanisms and produce treatment recommendations for individual patients based on a therapeutic biomarker panel. The proposed software framework will be accessible through a graphical interface that will facilitate its dissemination and use by researchers, clinicians, and biomedical industries. The framework will provide intuitive tools to deposit, share, analyze, and visualize molecular and clinical data; as well as to infer prognosis, elucidate implicated mechanisms and recommend therapy accordingly. This software framework will serve as a proof of concept for future development by industrial partners in Europe.

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2015-two-stage

Coordinator

TECHNIKON FORSCHUNGS- UND PLANUNGSGESELLSCHAFT MBH
Net EU contribution
€ 358 125,00
Address
Burgplatz 3a
9500 Villach
Austria

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Region
Südösterreich Kärnten Klagenfurt-Villach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00

Participants (9)

IBM RESEARCH GMBH
Switzerland
Net EU contribution
€ 0,00
Address
Saeumerstrasse 4
8803 Rueschlikon

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 1 256 250,00
TECHNISCHE UNIVERSITAT DARMSTADT
Germany
Net EU contribution
€ 539 375,00
Address
Karolinenplatz 5
64289 Darmstadt

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Region
Darmstadt Darmstadt, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITAETSKLINIKUM AACHEN
Germany
Net EU contribution
€ 620 937,50
Address
Pauwelsstrasse 30
52074 Aachen

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Region
Nordrhein-Westfalen Köln Städteregion Aachen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
Net EU contribution
€ 0,00
Address
Raemistrasse 101
8092 Zuerich

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Other funding
€ 520 200,00
UNIVERSITAT ZURICH
Switzerland
Net EU contribution
€ 0,00
Address
Ramistrasse 71
8006 Zurich

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Other funding
€ 828 950,00
BAYLOR COLLEGE OF MEDICINE
United States
Net EU contribution
€ 561 250,00
Address
One Baylor Plaza T119
77030 Houston Tx

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
INSTITUT CURIE
France
Net EU contribution
€ 535 625,00
Address
Rue D Ulm 26
75231 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 0,00
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
ASTRIDBIO TECHNOLOGIES KFT
Hungary
Net EU contribution
€ 475 000,00
Address
Also Kikoto Sor 11d
6726 Szeged

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Alföld és Észak Dél-Alföld Csongrád
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00