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Efficient, Flexible Synthesis of Molecules with Tailored Shapes: from Photo-switchable Helices to anti-Cancer Compounds

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Publications

Difunctionalization of C–C σ-Bonds Enabled by the Reaction of Bicyclo[1.1.0]butyl Boronate Complexes with Electrophiles: Reaction Development, Scope, and Stereochemical Origins

Author(s): Steven H. Bennett, Alexander Fawcett, Elliott H. Denton, Tobias Biberger, Valerio Fasano, Nils Winter, Varinder K. Aggarwal
Published in: Journal of the American Chemical Society, 142/39, 2020, Page(s) 16766-16775, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c07357

Conformationally Controlled Linear and Helical Hydrocarbons Bearing Extended Side Chains.

Author(s): Lin Guo; Oliver J. Dutton; Murat Kucukdisli; Matthew Davy; Olivier Wagnières; Craig P. Butts; Eddie L. Myers; Varinder K. Aggarwal
Published in: Journal of the American Chemical Society, 143/40, 2021, Page(s) 16682-16692, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c07778

Divergent, Strain‐Release Reactions of Azabicyclo[1.1.0]butyl Carbinols: Semipinacol or Spiroepoxy Azetidine Formation

Author(s): Charlotte H. U. Gregson, Adam Noble, Varinder K. Aggarwal
Published in: Angewandte Chemie International Edition, 60/13, 2021, Page(s) 7360-7365, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202100583

Enantiospecific Synthesis of ortho -Substituted Benzylic Boronic Esters by a 1,2-Metalate Rearrangement/1,3-Borotropic Shift Sequence

Author(s): Stefan Aichhorn, Raphael Bigler, Eddie L. Myers, Varinder K. Aggarwal
Published in: Journal of the American Chemical Society, 139/28, 2017, Page(s) 9519-9522, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.7b05880

Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes

Author(s): James R. Smith, Beatrice S. L. Collins, Matthew J. Hesse, Mark A. Graham, Eddie L. Myers, Varinder K. Aggarwal
Published in: Journal of the American Chemical Society, 139/27, 2017, Page(s) 9148-9151, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.7b05149

Photoinduced decarboxylative borylation of carboxylic acids

Author(s): Alexander Fawcett, Johan Pradeilles, Yahui Wang, Tatsuya Mutsuga, Eddie L. Myers, Varinder K. Aggarwal
Published in: Science, 357/6348, 2017, Page(s) 283-286, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aan3679

50 Years of Zweifel Olefination: A Transition-Metal-Free Coupling

Author(s): Varinder Aggarwal, Roly Armstrong
Published in: Synthesis, 49/15, 2017, Page(s) 3323-3336, ISSN 0039-7881
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0036-1589046

Synergy of synthesis, computation and NMR reveals correct baulamycin structures

Author(s): Jingjing Wu, Paula Lorenzo, Siying Zhong, Muhammad Ali, Craig P. Butts, Eddie L. Myers, Varinder K. Aggarwal
Published in: Nature, 547/7664, 2017, Page(s) 436-440, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature23265

Asymmetric Synthesis of Secondary and Tertiary Boronic Esters

Author(s): Beatrice S. L. Collins, Claire M. Wilson, Eddie L. Myers, Varinder K. Aggarwal
Published in: Angewandte Chemie International Edition, 56/39, 2017, Page(s) 11700-11733, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201701963

Stereospecific Allylic Functionalization: The Reactions of Allylboronate Complexes with Electrophiles

Author(s): Cristina García-Ruiz, Jack L.-Y. Chen, Christopher Sandford, Kathryn Feeney, Paula Lorenzo, Guillaume Berionni, Herbert Mayr, Varinder K. Aggarwal
Published in: Journal of the American Chemical Society, 139/43, 2017, Page(s) 15324-15327, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.7b10240

Enantiospecific sp 2 -sp 3 Coupling of ortho - and para -Phenols with Secondary and Tertiary Boronic Esters

Author(s): Claire M. Wilson, Venkataraman Ganesh, Adam Noble, Varinder K. Aggarwal
Published in: Angewandte Chemie International Edition, 56/51, 2017, Page(s) 16318-16322, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201710777

Enantioselective Synthesis of the Cyclopiazonic Acid Family Using Sulfur Ylides

Author(s): Oleksandr Zhurakovskyi, Yunus E. Türkmen, Lorenz E. Löffler, Vijayalakshmi A. Moorthie, C. Chun Chen, Michael A. Shaw, Mark R. Crimmin, Marco Ferrara, Mushtaq Ahmad, Mehrnoosh Ostovar, Johnathan V. Matlock, Varinder K. Aggarwal
Published in: Angewandte Chemie International Edition, 57/5, 2018, Page(s) 1346-1350, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201712065

Enantiospecific Three-Component Alkylation of Furan and Indole

Author(s): Mattia Silvi, Raffael Schrof, Adam Noble, Varinder K. Aggarwal
Published in: Chemistry - A European Journal, 24/17, 2018, Page(s) 4279-4282, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201800527

Stereocontrolled Synthesis of Polypropionate Fragments based on a Building Block Assembly Strategy using Lithiation-Borylation Methodologies

Author(s): Alba Millán, Pablo D. Grigol Martinez, Varinder K. Aggarwal
Published in: Chemistry - A European Journal, 24/3, 2018, Page(s) 730-735, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201704946

α-Sulfinyl Benzoates as Precursors to Li and Mg Carbenoids for the Stereoselective Iterative Homologation of Boronic Esters

Author(s): Giorgia Casoni, Murat Kucukdisli, James M. Fordham, Matthew Burns, Eddie L. Myers, Varinder K. Aggarwal
Published in: Journal of the American Chemical Society, 139/34, 2017, Page(s) 11877-11886, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.7b05457

Visible-Light-Mediated Decarboxylative Radical Additions to Vinyl Boronic Esters: Rapid Access to γ-Amino Boronic Esters

Author(s): Adam Noble, Riccardo S. Mega, Daniel Pflästerer, Eddie L. Myers, Varinder K. Aggarwal
Published in: Angewandte Chemie International Edition, 57/8, 2018, Page(s) 2155-2159, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201712186

Photoinduced Deaminative Borylation of Alkylamines

Author(s): Jingjing Wu, Lin He, Adam Noble, Varinder K. Aggarwal
Published in: Journal of the American Chemical Society, 140, 2018, Page(s) 10700–10704, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.8b07103

Stereo- and Regiocontrolled Methylboration of Terminal Alkynes

Author(s): Oleksandr Zhurakovskyi, Rafael M. P. Dias, Adam Noble, Varinder K. Aggarwal
Published in: Organic Letters, 20/10, 2018, Page(s) 3136-3139, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.8b01252

Complex Boron-Containing Molecules through a 1,2-Metalate Rearrangement/anti-S N 2′ Elimination/Cycloaddition Reaction Sequence

Author(s): Varinder Aggarwal, Chloe Tillin, Raphael Bigler, Renata Calo-Lapido, Beatrice Collins, Adam Noble
Published in: Synlett, 2018, ISSN 0936-5214
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0037-1610389

Enantiospecific Synthesis of ortho-Substituted 1,1-Diarylalkanes by a 1,2-Metalate Rearrangement/anti-SN2' Elimination/Rearomatizing Allylic Suzuki-Miyaura Reaction Sequence

Author(s): Belén Rubial, Beatrice S. L. Collins, Raphael Bigler, Stefan Aichhorn, Adam Noble, Varinder Kumar Aggarwal
Published in: Angewandte Chemie International Edition, 2018, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201811343

Enantiodivergent Synthesis of Allenes by Point-to-Axial Chirality Transfer

Author(s): Roly J. Armstrong, Meganathan Nandakumar, Rafael M. P. Dias, Adam Noble, Eddie L. Myers, Varinder K. Aggarwal
Published in: Angewandte Chemie International Edition, 57/27, 2018, Page(s) 8203-8208, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201804446

Investigation of the Deprotonative Generation and Borylation of Diamine-Ligated α-Lithiated Carbamates and Benzoates by in Situ IR spectroscopy

Author(s): Rory C. Mykura, Simon Veth, Ana Varela, Lydia Dewis, Joshua J. Farndon, Eddie L. Myers, Varinder K. Aggarwal
Published in: Journal of the American Chemical Society, 140/44, 2018, Page(s) 14677-14686, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.8b06871

Chiral Aniline Synthesis via Stereospecific C(sp 3 )–C(sp 2 ) Coupling of Boronic Esters with Aryl Hydrazines

Author(s): Venkataraman Ganesh, Adam Noble, Varinder K. Aggarwal
Published in: Organic Letters, 20/19, 2018, Page(s) 6144-6147, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.8b02615

Synthesis of Functionalized Cyclopropanes from Carboxylic Acids by a Radical Addition-Polar Cyclization Cascade

Author(s): Chao Shu, Riccardo S. Mega, Björn J. Andreassen, Adam Noble, Varinder K. Aggarwal
Published in: Angewandte Chemie International Edition, 57/47, 2018, Page(s) 15430-15434, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201808598

Stereospecific functionalizations and transformations of secondary and tertiary boronic esters

Author(s): Christopher Sandford, Varinder K. Aggarwal
Published in: Chem. Commun., 53/40, 2017, Page(s) 5481-5494, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7CC01254C

Full chirality transfer in the synthesis of hindered tertiary boronic esters under in situ lithiation–borylation conditions

Author(s): D. J. Blair, S. Zhong, M. J. Hesse, N. Zabaleta, E. L. Myers, V. K. Aggarwal
Published in: Chem. Commun., 52/30, 2016, Page(s) 5289-5292, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/C6CC00536E

Selective uni- and bidirectional homologation of diborylmethane

Author(s): Daniel J. Blair, Damiano Tanini, Joseph M. Bateman, Helen K. Scott, Eddie L. Myers, Varinder K. Aggarwal
Published in: Chem. Sci., 8/4, 2017, Page(s) 2898-2903, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/C6SC05338F

Iterative assembly line synthesis of polypropionates with full stereocontrol

Author(s): Teerawut Bootwicha, Julian M. Feilner, Eddie L. Myers, Varinder K. Aggarwal
Published in: Nature Chemistry, 2017, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/nchem.2757

Strain-Release-Driven Homologation of Boronic Esters: Application to the Modular Synthesis of Azetidines

Author(s): Alexander Fawcett, Amna Murtaza, Charlotte H. U. Gregson, Varinder K. Aggarwal
Published in: Journal of the American Chemical Society, 141/11, 2019, Page(s) 4573-4578, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b01513

Catalyst‐Free Deaminative Functionalizations of Primary Amines by Photoinduced Single‐Electron Transfer

Author(s): Jingjing Wu, Phillip S. Grant, Xiabing Li, Adam Noble, Varinder K. Aggarwal
Published in: Angewandte Chemie International Edition, 58/17, 2019, Page(s) 5697-5701, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201814452

Strain Release of Donor–Acceptor Cyclopropyl Boronate Complexes

Author(s): Charlotte H. U. Gregson, Venkataraman Ganesh, Varinder K. Aggarwal
Published in: Organic Letters, 21/9, 2019, Page(s) 3412-3416, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.9b01152

1,2-Boron Shifts of β-Boryl Radicals Generated from Bis-boronic Esters Using Photoredox Catalysis

Author(s): Daniel Kaiser, Adam Noble, Valerio Fasano, Varinder K. Aggarwal
Published in: Journal of the American Chemical Society, 141/36, 2019, Page(s) 14104-14109, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b07564

Photoredox‐Catalyzed Cyclobutane Synthesis by a Deboronative Radical Addition–Polar Cyclization Cascade

Author(s): Chao Shu, Adam Noble, Varinder K. Aggarwal
Published in: Angewandte Chemie International Edition, 58/12, 2019, Page(s) 3870-3874, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201813917

Carbopalladation of C–C σ-bonds enabled by strained boronate complexes

Author(s): Alexander Fawcett, Tobias Biberger, Varinder K. Aggarwal
Published in: Nature Chemistry, 11/2, 2019, Page(s) 117-122, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-018-0181-x

Decarboxylative Conjunctive Cross‐coupling of Vinyl Boronic Esters using Metallaphotoredox Catalysis

Author(s): Riccardo S. Mega, Vincent K. Duong, Adam Noble, Varinder K. Aggarwal
Published in: Angewandte Chemie International Edition, 59/11, 2020, Page(s) 4375-4379, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201916340

Photoinduced Deoxygenative Borylations of Aliphatic Alcohols

Author(s): Jingjing Wu, Robin M. Bär, Lin Guo, Adam Noble, Varinder K. Aggarwal
Published in: Angewandte Chemie International Edition, 58/52, 2019, Page(s) 18830-18834, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201910051

Odd–even alternations in helical propensity of a homologous series of hydrocarbons

Author(s): Johan A. Pradeilles, Siying Zhong, Márton Baglyas, György Tarczay, Craig P. Butts, Eddie L. Myers, Varinder K. Aggarwal
Published in: Nature Chemistry, 2020, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-020-0429-0

Visible-Light-Driven Strain-Increase Ring Contraction Allows the Synthesis of Cyclobutyl Boronic Esters.

Author(s): Davenport, Raffael; Silvi, Mattia; Noble, Adam; Hosni, Zied; Fey, Natalie; Aggarwal, Varinder K.
Published in: Angewandte Chemie International Edition, 59/16, 2020, Page(s) 6525-6528, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201915409

Stereospecific 1,2‐Migrations of Boronate Complexes Induced by Electrophiles

Author(s): Hui Wang, Changcheng Jing, Adam Noble, Varinder Kumar Aggarwal
Published in: Angewandte Chemie International Edition, 59/39, 2020, Page(s) 16859-16872, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202008096