Evolutionary genomics: new perspectives and novel medical applications

Informazioni relative al progetto

EvoGenMed

ID dell’accordo di sovvenzione: 669207

DOI

10.3030/669207

Progetto chiuso

Data della firma CE 18 Novembre 2015

Data di avvio 1 Gennaio 2016

Data di completamento 30 Giugno 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 497 996,00

Contributo UE

€ 2 497 996,00

Coordinato da

UNIVERSITY OF BATH
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (33)

Mitotic gene conversion can be as important as meiotic conversion in driving genetic variability in plants and other species without early germline segregation

Autori: Xianqing Jia, Qijun Zhang, Mengmeng Jiang, Ju Huang, Luyao Yu, Milton Brian Traw, Dacheng Tian, Laurence D. Hurst, Sihai Yang
Pubblicato in: PLOS Biology, Numero 19/3, 2021, Pagina/e e3001164, ISSN 1545-7885
Editore: PLOS
DOI: 10.1371/journal.pbio.3001164

Evidence for Strong Mutation Bias toward, and Selection against, U Content in SARS-CoV-2: Implications for Vaccine Design

Autori: Alan M Rice, Atahualpa Castillo Morales, Alexander T Ho, Christine Mordstein, Stefanie Mühlhausen, Samir Watson, Laura Cano, Bethan Young, Grzegorz Kudla, Laurence D Hurst
Pubblicato in: Molecular Biology and Evolution, Numero 38/1, 2020, Pagina/e 67-83, ISSN 1537-1719
Editore: Oxford University Press
DOI: 10.1093/molbev/msaa188

Causes and consequences of purifying selection on SARS-CoV-2

Autori: Atahualpa Castillo Morales, Alan M Rice, Alexander T Ho, Christine Mordstein, Stefanie Mühlhausen, Samir Watson, Laura Cano, Bethan Young, Grzegorz Kudla, Laurence D Hurst
Pubblicato in: Genome Biology and Evolution, 2021, ISSN 1759-6653
Editore: Oxford University Press
DOI: 10.1093/gbe/evab196

Variation in release factor abundance is not needed to explain trends in bacterial stop codon usage

Autori: Alexander T Ho, Laurence D Hurst
Pubblicato in: Molecular Biology and Evolution, 2021, ISSN 0737-4038
Editore: Oxford University Press
DOI: 10.1093/molbev/msab326

A Depletion of Stop Codons in lincRNA is Owing to Transfer of Selective Constraint from Coding Sequences

Autori: Liam Abrahams, Laurence D Hurst
Pubblicato in: Molecular Biology and Evolution, Numero 37/4, 2019, Pagina/e 1148-1164, ISSN 0737-4038
Editore: Oxford University Press
DOI: 10.1093/molbev/msz299

Effective Population Size Predicts Local Rates but Not Local Mitigation of Read-through Errors

Autori: Alexander T Ho, Laurence D Hurst
Pubblicato in: Molecular Biology and Evolution, Numero 38/1, 2020, Pagina/e 244-262, ISSN 1537-1719
Editore: Oxford University Press
DOI: 10.1093/molbev/msaa210

Transcription, mRNA export and immune evasion shape the codon usage of viruses

Autori: Christine Mordstein, Laura Cano, Atahualpa Castillo Morales, Bethan Young, Alexander T Ho, Alan M Rice, Michael Liss, Laurence D Hurst, Grzegorz Kudla
Pubblicato in: Genome Biology and Evolution, 2021, ISSN 1759-6653
Editore: Oxford University Press
DOI: 10.1093/gbe/evab106

Depletion of somatic mutations in splicing-associated sequences in cancer genomes

Autori: Laurence D. Hurst, Nizar N. Batada
Pubblicato in: Genome Biology, Numero 18/1, 2017, ISSN 1474-760X
Editore: BMC
DOI: 10.1186/s13059-017-1337-5

Faster Evolving Primate Genes Are More Likely to Duplicate

Autori: Áine N O’Toole, Laurence D Hurst, Aoife McLysaght
Pubblicato in: Molecular Biology and Evolution, Numero 35/1, 2017, Pagina/e 107-118, ISSN 0737-4038
Editore: Oxford University Press
DOI: 10.1093/molbev/msx270

Refining the ambush hypothesis: evidence that GC and AT rich bacteria employ different frameshift defence strategies

Autori: Liam Abrahams, Laurence D Hurst
Pubblicato in: Genome Biology and Evolution, 2018, ISSN 1759-6653
Editore: Oxford University Press
DOI: 10.1093/gbe/evy075

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker

Autori: Julianna Zadora, Manvendra Singh, Florian Herse, Lukasz Przybyl, Nadine Haase, Michaela Golic, Hong Wa Yung, Berthold Huppertz, Judith E. Cartwright, Guy Whitley, Guro M. Johnsen, Giovanni Levi, Annette Isbruch, Herbert Schulz, Friedrich C. Luft, Dominik N. Müller, Anne Cathrine Staff, Laurence D. Hurst, Ralf Dechend, Zsuzsanna Izsvák
Pubblicato in: Circulation, Numero 136/19, 2017, Pagina/e 1824-1839, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.117.028110

Adenine Enrichment at the Fourth CDS Residue in Bacterial Genes Is Consistent with Error Proofing for +1 Frameshifts

Autori: Liam Abrahams, Laurence D Hurst
Pubblicato in: Molecular Biology and Evolution, Numero 34/12, 2017, Pagina/e 3064-3080, ISSN 0737-4038
Editore: Oxford University Press
DOI: 10.1093/molbev/msx223

Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias

Autori: Haoxuan Liu, Ju Huang, Xiaoguang Sun, Jing Li, Yingwen Hu, Luyao Yu, Gianni Liti, Dacheng Tian, Laurence D. Hurst, Sihai Yang
Pubblicato in: Nature Ecology & Evolution, Numero 2/1, 2018, Pagina/e 164-173, ISSN 2397-334X
Editore: Nature publishing group
DOI: 10.1038/s41559-017-0372-7

Identifying a large number of high-yield genes in rice by pedigree analysis, whole-genome sequencing, and CRISPR-Cas9 gene knockout

Autori: Ju Huang, Jing Li, Jun Zhou, Long Wang, Sihai Yang, Laurence D. Hurst, Wen-Hsiung Li, Dacheng Tian
Pubblicato in: Proceedings of the National Academy of Sciences, 2018, Pagina/e 201806110, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1806110115

Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica

Autori: Stefanie Mühlhausen, Hans Dieter Schmitt, Kuan-Ting Pan, Uwe Plessmann, Henning Urlaub, Laurence D. Hurst, Martin Kollmar
Pubblicato in: Current Biology, Numero 28/13, 2018, Pagina/e 2046-2057.e5, ISSN 0960-9822
Editore: Cell Press
DOI: 10.1016/j.cub.2018.04.085

Exonic splice regulation imposes strong selection at synonymous sites

Autori: Rosina Savisaar, Laurence D. Hurst
Pubblicato in: Genome Research, 2018, ISSN 1088-9051
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.233999.117

Determinants of the Usage of Splice-Associated cis -Motifs Predict the Distribution of Human Pathogenic SNPs

Autori: XianMing Wu, Laurence D. Hurst
Pubblicato in: Molecular Biology and Evolution, Numero 33/2, 2016, Pagina/e 518-529, ISSN 0737-4038
Editore: Oxford University Press
DOI: 10.1093/molbev/msv251

The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome

Autori: Laurence D. Hurst, Avazeh T. Ghanbarian, Alistair R. R. Forrest, Lukasz Huminiecki
Pubblicato in: PLOS Biology, Numero 13/12, 2015, Pagina/e e1002315, ISSN 1545-7885
Editore: Public Library of Science
DOI: 10.1371/journal.pbio.1002315

Purifying Selection on Exonic Splice Enhancers in Intronless Genes

Autori: Rosina Savisaar, Laurence D. Hurst
Pubblicato in: Molecular Biology and Evolution, Numero 33/6, 2016, Pagina/e 1396-1418, ISSN 0737-4038
Editore: Oxford University Press
DOI: 10.1093/molbev/msw018

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

Autori: Jichang Wang, Manvendra Singh, Chuanbo Sun, Daniel Besser, Alessandro Prigione, Zoltán Ivics, Laurence D Hurst, Zsuzsanna Izsvák
Pubblicato in: Nature Protocols, Numero 11/2, 2016, Pagina/e 327-346, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/nprot.2016.016

Direct Determination of the Mutation Rate in the Bumblebee Reveals Evidence for Weak Recombination-Associated Mutation and an Approximate Rate Constancy in Insects

Autori: Haoxuan Liu, Yanxiao Jia, Xiaoguang Sun, Dacheng Tian, Laurence D. Hurst, Sihai Yang
Pubblicato in: Molecular Biology and Evolution, Numero 34/1, 2017, Pagina/e 119-130, ISSN 0737-4038
Editore: Oxford University Press
DOI: 10.1093/molbev/msw226

Mutation rate analysis via parent–progeny sequencing of the perennial peach. II. No evidence for recombination-associated mutation

Autori: Long Wang, Yanchun Zhang, Chao Qin, Dacheng Tian, Sihai Yang, Laurence D. Hurst
Pubblicato in: Proceedings of the Royal Society B: Biological Sciences, Numero 283/1841, 2016, Pagina/e 20161785, ISSN 0962-8452
Editore: Royal Society of London
DOI: 10.1098/rspb.2016.1785

Mutation rate analysis via parent–progeny sequencing of the perennial peach. I. A low rate in woody perennials and a higher mutagenicity in hybrids

Autori: Zhengqing Xie, Long Wang, Lirong Wang, Zhiqiang Wang, Zhenhua Lu, Dacheng Tian, Sihai Yang, Laurence D. Hurst
Pubblicato in: Proceedings of the Royal Society B: Biological Sciences, Numero 283/1841, 2016, Pagina/e 20161016, ISSN 0962-8452
Editore: Royal Society of London
DOI: 10.1098/rspb.2016.1016

Open questions in the study of de novo genes: what, how and why

Autori: Aoife McLysaght, Laurence D. Hurst
Pubblicato in: Nature Reviews Genetics, Numero 17/9, 2016, Pagina/e 567-578, ISSN 1471-0056
Editore: Nature Publishing Group
DOI: 10.1038/nrg.2016.78

The architecture of intra-organism mutation rate variation in plants

Autori: Long Wang, Yilun Ji, Yingwen Hu, Huaying Hu, Xianqin Jia, Mengmeng Jiang, Xiaohui Zhang, Lina Zhao, Yanchun Zhang, Yanxiao Jia, Chao Qin, Luyao Yu, Ju Huang, Sihai Yang, Laurence D. Hurst, Dacheng Tian
Pubblicato in: PLOS Biology, Numero 17/4, 2019, Pagina/e e3000191, ISSN 1545-7885
Editore: Public Library of Science
DOI: 10.1371/journal.pbio.3000191

In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3’ additional stop codons

Autori: Alexander T. Ho, Laurence D. Hurst
Pubblicato in: PLOS Genetics, Numero 15/9, 2019, Pagina/e e1008386, ISSN 1553-7404
Editore: Public Library of Science
DOI: 10.1371/journal.pgen.1008386

Codon Usage and Splicing Jointly Influence mRNA Localization

Autori: Christine Mordstein, Rosina Savisaar, Robert S. Young, Jeanne Bazile, Lana Talmane, Juliet Luft, Michael Liss, Martin S. Taylor, Laurence D. Hurst, Grzegorz Kudla
Pubblicato in: Cell Systems, 2020, ISSN 2405-4712
Editore: Cell Press
DOI: 10.1016/j.cels.2020.03.001

Estimating the prevalence of functional exonic splice regulatory information

Autori: Rosina Savisaar, Laurence D. Hurst
Pubblicato in: Human Genetics, 2017, ISSN 0340-6717
Editore: Springer Verlag
DOI: 10.1007/s00439-017-1798-3

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids

Autori: Gabriele Thumann, Nina Harmening, Cécile Prat-Souteyrand, Corinne Marie, Marie Pastor, Attila Sebe, Csaba Miskey, Laurence D. Hurst, Sabine Diarra, Martina Kropp, Peter Walter, Daniel Scherman, Zoltán Ivics, Zsuzsanna Izsvák, Sandra Johnen
Pubblicato in: Molecular Therapy - Nucleic Acids, Numero 6, 2017, Pagina/e 302-314, ISSN 2162-2531
Editore: Nature Publishing Group
DOI: 10.1016/j.omtn.2017.02.002

Both maintenance and avoidance of RNA-binding protein interactions constrain coding sequence evolution

Autori: Savisaar Rosina, Laurence D. Hurst
Pubblicato in: Molecular Biology and Evolution, Numero 34, 2017, Pagina/e msx061, ISSN 0737-4038
Editore: Oxford University Press
DOI: 10.1093/molbev/msx061

SDHA related tumorigenesis: a new case series and literature review for variant interpretation and pathogenicity

Autori: Ruth T. Casey, David B. Ascher, Eleanor Rattenberry, Louise Izatt, Katrina A. Andrews, Helen L. Simpson, Benjamen Challis, Soo-Mi Park, Venkata R. Bulusu, Fiona Lalloo, Douglas E. V. Pires, Hannah West, Graeme R. Clark, Philip S. Smith, James Whitworth, Thomas G. Papathomas, Phillipe Taniere, Rosina Savisaar, Laurence D. Hurst, Emma R. Woodward, Eamonn R. Maher
Pubblicato in: Molecular Genetics & Genomic Medicine, Numero 5/3, 2017, Pagina/e 237-250, ISSN 2324-9269
Editore: Wiley Periodicals, Inc.
DOI: 10.1002/mgg3.279

Repeat-induced point mutation in Neurospora crassa causes the highest known mutation rate and mutational burden of any cellular life

Autori: Long Wang, Yingying Sun, Xiaoguang Sun, Luyao Yu, Lan Xue, Zhen He, Ju Huang, Dacheng Tian, Laurence D. Hurst, Sihai Yang
Pubblicato in: Genome Biology, Numero 21/1, 2020, ISSN 1474-760X
Editore: SpringerNature
DOI: 10.1186/s13059-020-02060-w

Evidence in disease and non-disease contexts that nonsense mutations cause altered splicing via motif disruption

Autori: Liam Abrahams, Rosina Savisaar, Christine Mordstein, Bethan Young, Grzegorz Kudla, Laurence D Hurst
Pubblicato in: Nucleic Acids Research, 2021, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkab750