Cell circuits as targets and biomarkers for liver disease and cancer prevention

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Omics‐derived hepatocellular carcinoma risk biomarkers for precision care of chronic liver diseases

Author(s): Naoto Fujiwara; Naoto Fujiwara; Tongqi Qian; Bhuvaneswari Koneru; Yujin Hoshida
Published in: Hepatol Res, Issue 1, 2020, Page(s) 817-830, ISSN 1872-034X
Publisher: The Japan Society of Hepatology
DOI: 10.1111/hepr.13506

Viral Exposure Signature Associated with Liver Cancer Risk.

Author(s): Naoto Fujiwara; Naoto Fujiwara; Yujin Hoshida
Published in: Trends Mol Med, Issue 1, 2020, ISSN 1471-4914
Publisher: Elsevier BV
DOI: 10.1016/j.molmed.2020.06.008

Unraveling the role of liver sinusoidal endothelial cells in COVID-19 liver injury

Author(s): Antonio Saviano, Thomas F Baumert
Published in: J Hepatol, 2021, Page(s) 503–505, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2021.07.008

Perturbation of the circadian clock and pathogenesis of NAFLD

Author(s): Atish Mukherji, Mayssa Dachraoui, Thomas F Baumert
Published in: Metabolism, 2020, ISSN 0026-0495
Publisher: Elsevier BV
DOI: 10.1016/j.metabol.2020.154337

Liver cell circuits and therapeutic discovery for advanced liver disease and cancer

Author(s): Emilie Crouchet, Catherine Schuster, Thomas F Baumert
Published in: Comptes Rendus Biologie, 2021, Page(s) 233-248, ISSN 1631-0691
Publisher: Elsevier Masson
DOI: 10.5802/crbiol.64

A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis

Author(s): Naoto Fujiwara, Masahiro Kobayashi,3 Austin J Fobar,4 Ayaka Hoshida,1 Cesia A Marquez,1 Bhuvaneswari Koneru,1 Gayatri Panda,1 Masataka Taguri,5 Tongqi Qian,1 Indu Raman,6 Quan-Zhen Li,6 Hiroki Hoshida,1 Hitomi Sezaki,3 Hiromitsu Kumada,3 Ryosuke Tateishi,2 Takeshi Yokoo,7 Adam C Yopp,8 Raymond T Chung,9 Bryan C Fuchs,10,11 Thomas F Baumert,12 Jorge A Marrero,1 Neehar D Parikh, Shijia Zhu, Amit G S
Published in: Med (N Y)., 2021, ISSN 2666-6340
Publisher: John Wiley
DOI: 10.1016/j.medj.2021.03.017

Transcriptome-Guided Design of Physiological Multilineage Liver Organoids

Author(s): Shijia Zhu, Naoto Kubota, Yujin Hoshida
Published in: Trends Genet, 2021, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2021.01.007

The Nobel Prize in Medicine 2020 for the Discovery of Hepatitis C Virus: Transforming Hepatology.

Author(s): Thomas F. Baumert
Published in: ISSN: 1600-0641, Issue 25, 2020, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2020.10.017

Hepatitis B virus compartmentalization and single-cell differentiation in hepatocellular carcinoma.

Author(s): Frank Jühling; Antonio Saviano; Clara Ponsolles; Laura Heydmann; Emilie Crouchet; Sarah C. Durand; Houssein El Saghire; Emanuele Felli; Véronique Lindner; Patrick Pessaux; Nathalie Pochet; Nathalie Pochet; Catherine Schuster; Eloi R. Verrier; Thomas F. Baumert; Thomas F. Baumert
Published in: Life Science Alliance, Issue 1, 2021, ISSN 2575-1077
Publisher: Life Science Alliance LCC
DOI: 10.26508/lsa.202101036

Liver Abnormalities after Elimination of HCV Infection: Persistent Epigenetic and Immunological Perturbations Post-Cure

Author(s): Stephen J Polyak, I Nicholas Crispe, Thomas F Baumert
Published in: Pathogens, 2021, ISSN 2076-0817
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10010044

Role of Hepatocyte-DerivedOsteopontinin Liver Carcinogenesis

Author(s): "Romain Desert # 1, Xiaodong Ge # 1 2, Zhuolun Song 1, Hui Han 1, Daniel Lantvit 1, Wei Chen 1, Sukanta Das 1, Dipti Athavale 1, Ioana Abraham-Enachescu 2, Chuck Blajszczak 1, Yu Chen 1, Orlando Musso 3, Grace Guzman 1, Yujin Hoshida, Natalia Nieto 1 2 5"
Published in: Hepatol Commun, 2022, ISSN 2471-254X
Publisher: John Wiley & Sons, Inc.
DOI: 10.1002/hep4.1845

Atorvastatin favorably modulates a clinical hepatocellular carcinoma risk gene signature

Author(s): Myung-Ho Kim 1, Mi-Young Kim 1 2 3, Shadi Salloum 1, Tongqi Qian 4, Lai Ping Wong 5 6, Min Xu 1, Yoojin Lee 1, Stuti G Shroff 7, Ruslan I Sadreyev 5 7, Kathleen E Corey 1, Thomas F Baumert 8 9, Yujin Hoshida, Raymond T Chung 1
Published in: Hepatol Commun, 2022, ISSN 2471-254X
Publisher: John Wiley & Sons, Inc.
DOI: 10.1002/hep4.1991

Conventional and artificial intelligence-based imaging for biomarker discovery in chronic liver disease

Author(s): Jérémy Dana,1,2,3,4 Aïna Venkatasamy, Antonio Saviano, Joachim Lupberger, Yujin Hoshida, Valérie Vilgrain,9 Pierre Nahon,10,11,12 Caroline Reinhold,4,13,14 Benoit Gallix,2,3,4 and Thomas F. Baumert1,3,7
Published in: Hepatol Int, 2022, ISSN 1936-0533
Publisher: Springer Pub. Co.
DOI: 10.1007/s12072-022-10303-0

Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import

Author(s): Rodriguez-Bravo, Veronica; Pippa, Raffaella; Song, Won-Min; Carceles-Cordon, Marc; Dominguez-Andres, Ana; Fujiwara, Naoto; Woo, Jungreem; Koh, Anna P.; Ertel, Adam; Lokareddy, Ravi K.; Cuesta-Dominguez, Alvaro; Kim, Rosa S.; Rodriguez-Fernandez, Irene; Li, Peiyao; Gordon, Ronald; Hirschfield, Hadassa; Prats, Josep M.; Reddy, E. Premkumar; Fatatis, Alessandro; Petrylak, Daniel P.; Gomella, Leonard;
Published in: Cell, Issue 1, 2018, ISSN 1097-4172
Publisher: Elsevier Inc
DOI: 10.1016/j.cell.2018.07.015

Liver Disease and Coronavirus Disease 2019: From Pathogenesis to Clinical Care.

Author(s): Antonio Saviano; Florian Wrensch; Marc G. Ghany; Thomas F. Baumert; Thomas F. Baumert
Published in: Hepatology (Baltimore, Md.), Issue 20, 2021, Page(s) 088-1100, ISSN 1527-3350
Publisher: John Wiley & Sons, Inc
DOI: 10.1002/hep.31684

Virus-Induced Risk of Hepatocellular Carcinoma: Recent Progress and Future Challenges

Author(s): Joachim Lupberger, and Thomas F. Baumert
Published in: J Clin Med, 2021, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11010208

Plasma-Signature-Model for End-Stage Liver Disease Scoreto Predict Survival in Severe Alcoholic Hepatitis

Author(s): Naoto Fujiwara, Eric Trépo, Indu Raman, Quan-Zhen Li, Delphine Degré, Thierry Gustot, Christophe Moreno, Yujin Hoshida
Published in: Clin Gastroenterol Hepatol, 2022, ISSN 1542-3565
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cgh.2021.02.041

Viral manipulation of STAT3: Evade, exploit, and injure

Author(s): Armando Andres Roca Suarez, Nicolaas Van Renne, Thomas F. Baumert, Joachim Lupberger
Published in: PLOS Pathogens, Issue 14/3, 2018, Page(s) e1006839, ISSN 1553-7374
Publisher: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, c2011.
DOI: 10.1371/journal.ppat.1006839

Hepatitis C Virus (HCV)–Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design

Author(s): Florian Wrensch, Emilie Crouchet, Gaetan Ligat, Mirjam B. Zeisel, Zhen-Yong Keck, Steven K. H. Foung, Catherine Schuster, Thomas F. Baumert
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2018.01436

Mapping Determinants of Virus Neutralization and Viral Escape for Rational Design of a Hepatitis C Virus Vaccine

Author(s): Mei-Le Keck, Florian Wrensch, Brian G. Pierce, Thomas F. Baumert, Steven K. H. Foung
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.01194

Hepatitis B virus evasion from cyclic guanosine monophosphate-adenosine monophosphate synthase sensing in human hepatocytes

Author(s): Eloi R. Verrier, Seung-Ae Yim, Laura Heydmann, Houssein El Saghire, Charlotte Bach, Vincent Turon-Lagot, Laurent Mailly, Sarah C. Durand, Julie Lucifora, David Durantel, Patrick Pessaux, Nicolas Manel, Ivan Hirsch, Mirjam B. Zeisel, Nathalie Pochet, Catherine Schuster, Thomas F. Baumert
Published in: Hepatology, 2018, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.30054

Beyond viral dependence: The pathological consequences of HCV-induced EGF signaling

Author(s): Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Published in: Journal of Hepatology, Issue S0168-8278(18), 2018, Page(s) 32118-4, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2018.05.033

Host-targeting therapies for hepatitis C virus infection: current developments and future applications

Author(s): Emilie Crouchet, Florian Wrensch, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Published in: Therapeutic Advances in Gastroenterology, Issue 11, 2018, Page(s) 175628481875948, ISSN 1756-2848
Publisher: London : Sage Publications
DOI: 10.1177/1756284818759483

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

Author(s): Isabelle Desombere, Ahmed Atef Mesalam, Richard A. Urbanowicz, Freya Van Houtte, Lieven Verhoye, Zhen-Yong Keck, Ali Farhoudi, Koen Vercauteren, Karin E. Weening, Thomas F. Baumert, Arvind H. Patel, Steven K.H. Foung, Jonathan Ball, Geert Leroux-Roels, Philip Meuleman
Published in: Antiviral Research, Issue 148, 2017, Page(s) 53-64, ISSN 0166-3542
Publisher: Elsevier BV
DOI: 10.1016/j.antiviral.2017.10.015

Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8 + T Cells in Chronic versus Acute Infection

Author(s): David Wolski, Peter K. Foote, Diana Y. Chen, Lia L. Lewis-Ximenez, Catherine Fauvelle, Jasneet Aneja, Andreas Walker, Pierre Tonnerre, Almudena Torres-Cornejo, Daniel Kvistad, Sabrina Imam, Michael T. Waring, Damien C. Tully, Todd M. Allen, Raymond T. Chung, Jörg Timm, W. Nicholas Haining, Arthur Y. Kim, Thomas F. Baumert, Georg M. Lauer
Published in: Immunity, Issue 47/4, 2017, Page(s) 648-663.e8, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2017.09.006

Zooming in on liver zonation

Author(s): Daniel J. Felmlee, Dominic Grün, Thomas F. Baumert
Published in: Hepatology, Issue 67/2, 2018, Page(s) 784-787, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.29554

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

Author(s): Zhirong Zhang, Gergö Meszaros, Wan-ting He, Yanfang Xu, Helena de Fatima Magliarelli, Laurent Mailly, Michael Mihlan, Yansheng Liu, Marta Puig Gámez, Alexander Goginashvili, Adrien Pasquier, Olga Bielska, Bénédicte Neven, Pierre Quartier, Rudolf Aebersold, Thomas F. Baumert, Philippe Georgel, Jiahuai Han, Romeo Ricci
Published in: The Journal of Experimental Medicine, Issue 214/9, 2017, Page(s) 2671-2693, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20162040

Hepatitis C virus–apolipoprotein interactions: molecular mechanisms and clinical impact

Author(s): Emilie Crouchet, Thomas F. Baumert, Catherine Schuster
Published in: Expert Review of Proteomics, Issue 14/7, 2017, Page(s) 593-606, ISSN 1478-9450
Publisher: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1344102

Entry Inhibitors: A Perspective for Prevention of Hepatitis C Virus Infection in Organ Transplantation

Author(s): Che C. Colpitts, Raymond T. Chung, Thomas F. Baumert
Published in: ACS Infectious Diseases, Issue 3/9, 2017, Page(s) 620-623, ISSN 2373-8227
Publisher: Washington, DC : ACS Publications, [2015]-
DOI: 10.1021/acsinfecdis.7b00091

Advancing hepatitis B virus entry inhibitors

Author(s): Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Published in: Journal of Hepatology, Issue 66/4, 2017, Page(s) 677-679, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2016.11.028

SCARB1 variants and HCV infection: Host susceptibility is lost in translation

Author(s): Che C. Colpitts, Thomas F. Baumert
Published in: Journal of Hepatology, Issue 67/2, 2017, Page(s) 211-213, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2017.04.013

SMAD About Hepatitis C Virus Cell Entry and Liver Disease

Author(s): Che C. Colpitts, Thomas F. Baumert
Published in: Gastroenterology, Issue 152/1, 2017, Page(s) 21-23, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2016.11.029

miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis

Author(s): Nicolaas Van Renne, Armando Andres Roca Suarez, Francois H T Duong, Claire Gondeau, Diego Calabrese, Nelly Fontaine, Amina Ababsa, Simonetta Bandiera, Tom Croonenborghs, Nathalie Pochet, Vito De Blasi, Patrick Pessaux, Tullio Piardi, Daniele Sommacale, Atsushi Ono, Kazuaki Chayama, Masashi Fujita, Hidewaki Nakagawa, Yujin Hoshida, Mirjam B Zeisel, Markus H Heim, Thomas F Baumert, Joachim Lupberger
Published in: Gut, Issue 67/5, 2018, Page(s) 953-962, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-312270

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes

Author(s): Eloi R. Verrier, Che C. Colpitts, Charlotte Bach, Laura Heydmann, Laetitia Zona, Fei Xiao, Christine Thumann, Emilie Crouchet, Raphaël Gaudin, Camille Sureau, François-Loïc Cosset, Jane A. McKeating, Patrick Pessaux, Yujin Hoshida, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Published in: Cell Reports, Issue 17/5, 2016, Page(s) 1357-1368, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.09.084

Cell Culture Models for the Investigation of Hepatitis B and D Virus Infection

Author(s): Eloi Verrier, Che Colpitts, Catherine Schuster, Mirjam Zeisel, Thomas Baumert
Published in: Viruses, Issue 8/9, 2016, Page(s) 261, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v8090261

Claudins in viral infection: from entry to spread

Author(s): Che C. Colpitts, Thomas F. Baumert
Published in: Pflügers Archiv - European Journal of Physiology, Issue 469/1, 2017, Page(s) 27-34, ISSN 0031-6768
Publisher: Springer Verlag
DOI: 10.1007/s00424-016-1908-4

Hepatitis B virus: is a cure possible?

Author(s): Mirjam B. Zeisel, Thomas F. Baumert
Published in: Expert Review of Clinical Pharmacology, Issue 9/9, 2016, Page(s) 1129-1130, ISSN 1751-2433
Publisher: Future Drugs Ltd.
DOI: 10.1080/17512433.2016.1206466

Hepatitis C virus vaccine candidates inducing protective neutralizing antibodies

Author(s): Catherine Fauvelle, Che C. Colpitts, Zhen-yong Keck, Brian G. Pierce, Steven K. H. Foung, Thomas F. Baumert
Published in: Expert Review of Vaccines, Issue 15/12, 2016, Page(s) 1535-1544, ISSN 1476-0584
Publisher: Future Drugs Ltd.
DOI: 10.1080/14760584.2016.1194759

Circulating microRNAs for early detection of hepatitis B-related hepatocellular carcinoma

Author(s): Simonetta Bandiera, Thomas F. Baumert, Mirjam B. Zeisel
Published in: HepatoBiliary Surgery and Nutrition, Issue 5/3, 2016, Page(s) 198-200, ISSN 2304-3881
Publisher: Hong Kong : AME Publishing Company
DOI: 10.21037/hbsn.2016.03.08

Multifaceted role of E-cadherin in hepatitis C virus infection and pathogenesis

Author(s): Che C. Colpitts, Joachim Lupberger, Thomas F. Baumert
Published in: Proceedings of the National Academy of Sciences, Issue 113/27, 2016, Page(s) 7298-7300, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1607732113

Translation and protein expression of lncRNAs: Impact for liver disease and hepatocellular carcinoma

Author(s): Mirjam B. Zeisel, Thomas F. Baumert
Published in: Hepatology, Issue 64/2, 2016, Page(s) 671-674, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.28653

Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge

Author(s): Isabelle Desombere, Samira Fafi-Kremer, Freya Van Houtte, Patrick Pessaux, Ali Farhoudi, Laura Heydmann, Lieven Verhoye, Sarah Cole, Jane A. McKeating, Geert Leroux-Roels, Thomas F. Baumert, Arvind H. Patel, Philip Meuleman
Published in: Hepatology, Issue 63/4, 2016, Page(s) 1120-1134, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.28428

Tailored Algorithms for Hepatocellular Carcinoma Surveillance: Is One-Size-Fits-All Strategy Outdated?

Author(s): Nicolas Goossens, C. Billie Bian, Yujin Hoshida
Published in: Current Hepatology Reports, Issue 16/1, 2017, Page(s) 64-71, ISSN 2195-9595
Publisher: Springer
DOI: 10.1007/s11901-017-0336-z

Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine

Author(s): Naoto Fujiwara, Scott L. Friedman, Nicolas Goossens, Yujin Hoshida
Published in: Journal of Hepatology, Issue 68/3, 2018, Page(s) 526-549, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2017.09.016

Combination of Gene Expression Signature and Model for End-Stage Liver Disease Score Predicts Survival of Patients With Severe Alcoholic Hepatitis

Author(s): Eric Trépo, Nicolas Goossens, Naoto Fujiwara, Won-Min Song, Antonio Colaprico, Astrid Marot, Laurent Spahr, Pieter Demetter, Christine Sempoux, Gene Y. Im, Joan Saldarriaga, Thierry Gustot, Jacques Devière, Swan N. Thung, Charlotte Minsart, Thomas Sersté, Gianluca Bontempi, Karim Abdelrahman, Jean Henrion, Delphine Degré, Valerio Lucidi, Laura Rubbia-Brandt, Venugopalan D. Nair, Christophe Mor
Published in: Gastroenterology, Issue 154/4, 2018, Page(s) 965-975, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.10.048

In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment

Author(s): Hadassa Hirschfield, C Billie Bian, Takaaki Higashi, Shigeki Nakagawa, Tizita Z Zeleke, Venugopalan D Nair, Bryan C Fuchs, Yujin Hoshida
Published in: Experimental & Molecular Medicine, Issue 50/1, 2018, Page(s) e419, ISSN 2092-6413
Publisher: Seoul : Korean Society of Medical Biochemistry and Molecular Biology
DOI: 10.1038/emm.2017.164

The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer

Author(s): Derek J. Erstad, Andrew M. Tager, Yujin Hoshida, Bryan C. Fuchs
Published in: Molecular & Cellular Oncology, Issue 4/3, 2017, Page(s) e1311827, ISSN 2372-3556
Publisher: Taylor & Francis
DOI: 10.1080/23723556.2017.1311827

Generic chemoprevention of hepatocellular carcinoma

Author(s): Sai Krishna Athuluri-Divakar, Yujin Hoshida
Published in: Annals of the New York Academy of Sciences, 2018, ISSN 0077-8923
Publisher: New York Academy of Sciences
DOI: 10.1111/nyas.13971

A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer

Author(s): Takuma Tsuchida, Youngmin A. Lee, Naoto Fujiwara, Maria Ybanez, Brittany Allen, Sebastiao Martins, M. Isabel Fiel, Nicolas Goossens, Hsin-I. Chou, Yujin Hoshida, Scott L. Friedman
Published in: Journal of Hepatology, Issue 69/2, 2018, Page(s) 385-395, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2018.03.011

The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses

Author(s): Carla Eller, Laura Heydmann, Che C. Colpitts, Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Published in: Cellular and Molecular Life Sciences, Issue 75/21, 2018, Page(s) 3895-3905, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-018-2892-y

HBV core variants, liver fibrosis and hepatocellular carcinoma

Author(s): Gaetan Ligat, Catherine Schuster, Thomas F Baumert
Published in: Hepatology, 2018, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.30231

Status of Direct-acting Antiviral Therapy for HCV Infection and Remaining Challenges

Author(s): Thomas F. Baumert, Thomas Berg, Joseph K. Lim, David R. Nelson
Published in: Gastroenterology, 2018, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.10.024

Oncogenic Signaling Induced by HCV Infection

Author(s): Alessia Virzì, Armando Roca Suarez, Thomas Baumert, Joachim Lupberger
Published in: Viruses, Issue 10/10, 2018, Page(s) 538, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v10100538

Molecular heterogeneity in hepatocellular carcinoma

Author(s): Shijia Zhu, Yujin Hoshida
Published in: Hepatic Oncology, Issue 5/1, 2018, Page(s) HEP10, ISSN 2045-0923
Publisher: future medicine
DOI: 10.2217/hep-2018-0005

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

Author(s): James S.V. Lally, Sarani Ghoshal, Danielle K. DePeralta, Omeed Moaven, Lan Wei, Ricard Masia, Derek J. Erstad, Naoto Fujiwara, Vivian Leong, Vanessa P. Houde, Alexander E. Anagnostopoulos, Alice Wang, Lindsay A. Broadfield, Rebecca J. Ford, Robert A. Foster, Jamie Bates, Hailing Sun, Ting Wang, Henry Liu, Adrian S. Ray, Asish K. Saha, Jeremy Greenwood, Sathesh Bhat, Geraldine Harriman, Wenyan Miao
Published in: Cell Metabolism, 2018, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2018.08.020

Tight junction proteins in gastrointestinal and liver disease

Author(s): Mirjam B Zeisel, Punita Dhawan, Thomas F Baumert
Published in: Gut, 2018, Page(s) gutjnl-2018-316906, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-316906

Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

Author(s): Youngmin A. Lee, Luke A. Noon, Kemal M. Akat, Maria D. Ybanez, Ting-Fang Lee, Marie-Luise Berres, Naoto Fujiwara, Nicolas Goossens, Hsin-I Chou, Fatemeh P. Parvin-Nejad, Bilon Khambu, Elisabeth G. M. Kramer, Ronald Gordon, Cathie Pfleger, Doris Germain, Gareth R. John, Kirk N. Campbell, Zhenyu Yue, Xiao-Ming Yin, Ana Maria Cuervo, Mark J. Czaja, M. Isabel Fiel, Yujin Hoshida, Scott L. Friedman
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-07338-z

Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus–Infected Cells and Liver to Identify Pathways Associated With Disease Development

Author(s): Joachim Lupberger, Tom Croonenborghs, Armando Andres Roca Suarez, Nicolaas Van Renne, Frank Jühling, Marine A. Oudot, Alessia Virzì, Simonetta Bandiera, Carole Jamey, Gergö Meszaros, Daniel Brumaru, Atish Mukherji, Sarah C. Durand, Laura Heydmann, Eloi R. Verrier, Hussein El Saghire, Nourdine Hamdane, Ralf Bartenschlager, Shaunt Fereshetian, Evelyn Ramberger, Rileen Sinha, Mohsen Nabian, Celine
Published in: Gastroenterology, Issue 157/2, 2019, Page(s) 537-551.e9, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.04.003

A human liver cell atlas reveals heterogeneity and epithelial progenitors

Author(s): Nadim Aizarani, Antonio Saviano, Sagar, Laurent Mailly, Sarah Durand, Josip S. Herman, Patrick Pessaux, Thomas F. Baumert, Dominic Grün
Published in: Nature, 2019, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1373-2

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

Author(s): Nourdine Hamdane, Frank Jühling, Emilie Crouchet, Houssein El Saghire, Christine Thumann, Marine A. Oudot, Simonetta Bandiera, Antonio Saviano, Clara Ponsolles, Armando Andres Roca Suarez, Shen Li, Naoto Fujiwara, Atsushi Ono, Irwin Davidson, Nabeel Bardeesy, Christian Schmidl, Christoph Bock, Catherine Schuster, Joachim Lupberger, François Habersetzer, Michel Doffoël, Tullio Piardi, Daniele So
Published in: Gastroenterology, Issue 156/8, 2019, Page(s) 2313-2329.e7, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.02.038

Functional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity

Author(s): Katharina Herzog, Simonetta Bandiera, Sophie Pernot, Catherine Fauvelle, Frank Jühling, Amélie Weiss, Anne Bull, Sarah C Durand, Béatrice Chane-Woon-Ming, Sébastien Pfeffer, Marion Mercey, Hervé Lerat, Jean-Christophe Meunier, Wolfgang Raffelsberger, Laurent Brino, Thomas F Baumert, Mirjam B Zeisel
Published in: Gut, 2019, Page(s) gutjnl-2018-317423, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317423

Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets

Author(s): Eloi R Verrier, Amélie Weiss, Charlotte Bach, Laura Heydmann, Vincent Turon-Lagot, Arnaud Kopp, Houssein El Saghire, Emilie Crouchet, Patrick Pessaux, Thomas Garcia, Patrick Pale, Mirjam B Zeisel, Camille Sureau, Catherine Schuster, Laurent Brino, Thomas F Baumert
Published in: Gut, 2019, Page(s) gutjnl-2018-317065, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317065

IFITM s mediate viral evasion in acute and chronic hepatitis C virus infection

Author(s): Florian Wrensch, Gaëtan Ligat, Laura Heydmann, Catherine Schuster, Mirjam B. Zeisel, Patrick Pessaux, François Habersetzer, Barnabas J. King, Alexander W. Tarr, Jonathan K. Ball, Michael Winkler, Stefan Pöhlmann, Zhen‐yong Keck, Steven K.H. Foung, Thomas F. Baumert
Published in: Hepatology, 2019, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.30699

Oxidative Stress Triggers Selective tRNA Retrograde Transport in Human Cells during the Integrated Stress Response

Author(s): Hagen Schwenzer, Frank Jühling, Alexander Chu, Laura J. Pallett, Thomas F. Baumert, Mala Maini, Ariberto Fassati
Published in: Cell Reports, Issue 26/12, 2019, Page(s) 3416-3428.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.02.077

In vivo combination of human anti-envelope glycoprotein E2 and -Claudin-1 monoclonal antibodies for prevention of hepatitis C virus infection

Author(s): Laurent Mailly, Florian Wrensch, Laura Heydmann, Catherine Fauvelle, Nicolas Brignon, Mirjam B. Zeisel, Patrick Pessaux, Zhen-yong Keck, Catherine Schuster, Thomas R. Fuerst, Steven K.H. Foung, Thomas F. Baumert
Published in: Antiviral Research, Issue 162, 2019, Page(s) 136-141, ISSN 0166-3542
Publisher: Elsevier BV
DOI: 10.1016/j.antiviral.2018.12.018

An E. coli-produced single-chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion

Author(s): Cheng Li, Yang Wang, Tiantian Liu, Matthias Niklasch, Ke Qiao, Sarah Durand, Li Chen, Mifang Liang, Thomas F. Baumert, Shuping Tong, Michael Nassal, Yu-Mei Wen, Yong-Xiang Wang
Published in: Antiviral Research, Issue 162, 2019, Page(s) 118-129, ISSN 0166-3542
Publisher: Elsevier BV
DOI: 10.1016/j.antiviral.2018.12.019

Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma: preliminary results

Author(s): Bachir Taouli, Yujin Hoshida, Suguru Kakite, Xintong Chen, Poh Seng Tan, Xiaochen Sun, Shingo Kihira, Kensuke Kojima, Sara Toffanin, M. Isabel Fiel, Hadassa Hirschfield, Mathilde Wagner, Josep M. Llovet
Published in: European Radiology, Issue 27/11, 2017, Page(s) 4472-4481, ISSN 0938-7994
Publisher: Springer Verlag
DOI: 10.1007/s00330-017-4844-6

Ultrasound‐Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma

Author(s): Ghina Bou About, Emilie Thiebault, Marie Wattenhofer‐Donzé, Hugues Jacobs, Alain Guimond, Tania Sorg, Eric Robinet, Thomas F. Baumert, Laurent Monassier, Yann Herault
Published in: Current Protocols in Mouse Biology, Issue 9/2, 2019, ISSN 2161-2617
Publisher: Wiley
DOI: 10.1002/cpmo.62

Learning from a clinical cohort for HCV vaccine development

Author(s): Florian Wrensch, Zhen-yong Keck, Steven K.H. Foung, Thomas F. Baumert
Published in: Journal of Hepatology, Issue 71/1, 2019, Page(s) 9-11, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2019.03.030

The circadian clock and liver function in health and disease

Author(s): Atish Mukherji, Shannon M. Bailey, Bart Staels, Thomas F. Baumert
Published in: Journal of Hepatology, Issue 71/1, 2019, Page(s) 200-211, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2019.03.020

Editorial: Current Progress and Challenges in the Development of a B Cell Based Hepatitis C Virus Vaccine

Author(s): Steven K. H. Foung, Thomas F. Baumert
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2018.02577

Hepatocellular Carcinoma Risk Stratification by Genetic Profiling in Patients with Cirrhosis

Author(s): Naoto Fujiwara, Yujin Hoshida
Published in: Seminars in Liver Disease, Issue 39/02, 2019, Page(s) 153-162, ISSN 0272-8087
Publisher: Thieme Medical Publishers
DOI: 10.1055/s-0039-1681031

Addressing the Challenges of Hepatitis C Cure and Persistent Risk of Hepatocellular Carcinoma

Author(s): Thomas F. Baumert, Yujin Hoshida
Published in: Viruses, Issue 11/5, 2019, Page(s) 441, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11050441

Mortality from liver cirrhosis and HCC in the DAA era: success in viral control is darkened by raise of metabolic disease

Author(s): Antonio Saviano, Thomas F. Baumert
Published in: HepatoBiliary Surgery and Nutrition, Issue 8/3, 2019, Page(s) 307-310, ISSN 2304-3881
Publisher: AME Publishing Company
DOI: 10.21037/hbsn.2019.01.21

Use of big data in drug development for precision medicine: an update

Author(s): Tongqi Qian, Shijia Zhu, Yujin Hoshida
Published in: Expert Review of Precision Medicine and Drug Development, Issue 4/3, 2019, Page(s) 189-200, ISSN 2380-8993
Publisher: Taylor & Francis
DOI: 10.1080/23808993.2019.1617632

Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis

Author(s): Simonetta Bandiera, Sophie Pernot, Hussein El Saghire, Sarah C. Durand, Christine Thumann, Emilie Crouchet, Tao Ye, Isabel Fofana, Marine A. Oudot, Jochen Barths, Catherine Schuster, Patrick Pessaux, Markus H. Heim, Thomas F. Baumert, Mirjam B. Zeisel
Published in: Journal of Virology, Issue 90/14, 2016, Page(s) 6387-6400, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/JVI.00619-16

Extracellular lipid-free apolipoprotein E inhibits HCV replication and induces ABCG1-dependent cholesterol efflux

Author(s): Emilie Crouchet, Mathieu Lefèvre, Eloi R Verrier, Marine A Oudot, Thomas F Baumert, Catherine Schuster
Published in: Gut, Issue 66/5, 2017, Page(s) 896-907, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2015-311289

Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice

Author(s): Tao Wu, Emilie Heuillard, Véronique Lindner, Ghina Bou About, Mihaela Ignat, Jean-Philippe Dillenseger, Nicolas Anton, Eugénie Dalimier, Francine Gossé, Gael Fouré, Franck Blindauer, Céline Giraudeau, Hussein El-Saghire, Mourad Bouhadjar, Cynthia Calligaro, Tania Sorg, Philippe Choquet, Thierry Vandamme, Christophe Ferrand, Jacques Marescaux, Thomas F. Baumert, Michele Diana, Patrick Pessaux,
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep35230

Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition

Author(s): Shigeki Nakagawa, Lan Wei, Won Min Song, Takaaki Higashi, Sarani Ghoshal, Rosa S. Kim, C. Billie Bian, Suguru Yamada, Xiaochen Sun, Anu Venkatesh, Nicolas Goossens, Gretchen Bain, Gregory Y. Lauwers, Anna P. Koh, Mohamed El-Abtah, Noor B. Ahmad, Hiroki Hoshida, Derek J. Erstad, Ganesh Gunasekaran, Youngmin Lee, Ming-Lung Yu, Wan-Long Chuang, Chia-Yen Dai, Masahiro Kobayashi, Hiromitsu Kumada, Toru
Published in: Cancer Cell, Issue 30/6, 2016, Page(s) 879-890, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2016.11.004

Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape

Author(s): Che C Colpitts, Rajiv G Tawar, Laurent Mailly, Christine Thumann, Laura Heydmann, Sarah C Durand, Fei Xiao, Eric Robinet, Patrick Pessaux, Mirjam B Zeisel, Thomas F Baumert
Published in: Gut, 2017, Page(s) gutjnl-2016-312577, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-312577

Plasmodium P36 determines host cell receptor usage during sporozoite invasion

Author(s): Giulia Manzoni, Carine Marinach, Selma Topçu, Sylvie Briquet, Morgane Grand, Matthieu Tolle, Marion Gransagne, Julien Lescar, Chiara Andolina, Jean-François Franetich, Mirjam B Zeisel, Thierry Huby, Eric Rubinstein, Georges Snounou, Dominique Mazier, François Nosten, Thomas F Baumert, Olivier Silvie
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.25903

Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy

Author(s): Tanvi Khera, Daniel Todt, Koen Vercauteren, C. Patrick McClure, Lieven Verhoye, Ali Farhoudi, Sabin Bhuju, Robert Geffers, Thomas F. Baumert, Eike Steinmann, Philip Meuleman, Thomas Pietschmann, Richard J.P. Brown
Published in: Antiviral Research, Issue 139, 2017, Page(s) 129-137, ISSN 0166-3542
Publisher: Elsevier BV
DOI: 10.1016/j.antiviral.2017.01.001

Cost-Effectiveness of Risk Score–Stratified Hepatocellular Carcinoma Screening in Patients with Cirrhosis

Author(s): Nicolas Goossens, Amit G Singal, Lindsay Y King, Karin L Andersson, Bryan C Fuchs, Cecilia Besa, Bachir Taouli, Raymond T Chung, Yujin Hoshida
Published in: Clinical and Translational Gastroenterology, Issue 8/6, 2017, Page(s) e101, ISSN 2155-384X
Publisher: Nature Publishing Group
DOI: 10.1038/ctg.2017.26

Hepatic stellate cells as key target in liver fibrosis

Author(s): Takaaki Higashi, Scott L. Friedman, Yujin Hoshida
Published in: Advanced Drug Delivery Reviews, 2017, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2017.05.007

Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging

Author(s): Stefanie J. Hectors, Mathilde Wagner, Octavia Bane, Cecilia Besa, Sara Lewis, Romain Remark, Nelson Chen, M. Isabel Fiel, Hongfa Zhu, Sacha Gnjatic, Miriam Merad, Yujin Hoshida, Bachir Taouli
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-02706-z

Persisting risk of hepatocellular carcinoma after HCV cure monitored by a liver transcriptome signature

Author(s): Atsushi Ono, Nicolas Goossens, Richard S Finn, Warren N Schmidt, Swan N Thung, Gene Y Im, Yujin Hoshida
Published in: Hepatology, 2017, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.29203

Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases

Author(s): Benjamin Wooden, Nicolas Goossens, Yujin Hoshida, Scott L. Friedman
Published in: Gastroenterology, Issue 152/1, 2017, Page(s) 53-67.e3, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2016.09.065

Novel substituted aminothiazoles as potent and selective anti-hepatocellular carcinoma agents

Author(s): Huagang Lu, John Rogowskyj, Wenquan Yu, Anu Venkatesh, Noshena Khan, Shigeki Nakagawa, Nicolas Goossens, Anna P. Koh, Takaaki Higashi, Ganesh Gunasekaran, Myron E. Schwarz, Spiros P. Hiotis, Xiaodong Xu, William Kinney, Yujin Hoshida, Timothy Block, Andrea Cuconati, Yanming Du
Published in: Bioorganic & Medicinal Chemistry Letters, Issue 26/23, 2016, Page(s) 5819-5824, ISSN 0960-894X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2016.10.015

Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells

Author(s): Daniel F. Hicks, Nicolas Goossens, Ana Blas-García, Takuma Tsuchida, Benjamin Wooden, Michael C. Wallace, Natalia Nieto, Abigale Lade, Benjamin Redhead, Arthur I Cederbaum, Joel T. Dudley, Bryan C. Fuchs, Youngmin A. Lee, Yujin Hoshida, Scott L. Friedman
Published in: Scientific Reports, Issue 7, 2017, Page(s) 42563, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep42563

New perspectives for preventing hepatitis C virus liver graft infection

Author(s): Daniel J Felmlee, Audrey Coilly, Raymond T Chung, Didier Samuel, Thomas F Baumert
Published in: The Lancet Infectious Diseases, Issue 16/6, 2016, Page(s) 735-745, ISSN 1473-3099
Publisher: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(16)00120-1

Hepatitis B virus receptors and molecular drug targets

Author(s): Eloi R. Verrier, Che C. Colpitts, Camille Sureau, Thomas F. Baumert
Published in: Hepatology International, Issue 10/4, 2016, Page(s) 567-573, ISSN 1936-0533
Publisher: Springer Pub. Co.
DOI: 10.1007/s12072-016-9718-5

Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma

Author(s): Simonetta Bandiera, C Billie Bian, Yujin Hoshida, Thomas F Baumert, Mirjam B Zeisel
Published in: Current Opinion in Virology, Issue 20, 2016, Page(s) 99-105, ISSN 1879-6257
Publisher: Elsevier BV
DOI: 10.1016/j.coviro.2016.09.010

Author(s): Thomas F. Baumert, Frank Jühling, Atsushi Ono, Yujin Hoshida
Published in: BMC Medicine, Issue 15/1, 2017, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-017-0815-7

Toward novel immunocompetent animal models for hepatitis B virus infection

Author(s): Laurent Mailly, Mirjam B. Zeisel, Thomas F. Baumert
Published in: Hepatology, 2017, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.29249

Characterisation of endogenous Claudin‐1 expression, motility and susceptibility to hepatitis C virus in CRISPR knock‐in cells

Author(s): Camille M.H. Clément, Maika S. Deffieu, Cristina M. Dorobantu, Thomas F. Baumert, Nilda Vanesa Ayala‐Nunez, Yves Mély, Philippe Ronde, Raphael Gaudin
Published in: Biology of the Cell, Issue 112/5, 2020, Page(s) 140-151, ISSN 0248-4900
Publisher: Portland Press, Ltd.
DOI: 10.1111/boc.201900085

Addressing the next challenges: A summary of the 22nd international symposium on hepatitis C virus and related viruses

Author(s): Thomas F. Baumert, Catherine Schuster, François-Loïc Cosset, Jean Dubuisson, Maike Hofmann, Norbert Tautz, Mirjam B. Zeisel, Robert Thimme
Published in: Journal of Hepatology, Issue 64/4, 2016, Page(s) 968-973, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2015.12.021

Hepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals

Author(s): Che C. Colpitts, Thomas F. Baumert
Published in: Hepatology International, Issue 10/5, 2016, Page(s) 741-748, ISSN 1936-0533
Publisher: Springer Pub. Co.
DOI: 10.1007/s12072-016-9724-7

A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

Author(s): Carla Eller, Laura Heydmann, Che C. Colpitts, Houssein El Saghire, Federica Piccioni, Frank Jühling, Karim Majzoub, Caroline Pons, Charlotte Bach, Julie Lucifora, Joachim Lupberger, Michael Nassal, Glenn S. Cowley, Naoto Fujiwara, Sen-Yung Hsieh, Yujin Hoshida, Emanuele Felli, Patrick Pessaux, Camille Sureau, Catherine Schuster, David E. Root, Eloi R. Verrier, Thomas F. Baumert
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16517-w

Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma

Author(s): Frank Jühling, Nourdine Hamdane, Emilie Crouchet, Shen Li, Houssein El Saghire, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Christine Thumann, Antonio Saviano, Armando Andres Roca Suarez, Kaku Goto, Ricard Masia, Mozhdeh Sojoodi, Gunisha Arora, Hiroshi Aikata, Atsushi Ono, Parissa Tabrizian, Myron Schwartz, Stephen J Polyak, Irwin Davidson, Christian Schmidl, Christoph Bock, Catherine Schuste
Published in: Gut, 2020, Page(s) gutjnl-2019-318918, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-318918

Hepatitis C Virus and Hepatocellular Carcinoma: When the Host Loses Its Grip

Author(s): Kaku Goto, Armando Andres Roca Suarez, Florian Wrensch, Thomas F. Baumert, Joachim Lupberger
Published in: International Journal of Molecular Sciences, Issue 21/9, 2020, Page(s) 3057, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093057

Signalome-wide assessment of host cell response to hepatitis C virus

Author(s): Gholamreza Haqshenas, Jianmin Wu, Kaylene J. Simpson, Roger J. Daly, Hans J. Netter, Thomas F. Baumert, Christian Doerig
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms15158

Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design

Author(s): Zhen-Yong Keck, Brian G. Pierce, Patrick Lau, Janine Lu, Yong Wang, Alexander Underwood, Rowena A. Bull, Jannick Prentoe, Rodrigo Velázquez-Moctezuma, Melanie R. Walker, Fabio Luciani, Johnathan D. Guest, Catherine Fauvelle, Thomas F. Baumert, Jens Bukh, Andrew R. Lloyd, Steven K. H. Foung
Published in: PLOS Pathogens, Issue 15/5, 2019, Page(s) e1007772, ISSN 1553-7374
Publisher: PLOS
DOI: 10.1371/journal.ppat.1007772

Hepatitis C virus infection and tight junction proteins: The ties that bind

Author(s): Laurent Mailly, Thomas F. Baumert
Published in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Issue 1862/7, 2020, Page(s) 183296, ISSN 0005-2736
Publisher: Elsevier BV
DOI: 10.1016/j.bbamem.2020.183296

The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans

Author(s): Karim Majzoub, Florian Wrensch, Thomas F. Baumert
Published in: Viruses, Issue 11/8, 2019, Page(s) 758, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11080758

Uncovering the mechanism of action of aspirin in HCC chemoprevention

Author(s): Natascha Roehlen, Thomas F. Baumert
Published in: EBioMedicine, Issue 46, 2019, Page(s) 21-22, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2019.07.047

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

Author(s): Natascha Roehlen, Emilie Crouchet, Thomas F. Baumert
Published in: Cells, Issue 9/4, 2020, Page(s) 875, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9040875

Tight Junction Proteins and the Biology of Hepatobiliary Disease

Author(s): Natascha Roehlen, Armando Andres Roca Suarez, Houssein El Saghire, Antonio Saviano, Catherine Schuster, Joachim Lupberger, Thomas F. Baumert
Published in: International Journal of Molecular Sciences, Issue 21/3, 2020, Page(s) 825, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21030825

Single-cell genomics and spatial transcriptomics: discovery of novel cell states and cellular interactions in liver physiology and disease biology

Author(s): Antonio Saviano, Neil C. Henderson, Thomas F. Baumert
Published in: Journal of Hepatology, 2020, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2020.06.004

Follicular T helper cells shape the HCV-specific CD4+ T cell repertoire after virus elimination

Author(s): Maike Smits, Katharina Zoldan, Naveed Ishaque, Zuguang Gu, Katharina Jechow, Dominik Wieland, Christian Conrad, Roland Eils, Catherine Fauvelle, Thomas F. Baumert, Florian Emmerich, Bertram Bengsch, Christoph Neumann-Haefelin, Maike Hofmann, Robert Thimme, Tobias Boettler
Published in: Journal of Clinical Investigation, Issue 130/2, 2019, Page(s) 998-1009, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci129642

Hepatitis B Virus–Hepatocyte Interactions and Innate Immune Responses: Experimental Models and Molecular Mechanisms

Author(s): Emmanuel Thomas, Thomas F. Baumert
Published in: Seminars in Liver Disease, Issue 39/03, 2019, Page(s) 301-314, ISSN 0272-8087
Publisher: Thieme Medical Publishers
DOI: 10.1055/s-0039-1685518

Radiomics in hepatocellular carcinoma: a quantitative review

Author(s): Taiga Wakabayashi, Farid Ouhmich, Cristians Gonzalez-Cabrera, Emanuele Felli, Antonio Saviano, Vincent Agnus, Peter Savadjiev, Thomas F. Baumert, Patrick Pessaux, Jacques Marescaux, Benoit Gallix
Published in: Hepatology International, Issue 13/5, 2019, Page(s) 546-559, ISSN 1936-0533
Publisher: Springer Pub. Co.
DOI: 10.1007/s12072-019-09973-0

Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis

Author(s): Alessia Virzì, Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Published in: Cold Spring Harbor Perspectives in Medicine, Issue 10/1, 2020, Page(s) a037366, ISSN 2157-1422
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a037366

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

Author(s): Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai, Abhinav Kumar, Srinivasa Bhargav Rambhatla, Claire L. Donald, Andrea F. Lopez-Clavijo, Simon Rudge, Katherine Pinnick, Wai Hoong Chang, Peter A. C. Wing, Ryan Brown, Ximing Qin, Peter Simmonds, Thomas F. Baumert, David Ray, Andrew Loudon, Peter Balfe, Michael Wakelam, Sam Butterworth, Alain Kohl, Catherine L. Jopling, Nicole Zitzmann, Ja
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-08299-7

MPIC: Molecular Prognostic Indicators in Cirrhosis Database for Clinical Context-Specific in Silico Prognostic Biomarker Validation

Author(s): Shun H. Yip, Naoto Fujiwara, Jason Burke, Anand Shetler, Celina Peralta, Tongqi Qian, Hiroki Hoshida, Shijia Zhu, Yujin Hoshida
Published in: Frontiers in Genetics, Issue 10, 2019, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2019.00830

Gene signature-MELD score and alcohol relapse determine long-term prognosis of patients with severe alcoholic hepatitis

Author(s): Pierre Deltenre 1 2, Eric Trépo 1 3, Naoto Fujiwara, Nicolas Goossens 4 5, Astrid Marot 6, Margaux Dubois 7, Laurent Spahr 5, Jean Henrion 8, Christophe Moreno 1 3, Yujin Hoshida
Published in: Liver Int, 2020, ISSN 1478-3231
Publisher: John Wiley & Sons, Inc.
DOI: 10.1111/liv.14265

FIB-4 score and hepatocellular carcinoma risk after hepatitis C virus cure: time to revise surveillance?

Author(s): Antonio Saviano, Simona Tripon, Thomas F Baumert
Published in: Hepatobiliary Surgery and Nutrition, 2020, Page(s) 661-664, ISSN 2304-3881
Publisher: AME Publishing Company
DOI: 10.21037/hbsn.2020.01.05

Steatohepatitic Variant of Hepatocellular Carcinoma Is Associated With Both Alcoholic Steatohepatitis and Nonalcoholic Steatohepatitis: A Study of 2 Cohorts With Molecular Insights.

Author(s): Jia Qin, MD, PhD,1 Takaaki Higashi, MD, PhD,2 Shigeki Nakagawa, MD, PhD,2 Yo-ichi Yamashita, MD, PhD,2 Toru Beppu, MD, PhD,2 Hideo Baba, MD, PhD,2 Masahiro Kobayashi, MD,3 Hiromitsu Kumada, MD,3 Ganesh Gunasekaran, MD,4 Thomas D. Schiano, MD,5 Swan N. Thung, MD,6 M. Isabel Fiel, MD, Yujin Hoshida, and Stephen C. Ward, MD, PhD6
Published in: Am J Surg Pathol, 2021, ISSN 0147-5185
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/pas.0000000000001533

Composite vector formulation for multiple siRNA delivery as a host targeting antiviral in a cell culture model of hepatitis C virus (HCV) infection

Author(s): E Crouchet, R Saad, C Affolter-Zbaraszczuk, J Ogier, T F Baumert, C Schuster, F Meyer
Published in: Journal of Materials Chemistry B, 2016, Page(s) 858-865, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/c6tb01718e

International Liver Cancer Association (ILCA) White Paper on Biomarker Development for Hepatocellular Carcinoma

Author(s): Amit G. Singal,Yujin Hoshida,1 David J. Pinato,2 Jorge Marrero,1 Jean-Charles Nault,3,4,5 Valerie Paradis,6 Nabihah Tayob,7 Morris Sherman,8 Young Suk Lim,9 Ziding Feng,10 Anna S. Lok,11 Jo Ann Rinaudo,12 Sudhir Srivastava,12 Josep Llovet,13,14,15 and Augusto Villanueva13
Published in: Gastroenterology, 2021, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2021.01.233

Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis

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Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin

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Un criblage gain-de-fonction identifie CDKN2C comme facteur d'hôte impliqué dans le cycle viral du virus de l'hépatite B

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Published in: https://tel.archives-ouvertes.fr/tel-02924142, Issue 1, 2019
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ANTI-CLAUDIN 1 MONOCLONAL ANTIBODIES FOR THE PREVENTION AND TREATMENT OF HEPATOCELLULAR CARCINOMA

Application/Publication number: 20 16055942
Date: 2016-03-18
Applicant(s): UNIVERSITE DE STRASBOURG

ANTI-CLAUDIN 1 MONOCLONAL ANTIBODIES FOR THE PREVENTION AND TREATMENT OF HEPATOCELLULAR CARCINOMA

Application/Publication number: 20 16055942
Date: 2016-03-18
Applicant(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

CLINICAL GENE SIGNATURE-BASED HUMAN CELL CULTURE MODEL AND USES THEREOF

Application/Publication number: EP 16719852
Date: 2016-04-28
Applicant(s): UNIVERSITE DE STRASBOURG

METHOD FOR DIAGNOSIS AND/OR PROGNOSIS OF LIVER DISEASE PROGRESSION AND RISK OF HEPATOCELLULAR CARCINOMA AND DISCOVERY OF THERAPEUTIC COMPOUNDS AND TARGETS TO TREAT LIVER DISEASE AND CANCER

Application/Publication number: 20 21055203
Date: 2021-03-02
Applicant(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

HUMANIZED ANTI-CLAUDIN-1 ANTIBODIES AND USES THEREOF

Application/Publication number: 20 17056703
Date: 2016-03-22
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Date: 2021-08-11
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Application/Publication number: 20 20081941
Date: 2020-11-12
Applicant(s): UNIVERSITE DE STRASBOURG

ANTI-CLAUDIN-1 MONOCLONAL ANTIBODIES FOR THE PREVENTION AND TREATMENT OF FIBROTIC DISEASES

Application/Publication number: 20 20081941
Date: 2020-11-12
Applicant(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

CLINICAL GENE SIGNATURE-BASED HUMAN CELL CULTURE MODEL AND USES THEREOF

Application/Publication number: EP 16719852
Date: 2016-04-28
Applicant(s): ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

H2 BLOCKERS TARGETING LIVER MACROPHAGES FOR THE PREVENTION AND TREATMENT OF LIVER DISEASE AND CANCER

Application/Publication number: 20 21072341
Date: 2021-08-11
Applicant(s): UNIVERSITE DE STRASBOURG

CLINICAL GENE SIGNATURE-BASED HUMAN CELL CULTURE MODEL AND USES THEREOF

Application/Publication number: EP 16719852
Date: 2016-04-28
Applicant(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

HUMANIZED ANTI-CLAUDIN-1 ANTIBODIES AND USES THEREOF

Application/Publication number: 20 17056703
Date: 2016-03-22
Applicant(s): UNIVERSITE DE STRASBOURG

METHOD FOR DIAGNOSIS AND/OR PROGNOSIS OF LIVER DISEASE PROGRESSION AND RISK OF HEPATOCELLULAR CARCINOMA AND DISCOVERY OF THERAPEUTIC COMPOUNDS AND TARGETS TO TREAT LIVER DISEASE AND CANCER

Application/Publication number: 20 21055203
Date: 2021-03-02
Applicant(s): UNIVERSITE DE STRASBOURG

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