Evolutionary genomics: new perspectives and novel medical applications

Información del proyecto

EvoGenMed

Identificador del acuerdo de subvención: 669207

DOI

10.3030/669207

Proyecto cerrado

Fecha de la firma de la CE 18 Noviembre 2015

Fecha de inicio 1 Enero 2016

Fecha de finalización 30 Junio 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 497 996,00

Aportación de la UE

€ 2 497 996,00

Coordinado por

UNIVERSITY OF BATH
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (33)

Mitotic gene conversion can be as important as meiotic conversion in driving genetic variability in plants and other species without early germline segregation

Autores: Xianqing Jia, Qijun Zhang, Mengmeng Jiang, Ju Huang, Luyao Yu, Milton Brian Traw, Dacheng Tian, Laurence D. Hurst, Sihai Yang
Publicado en: PLOS Biology, Edición 19/3, 2021, Página(s) e3001164, ISSN 1545-7885
Editor: PLOS
DOI: 10.1371/journal.pbio.3001164

Evidence for Strong Mutation Bias toward, and Selection against, U Content in SARS-CoV-2: Implications for Vaccine Design

Autores: Alan M Rice, Atahualpa Castillo Morales, Alexander T Ho, Christine Mordstein, Stefanie Mühlhausen, Samir Watson, Laura Cano, Bethan Young, Grzegorz Kudla, Laurence D Hurst
Publicado en: Molecular Biology and Evolution, Edición 38/1, 2020, Página(s) 67-83, ISSN 1537-1719
Editor: Oxford University Press
DOI: 10.1093/molbev/msaa188

Causes and consequences of purifying selection on SARS-CoV-2

Autores: Atahualpa Castillo Morales, Alan M Rice, Alexander T Ho, Christine Mordstein, Stefanie Mühlhausen, Samir Watson, Laura Cano, Bethan Young, Grzegorz Kudla, Laurence D Hurst
Publicado en: Genome Biology and Evolution, 2021, ISSN 1759-6653
Editor: Oxford University Press
DOI: 10.1093/gbe/evab196

Variation in release factor abundance is not needed to explain trends in bacterial stop codon usage

Autores: Alexander T Ho, Laurence D Hurst
Publicado en: Molecular Biology and Evolution, 2021, ISSN 0737-4038
Editor: Oxford University Press
DOI: 10.1093/molbev/msab326

A Depletion of Stop Codons in lincRNA is Owing to Transfer of Selective Constraint from Coding Sequences

Autores: Liam Abrahams, Laurence D Hurst
Publicado en: Molecular Biology and Evolution, Edición 37/4, 2019, Página(s) 1148-1164, ISSN 0737-4038
Editor: Oxford University Press
DOI: 10.1093/molbev/msz299

Effective Population Size Predicts Local Rates but Not Local Mitigation of Read-through Errors

Autores: Alexander T Ho, Laurence D Hurst
Publicado en: Molecular Biology and Evolution, Edición 38/1, 2020, Página(s) 244-262, ISSN 1537-1719
Editor: Oxford University Press
DOI: 10.1093/molbev/msaa210

Transcription, mRNA export and immune evasion shape the codon usage of viruses

Autores: Christine Mordstein, Laura Cano, Atahualpa Castillo Morales, Bethan Young, Alexander T Ho, Alan M Rice, Michael Liss, Laurence D Hurst, Grzegorz Kudla
Publicado en: Genome Biology and Evolution, 2021, ISSN 1759-6653
Editor: Oxford University Press
DOI: 10.1093/gbe/evab106

Depletion of somatic mutations in splicing-associated sequences in cancer genomes

Autores: Laurence D. Hurst, Nizar N. Batada
Publicado en: Genome Biology, Edición 18/1, 2017, ISSN 1474-760X
Editor: BMC
DOI: 10.1186/s13059-017-1337-5

Faster Evolving Primate Genes Are More Likely to Duplicate

Autores: Áine N O’Toole, Laurence D Hurst, Aoife McLysaght
Publicado en: Molecular Biology and Evolution, Edición 35/1, 2017, Página(s) 107-118, ISSN 0737-4038
Editor: Oxford University Press
DOI: 10.1093/molbev/msx270

Refining the ambush hypothesis: evidence that GC and AT rich bacteria employ different frameshift defence strategies

Autores: Liam Abrahams, Laurence D Hurst
Publicado en: Genome Biology and Evolution, 2018, ISSN 1759-6653
Editor: Oxford University Press
DOI: 10.1093/gbe/evy075

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker

Autores: Julianna Zadora, Manvendra Singh, Florian Herse, Lukasz Przybyl, Nadine Haase, Michaela Golic, Hong Wa Yung, Berthold Huppertz, Judith E. Cartwright, Guy Whitley, Guro M. Johnsen, Giovanni Levi, Annette Isbruch, Herbert Schulz, Friedrich C. Luft, Dominik N. Müller, Anne Cathrine Staff, Laurence D. Hurst, Ralf Dechend, Zsuzsanna Izsvák
Publicado en: Circulation, Edición 136/19, 2017, Página(s) 1824-1839, ISSN 0009-7322
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.117.028110

Adenine Enrichment at the Fourth CDS Residue in Bacterial Genes Is Consistent with Error Proofing for +1 Frameshifts

Autores: Liam Abrahams, Laurence D Hurst
Publicado en: Molecular Biology and Evolution, Edición 34/12, 2017, Página(s) 3064-3080, ISSN 0737-4038
Editor: Oxford University Press
DOI: 10.1093/molbev/msx223

Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias

Autores: Haoxuan Liu, Ju Huang, Xiaoguang Sun, Jing Li, Yingwen Hu, Luyao Yu, Gianni Liti, Dacheng Tian, Laurence D. Hurst, Sihai Yang
Publicado en: Nature Ecology & Evolution, Edición 2/1, 2018, Página(s) 164-173, ISSN 2397-334X
Editor: Nature publishing group
DOI: 10.1038/s41559-017-0372-7

Identifying a large number of high-yield genes in rice by pedigree analysis, whole-genome sequencing, and CRISPR-Cas9 gene knockout

Autores: Ju Huang, Jing Li, Jun Zhou, Long Wang, Sihai Yang, Laurence D. Hurst, Wen-Hsiung Li, Dacheng Tian
Publicado en: Proceedings of the National Academy of Sciences, 2018, Página(s) 201806110, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1806110115

Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica

Autores: Stefanie Mühlhausen, Hans Dieter Schmitt, Kuan-Ting Pan, Uwe Plessmann, Henning Urlaub, Laurence D. Hurst, Martin Kollmar
Publicado en: Current Biology, Edición 28/13, 2018, Página(s) 2046-2057.e5, ISSN 0960-9822
Editor: Cell Press
DOI: 10.1016/j.cub.2018.04.085

Exonic splice regulation imposes strong selection at synonymous sites

Autores: Rosina Savisaar, Laurence D. Hurst
Publicado en: Genome Research, 2018, ISSN 1088-9051
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.233999.117

Determinants of the Usage of Splice-Associated cis -Motifs Predict the Distribution of Human Pathogenic SNPs

Autores: XianMing Wu, Laurence D. Hurst
Publicado en: Molecular Biology and Evolution, Edición 33/2, 2016, Página(s) 518-529, ISSN 0737-4038
Editor: Oxford University Press
DOI: 10.1093/molbev/msv251

The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome

Autores: Laurence D. Hurst, Avazeh T. Ghanbarian, Alistair R. R. Forrest, Lukasz Huminiecki
Publicado en: PLOS Biology, Edición 13/12, 2015, Página(s) e1002315, ISSN 1545-7885
Editor: Public Library of Science
DOI: 10.1371/journal.pbio.1002315

Purifying Selection on Exonic Splice Enhancers in Intronless Genes

Autores: Rosina Savisaar, Laurence D. Hurst
Publicado en: Molecular Biology and Evolution, Edición 33/6, 2016, Página(s) 1396-1418, ISSN 0737-4038
Editor: Oxford University Press
DOI: 10.1093/molbev/msw018

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

Autores: Jichang Wang, Manvendra Singh, Chuanbo Sun, Daniel Besser, Alessandro Prigione, Zoltán Ivics, Laurence D Hurst, Zsuzsanna Izsvák
Publicado en: Nature Protocols, Edición 11/2, 2016, Página(s) 327-346, ISSN 1754-2189
Editor: Nature Publishing Group
DOI: 10.1038/nprot.2016.016

Direct Determination of the Mutation Rate in the Bumblebee Reveals Evidence for Weak Recombination-Associated Mutation and an Approximate Rate Constancy in Insects

Autores: Haoxuan Liu, Yanxiao Jia, Xiaoguang Sun, Dacheng Tian, Laurence D. Hurst, Sihai Yang
Publicado en: Molecular Biology and Evolution, Edición 34/1, 2017, Página(s) 119-130, ISSN 0737-4038
Editor: Oxford University Press
DOI: 10.1093/molbev/msw226

Mutation rate analysis via parent–progeny sequencing of the perennial peach. II. No evidence for recombination-associated mutation

Autores: Long Wang, Yanchun Zhang, Chao Qin, Dacheng Tian, Sihai Yang, Laurence D. Hurst
Publicado en: Proceedings of the Royal Society B: Biological Sciences, Edición 283/1841, 2016, Página(s) 20161785, ISSN 0962-8452
Editor: Royal Society of London
DOI: 10.1098/rspb.2016.1785

Mutation rate analysis via parent–progeny sequencing of the perennial peach. I. A low rate in woody perennials and a higher mutagenicity in hybrids

Autores: Zhengqing Xie, Long Wang, Lirong Wang, Zhiqiang Wang, Zhenhua Lu, Dacheng Tian, Sihai Yang, Laurence D. Hurst
Publicado en: Proceedings of the Royal Society B: Biological Sciences, Edición 283/1841, 2016, Página(s) 20161016, ISSN 0962-8452
Editor: Royal Society of London
DOI: 10.1098/rspb.2016.1016

Open questions in the study of de novo genes: what, how and why

Autores: Aoife McLysaght, Laurence D. Hurst
Publicado en: Nature Reviews Genetics, Edición 17/9, 2016, Página(s) 567-578, ISSN 1471-0056
Editor: Nature Publishing Group
DOI: 10.1038/nrg.2016.78

The architecture of intra-organism mutation rate variation in plants

Autores: Long Wang, Yilun Ji, Yingwen Hu, Huaying Hu, Xianqin Jia, Mengmeng Jiang, Xiaohui Zhang, Lina Zhao, Yanchun Zhang, Yanxiao Jia, Chao Qin, Luyao Yu, Ju Huang, Sihai Yang, Laurence D. Hurst, Dacheng Tian
Publicado en: PLOS Biology, Edición 17/4, 2019, Página(s) e3000191, ISSN 1545-7885
Editor: Public Library of Science
DOI: 10.1371/journal.pbio.3000191

In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3’ additional stop codons

Autores: Alexander T. Ho, Laurence D. Hurst
Publicado en: PLOS Genetics, Edición 15/9, 2019, Página(s) e1008386, ISSN 1553-7404
Editor: Public Library of Science
DOI: 10.1371/journal.pgen.1008386

Codon Usage and Splicing Jointly Influence mRNA Localization

Autores: Christine Mordstein, Rosina Savisaar, Robert S. Young, Jeanne Bazile, Lana Talmane, Juliet Luft, Michael Liss, Martin S. Taylor, Laurence D. Hurst, Grzegorz Kudla
Publicado en: Cell Systems, 2020, ISSN 2405-4712
Editor: Cell Press
DOI: 10.1016/j.cels.2020.03.001

Estimating the prevalence of functional exonic splice regulatory information

Autores: Rosina Savisaar, Laurence D. Hurst
Publicado en: Human Genetics, 2017, ISSN 0340-6717
Editor: Springer Verlag
DOI: 10.1007/s00439-017-1798-3

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids

Autores: Gabriele Thumann, Nina Harmening, Cécile Prat-Souteyrand, Corinne Marie, Marie Pastor, Attila Sebe, Csaba Miskey, Laurence D. Hurst, Sabine Diarra, Martina Kropp, Peter Walter, Daniel Scherman, Zoltán Ivics, Zsuzsanna Izsvák, Sandra Johnen
Publicado en: Molecular Therapy - Nucleic Acids, Edición 6, 2017, Página(s) 302-314, ISSN 2162-2531
Editor: Nature Publishing Group
DOI: 10.1016/j.omtn.2017.02.002

Both maintenance and avoidance of RNA-binding protein interactions constrain coding sequence evolution

Autores: Savisaar Rosina, Laurence D. Hurst
Publicado en: Molecular Biology and Evolution, Edición 34, 2017, Página(s) msx061, ISSN 0737-4038
Editor: Oxford University Press
DOI: 10.1093/molbev/msx061

SDHA related tumorigenesis: a new case series and literature review for variant interpretation and pathogenicity

Autores: Ruth T. Casey, David B. Ascher, Eleanor Rattenberry, Louise Izatt, Katrina A. Andrews, Helen L. Simpson, Benjamen Challis, Soo-Mi Park, Venkata R. Bulusu, Fiona Lalloo, Douglas E. V. Pires, Hannah West, Graeme R. Clark, Philip S. Smith, James Whitworth, Thomas G. Papathomas, Phillipe Taniere, Rosina Savisaar, Laurence D. Hurst, Emma R. Woodward, Eamonn R. Maher
Publicado en: Molecular Genetics & Genomic Medicine, Edición 5/3, 2017, Página(s) 237-250, ISSN 2324-9269
Editor: Wiley Periodicals, Inc.
DOI: 10.1002/mgg3.279

Repeat-induced point mutation in Neurospora crassa causes the highest known mutation rate and mutational burden of any cellular life

Autores: Long Wang, Yingying Sun, Xiaoguang Sun, Luyao Yu, Lan Xue, Zhen He, Ju Huang, Dacheng Tian, Laurence D. Hurst, Sihai Yang
Publicado en: Genome Biology, Edición 21/1, 2020, ISSN 1474-760X
Editor: SpringerNature
DOI: 10.1186/s13059-020-02060-w

Evidence in disease and non-disease contexts that nonsense mutations cause altered splicing via motif disruption

Autores: Liam Abrahams, Rosina Savisaar, Christine Mordstein, Bethan Young, Grzegorz Kudla, Laurence D Hurst
Publicado en: Nucleic Acids Research, 2021, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkab750