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Cell circuits as targets and biomarkers for liver disease and cancer prevention

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Publications

Viral manipulation of STAT3: Evade, exploit, and injure

Author(s): Armando Andres Roca Suarez, Nicolaas Van Renne, Thomas F. Baumert, Joachim Lupberger
Published in: PLOS Pathogens, Issue 14/3, 2018, Page(s) e1006839, ISSN 1553-7374
DOI: 10.1371/journal.ppat.1006839

Hepatitis C Virus (HCV)–Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design

Author(s): Florian Wrensch, Emilie Crouchet, Gaetan Ligat, Mirjam B. Zeisel, Zhen-Yong Keck, Steven K. H. Foung, Catherine Schuster, Thomas F. Baumert
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.01436

Mapping Determinants of Virus Neutralization and Viral Escape for Rational Design of a Hepatitis C Virus Vaccine

Author(s): Mei-Le Keck, Florian Wrensch, Brian G. Pierce, Thomas F. Baumert, Steven K. H. Foung
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.01194

Beyond viral dependence: The pathological consequences of HCV-induced EGF signaling

Author(s): Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Published in: Journal of Hepatology, Issue S0168-8278(18), 2018, Page(s) 32118-4, ISSN 0168-8278
DOI: 10.1016/j.jhep.2018.05.033

Host-targeting therapies for hepatitis C virus infection: current developments and future applications

Author(s): Emilie Crouchet, Florian Wrensch, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Published in: Therapeutic Advances in Gastroenterology, Issue 11, 2018, Page(s) 175628481875948, ISSN 1756-2848
DOI: 10.1177/1756284818759483

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

Author(s): Isabelle Desombere, Ahmed Atef Mesalam, Richard A. Urbanowicz, Freya Van Houtte, Lieven Verhoye, Zhen-Yong Keck, Ali Farhoudi, Koen Vercauteren, Karin E. Weening, Thomas F. Baumert, Arvind H. Patel, Steven K.H. Foung, Jonathan Ball, Geert Leroux-Roels, Philip Meuleman
Published in: Antiviral Research, Issue 148, 2017, Page(s) 53-64, ISSN 0166-3542
DOI: 10.1016/j.antiviral.2017.10.015

Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8 + T Cells in Chronic versus Acute Infection

Author(s): David Wolski, Peter K. Foote, Diana Y. Chen, Lia L. Lewis-Ximenez, Catherine Fauvelle, Jasneet Aneja, Andreas Walker, Pierre Tonnerre, Almudena Torres-Cornejo, Daniel Kvistad, Sabrina Imam, Michael T. Waring, Damien C. Tully, Todd M. Allen, Raymond T. Chung, Jörg Timm, W. Nicholas Haining, Arthur Y. Kim, Thomas F. Baumert, Georg M. Lauer
Published in: Immunity, Issue 47/4, 2017, Page(s) 648-663.e8, ISSN 1074-7613
DOI: 10.1016/j.immuni.2017.09.006

Zooming in on liver zonation


Published in: ISSN 0270-9139
DOI: 10.1002/hep.29554

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

Author(s): Zhirong Zhang, Gergö Meszaros, Wan-ting He, Yanfang Xu, Helena de Fatima Magliarelli, Laurent Mailly, Michael Mihlan, Yansheng Liu, Marta Puig Gámez, Alexander Goginashvili, Adrien Pasquier, Olga Bielska, Bénédicte Neven, Pierre Quartier, Rudolf Aebersold, Thomas F. Baumert, Philippe Georgel, Jiahuai Han, Romeo Ricci
Published in: The Journal of Experimental Medicine, Issue 214/9, 2017, Page(s) 2671-2693, ISSN 0022-1007
DOI: 10.1084/jem.20162040

Hepatitis C virus–apolipoprotein interactions: molecular mechanisms and clinical impact

Author(s): Emilie Crouchet, Thomas F. Baumert, Catherine Schuster
Published in: Expert Review of Proteomics, Issue 14/7, 2017, Page(s) 593-606, ISSN 1478-9450
DOI: 10.1080/14789450.2017.1344102

Entry Inhibitors: A Perspective for Prevention of Hepatitis C Virus Infection in Organ Transplantation

Author(s): Che C. Colpitts, Raymond T. Chung, Thomas F. Baumert
Published in: ACS Infectious Diseases, Issue 3/9, 2017, Page(s) 620-623, ISSN 2373-8227
DOI: 10.1021/acsinfecdis.7b00091

Advancing hepatitis B virus entry inhibitors

Author(s): Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Published in: Journal of Hepatology, Issue 66/4, 2017, Page(s) 677-679, ISSN 0168-8278
DOI: 10.1016/j.jhep.2016.11.028

SCARB1 variants and HCV infection: Host susceptibility is lost in translation

Author(s): Che C. Colpitts, Thomas F. Baumert
Published in: Journal of Hepatology, Issue 67/2, 2017, Page(s) 211-213, ISSN 0168-8278
DOI: 10.1016/j.jhep.2017.04.013

SMAD About Hepatitis C Virus Cell Entry and Liver Disease

Author(s): Che C. Colpitts, Thomas F. Baumert
Published in: Gastroenterology, Issue 152/1, 2017, Page(s) 21-23, ISSN 0016-5085
DOI: 10.1053/j.gastro.2016.11.029

miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis

Author(s): Nicolaas Van Renne, Armando Andres Roca Suarez, Francois H T Duong, Claire Gondeau, Diego Calabrese, Nelly Fontaine, Amina Ababsa, Simonetta Bandiera, Tom Croonenborghs, Nathalie Pochet, Vito De Blasi, Patrick Pessaux, Tullio Piardi, Daniele Sommacale, Atsushi Ono, Kazuaki Chayama, Masashi Fujita, Hidewaki Nakagawa, Yujin Hoshida, Mirjam B Zeisel, Markus H Heim, Thomas F Baumert, Joachim Lupberger
Published in: Gut, Issue 67/5, 2018, Page(s) 953-962, ISSN 0017-5749
DOI: 10.1136/gutjnl-2016-312270

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes

Author(s): Eloi R. Verrier, Che C. Colpitts, Charlotte Bach, Laura Heydmann, Laetitia Zona, Fei Xiao, Christine Thumann, Emilie Crouchet, Raphaël Gaudin, Camille Sureau, François-Loïc Cosset, Jane A. McKeating, Patrick Pessaux, Yujin Hoshida, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Published in: Cell Reports, Issue 17/5, 2016, Page(s) 1357-1368, ISSN 2211-1247
DOI: 10.1016/j.celrep.2016.09.084

Cell Culture Models for the Investigation of Hepatitis B and D Virus Infection

Author(s): Eloi Verrier, Che Colpitts, Catherine Schuster, Mirjam Zeisel, Thomas Baumert
Published in: Viruses, Issue 8/9, 2016, Page(s) 261, ISSN 1999-4915
DOI: 10.3390/v8090261

Claudins in viral infection: from entry to spread

Author(s): Che C. Colpitts, Thomas F. Baumert
Published in: Pflügers Archiv - European Journal of Physiology, Issue 469/1, 2017, Page(s) 27-34, ISSN 0031-6768
DOI: 10.1007/s00424-016-1908-4

Hepatitis B virus: is a cure possible?

Author(s): Mirjam B. Zeisel, Thomas F. Baumert
Published in: Expert Review of Clinical Pharmacology, Issue 9/9, 2016, Page(s) 1129-1130, ISSN 1751-2433
DOI: 10.1080/17512433.2016.1206466

Hepatitis C virus vaccine candidates inducing protective neutralizing antibodies

Author(s): Catherine Fauvelle, Che C. Colpitts, Zhen-yong Keck, Brian G. Pierce, Steven K. H. Foung, Thomas F. Baumert
Published in: Expert Review of Vaccines, Issue 15/12, 2016, Page(s) 1535-1544, ISSN 1476-0584
DOI: 10.1080/14760584.2016.1194759

Circulating microRNAs for early detection of hepatitis B-related hepatocellular carcinoma

Author(s): Simonetta Bandiera, Thomas F. Baumert, Mirjam B. Zeisel
Published in: HepatoBiliary Surgery and Nutrition, Issue 5/3, 2016, Page(s) 198-200, ISSN 2304-3881
DOI: 10.21037/hbsn.2016.03.08

Multifaceted role of E-cadherin in hepatitis C virus infection and pathogenesis

Author(s): Che C. Colpitts, Joachim Lupberger, Thomas F. Baumert
Published in: Proceedings of the National Academy of Sciences, Issue 113/27, 2016, Page(s) 7298-7300, ISSN 0027-8424
DOI: 10.1073/pnas.1607732113

Tailored Algorithms for Hepatocellular Carcinoma Surveillance: Is One-Size-Fits-All Strategy Outdated?

Author(s): Nicolas Goossens, C. Billie Bian, Yujin Hoshida
Published in: Current Hepatology Reports, Issue 16/1, 2017, Page(s) 64-71, ISSN 2195-9595
DOI: 10.1007/s11901-017-0336-z

Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine

Author(s): Naoto Fujiwara, Scott L. Friedman, Nicolas Goossens, Yujin Hoshida
Published in: Journal of Hepatology, Issue 68/3, 2018, Page(s) 526-549, ISSN 0168-8278
DOI: 10.1016/j.jhep.2017.09.016

Cell type-specific pharmacological kinase inhibition for cancer chemoprevention

Author(s): Manjeet Deshmukh, Shigeki Nakagawa, Takaaki Higashi, Adam Vincek, Anu Venkatesh, Marina Ruiz de Galarreta, Anna P Koh, Nicolas Goossens, Hadassa Hirschfield, C Billie Bian, Naoto Fujiwara, Atsushi Ono, Hiroki Hoshida, Mohamed El-Abtah, Noor B Ahmad, Amaia Lujambio, Roberto Sanchez, Bryan C Fuchs, Klaas Poelstra, Jai Prakash, Yujin Hoshida
Published in: Nanomedicine: Nanotechnology, Biology and Medicine, Issue 14/2, 2018, Page(s) 317-325, ISSN 1549-9634
DOI: 10.1016/j.nano.2017.11.004

Combination of Gene Expression Signature and Model for End-Stage Liver Disease Score Predicts Survival of Patients With Severe Alcoholic Hepatitis

Author(s): Eric Trépo, Nicolas Goossens, Naoto Fujiwara, Won-Min Song, Antonio Colaprico, Astrid Marot, Laurent Spahr, Pieter Demetter, Christine Sempoux, Gene Y. Im, Joan Saldarriaga, Thierry Gustot, Jacques Devière, Swan N. Thung, Charlotte Minsart, Thomas Sersté, Gianluca Bontempi, Karim Abdelrahman, Jean Henrion, Delphine Degré, Valerio Lucidi, Laura Rubbia-Brandt, Venugopalan D. Nair, Christophe Mor
Published in: Gastroenterology, Issue 154/4, 2018, Page(s) 965-975, ISSN 0016-5085
DOI: 10.1053/j.gastro.2017.10.048

Generic chemoprevention of hepatocellular carcinoma

Author(s): Sai Krishna Athuluri-Divakar, Yujin Hoshida
Published in: Annals of the New York Academy of Sciences, 2018, ISSN 0077-8923
DOI: 10.1111/nyas.13971

A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer

Author(s): Takuma Tsuchida, Youngmin A. Lee, Naoto Fujiwara, Maria Ybanez, Brittany Allen, Sebastiao Martins, M. Isabel Fiel, Nicolas Goossens, Hsin-I. Chou, Yujin Hoshida, Scott L. Friedman
Published in: Journal of Hepatology, Issue 69/2, 2018, Page(s) 385-395, ISSN 0168-8278
DOI: 10.1016/j.jhep.2018.03.011

The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses

Author(s): Carla Eller, Laura Heydmann, Che C. Colpitts, Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Published in: Cellular and Molecular Life Sciences, Issue 75/21, 2018, Page(s) 3895-3905, ISSN 1420-682X
DOI: 10.1007/s00018-018-2892-y

HBV core variants, liver fibrosis and hepatocellular carcinoma


Published in: ISSN 0270-9139
DOI: 10.1002/hep.30231

Status of Direct-acting Antiviral Therapy for HCV Infection and Remaining Challenges

Author(s): Thomas F. Baumert, Thomas Berg, Joseph K. Lim, David R. Nelson
Published in: Gastroenterology, 2018, ISSN 0016-5085
DOI: 10.1053/j.gastro.2018.10.024

Oncogenic Signaling Induced by HCV Infection

Author(s): Alessia Virzì, Armando Roca Suarez, Thomas Baumert, Joachim Lupberger
Published in: Viruses, Issue 10/10, 2018, Page(s) 538, ISSN 1999-4915
DOI: 10.3390/v10100538

Molecular heterogeneity in hepatocellular carcinoma

Author(s): Shijia Zhu, Yujin Hoshida
Published in: Hepatic Oncology, Issue 5/1, 2018, Page(s) HEP10, ISSN 2045-0923
DOI: 10.2217/hep-2018-0005

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

Author(s): James S.V. Lally, Sarani Ghoshal, Danielle K. DePeralta, Omeed Moaven, Lan Wei, Ricard Masia, Derek J. Erstad, Naoto Fujiwara, Vivian Leong, Vanessa P. Houde, Alexander E. Anagnostopoulos, Alice Wang, Lindsay A. Broadfield, Rebecca J. Ford, Robert A. Foster, Jamie Bates, Hailing Sun, Ting Wang, Henry Liu, Adrian S. Ray, Asish K. Saha, Jeremy Greenwood, Sathesh Bhat, Geraldine Harriman, Wenyan Miao
Published in: Cell Metabolism, 2018, ISSN 1550-4131
DOI: 10.1016/j.cmet.2018.08.020

Tight junction proteins in gastrointestinal and liver disease

Author(s): Mirjam B Zeisel, Punita Dhawan, Thomas F Baumert
Published in: Gut, 2018, Page(s) gutjnl-2018-316906, ISSN 0017-5749
DOI: 10.1136/gutjnl-2018-316906

Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

Author(s): Youngmin A. Lee, Luke A. Noon, Kemal M. Akat, Maria D. Ybanez, Ting-Fang Lee, Marie-Luise Berres, Naoto Fujiwara, Nicolas Goossens, Hsin-I Chou, Fatemeh P. Parvin-Nejad, Bilon Khambu, Elisabeth G. M. Kramer, Ronald Gordon, Cathie Pfleger, Doris Germain, Gareth R. John, Kirk N. Campbell, Zhenyu Yue, Xiao-Ming Yin, Ana Maria Cuervo, Mark J. Czaja, M. Isabel Fiel, Yujin Hoshida, Scott L. Friedman
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-07338-z

Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus–Infected Cells and Liver to Identify Pathways Associated With Disease Development

Author(s): Joachim Lupberger, Tom Croonenborghs, Armando Andres Roca Suarez, Nicolaas Van Renne, Frank Jühling, Marine A. Oudot, Alessia Virzì, Simonetta Bandiera, Carole Jamey, Gergö Meszaros, Daniel Brumaru, Atish Mukherji, Sarah C. Durand, Laura Heydmann, Eloi R. Verrier, Hussein El Saghire, Nourdine Hamdane, Ralf Bartenschlager, Shaunt Fereshetian, Evelyn Ramberger, Rileen Sinha, Mohsen Nabian, Celine
Published in: Gastroenterology, Issue 157/2, 2019, Page(s) 537-551.e9, ISSN 0016-5085
DOI: 10.1053/j.gastro.2019.04.003

A human liver cell atlas reveals heterogeneity and epithelial progenitors

Author(s): Nadim Aizarani, Antonio Saviano, Sagar, Laurent Mailly, Sarah Durand, Josip S. Herman, Patrick Pessaux, Thomas F. Baumert, Dominic Grün
Published in: Nature, 2019, ISSN 0028-0836
DOI: 10.1038/s41586-019-1373-2

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

Author(s): Nourdine Hamdane, Frank Jühling, Emilie Crouchet, Houssein El Saghire, Christine Thumann, Marine A. Oudot, Simonetta Bandiera, Antonio Saviano, Clara Ponsolles, Armando Andres Roca Suarez, Shen Li, Naoto Fujiwara, Atsushi Ono, Irwin Davidson, Nabeel Bardeesy, Christian Schmidl, Christoph Bock, Catherine Schuster, Joachim Lupberger, François Habersetzer, Michel Doffoël, Tullio Piardi, Daniele So
Published in: Gastroenterology, Issue 156/8, 2019, Page(s) 2313-2329.e7, ISSN 0016-5085
DOI: 10.1053/j.gastro.2019.02.038

Functional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity

Author(s): Katharina Herzog, Simonetta Bandiera, Sophie Pernot, Catherine Fauvelle, Frank Jühling, Amélie Weiss, Anne Bull, Sarah C Durand, Béatrice Chane-Woon-Ming, Sébastien Pfeffer, Marion Mercey, Hervé Lerat, Jean-Christophe Meunier, Wolfgang Raffelsberger, Laurent Brino, Thomas F Baumert, Mirjam B Zeisel
Published in: Gut, 2019, Page(s) gutjnl-2018-317423, ISSN 0017-5749
DOI: 10.1136/gutjnl-2018-317423

Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets

Author(s): Eloi R Verrier, Amélie Weiss, Charlotte Bach, Laura Heydmann, Vincent Turon-Lagot, Arnaud Kopp, Houssein El Saghire, Emilie Crouchet, Patrick Pessaux, Thomas Garcia, Patrick Pale, Mirjam B Zeisel, Camille Sureau, Catherine Schuster, Laurent Brino, Thomas F Baumert
Published in: Gut, 2019, Page(s) gutjnl-2018-317065, ISSN 0017-5749
DOI: 10.1136/gutjnl-2018-317065

IFITM s mediate viral evasion in acute and chronic hepatitis C virus infection


Published in: ISSN 0270-9139
DOI: 10.1002/hep.30699

Oxidative Stress Triggers Selective tRNA Retrograde Transport in Human Cells during the Integrated Stress Response

Author(s): Hagen Schwenzer, Frank Jühling, Alexander Chu, Laura J. Pallett, Thomas F. Baumert, Mala Maini, Ariberto Fassati
Published in: Cell Reports, Issue 26/12, 2019, Page(s) 3416-3428.e5, ISSN 2211-1247
DOI: 10.1016/j.celrep.2019.02.077

In vivo combination of human anti-envelope glycoprotein E2 and -Claudin-1 monoclonal antibodies for prevention of hepatitis C virus infection

Author(s): Laurent Mailly, Florian Wrensch, Laura Heydmann, Catherine Fauvelle, Nicolas Brignon, Mirjam B. Zeisel, Patrick Pessaux, Zhen-yong Keck, Catherine Schuster, Thomas R. Fuerst, Steven K.H. Foung, Thomas F. Baumert
Published in: Antiviral Research, Issue 162, 2019, Page(s) 136-141, ISSN 0166-3542
DOI: 10.1016/j.antiviral.2018.12.018

An E. coli-produced single-chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion

Author(s): Cheng Li, Yang Wang, Tiantian Liu, Matthias Niklasch, Ke Qiao, Sarah Durand, Li Chen, Mifang Liang, Thomas F. Baumert, Shuping Tong, Michael Nassal, Yu-Mei Wen, Yong-Xiang Wang
Published in: Antiviral Research, Issue 162, 2019, Page(s) 118-129, ISSN 0166-3542
DOI: 10.1016/j.antiviral.2018.12.019

Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma: preliminary results

Author(s): Bachir Taouli, Yujin Hoshida, Suguru Kakite, Xintong Chen, Poh Seng Tan, Xiaochen Sun, Shingo Kihira, Kensuke Kojima, Sara Toffanin, M. Isabel Fiel, Hadassa Hirschfield, Mathilde Wagner, Josep M. Llovet
Published in: European Radiology, Issue 27/11, 2017, Page(s) 4472-4481, ISSN 0938-7994
DOI: 10.1007/s00330-017-4844-6

Ultrasound‐Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma

Author(s): Ghina Bou About, Emilie Thiebault, Marie Wattenhofer‐Donzé, Hugues Jacobs, Alain Guimond, Tania Sorg, Eric Robinet, Thomas F. Baumert, Laurent Monassier, Yann Herault
Published in: Current Protocols in Mouse Biology, Issue 9/2, 2019, ISSN 2161-2617
DOI: 10.1002/cpmo.62

Learning from a clinical cohort for HCV vaccine development

Author(s): Florian Wrensch, Zhen-yong Keck, Steven K.H. Foung, Thomas F. Baumert
Published in: Journal of Hepatology, Issue 71/1, 2019, Page(s) 9-11, ISSN 0168-8278
DOI: 10.1016/j.jhep.2019.03.030

The circadian clock and liver function in health and disease

Author(s): Atish Mukherji, Shannon M. Bailey, Bart Staels, Thomas F. Baumert
Published in: Journal of Hepatology, Issue 71/1, 2019, Page(s) 200-211, ISSN 0168-8278
DOI: 10.1016/j.jhep.2019.03.020

Editorial: Current Progress and Challenges in the Development of a B Cell Based Hepatitis C Virus Vaccine

Author(s): Steven K. H. Foung, Thomas F. Baumert
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.02577

Dose and Duration of Aspirin Use to Reduce Incident Hepatocellular Carcinoma


Published in: ISSN 0270-9139
DOI: 10.1002/hep.30813

Hepatocellular Carcinoma Risk Stratification by Genetic Profiling in Patients with Cirrhosis

Author(s): Naoto Fujiwara, Yujin Hoshida
Published in: Seminars in Liver Disease, Issue 39/02, 2019, Page(s) 153-162, ISSN 0272-8087
DOI: 10.1055/s-0039-1681031

Addressing the Challenges of Hepatitis C Cure and Persistent Risk of Hepatocellular Carcinoma

Author(s): Thomas F. Baumert, Yujin Hoshida
Published in: Viruses, Issue 11/5, 2019, Page(s) 441, ISSN 1999-4915
DOI: 10.3390/v11050441

Mortality from liver cirrhosis and HCC in the DAA era: success in viral control is darkened by raise of metabolic disease

Author(s): Antonio Saviano, Thomas F. Baumert
Published in: HepatoBiliary Surgery and Nutrition, Issue 8/3, 2019, Page(s) 307-310, ISSN 2304-3881
DOI: 10.21037/hbsn.2019.01.21

Use of big data in drug development for precision medicine: an update


Published in: ISSN 2380-8993
DOI: 10.1080/23808993.2019.1617632

Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis

Author(s): Simonetta Bandiera, Sophie Pernot, Hussein El Saghire, Sarah C. Durand, Christine Thumann, Emilie Crouchet, Tao Ye, Isabel Fofana, Marine A. Oudot, Jochen Barths, Catherine Schuster, Patrick Pessaux, Markus H. Heim, Thomas F. Baumert, Mirjam B. Zeisel
Published in: Journal of Virology, Issue 90/14, 2016, Page(s) 6387-6400, ISSN 0022-538X
DOI: 10.1128/JVI.00619-16

Extracellular lipid-free apolipoprotein E inhibits HCV replication and induces ABCG1-dependent cholesterol efflux

Author(s): Emilie Crouchet, Mathieu Lefèvre, Eloi R Verrier, Marine A Oudot, Thomas F Baumert, Catherine Schuster
Published in: Gut, Issue 66/5, 2017, Page(s) 896-907, ISSN 0017-5749
DOI: 10.1136/gutjnl-2015-311289

Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice

Author(s): Tao Wu, Emilie Heuillard, Véronique Lindner, Ghina Bou About, Mihaela Ignat, Jean-Philippe Dillenseger, Nicolas Anton, Eugénie Dalimier, Francine Gossé, Gael Fouré, Franck Blindauer, Céline Giraudeau, Hussein El-Saghire, Mourad Bouhadjar, Cynthia Calligaro, Tania Sorg, Philippe Choquet, Thierry Vandamme, Christophe Ferrand, Jacques Marescaux, Thomas F. Baumert, Michele Diana, Patrick Pessaux,
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
DOI: 10.1038/srep35230

Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition

Author(s): Shigeki Nakagawa, Lan Wei, Won Min Song, Takaaki Higashi, Sarani Ghoshal, Rosa S. Kim, C. Billie Bian, Suguru Yamada, Xiaochen Sun, Anu Venkatesh, Nicolas Goossens, Gretchen Bain, Gregory Y. Lauwers, Anna P. Koh, Mohamed El-Abtah, Noor B. Ahmad, Hiroki Hoshida, Derek J. Erstad, Ganesh Gunasekaran, Youngmin Lee, Ming-Lung Yu, Wan-Long Chuang, Chia-Yen Dai, Masahiro Kobayashi, Hiromitsu Kumada, Toru
Published in: Cancer Cell, Issue 30/6, 2016, Page(s) 879-890, ISSN 1535-6108
DOI: 10.1016/j.ccell.2016.11.004

Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape

Author(s): Che C Colpitts, Rajiv G Tawar, Laurent Mailly, Christine Thumann, Laura Heydmann, Sarah C Durand, Fei Xiao, Eric Robinet, Patrick Pessaux, Mirjam B Zeisel, Thomas F Baumert
Published in: Gut, 2017, Page(s) gutjnl-2016-312577, ISSN 0017-5749
DOI: 10.1136/gutjnl-2016-312577

Plasmodium P36 determines host cell receptor usage during sporozoite invasion

Author(s): Giulia Manzoni, Carine Marinach, Selma Topçu, Sylvie Briquet, Morgane Grand, Matthieu Tolle, Marion Gransagne, Julien Lescar, Chiara Andolina, Jean-François Franetich, Mirjam B Zeisel, Thierry Huby, Eric Rubinstein, Georges Snounou, Dominique Mazier, François Nosten, Thomas F Baumert, Olivier Silvie
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
DOI: 10.7554/eLife.25903

Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy

Author(s): Tanvi Khera, Daniel Todt, Koen Vercauteren, C. Patrick McClure, Lieven Verhoye, Ali Farhoudi, Sabin Bhuju, Robert Geffers, Thomas F. Baumert, Eike Steinmann, Philip Meuleman, Thomas Pietschmann, Richard J.P. Brown
Published in: Antiviral Research, Issue 139, 2017, Page(s) 129-137, ISSN 0166-3542
DOI: 10.1016/j.antiviral.2017.01.001

Cost-Effectiveness of Risk Score–Stratified Hepatocellular Carcinoma Screening in Patients with Cirrhosis

Author(s): Nicolas Goossens, Amit G Singal, Lindsay Y King, Karin L Andersson, Bryan C Fuchs, Cecilia Besa, Bachir Taouli, Raymond T Chung, Yujin Hoshida
Published in: Clinical and Translational Gastroenterology, Issue 8/6, 2017, Page(s) e101, ISSN 2155-384X
DOI: 10.1038/ctg.2017.26

Hepatic stellate cells as key target in liver fibrosis

Author(s): Takaaki Higashi, Scott L. Friedman, Yujin Hoshida
Published in: Advanced Drug Delivery Reviews, 2017, ISSN 0169-409X
DOI: 10.1016/j.addr.2017.05.007

Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging

Author(s): Stefanie J. Hectors, Mathilde Wagner, Octavia Bane, Cecilia Besa, Sara Lewis, Romain Remark, Nelson Chen, M. Isabel Fiel, Hongfa Zhu, Sacha Gnjatic, Miriam Merad, Yujin Hoshida, Bachir Taouli
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/s41598-017-02706-z

Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases

Author(s): Benjamin Wooden, Nicolas Goossens, Yujin Hoshida, Scott L. Friedman
Published in: Gastroenterology, Issue 152/1, 2017, Page(s) 53-67.e3, ISSN 0016-5085
DOI: 10.1053/j.gastro.2016.09.065

Novel substituted aminothiazoles as potent and selective anti-hepatocellular carcinoma agents


Published in: ISSN 0960-894X
DOI: 10.1016/j.bmcl.2016.10.015

Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells

Author(s): Daniel F. Hicks, Nicolas Goossens, Ana Blas-García, Takuma Tsuchida, Benjamin Wooden, Michael C. Wallace, Natalia Nieto, Abigale Lade, Benjamin Redhead, Arthur I Cederbaum, Joel T. Dudley, Bryan C. Fuchs, Youngmin A. Lee, Yujin Hoshida, Scott L. Friedman
Published in: Scientific Reports, Issue 7, 2017, Page(s) 42563, ISSN 2045-2322
DOI: 10.1038/srep42563

New perspectives for preventing hepatitis C virus liver graft infection

Author(s): Daniel J Felmlee, Audrey Coilly, Raymond T Chung, Didier Samuel, Thomas F Baumert
Published in: The Lancet Infectious Diseases, Issue 16/6, 2016, Page(s) 735-745, ISSN 1473-3099
DOI: 10.1016/S1473-3099(16)00120-1

Hepatitis B virus receptors and molecular drug targets

Author(s): Eloi R. Verrier, Che C. Colpitts, Camille Sureau, Thomas F. Baumert
Published in: Hepatology International, Issue 10/4, 2016, Page(s) 567-573, ISSN 1936-0533
DOI: 10.1007/s12072-016-9718-5

Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma

Author(s): Simonetta Bandiera, C Billie Bian, Yujin Hoshida, Thomas F Baumert, Mirjam B Zeisel
Published in: Current Opinion in Virology, Issue 20, 2016, Page(s) 99-105, ISSN 1879-6257
DOI: 10.1016/j.coviro.2016.09.010

Hepatitis C-related hepatocellular carcinoma in the era of new generation antivirals

Author(s): Thomas F. Baumert, Frank Jühling, Atsushi Ono, Yujin Hoshida
Published in: BMC Medicine, Issue 15/1, 2017, ISSN 1741-7015
DOI: 10.1186/s12916-017-0815-7

Toward novel immunocompetent animal models for hepatitis B virus infection


Published in: ISSN 0270-9139
DOI: 10.1002/hep.29249

Characterisation of endogenous Claudin‐1 expression, motility and susceptibility to hepatitis C virus in CRISPR knock‐in cells

Author(s): Camille M.H. Clément, Maika S. Deffieu, Cristina M. Dorobantu, Thomas F. Baumert, Nilda Vanesa Ayala‐Nunez, Yves Mély, Philippe Ronde, Raphael Gaudin
Published in: Biology of the Cell, Issue 112/5, 2020, Page(s) 140-151, ISSN 0248-4900
DOI: 10.1111/boc.201900085

Addressing the next challenges: A summary of the 22nd international symposium on hepatitis C virus and related viruses

Author(s): Thomas F. Baumert, Catherine Schuster, François-Loïc Cosset, Jean Dubuisson, Maike Hofmann, Norbert Tautz, Mirjam B. Zeisel, Robert Thimme
Published in: Journal of Hepatology, Issue 64/4, 2016, Page(s) 968-973, ISSN 0168-8278
DOI: 10.1016/j.jhep.2015.12.021

Hepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals

Author(s): Che C. Colpitts, Thomas F. Baumert
Published in: Hepatology International, Issue 10/5, 2016, Page(s) 741-748, ISSN 1936-0533
DOI: 10.1007/s12072-016-9724-7

A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

Author(s): Carla Eller, Laura Heydmann, Che C. Colpitts, Houssein El Saghire, Federica Piccioni, Frank Jühling, Karim Majzoub, Caroline Pons, Charlotte Bach, Julie Lucifora, Joachim Lupberger, Michael Nassal, Glenn S. Cowley, Naoto Fujiwara, Sen-Yung Hsieh, Yujin Hoshida, Emanuele Felli, Patrick Pessaux, Camille Sureau, Catherine Schuster, David E. Root, Eloi R. Verrier, Thomas F. Baumert
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-16517-w

CD147 handles lipid: a new role for anti-cancer target

Author(s): Daniel J. Felmlee, Thomas F. Baumert
Published in: Translational Cancer Research, Issue 5/3, 2016, Page(s) 238-240, ISSN 2218-676X
DOI: 10.21037/tcr.2016.06.28

Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma

Author(s): Frank Jühling, Nourdine Hamdane, Emilie Crouchet, Shen Li, Houssein El Saghire, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Christine Thumann, Antonio Saviano, Armando Andres Roca Suarez, Kaku Goto, Ricard Masia, Mozhdeh Sojoodi, Gunisha Arora, Hiroshi Aikata, Atsushi Ono, Parissa Tabrizian, Myron Schwartz, Stephen J Polyak, Irwin Davidson, Christian Schmidl, Christoph Bock, Catherine Schuste
Published in: Gut, 2020, Page(s) gutjnl-2019-318918, ISSN 0017-5749
DOI: 10.1136/gutjnl-2019-318918

Hepatitis C Virus and Hepatocellular Carcinoma: When the Host Loses Its Grip

Author(s): Kaku Goto, Armando Andres Roca Suarez, Florian Wrensch, Thomas F. Baumert, Joachim Lupberger
Published in: International Journal of Molecular Sciences, Issue 21/9, 2020, Page(s) 3057, ISSN 1422-0067
DOI: 10.3390/ijms21093057

Signalome-wide assessment of host cell response to hepatitis C virus

Author(s): Gholamreza Haqshenas, Jianmin Wu, Kaylene J. Simpson, Roger J. Daly, Hans J. Netter, Thomas F. Baumert, Christian Doerig
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
DOI: 10.1038/ncomms15158

Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design

Author(s): Zhen-Yong Keck, Brian G. Pierce, Patrick Lau, Janine Lu, Yong Wang, Alexander Underwood, Rowena A. Bull, Jannick Prentoe, Rodrigo Velázquez-Moctezuma, Melanie R. Walker, Fabio Luciani, Johnathan D. Guest, Catherine Fauvelle, Thomas F. Baumert, Jens Bukh, Andrew R. Lloyd, Steven K. H. Foung
Published in: PLOS Pathogens, Issue 15/5, 2019, Page(s) e1007772, ISSN 1553-7374
DOI: 10.1371/journal.ppat.1007772

Hepatitis C virus infection and tight junction proteins: The ties that bind

Author(s): Laurent Mailly, Thomas F. Baumert
Published in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Issue 1862/7, 2020, Page(s) 183296, ISSN 0005-2736
DOI: 10.1016/j.bbamem.2020.183296

The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans

Author(s): Karim Majzoub, Florian Wrensch, Thomas F. Baumert
Published in: Viruses, Issue 11/8, 2019, Page(s) 758, ISSN 1999-4915
DOI: 10.3390/v11080758

Uncovering the mechanism of action of aspirin in HCC chemoprevention

Author(s): Natascha Roehlen, Thomas F. Baumert
Published in: EBioMedicine, Issue 46, 2019, Page(s) 21-22, ISSN 2352-3964
DOI: 10.1016/j.ebiom.2019.07.047

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

Author(s): Natascha Roehlen, Emilie Crouchet, Thomas F. Baumert
Published in: Cells, Issue 9/4, 2020, Page(s) 875, ISSN 2073-4409
DOI: 10.3390/cells9040875

Tight Junction Proteins and the Biology of Hepatobiliary Disease

Author(s): Natascha Roehlen, Armando Andres Roca Suarez, Houssein El Saghire, Antonio Saviano, Catherine Schuster, Joachim Lupberger, Thomas F. Baumert
Published in: International Journal of Molecular Sciences, Issue 21/3, 2020, Page(s) 825, ISSN 1422-0067
DOI: 10.3390/ijms21030825

Single-cell genomics and spatial transcriptomics: discovery of novel cell states and cellular interactions in liver physiology and disease biology

Author(s): Antonio Saviano, Neil C. Henderson, Thomas F. Baumert
Published in: Journal of Hepatology, 2020, ISSN 0168-8278
DOI: 10.1016/j.jhep.2020.06.004

Follicular T helper cells shape the HCV-specific CD4+ T cell repertoire after virus elimination

Author(s): Maike Smits, Katharina Zoldan, Naveed Ishaque, Zuguang Gu, Katharina Jechow, Dominik Wieland, Christian Conrad, Roland Eils, Catherine Fauvelle, Thomas F. Baumert, Florian Emmerich, Bertram Bengsch, Christoph Neumann-Haefelin, Maike Hofmann, Robert Thimme, Tobias Boettler
Published in: Journal of Clinical Investigation, Issue 130/2, 2019, Page(s) 998-1009, ISSN 0021-9738
DOI: 10.1172/jci129642

Hepatitis B Virus–Hepatocyte Interactions and Innate Immune Responses: Experimental Models and Molecular Mechanisms

Author(s): Emmanuel Thomas, Thomas F. Baumert
Published in: Seminars in Liver Disease, Issue 39/03, 2019, Page(s) 301-314, ISSN 0272-8087
DOI: 10.1055/s-0039-1685518

Radiomics in hepatocellular carcinoma: a quantitative review

Author(s): Taiga Wakabayashi, Farid Ouhmich, Cristians Gonzalez-Cabrera, Emanuele Felli, Antonio Saviano, Vincent Agnus, Peter Savadjiev, Thomas F. Baumert, Patrick Pessaux, Jacques Marescaux, Benoit Gallix
Published in: Hepatology International, Issue 13/5, 2019, Page(s) 546-559, ISSN 1936-0533
DOI: 10.1007/s12072-019-09973-0

Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis

Author(s): Alessia Virzì, Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Published in: Cold Spring Harbor Perspectives in Medicine, Issue 10/1, 2020, Page(s) a037366, ISSN 2157-1422
DOI: 10.1101/cshperspect.a037366

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

Author(s): Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai, Abhinav Kumar, Srinivasa Bhargav Rambhatla, Claire L. Donald, Andrea F. Lopez-Clavijo, Simon Rudge, Katherine Pinnick, Wai Hoong Chang, Peter A. C. Wing, Ryan Brown, Ximing Qin, Peter Simmonds, Thomas F. Baumert, David Ray, Andrew Loudon, Peter Balfe, Michael Wakelam, Sam Butterworth, Alain Kohl, Catherine L. Jopling, Nicole Zitzmann, Ja
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-08299-7

MPIC: Molecular Prognostic Indicators in Cirrhosis Database for Clinical Context-Specific in Silico Prognostic Biomarker Validation

Author(s): Shun H. Yip, Naoto Fujiwara, Jason Burke, Anand Shetler, Celina Peralta, Tongqi Qian, Hiroki Hoshida, Shijia Zhu, Yujin Hoshida
Published in: Frontiers in Genetics, Issue 10, 2019, ISSN 1664-8021
DOI: 10.3389/fgene.2019.00830