Cell circuits as targets and biomarkers for liver disease and cancer prevention

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Omics‐derived hepatocellular carcinoma risk biomarkers for precision care of chronic liver diseases

Autori: Naoto Fujiwara; Naoto Fujiwara; Tongqi Qian; Bhuvaneswari Koneru; Yujin Hoshida
Pubblicato in: Hepatol Res, Numero 1, 2020, Pagina/e 817-830, ISSN 1872-034X
Editore: The Japan Society of Hepatology
DOI: 10.1111/hepr.13506

Viral Exposure Signature Associated with Liver Cancer Risk.

Autori: Naoto Fujiwara; Naoto Fujiwara; Yujin Hoshida
Pubblicato in: Trends Mol Med, Numero 1, 2020, ISSN 1471-4914
Editore: Elsevier BV
DOI: 10.1016/j.molmed.2020.06.008

Unraveling the role of liver sinusoidal endothelial cells in COVID-19 liver injury

Autori: Antonio Saviano, Thomas F Baumert
Pubblicato in: J Hepatol, 2021, Pagina/e 503–505, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2021.07.008

Perturbation of the circadian clock and pathogenesis of NAFLD

Autori: Atish Mukherji, Mayssa Dachraoui, Thomas F Baumert
Pubblicato in: Metabolism, 2020, ISSN 0026-0495
Editore: Elsevier BV
DOI: 10.1016/j.metabol.2020.154337

Liver cell circuits and therapeutic discovery for advanced liver disease and cancer

Autori: Emilie Crouchet, Catherine Schuster, Thomas F Baumert
Pubblicato in: Comptes Rendus Biologie, 2021, Pagina/e 233-248, ISSN 1631-0691
Editore: Elsevier Masson
DOI: 10.5802/crbiol.64

A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis

Autori: Naoto Fujiwara, Masahiro Kobayashi,3 Austin J Fobar,4 Ayaka Hoshida,1 Cesia A Marquez,1 Bhuvaneswari Koneru,1 Gayatri Panda,1 Masataka Taguri,5 Tongqi Qian,1 Indu Raman,6 Quan-Zhen Li,6 Hiroki Hoshida,1 Hitomi Sezaki,3 Hiromitsu Kumada,3 Ryosuke Tateishi,2 Takeshi Yokoo,7 Adam C Yopp,8 Raymond T Chung,9 Bryan C Fuchs,10,11 Thomas F Baumert,12 Jorge A Marrero,1 Neehar D Parikh, Shijia Zhu, Amit G S
Pubblicato in: Med (N Y)., 2021, ISSN 2666-6340
Editore: John Wiley
DOI: 10.1016/j.medj.2021.03.017

Transcriptome-Guided Design of Physiological Multilineage Liver Organoids

Autori: Shijia Zhu, Naoto Kubota, Yujin Hoshida
Pubblicato in: Trends Genet, 2021, ISSN 0168-9525
Editore: Elsevier BV
DOI: 10.1016/j.tig.2021.01.007

The Nobel Prize in Medicine 2020 for the Discovery of Hepatitis C Virus: Transforming Hepatology.

Autori: Thomas F. Baumert
Pubblicato in: ISSN: 1600-0641, Numero 25, 2020, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2020.10.017

Hepatitis B virus compartmentalization and single-cell differentiation in hepatocellular carcinoma.

Autori: Frank Jühling; Antonio Saviano; Clara Ponsolles; Laura Heydmann; Emilie Crouchet; Sarah C. Durand; Houssein El Saghire; Emanuele Felli; Véronique Lindner; Patrick Pessaux; Nathalie Pochet; Nathalie Pochet; Catherine Schuster; Eloi R. Verrier; Thomas F. Baumert; Thomas F. Baumert
Pubblicato in: Life Science Alliance, Numero 1, 2021, ISSN 2575-1077
Editore: Life Science Alliance LCC
DOI: 10.26508/lsa.202101036

Liver Abnormalities after Elimination of HCV Infection: Persistent Epigenetic and Immunological Perturbations Post-Cure

Autori: Stephen J Polyak, I Nicholas Crispe, Thomas F Baumert
Pubblicato in: Pathogens, 2021, ISSN 2076-0817
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10010044

Role of Hepatocyte-DerivedOsteopontinin Liver Carcinogenesis

Autori: "Romain Desert # 1, Xiaodong Ge # 1 2, Zhuolun Song 1, Hui Han 1, Daniel Lantvit 1, Wei Chen 1, Sukanta Das 1, Dipti Athavale 1, Ioana Abraham-Enachescu 2, Chuck Blajszczak 1, Yu Chen 1, Orlando Musso 3, Grace Guzman 1, Yujin Hoshida, Natalia Nieto 1 2 5"
Pubblicato in: Hepatol Commun, 2022, ISSN 2471-254X
Editore: John Wiley & Sons, Inc.
DOI: 10.1002/hep4.1845

Atorvastatin favorably modulates a clinical hepatocellular carcinoma risk gene signature

Autori: Myung-Ho Kim 1, Mi-Young Kim 1 2 3, Shadi Salloum 1, Tongqi Qian 4, Lai Ping Wong 5 6, Min Xu 1, Yoojin Lee 1, Stuti G Shroff 7, Ruslan I Sadreyev 5 7, Kathleen E Corey 1, Thomas F Baumert 8 9, Yujin Hoshida, Raymond T Chung 1
Pubblicato in: Hepatol Commun, 2022, ISSN 2471-254X
Editore: John Wiley & Sons, Inc.
DOI: 10.1002/hep4.1991

Conventional and artificial intelligence-based imaging for biomarker discovery in chronic liver disease

Autori: Jérémy Dana,1,2,3,4 Aïna Venkatasamy, Antonio Saviano, Joachim Lupberger, Yujin Hoshida, Valérie Vilgrain,9 Pierre Nahon,10,11,12 Caroline Reinhold,4,13,14 Benoit Gallix,2,3,4 and Thomas F. Baumert1,3,7
Pubblicato in: Hepatol Int, 2022, ISSN 1936-0533
Editore: Springer Pub. Co.
DOI: 10.1007/s12072-022-10303-0

Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import

Autori: Rodriguez-Bravo, Veronica; Pippa, Raffaella; Song, Won-Min; Carceles-Cordon, Marc; Dominguez-Andres, Ana; Fujiwara, Naoto; Woo, Jungreem; Koh, Anna P.; Ertel, Adam; Lokareddy, Ravi K.; Cuesta-Dominguez, Alvaro; Kim, Rosa S.; Rodriguez-Fernandez, Irene; Li, Peiyao; Gordon, Ronald; Hirschfield, Hadassa; Prats, Josep M.; Reddy, E. Premkumar; Fatatis, Alessandro; Petrylak, Daniel P.; Gomella, Leonard;
Pubblicato in: Cell, Numero 1, 2018, ISSN 1097-4172
Editore: Elsevier Inc
DOI: 10.1016/j.cell.2018.07.015

Liver Disease and Coronavirus Disease 2019: From Pathogenesis to Clinical Care.

Autori: Antonio Saviano; Florian Wrensch; Marc G. Ghany; Thomas F. Baumert; Thomas F. Baumert
Pubblicato in: Hepatology (Baltimore, Md.), Numero 20, 2021, Pagina/e 088-1100, ISSN 1527-3350
Editore: John Wiley & Sons, Inc
DOI: 10.1002/hep.31684

Virus-Induced Risk of Hepatocellular Carcinoma: Recent Progress and Future Challenges

Autori: Joachim Lupberger, and Thomas F. Baumert
Pubblicato in: J Clin Med, 2021, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11010208

Plasma-Signature-Model for End-Stage Liver Disease Scoreto Predict Survival in Severe Alcoholic Hepatitis

Autori: Naoto Fujiwara, Eric Trépo, Indu Raman, Quan-Zhen Li, Delphine Degré, Thierry Gustot, Christophe Moreno, Yujin Hoshida
Pubblicato in: Clin Gastroenterol Hepatol, 2022, ISSN 1542-3565
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cgh.2021.02.041

Viral manipulation of STAT3: Evade, exploit, and injure

Autori: Armando Andres Roca Suarez, Nicolaas Van Renne, Thomas F. Baumert, Joachim Lupberger
Pubblicato in: PLOS Pathogens, Numero 14/3, 2018, Pagina/e e1006839, ISSN 1553-7374
Editore: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, c2011.
DOI: 10.1371/journal.ppat.1006839

Hepatitis C Virus (HCV)–Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design

Autori: Florian Wrensch, Emilie Crouchet, Gaetan Ligat, Mirjam B. Zeisel, Zhen-Yong Keck, Steven K. H. Foung, Catherine Schuster, Thomas F. Baumert
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2018.01436

Mapping Determinants of Virus Neutralization and Viral Escape for Rational Design of a Hepatitis C Virus Vaccine

Autori: Mei-Le Keck, Florian Wrensch, Brian G. Pierce, Thomas F. Baumert, Steven K. H. Foung
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2018.01194

Hepatitis B virus evasion from cyclic guanosine monophosphate-adenosine monophosphate synthase sensing in human hepatocytes

Autori: Eloi R. Verrier, Seung-Ae Yim, Laura Heydmann, Houssein El Saghire, Charlotte Bach, Vincent Turon-Lagot, Laurent Mailly, Sarah C. Durand, Julie Lucifora, David Durantel, Patrick Pessaux, Nicolas Manel, Ivan Hirsch, Mirjam B. Zeisel, Nathalie Pochet, Catherine Schuster, Thomas F. Baumert
Pubblicato in: Hepatology, 2018, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.30054

Beyond viral dependence: The pathological consequences of HCV-induced EGF signaling

Autori: Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Pubblicato in: Journal of Hepatology, Numero S0168-8278(18), 2018, Pagina/e 32118-4, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2018.05.033

Host-targeting therapies for hepatitis C virus infection: current developments and future applications

Autori: Emilie Crouchet, Florian Wrensch, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Pubblicato in: Therapeutic Advances in Gastroenterology, Numero 11, 2018, Pagina/e 175628481875948, ISSN 1756-2848
Editore: London : Sage Publications
DOI: 10.1177/1756284818759483

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

Autori: Isabelle Desombere, Ahmed Atef Mesalam, Richard A. Urbanowicz, Freya Van Houtte, Lieven Verhoye, Zhen-Yong Keck, Ali Farhoudi, Koen Vercauteren, Karin E. Weening, Thomas F. Baumert, Arvind H. Patel, Steven K.H. Foung, Jonathan Ball, Geert Leroux-Roels, Philip Meuleman
Pubblicato in: Antiviral Research, Numero 148, 2017, Pagina/e 53-64, ISSN 0166-3542
Editore: Elsevier BV
DOI: 10.1016/j.antiviral.2017.10.015

Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8 + T Cells in Chronic versus Acute Infection

Autori: David Wolski, Peter K. Foote, Diana Y. Chen, Lia L. Lewis-Ximenez, Catherine Fauvelle, Jasneet Aneja, Andreas Walker, Pierre Tonnerre, Almudena Torres-Cornejo, Daniel Kvistad, Sabrina Imam, Michael T. Waring, Damien C. Tully, Todd M. Allen, Raymond T. Chung, Jörg Timm, W. Nicholas Haining, Arthur Y. Kim, Thomas F. Baumert, Georg M. Lauer
Pubblicato in: Immunity, Numero 47/4, 2017, Pagina/e 648-663.e8, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2017.09.006

Zooming in on liver zonation

Autori: Daniel J. Felmlee, Dominic Grün, Thomas F. Baumert
Pubblicato in: Hepatology, Numero 67/2, 2018, Pagina/e 784-787, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.29554

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

Autori: Zhirong Zhang, Gergö Meszaros, Wan-ting He, Yanfang Xu, Helena de Fatima Magliarelli, Laurent Mailly, Michael Mihlan, Yansheng Liu, Marta Puig Gámez, Alexander Goginashvili, Adrien Pasquier, Olga Bielska, Bénédicte Neven, Pierre Quartier, Rudolf Aebersold, Thomas F. Baumert, Philippe Georgel, Jiahuai Han, Romeo Ricci
Pubblicato in: The Journal of Experimental Medicine, Numero 214/9, 2017, Pagina/e 2671-2693, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20162040

Hepatitis C virus–apolipoprotein interactions: molecular mechanisms and clinical impact

Autori: Emilie Crouchet, Thomas F. Baumert, Catherine Schuster
Pubblicato in: Expert Review of Proteomics, Numero 14/7, 2017, Pagina/e 593-606, ISSN 1478-9450
Editore: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1344102

Entry Inhibitors: A Perspective for Prevention of Hepatitis C Virus Infection in Organ Transplantation

Autori: Che C. Colpitts, Raymond T. Chung, Thomas F. Baumert
Pubblicato in: ACS Infectious Diseases, Numero 3/9, 2017, Pagina/e 620-623, ISSN 2373-8227
Editore: Washington, DC : ACS Publications, [2015]-
DOI: 10.1021/acsinfecdis.7b00091

Advancing hepatitis B virus entry inhibitors

Autori: Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Pubblicato in: Journal of Hepatology, Numero 66/4, 2017, Pagina/e 677-679, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2016.11.028

SCARB1 variants and HCV infection: Host susceptibility is lost in translation

Autori: Che C. Colpitts, Thomas F. Baumert
Pubblicato in: Journal of Hepatology, Numero 67/2, 2017, Pagina/e 211-213, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2017.04.013

SMAD About Hepatitis C Virus Cell Entry and Liver Disease

Autori: Che C. Colpitts, Thomas F. Baumert
Pubblicato in: Gastroenterology, Numero 152/1, 2017, Pagina/e 21-23, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2016.11.029

miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis

Autori: Nicolaas Van Renne, Armando Andres Roca Suarez, Francois H T Duong, Claire Gondeau, Diego Calabrese, Nelly Fontaine, Amina Ababsa, Simonetta Bandiera, Tom Croonenborghs, Nathalie Pochet, Vito De Blasi, Patrick Pessaux, Tullio Piardi, Daniele Sommacale, Atsushi Ono, Kazuaki Chayama, Masashi Fujita, Hidewaki Nakagawa, Yujin Hoshida, Mirjam B Zeisel, Markus H Heim, Thomas F Baumert, Joachim Lupberger
Pubblicato in: Gut, Numero 67/5, 2018, Pagina/e 953-962, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-312270

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes

Autori: Eloi R. Verrier, Che C. Colpitts, Charlotte Bach, Laura Heydmann, Laetitia Zona, Fei Xiao, Christine Thumann, Emilie Crouchet, Raphaël Gaudin, Camille Sureau, François-Loïc Cosset, Jane A. McKeating, Patrick Pessaux, Yujin Hoshida, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Pubblicato in: Cell Reports, Numero 17/5, 2016, Pagina/e 1357-1368, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.09.084

Cell Culture Models for the Investigation of Hepatitis B and D Virus Infection

Autori: Eloi Verrier, Che Colpitts, Catherine Schuster, Mirjam Zeisel, Thomas Baumert
Pubblicato in: Viruses, Numero 8/9, 2016, Pagina/e 261, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v8090261

Claudins in viral infection: from entry to spread

Autori: Che C. Colpitts, Thomas F. Baumert
Pubblicato in: Pflügers Archiv - European Journal of Physiology, Numero 469/1, 2017, Pagina/e 27-34, ISSN 0031-6768
Editore: Springer Verlag
DOI: 10.1007/s00424-016-1908-4

Hepatitis B virus: is a cure possible?

Autori: Mirjam B. Zeisel, Thomas F. Baumert
Pubblicato in: Expert Review of Clinical Pharmacology, Numero 9/9, 2016, Pagina/e 1129-1130, ISSN 1751-2433
Editore: Future Drugs Ltd.
DOI: 10.1080/17512433.2016.1206466

Hepatitis C virus vaccine candidates inducing protective neutralizing antibodies

Autori: Catherine Fauvelle, Che C. Colpitts, Zhen-yong Keck, Brian G. Pierce, Steven K. H. Foung, Thomas F. Baumert
Pubblicato in: Expert Review of Vaccines, Numero 15/12, 2016, Pagina/e 1535-1544, ISSN 1476-0584
Editore: Future Drugs Ltd.
DOI: 10.1080/14760584.2016.1194759

Circulating microRNAs for early detection of hepatitis B-related hepatocellular carcinoma

Autori: Simonetta Bandiera, Thomas F. Baumert, Mirjam B. Zeisel
Pubblicato in: HepatoBiliary Surgery and Nutrition, Numero 5/3, 2016, Pagina/e 198-200, ISSN 2304-3881
Editore: Hong Kong : AME Publishing Company
DOI: 10.21037/hbsn.2016.03.08

Multifaceted role of E-cadherin in hepatitis C virus infection and pathogenesis

Autori: Che C. Colpitts, Joachim Lupberger, Thomas F. Baumert
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 113/27, 2016, Pagina/e 7298-7300, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1607732113

Translation and protein expression of lncRNAs: Impact for liver disease and hepatocellular carcinoma

Autori: Mirjam B. Zeisel, Thomas F. Baumert
Pubblicato in: Hepatology, Numero 64/2, 2016, Pagina/e 671-674, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.28653

Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge

Autori: Isabelle Desombere, Samira Fafi-Kremer, Freya Van Houtte, Patrick Pessaux, Ali Farhoudi, Laura Heydmann, Lieven Verhoye, Sarah Cole, Jane A. McKeating, Geert Leroux-Roels, Thomas F. Baumert, Arvind H. Patel, Philip Meuleman
Pubblicato in: Hepatology, Numero 63/4, 2016, Pagina/e 1120-1134, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.28428

Tailored Algorithms for Hepatocellular Carcinoma Surveillance: Is One-Size-Fits-All Strategy Outdated?

Autori: Nicolas Goossens, C. Billie Bian, Yujin Hoshida
Pubblicato in: Current Hepatology Reports, Numero 16/1, 2017, Pagina/e 64-71, ISSN 2195-9595
Editore: Springer
DOI: 10.1007/s11901-017-0336-z

Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine

Autori: Naoto Fujiwara, Scott L. Friedman, Nicolas Goossens, Yujin Hoshida
Pubblicato in: Journal of Hepatology, Numero 68/3, 2018, Pagina/e 526-549, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2017.09.016

Combination of Gene Expression Signature and Model for End-Stage Liver Disease Score Predicts Survival of Patients With Severe Alcoholic Hepatitis

Autori: Eric Trépo, Nicolas Goossens, Naoto Fujiwara, Won-Min Song, Antonio Colaprico, Astrid Marot, Laurent Spahr, Pieter Demetter, Christine Sempoux, Gene Y. Im, Joan Saldarriaga, Thierry Gustot, Jacques Devière, Swan N. Thung, Charlotte Minsart, Thomas Sersté, Gianluca Bontempi, Karim Abdelrahman, Jean Henrion, Delphine Degré, Valerio Lucidi, Laura Rubbia-Brandt, Venugopalan D. Nair, Christophe Mor
Pubblicato in: Gastroenterology, Numero 154/4, 2018, Pagina/e 965-975, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.10.048

In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment

Autori: Hadassa Hirschfield, C Billie Bian, Takaaki Higashi, Shigeki Nakagawa, Tizita Z Zeleke, Venugopalan D Nair, Bryan C Fuchs, Yujin Hoshida
Pubblicato in: Experimental & Molecular Medicine, Numero 50/1, 2018, Pagina/e e419, ISSN 2092-6413
Editore: Seoul : Korean Society of Medical Biochemistry and Molecular Biology
DOI: 10.1038/emm.2017.164

The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer

Autori: Derek J. Erstad, Andrew M. Tager, Yujin Hoshida, Bryan C. Fuchs
Pubblicato in: Molecular & Cellular Oncology, Numero 4/3, 2017, Pagina/e e1311827, ISSN 2372-3556
Editore: Taylor & Francis
DOI: 10.1080/23723556.2017.1311827

Generic chemoprevention of hepatocellular carcinoma

Autori: Sai Krishna Athuluri-Divakar, Yujin Hoshida
Pubblicato in: Annals of the New York Academy of Sciences, 2018, ISSN 0077-8923
Editore: New York Academy of Sciences
DOI: 10.1111/nyas.13971

A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer

Autori: Takuma Tsuchida, Youngmin A. Lee, Naoto Fujiwara, Maria Ybanez, Brittany Allen, Sebastiao Martins, M. Isabel Fiel, Nicolas Goossens, Hsin-I. Chou, Yujin Hoshida, Scott L. Friedman
Pubblicato in: Journal of Hepatology, Numero 69/2, 2018, Pagina/e 385-395, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2018.03.011

The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses

Autori: Carla Eller, Laura Heydmann, Che C. Colpitts, Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Pubblicato in: Cellular and Molecular Life Sciences, Numero 75/21, 2018, Pagina/e 3895-3905, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-018-2892-y

HBV core variants, liver fibrosis and hepatocellular carcinoma

Autori: Gaetan Ligat, Catherine Schuster, Thomas F Baumert
Pubblicato in: Hepatology, 2018, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.30231

Status of Direct-acting Antiviral Therapy for HCV Infection and Remaining Challenges

Autori: Thomas F. Baumert, Thomas Berg, Joseph K. Lim, David R. Nelson
Pubblicato in: Gastroenterology, 2018, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.10.024

Oncogenic Signaling Induced by HCV Infection

Autori: Alessia Virzì, Armando Roca Suarez, Thomas Baumert, Joachim Lupberger
Pubblicato in: Viruses, Numero 10/10, 2018, Pagina/e 538, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v10100538

Molecular heterogeneity in hepatocellular carcinoma

Autori: Shijia Zhu, Yujin Hoshida
Pubblicato in: Hepatic Oncology, Numero 5/1, 2018, Pagina/e HEP10, ISSN 2045-0923
Editore: future medicine
DOI: 10.2217/hep-2018-0005

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

Autori: James S.V. Lally, Sarani Ghoshal, Danielle K. DePeralta, Omeed Moaven, Lan Wei, Ricard Masia, Derek J. Erstad, Naoto Fujiwara, Vivian Leong, Vanessa P. Houde, Alexander E. Anagnostopoulos, Alice Wang, Lindsay A. Broadfield, Rebecca J. Ford, Robert A. Foster, Jamie Bates, Hailing Sun, Ting Wang, Henry Liu, Adrian S. Ray, Asish K. Saha, Jeremy Greenwood, Sathesh Bhat, Geraldine Harriman, Wenyan Miao
Pubblicato in: Cell Metabolism, 2018, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2018.08.020

Tight junction proteins in gastrointestinal and liver disease

Autori: Mirjam B Zeisel, Punita Dhawan, Thomas F Baumert
Pubblicato in: Gut, 2018, Pagina/e gutjnl-2018-316906, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-316906

Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

Autori: Youngmin A. Lee, Luke A. Noon, Kemal M. Akat, Maria D. Ybanez, Ting-Fang Lee, Marie-Luise Berres, Naoto Fujiwara, Nicolas Goossens, Hsin-I Chou, Fatemeh P. Parvin-Nejad, Bilon Khambu, Elisabeth G. M. Kramer, Ronald Gordon, Cathie Pfleger, Doris Germain, Gareth R. John, Kirk N. Campbell, Zhenyu Yue, Xiao-Ming Yin, Ana Maria Cuervo, Mark J. Czaja, M. Isabel Fiel, Yujin Hoshida, Scott L. Friedman
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-07338-z

Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus–Infected Cells and Liver to Identify Pathways Associated With Disease Development

Autori: Joachim Lupberger, Tom Croonenborghs, Armando Andres Roca Suarez, Nicolaas Van Renne, Frank Jühling, Marine A. Oudot, Alessia Virzì, Simonetta Bandiera, Carole Jamey, Gergö Meszaros, Daniel Brumaru, Atish Mukherji, Sarah C. Durand, Laura Heydmann, Eloi R. Verrier, Hussein El Saghire, Nourdine Hamdane, Ralf Bartenschlager, Shaunt Fereshetian, Evelyn Ramberger, Rileen Sinha, Mohsen Nabian, Celine
Pubblicato in: Gastroenterology, Numero 157/2, 2019, Pagina/e 537-551.e9, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.04.003

A human liver cell atlas reveals heterogeneity and epithelial progenitors

Autori: Nadim Aizarani, Antonio Saviano, Sagar, Laurent Mailly, Sarah Durand, Josip S. Herman, Patrick Pessaux, Thomas F. Baumert, Dominic Grün
Pubblicato in: Nature, 2019, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1373-2

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

Autori: Nourdine Hamdane, Frank Jühling, Emilie Crouchet, Houssein El Saghire, Christine Thumann, Marine A. Oudot, Simonetta Bandiera, Antonio Saviano, Clara Ponsolles, Armando Andres Roca Suarez, Shen Li, Naoto Fujiwara, Atsushi Ono, Irwin Davidson, Nabeel Bardeesy, Christian Schmidl, Christoph Bock, Catherine Schuster, Joachim Lupberger, François Habersetzer, Michel Doffoël, Tullio Piardi, Daniele So
Pubblicato in: Gastroenterology, Numero 156/8, 2019, Pagina/e 2313-2329.e7, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.02.038

Functional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity

Autori: Katharina Herzog, Simonetta Bandiera, Sophie Pernot, Catherine Fauvelle, Frank Jühling, Amélie Weiss, Anne Bull, Sarah C Durand, Béatrice Chane-Woon-Ming, Sébastien Pfeffer, Marion Mercey, Hervé Lerat, Jean-Christophe Meunier, Wolfgang Raffelsberger, Laurent Brino, Thomas F Baumert, Mirjam B Zeisel
Pubblicato in: Gut, 2019, Pagina/e gutjnl-2018-317423, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317423

Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets

Autori: Eloi R Verrier, Amélie Weiss, Charlotte Bach, Laura Heydmann, Vincent Turon-Lagot, Arnaud Kopp, Houssein El Saghire, Emilie Crouchet, Patrick Pessaux, Thomas Garcia, Patrick Pale, Mirjam B Zeisel, Camille Sureau, Catherine Schuster, Laurent Brino, Thomas F Baumert
Pubblicato in: Gut, 2019, Pagina/e gutjnl-2018-317065, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317065

IFITM s mediate viral evasion in acute and chronic hepatitis C virus infection

Autori: Florian Wrensch, Gaëtan Ligat, Laura Heydmann, Catherine Schuster, Mirjam B. Zeisel, Patrick Pessaux, François Habersetzer, Barnabas J. King, Alexander W. Tarr, Jonathan K. Ball, Michael Winkler, Stefan Pöhlmann, Zhen‐yong Keck, Steven K.H. Foung, Thomas F. Baumert
Pubblicato in: Hepatology, 2019, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.30699

Oxidative Stress Triggers Selective tRNA Retrograde Transport in Human Cells during the Integrated Stress Response

Autori: Hagen Schwenzer, Frank Jühling, Alexander Chu, Laura J. Pallett, Thomas F. Baumert, Mala Maini, Ariberto Fassati
Pubblicato in: Cell Reports, Numero 26/12, 2019, Pagina/e 3416-3428.e5, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.02.077

In vivo combination of human anti-envelope glycoprotein E2 and -Claudin-1 monoclonal antibodies for prevention of hepatitis C virus infection

Autori: Laurent Mailly, Florian Wrensch, Laura Heydmann, Catherine Fauvelle, Nicolas Brignon, Mirjam B. Zeisel, Patrick Pessaux, Zhen-yong Keck, Catherine Schuster, Thomas R. Fuerst, Steven K.H. Foung, Thomas F. Baumert
Pubblicato in: Antiviral Research, Numero 162, 2019, Pagina/e 136-141, ISSN 0166-3542
Editore: Elsevier BV
DOI: 10.1016/j.antiviral.2018.12.018

An E. coli-produced single-chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion

Autori: Cheng Li, Yang Wang, Tiantian Liu, Matthias Niklasch, Ke Qiao, Sarah Durand, Li Chen, Mifang Liang, Thomas F. Baumert, Shuping Tong, Michael Nassal, Yu-Mei Wen, Yong-Xiang Wang
Pubblicato in: Antiviral Research, Numero 162, 2019, Pagina/e 118-129, ISSN 0166-3542
Editore: Elsevier BV
DOI: 10.1016/j.antiviral.2018.12.019

Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma: preliminary results

Autori: Bachir Taouli, Yujin Hoshida, Suguru Kakite, Xintong Chen, Poh Seng Tan, Xiaochen Sun, Shingo Kihira, Kensuke Kojima, Sara Toffanin, M. Isabel Fiel, Hadassa Hirschfield, Mathilde Wagner, Josep M. Llovet
Pubblicato in: European Radiology, Numero 27/11, 2017, Pagina/e 4472-4481, ISSN 0938-7994
Editore: Springer Verlag
DOI: 10.1007/s00330-017-4844-6

Ultrasound‐Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma

Autori: Ghina Bou About, Emilie Thiebault, Marie Wattenhofer‐Donzé, Hugues Jacobs, Alain Guimond, Tania Sorg, Eric Robinet, Thomas F. Baumert, Laurent Monassier, Yann Herault
Pubblicato in: Current Protocols in Mouse Biology, Numero 9/2, 2019, ISSN 2161-2617
Editore: Wiley
DOI: 10.1002/cpmo.62

Learning from a clinical cohort for HCV vaccine development

Autori: Florian Wrensch, Zhen-yong Keck, Steven K.H. Foung, Thomas F. Baumert
Pubblicato in: Journal of Hepatology, Numero 71/1, 2019, Pagina/e 9-11, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2019.03.030

The circadian clock and liver function in health and disease

Autori: Atish Mukherji, Shannon M. Bailey, Bart Staels, Thomas F. Baumert
Pubblicato in: Journal of Hepatology, Numero 71/1, 2019, Pagina/e 200-211, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2019.03.020

Editorial: Current Progress and Challenges in the Development of a B Cell Based Hepatitis C Virus Vaccine

Autori: Steven K. H. Foung, Thomas F. Baumert
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2018.02577

Hepatocellular Carcinoma Risk Stratification by Genetic Profiling in Patients with Cirrhosis

Autori: Naoto Fujiwara, Yujin Hoshida
Pubblicato in: Seminars in Liver Disease, Numero 39/02, 2019, Pagina/e 153-162, ISSN 0272-8087
Editore: Thieme Medical Publishers
DOI: 10.1055/s-0039-1681031

Addressing the Challenges of Hepatitis C Cure and Persistent Risk of Hepatocellular Carcinoma

Autori: Thomas F. Baumert, Yujin Hoshida
Pubblicato in: Viruses, Numero 11/5, 2019, Pagina/e 441, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11050441

Mortality from liver cirrhosis and HCC in the DAA era: success in viral control is darkened by raise of metabolic disease

Autori: Antonio Saviano, Thomas F. Baumert
Pubblicato in: HepatoBiliary Surgery and Nutrition, Numero 8/3, 2019, Pagina/e 307-310, ISSN 2304-3881
Editore: AME Publishing Company
DOI: 10.21037/hbsn.2019.01.21

Use of big data in drug development for precision medicine: an update

Autori: Tongqi Qian, Shijia Zhu, Yujin Hoshida
Pubblicato in: Expert Review of Precision Medicine and Drug Development, Numero 4/3, 2019, Pagina/e 189-200, ISSN 2380-8993
Editore: Taylor & Francis
DOI: 10.1080/23808993.2019.1617632

Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis

Autori: Simonetta Bandiera, Sophie Pernot, Hussein El Saghire, Sarah C. Durand, Christine Thumann, Emilie Crouchet, Tao Ye, Isabel Fofana, Marine A. Oudot, Jochen Barths, Catherine Schuster, Patrick Pessaux, Markus H. Heim, Thomas F. Baumert, Mirjam B. Zeisel
Pubblicato in: Journal of Virology, Numero 90/14, 2016, Pagina/e 6387-6400, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/JVI.00619-16

Extracellular lipid-free apolipoprotein E inhibits HCV replication and induces ABCG1-dependent cholesterol efflux

Autori: Emilie Crouchet, Mathieu Lefèvre, Eloi R Verrier, Marine A Oudot, Thomas F Baumert, Catherine Schuster
Pubblicato in: Gut, Numero 66/5, 2017, Pagina/e 896-907, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2015-311289

Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice

Autori: Tao Wu, Emilie Heuillard, Véronique Lindner, Ghina Bou About, Mihaela Ignat, Jean-Philippe Dillenseger, Nicolas Anton, Eugénie Dalimier, Francine Gossé, Gael Fouré, Franck Blindauer, Céline Giraudeau, Hussein El-Saghire, Mourad Bouhadjar, Cynthia Calligaro, Tania Sorg, Philippe Choquet, Thierry Vandamme, Christophe Ferrand, Jacques Marescaux, Thomas F. Baumert, Michele Diana, Patrick Pessaux,
Pubblicato in: Scientific Reports, Numero 6/1, 2016, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep35230

Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition

Autori: Shigeki Nakagawa, Lan Wei, Won Min Song, Takaaki Higashi, Sarani Ghoshal, Rosa S. Kim, C. Billie Bian, Suguru Yamada, Xiaochen Sun, Anu Venkatesh, Nicolas Goossens, Gretchen Bain, Gregory Y. Lauwers, Anna P. Koh, Mohamed El-Abtah, Noor B. Ahmad, Hiroki Hoshida, Derek J. Erstad, Ganesh Gunasekaran, Youngmin Lee, Ming-Lung Yu, Wan-Long Chuang, Chia-Yen Dai, Masahiro Kobayashi, Hiromitsu Kumada, Toru
Pubblicato in: Cancer Cell, Numero 30/6, 2016, Pagina/e 879-890, ISSN 1535-6108
Editore: Cell Press
DOI: 10.1016/j.ccell.2016.11.004

Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape

Autori: Che C Colpitts, Rajiv G Tawar, Laurent Mailly, Christine Thumann, Laura Heydmann, Sarah C Durand, Fei Xiao, Eric Robinet, Patrick Pessaux, Mirjam B Zeisel, Thomas F Baumert
Pubblicato in: Gut, 2017, Pagina/e gutjnl-2016-312577, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-312577

Plasmodium P36 determines host cell receptor usage during sporozoite invasion

Autori: Giulia Manzoni, Carine Marinach, Selma Topçu, Sylvie Briquet, Morgane Grand, Matthieu Tolle, Marion Gransagne, Julien Lescar, Chiara Andolina, Jean-François Franetich, Mirjam B Zeisel, Thierry Huby, Eric Rubinstein, Georges Snounou, Dominique Mazier, François Nosten, Thomas F Baumert, Olivier Silvie
Pubblicato in: eLife, Numero 6, 2017, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.25903

Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy

Autori: Tanvi Khera, Daniel Todt, Koen Vercauteren, C. Patrick McClure, Lieven Verhoye, Ali Farhoudi, Sabin Bhuju, Robert Geffers, Thomas F. Baumert, Eike Steinmann, Philip Meuleman, Thomas Pietschmann, Richard J.P. Brown
Pubblicato in: Antiviral Research, Numero 139, 2017, Pagina/e 129-137, ISSN 0166-3542
Editore: Elsevier BV
DOI: 10.1016/j.antiviral.2017.01.001

Cost-Effectiveness of Risk Score–Stratified Hepatocellular Carcinoma Screening in Patients with Cirrhosis

Autori: Nicolas Goossens, Amit G Singal, Lindsay Y King, Karin L Andersson, Bryan C Fuchs, Cecilia Besa, Bachir Taouli, Raymond T Chung, Yujin Hoshida
Pubblicato in: Clinical and Translational Gastroenterology, Numero 8/6, 2017, Pagina/e e101, ISSN 2155-384X
Editore: Nature Publishing Group
DOI: 10.1038/ctg.2017.26

Hepatic stellate cells as key target in liver fibrosis

Autori: Takaaki Higashi, Scott L. Friedman, Yujin Hoshida
Pubblicato in: Advanced Drug Delivery Reviews, 2017, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2017.05.007

Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging

Autori: Stefanie J. Hectors, Mathilde Wagner, Octavia Bane, Cecilia Besa, Sara Lewis, Romain Remark, Nelson Chen, M. Isabel Fiel, Hongfa Zhu, Sacha Gnjatic, Miriam Merad, Yujin Hoshida, Bachir Taouli
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-02706-z

Persisting risk of hepatocellular carcinoma after HCV cure monitored by a liver transcriptome signature

Autori: Atsushi Ono, Nicolas Goossens, Richard S Finn, Warren N Schmidt, Swan N Thung, Gene Y Im, Yujin Hoshida
Pubblicato in: Hepatology, 2017, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.29203

Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases

Autori: Benjamin Wooden, Nicolas Goossens, Yujin Hoshida, Scott L. Friedman
Pubblicato in: Gastroenterology, Numero 152/1, 2017, Pagina/e 53-67.e3, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2016.09.065

Novel substituted aminothiazoles as potent and selective anti-hepatocellular carcinoma agents

Autori: Huagang Lu, John Rogowskyj, Wenquan Yu, Anu Venkatesh, Noshena Khan, Shigeki Nakagawa, Nicolas Goossens, Anna P. Koh, Takaaki Higashi, Ganesh Gunasekaran, Myron E. Schwarz, Spiros P. Hiotis, Xiaodong Xu, William Kinney, Yujin Hoshida, Timothy Block, Andrea Cuconati, Yanming Du
Pubblicato in: Bioorganic & Medicinal Chemistry Letters, Numero 26/23, 2016, Pagina/e 5819-5824, ISSN 0960-894X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2016.10.015

Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells

Autori: Daniel F. Hicks, Nicolas Goossens, Ana Blas-García, Takuma Tsuchida, Benjamin Wooden, Michael C. Wallace, Natalia Nieto, Abigale Lade, Benjamin Redhead, Arthur I Cederbaum, Joel T. Dudley, Bryan C. Fuchs, Youngmin A. Lee, Yujin Hoshida, Scott L. Friedman
Pubblicato in: Scientific Reports, Numero 7, 2017, Pagina/e 42563, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep42563

New perspectives for preventing hepatitis C virus liver graft infection

Autori: Daniel J Felmlee, Audrey Coilly, Raymond T Chung, Didier Samuel, Thomas F Baumert
Pubblicato in: The Lancet Infectious Diseases, Numero 16/6, 2016, Pagina/e 735-745, ISSN 1473-3099
Editore: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(16)00120-1

Hepatitis B virus receptors and molecular drug targets

Autori: Eloi R. Verrier, Che C. Colpitts, Camille Sureau, Thomas F. Baumert
Pubblicato in: Hepatology International, Numero 10/4, 2016, Pagina/e 567-573, ISSN 1936-0533
Editore: Springer Pub. Co.
DOI: 10.1007/s12072-016-9718-5

Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma

Autori: Simonetta Bandiera, C Billie Bian, Yujin Hoshida, Thomas F Baumert, Mirjam B Zeisel
Pubblicato in: Current Opinion in Virology, Numero 20, 2016, Pagina/e 99-105, ISSN 1879-6257
Editore: Elsevier BV
DOI: 10.1016/j.coviro.2016.09.010

Autori: Thomas F. Baumert, Frank Jühling, Atsushi Ono, Yujin Hoshida
Pubblicato in: BMC Medicine, Numero 15/1, 2017, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/s12916-017-0815-7

Toward novel immunocompetent animal models for hepatitis B virus infection

Autori: Laurent Mailly, Mirjam B. Zeisel, Thomas F. Baumert
Pubblicato in: Hepatology, 2017, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.29249

Characterisation of endogenous Claudin‐1 expression, motility and susceptibility to hepatitis C virus in CRISPR knock‐in cells

Autori: Camille M.H. Clément, Maika S. Deffieu, Cristina M. Dorobantu, Thomas F. Baumert, Nilda Vanesa Ayala‐Nunez, Yves Mély, Philippe Ronde, Raphael Gaudin
Pubblicato in: Biology of the Cell, Numero 112/5, 2020, Pagina/e 140-151, ISSN 0248-4900
Editore: Portland Press, Ltd.
DOI: 10.1111/boc.201900085

Addressing the next challenges: A summary of the 22nd international symposium on hepatitis C virus and related viruses

Autori: Thomas F. Baumert, Catherine Schuster, François-Loïc Cosset, Jean Dubuisson, Maike Hofmann, Norbert Tautz, Mirjam B. Zeisel, Robert Thimme
Pubblicato in: Journal of Hepatology, Numero 64/4, 2016, Pagina/e 968-973, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2015.12.021

Hepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals

Autori: Che C. Colpitts, Thomas F. Baumert
Pubblicato in: Hepatology International, Numero 10/5, 2016, Pagina/e 741-748, ISSN 1936-0533
Editore: Springer Pub. Co.
DOI: 10.1007/s12072-016-9724-7

A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

Autori: Carla Eller, Laura Heydmann, Che C. Colpitts, Houssein El Saghire, Federica Piccioni, Frank Jühling, Karim Majzoub, Caroline Pons, Charlotte Bach, Julie Lucifora, Joachim Lupberger, Michael Nassal, Glenn S. Cowley, Naoto Fujiwara, Sen-Yung Hsieh, Yujin Hoshida, Emanuele Felli, Patrick Pessaux, Camille Sureau, Catherine Schuster, David E. Root, Eloi R. Verrier, Thomas F. Baumert
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-16517-w

Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma

Autori: Frank Jühling, Nourdine Hamdane, Emilie Crouchet, Shen Li, Houssein El Saghire, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Christine Thumann, Antonio Saviano, Armando Andres Roca Suarez, Kaku Goto, Ricard Masia, Mozhdeh Sojoodi, Gunisha Arora, Hiroshi Aikata, Atsushi Ono, Parissa Tabrizian, Myron Schwartz, Stephen J Polyak, Irwin Davidson, Christian Schmidl, Christoph Bock, Catherine Schuste
Pubblicato in: Gut, 2020, Pagina/e gutjnl-2019-318918, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-318918

Hepatitis C Virus and Hepatocellular Carcinoma: When the Host Loses Its Grip

Autori: Kaku Goto, Armando Andres Roca Suarez, Florian Wrensch, Thomas F. Baumert, Joachim Lupberger
Pubblicato in: International Journal of Molecular Sciences, Numero 21/9, 2020, Pagina/e 3057, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093057

Signalome-wide assessment of host cell response to hepatitis C virus

Autori: Gholamreza Haqshenas, Jianmin Wu, Kaylene J. Simpson, Roger J. Daly, Hans J. Netter, Thomas F. Baumert, Christian Doerig
Pubblicato in: Nature Communications, Numero 8/1, 2017, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms15158

Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design

Autori: Zhen-Yong Keck, Brian G. Pierce, Patrick Lau, Janine Lu, Yong Wang, Alexander Underwood, Rowena A. Bull, Jannick Prentoe, Rodrigo Velázquez-Moctezuma, Melanie R. Walker, Fabio Luciani, Johnathan D. Guest, Catherine Fauvelle, Thomas F. Baumert, Jens Bukh, Andrew R. Lloyd, Steven K. H. Foung
Pubblicato in: PLOS Pathogens, Numero 15/5, 2019, Pagina/e e1007772, ISSN 1553-7374
Editore: PLOS
DOI: 10.1371/journal.ppat.1007772

Hepatitis C virus infection and tight junction proteins: The ties that bind

Autori: Laurent Mailly, Thomas F. Baumert
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Numero 1862/7, 2020, Pagina/e 183296, ISSN 0005-2736
Editore: Elsevier BV
DOI: 10.1016/j.bbamem.2020.183296

The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans

Autori: Karim Majzoub, Florian Wrensch, Thomas F. Baumert
Pubblicato in: Viruses, Numero 11/8, 2019, Pagina/e 758, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11080758

Uncovering the mechanism of action of aspirin in HCC chemoprevention

Autori: Natascha Roehlen, Thomas F. Baumert
Pubblicato in: EBioMedicine, Numero 46, 2019, Pagina/e 21-22, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2019.07.047

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

Autori: Natascha Roehlen, Emilie Crouchet, Thomas F. Baumert
Pubblicato in: Cells, Numero 9/4, 2020, Pagina/e 875, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells9040875

Tight Junction Proteins and the Biology of Hepatobiliary Disease

Autori: Natascha Roehlen, Armando Andres Roca Suarez, Houssein El Saghire, Antonio Saviano, Catherine Schuster, Joachim Lupberger, Thomas F. Baumert
Pubblicato in: International Journal of Molecular Sciences, Numero 21/3, 2020, Pagina/e 825, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21030825

Single-cell genomics and spatial transcriptomics: discovery of novel cell states and cellular interactions in liver physiology and disease biology

Autori: Antonio Saviano, Neil C. Henderson, Thomas F. Baumert
Pubblicato in: Journal of Hepatology, 2020, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2020.06.004

Follicular T helper cells shape the HCV-specific CD4+ T cell repertoire after virus elimination

Autori: Maike Smits, Katharina Zoldan, Naveed Ishaque, Zuguang Gu, Katharina Jechow, Dominik Wieland, Christian Conrad, Roland Eils, Catherine Fauvelle, Thomas F. Baumert, Florian Emmerich, Bertram Bengsch, Christoph Neumann-Haefelin, Maike Hofmann, Robert Thimme, Tobias Boettler
Pubblicato in: Journal of Clinical Investigation, Numero 130/2, 2019, Pagina/e 998-1009, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci129642

Hepatitis B Virus–Hepatocyte Interactions and Innate Immune Responses: Experimental Models and Molecular Mechanisms

Autori: Emmanuel Thomas, Thomas F. Baumert
Pubblicato in: Seminars in Liver Disease, Numero 39/03, 2019, Pagina/e 301-314, ISSN 0272-8087
Editore: Thieme Medical Publishers
DOI: 10.1055/s-0039-1685518

Radiomics in hepatocellular carcinoma: a quantitative review

Autori: Taiga Wakabayashi, Farid Ouhmich, Cristians Gonzalez-Cabrera, Emanuele Felli, Antonio Saviano, Vincent Agnus, Peter Savadjiev, Thomas F. Baumert, Patrick Pessaux, Jacques Marescaux, Benoit Gallix
Pubblicato in: Hepatology International, Numero 13/5, 2019, Pagina/e 546-559, ISSN 1936-0533
Editore: Springer Pub. Co.
DOI: 10.1007/s12072-019-09973-0

Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis

Autori: Alessia Virzì, Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Pubblicato in: Cold Spring Harbor Perspectives in Medicine, Numero 10/1, 2020, Pagina/e a037366, ISSN 2157-1422
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a037366

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

Autori: Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai, Abhinav Kumar, Srinivasa Bhargav Rambhatla, Claire L. Donald, Andrea F. Lopez-Clavijo, Simon Rudge, Katherine Pinnick, Wai Hoong Chang, Peter A. C. Wing, Ryan Brown, Ximing Qin, Peter Simmonds, Thomas F. Baumert, David Ray, Andrew Loudon, Peter Balfe, Michael Wakelam, Sam Butterworth, Alain Kohl, Catherine L. Jopling, Nicole Zitzmann, Ja
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-08299-7

MPIC: Molecular Prognostic Indicators in Cirrhosis Database for Clinical Context-Specific in Silico Prognostic Biomarker Validation

Autori: Shun H. Yip, Naoto Fujiwara, Jason Burke, Anand Shetler, Celina Peralta, Tongqi Qian, Hiroki Hoshida, Shijia Zhu, Yujin Hoshida
Pubblicato in: Frontiers in Genetics, Numero 10, 2019, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2019.00830

Gene signature-MELD score and alcohol relapse determine long-term prognosis of patients with severe alcoholic hepatitis

Autori: Pierre Deltenre 1 2, Eric Trépo 1 3, Naoto Fujiwara, Nicolas Goossens 4 5, Astrid Marot 6, Margaux Dubois 7, Laurent Spahr 5, Jean Henrion 8, Christophe Moreno 1 3, Yujin Hoshida
Pubblicato in: Liver Int, 2020, ISSN 1478-3231
Editore: John Wiley & Sons, Inc.
DOI: 10.1111/liv.14265

FIB-4 score and hepatocellular carcinoma risk after hepatitis C virus cure: time to revise surveillance?

Autori: Antonio Saviano, Simona Tripon, Thomas F Baumert
Pubblicato in: Hepatobiliary Surgery and Nutrition, 2020, Pagina/e 661-664, ISSN 2304-3881
Editore: AME Publishing Company
DOI: 10.21037/hbsn.2020.01.05

Steatohepatitic Variant of Hepatocellular Carcinoma Is Associated With Both Alcoholic Steatohepatitis and Nonalcoholic Steatohepatitis: A Study of 2 Cohorts With Molecular Insights.

Autori: Jia Qin, MD, PhD,1 Takaaki Higashi, MD, PhD,2 Shigeki Nakagawa, MD, PhD,2 Yo-ichi Yamashita, MD, PhD,2 Toru Beppu, MD, PhD,2 Hideo Baba, MD, PhD,2 Masahiro Kobayashi, MD,3 Hiromitsu Kumada, MD,3 Ganesh Gunasekaran, MD,4 Thomas D. Schiano, MD,5 Swan N. Thung, MD,6 M. Isabel Fiel, MD, Yujin Hoshida, and Stephen C. Ward, MD, PhD6
Pubblicato in: Am J Surg Pathol, 2021, ISSN 0147-5185
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/pas.0000000000001533

Composite vector formulation for multiple siRNA delivery as a host targeting antiviral in a cell culture model of hepatitis C virus (HCV) infection

Autori: E Crouchet, R Saad, C Affolter-Zbaraszczuk, J Ogier, T F Baumert, C Schuster, F Meyer
Pubblicato in: Journal of Materials Chemistry B, 2016, Pagina/e 858-865, ISSN 2050-7518
Editore: Royal Society of Chemistry
DOI: 10.1039/c6tb01718e

International Liver Cancer Association (ILCA) White Paper on Biomarker Development for Hepatocellular Carcinoma

Autori: Amit G. Singal,Yujin Hoshida,1 David J. Pinato,2 Jorge Marrero,1 Jean-Charles Nault,3,4,5 Valerie Paradis,6 Nabihah Tayob,7 Morris Sherman,8 Young Suk Lim,9 Ziding Feng,10 Anna S. Lok,11 Jo Ann Rinaudo,12 Sudhir Srivastava,12 Josep Llovet,13,14,15 and Augusto Villanueva13
Pubblicato in: Gastroenterology, 2021, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2021.01.233

Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis

Autori: Satoshi Kawamura 1, Yuki Matsushita 1, Shigeyuki Kurosaki 1, Mizuki Tange 1, Naoto Fujiwara 1 2, Yuki Hayata 1, Yoku Hayakawa 1, Nobumi Suzuki 1, Masahiro Hata 1, Mayo Tsuboi 1, Takahiro Kishikawa 1, Hiroto Kinoshita 3, Takuma Nakatsuka 1, Masaya Sato 1, Yotaro Kudo 1, Yujin Hoshida, Atsushi Umemura 4, Akiko Eguchi 5, Tsuneo Ikenoue 6, Yoshihiro Hirata 7, Motonari Uesugi 8, Ryosuke Tateishi 1, Kei
Pubblicato in: J Clin Invest., 2022, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci151895

Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin

Autori: Rajiv G. Tawar, Laura Heydmann, Charlotte Bach, Jörg Schüttrumpf, Shailesh Chavan, Barnabas J. King, C. Patrick McClure, Jonathan K. Ball, Patrick Pessaux, François Habersetzer, Ralf Bartenschlager, Mirjam B. Zeisel, Thomas F. Baumert
Pubblicato in: Hepatology, 2016, Pagina/e 1495-1506, ISSN 1527-3350
Editore: Wiley
DOI: 10.1002/hep.28767

Cell type-specific pharmacological kinase inhibition for cancer chemoprevention.

Autori: Manjeet Deshmukh; Shigeki Nakagawa; Shigeki Nakagawa; Takaaki Higashi; Takaaki Higashi; Adam Vincek; Anu Venkatesh; Marina Ruiz de Galarreta; Anna P. Koh; Nicolas Goossens; Nicolas Goossens; Hadassa Hirschfield; C Billie Bian; Naoto Fujiwara; Naoto Fujiwara; Atsushi Ono; Atsushi Ono; Hiroki Hoshida; Mohamed El-Abtah; Noor B. Ahmad; Amaia Lujambio; Roberto Sanchez; Bryan C. Fuchs; Klaas Poelstra; J
Pubblicato in: Nanomedicine, Numero 1, 2018, Pagina/e 317-325, ISSN 1748-6963
Editore: Elsevier Inc
DOI: 10.1016/j.nano.2017.11.004

Dose and Duration of Aspirin Use to Reduce Incident Hepatocellular Carcinoma

Autori: Naoto Fujiwara; Naoto Fujiwara; Amit G. Singal; Yujin Hoshida
Pubblicato in: Hepatology, Numero 1, 2019, ISSN 1527-3350
Editore: John Wiley & Sons, Inc
DOI: 10.1002/hep.30813

Un criblage gain-de-fonction identifie CDKN2C comme facteur d'hôte impliqué dans le cycle viral du virus de l'hépatite B

Autori: Eller, Carla
Pubblicato in: https://tel.archives-ouvertes.fr/tel-02924142, Numero 1, 2019
Editore: University of Strasbourg

Diritti di proprietà intellettuale

ANTI-CLAUDIN 1 MONOCLONAL ANTIBODIES FOR THE PREVENTION AND TREATMENT OF HEPATOCELLULAR CARCINOMA

Numero candidatura/pubblicazione: 20 16055942
Data: 2016-03-18
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Data: 2016-03-18
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Data: 2016-04-28
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Data: 2021-03-02
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Data: 2016-03-22
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Data: 2021-08-11
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Numero candidatura/pubblicazione: EP 16719852
Data: 2016-04-28
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Data: 2016-04-28
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Numero candidatura/pubblicazione: 20 17056703
Data: 2016-03-22
Candidato/i: UNIVERSITE DE STRASBOURG

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Numero candidatura/pubblicazione: 20 21055203
Data: 2021-03-02
Candidato/i: UNIVERSITE DE STRASBOURG

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