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Brain-viscera interactions underlie subjectivity

Project description

The role of internal organs in consciousness

Subjectivity refers to the individual's unique and personal experience of the world, which includes thoughts, emotions, and perceptions. The neural mechanisms underlying subjectivity are complex and not yet fully understood. Funded by the European Research Council, the BRAVIUS project is working under the hypothesis that subjectivity is related to the neural monitoring of visceral organs such as the heart and the stomach. Researchers will measure brain responses to heartbeats and gastric activity to validate the information flow to the cerebral cortex. Results will provide unprecedented insight into how ascending visceral signals contribute to subjectivity and the organisation of brain activity.

Objective

Subjectivity defines the subject who is perceiving, feeling, thinking, acting, and is essential to understand the conscious mind from the inside. However, subjectivity, or non-reflective first-person perspective, is not identified as a core concept in cognitive neuroscience and its neural basis remain largely unknown. BRAVIUS offers a unified framework to appraise both the concept and the neural mechanisms generating subjectivity. The hypothesis relies on two vital organs that generate their own rhythmic electrical activity, the stomach and the heart, and therefore constantly send information up to the neocortex, even in the absence of bodily change. Cortical responses to those visceral organs would define the organism as an entity at the neural level, and create a subject-centered referential from which first-person perspective can develop. In other words, the cardiac and gastric pacemakers could feed the brain with self-specifying inputs. BRAVIUS builds on previous theories and studies on visceral states but focuses on ascending information, from viscera to brain, and does not require visceral states to change nor to be consciously perceived. Experimentally, BRAVIUS measures the understudied neural response evoked by heartbeats and introduces a new measure, the electrogastrogram, to quantify the slow gastric pacemaker. BRAVIUS will test with magneto-encephalography (MEG) the role of neural responses to ascending visceral signals in generating subjectivity by cutting across domains of cognitive sciences and exploring diverse paradigms where subjectivity is engaged: perceptual consciousness, self-consciousness, emotions and decision making. BRAVIUS will further explore how cardiac and gastric ascending signals shape the temporal (MEG) and spatial (fMRI) organization of spontaneous brain activity. The project outcome is a detailed mechanistic neural account of the most private part of the human mind, and a unified concept of subjectivity across cognitive domains.

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ERC-ADG - Advanced Grant

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Call for proposal

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(opens in new window) ERC-2014-ADG

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Host institution

ECOLE NORMALE SUPERIEURE
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 706 510,00
Address
45, RUE D'ULM
75230 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 2 080 000,00

Beneficiaries (2)

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