Cell circuits as targets and biomarkers for liver disease and cancer prevention

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Omics‐derived hepatocellular carcinoma risk biomarkers for precision care of chronic liver diseases

Autores: Naoto Fujiwara; Naoto Fujiwara; Tongqi Qian; Bhuvaneswari Koneru; Yujin Hoshida
Publicado en: Hepatol Res, Edición 1, 2020, Página(s) 817-830, ISSN 1872-034X
Editor: The Japan Society of Hepatology
DOI: 10.1111/hepr.13506

Viral Exposure Signature Associated with Liver Cancer Risk.

Autores: Naoto Fujiwara; Naoto Fujiwara; Yujin Hoshida
Publicado en: Trends Mol Med, Edición 1, 2020, ISSN 1471-4914
Editor: Elsevier BV
DOI: 10.1016/j.molmed.2020.06.008

Unraveling the role of liver sinusoidal endothelial cells in COVID-19 liver injury

Autores: Antonio Saviano, Thomas F Baumert
Publicado en: J Hepatol, 2021, Página(s) 503–505, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2021.07.008

Perturbation of the circadian clock and pathogenesis of NAFLD

Autores: Atish Mukherji, Mayssa Dachraoui, Thomas F Baumert
Publicado en: Metabolism, 2020, ISSN 0026-0495
Editor: Elsevier BV
DOI: 10.1016/j.metabol.2020.154337

Liver cell circuits and therapeutic discovery for advanced liver disease and cancer

Autores: Emilie Crouchet, Catherine Schuster, Thomas F Baumert
Publicado en: Comptes Rendus Biologie, 2021, Página(s) 233-248, ISSN 1631-0691
Editor: Elsevier Masson
DOI: 10.5802/crbiol.64

A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis

Autores: Naoto Fujiwara, Masahiro Kobayashi,3 Austin J Fobar,4 Ayaka Hoshida,1 Cesia A Marquez,1 Bhuvaneswari Koneru,1 Gayatri Panda,1 Masataka Taguri,5 Tongqi Qian,1 Indu Raman,6 Quan-Zhen Li,6 Hiroki Hoshida,1 Hitomi Sezaki,3 Hiromitsu Kumada,3 Ryosuke Tateishi,2 Takeshi Yokoo,7 Adam C Yopp,8 Raymond T Chung,9 Bryan C Fuchs,10,11 Thomas F Baumert,12 Jorge A Marrero,1 Neehar D Parikh, Shijia Zhu, Amit G S
Publicado en: Med (N Y)., 2021, ISSN 2666-6340
Editor: John Wiley
DOI: 10.1016/j.medj.2021.03.017

Transcriptome-Guided Design of Physiological Multilineage Liver Organoids

Autores: Shijia Zhu, Naoto Kubota, Yujin Hoshida
Publicado en: Trends Genet, 2021, ISSN 0168-9525
Editor: Elsevier BV
DOI: 10.1016/j.tig.2021.01.007

The Nobel Prize in Medicine 2020 for the Discovery of Hepatitis C Virus: Transforming Hepatology.

Autores: Thomas F. Baumert
Publicado en: ISSN: 1600-0641, Edición 25, 2020, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2020.10.017

Hepatitis B virus compartmentalization and single-cell differentiation in hepatocellular carcinoma.

Autores: Frank Jühling; Antonio Saviano; Clara Ponsolles; Laura Heydmann; Emilie Crouchet; Sarah C. Durand; Houssein El Saghire; Emanuele Felli; Véronique Lindner; Patrick Pessaux; Nathalie Pochet; Nathalie Pochet; Catherine Schuster; Eloi R. Verrier; Thomas F. Baumert; Thomas F. Baumert
Publicado en: Life Science Alliance, Edición 1, 2021, ISSN 2575-1077
Editor: Life Science Alliance LCC
DOI: 10.26508/lsa.202101036

Liver Abnormalities after Elimination of HCV Infection: Persistent Epigenetic and Immunological Perturbations Post-Cure

Autores: Stephen J Polyak, I Nicholas Crispe, Thomas F Baumert
Publicado en: Pathogens, 2021, ISSN 2076-0817
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10010044

Role of Hepatocyte-DerivedOsteopontinin Liver Carcinogenesis

Autores: "Romain Desert # 1, Xiaodong Ge # 1 2, Zhuolun Song 1, Hui Han 1, Daniel Lantvit 1, Wei Chen 1, Sukanta Das 1, Dipti Athavale 1, Ioana Abraham-Enachescu 2, Chuck Blajszczak 1, Yu Chen 1, Orlando Musso 3, Grace Guzman 1, Yujin Hoshida, Natalia Nieto 1 2 5"
Publicado en: Hepatol Commun, 2022, ISSN 2471-254X
Editor: John Wiley & Sons, Inc.
DOI: 10.1002/hep4.1845

Atorvastatin favorably modulates a clinical hepatocellular carcinoma risk gene signature

Autores: Myung-Ho Kim 1, Mi-Young Kim 1 2 3, Shadi Salloum 1, Tongqi Qian 4, Lai Ping Wong 5 6, Min Xu 1, Yoojin Lee 1, Stuti G Shroff 7, Ruslan I Sadreyev 5 7, Kathleen E Corey 1, Thomas F Baumert 8 9, Yujin Hoshida, Raymond T Chung 1
Publicado en: Hepatol Commun, 2022, ISSN 2471-254X
Editor: John Wiley & Sons, Inc.
DOI: 10.1002/hep4.1991

Conventional and artificial intelligence-based imaging for biomarker discovery in chronic liver disease

Autores: Jérémy Dana,1,2,3,4 Aïna Venkatasamy, Antonio Saviano, Joachim Lupberger, Yujin Hoshida, Valérie Vilgrain,9 Pierre Nahon,10,11,12 Caroline Reinhold,4,13,14 Benoit Gallix,2,3,4 and Thomas F. Baumert1,3,7
Publicado en: Hepatol Int, 2022, ISSN 1936-0533
Editor: Springer Pub. Co.
DOI: 10.1007/s12072-022-10303-0

Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import

Autores: Rodriguez-Bravo, Veronica; Pippa, Raffaella; Song, Won-Min; Carceles-Cordon, Marc; Dominguez-Andres, Ana; Fujiwara, Naoto; Woo, Jungreem; Koh, Anna P.; Ertel, Adam; Lokareddy, Ravi K.; Cuesta-Dominguez, Alvaro; Kim, Rosa S.; Rodriguez-Fernandez, Irene; Li, Peiyao; Gordon, Ronald; Hirschfield, Hadassa; Prats, Josep M.; Reddy, E. Premkumar; Fatatis, Alessandro; Petrylak, Daniel P.; Gomella, Leonard;
Publicado en: Cell, Edición 1, 2018, ISSN 1097-4172
Editor: Elsevier Inc
DOI: 10.1016/j.cell.2018.07.015

Liver Disease and Coronavirus Disease 2019: From Pathogenesis to Clinical Care.

Autores: Antonio Saviano; Florian Wrensch; Marc G. Ghany; Thomas F. Baumert; Thomas F. Baumert
Publicado en: Hepatology (Baltimore, Md.), Edición 20, 2021, Página(s) 088-1100, ISSN 1527-3350
Editor: John Wiley & Sons, Inc
DOI: 10.1002/hep.31684

Virus-Induced Risk of Hepatocellular Carcinoma: Recent Progress and Future Challenges

Autores: Joachim Lupberger, and Thomas F. Baumert
Publicado en: J Clin Med, 2021, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11010208

Plasma-Signature-Model for End-Stage Liver Disease Scoreto Predict Survival in Severe Alcoholic Hepatitis

Autores: Naoto Fujiwara, Eric Trépo, Indu Raman, Quan-Zhen Li, Delphine Degré, Thierry Gustot, Christophe Moreno, Yujin Hoshida
Publicado en: Clin Gastroenterol Hepatol, 2022, ISSN 1542-3565
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cgh.2021.02.041

Viral manipulation of STAT3: Evade, exploit, and injure

Autores: Armando Andres Roca Suarez, Nicolaas Van Renne, Thomas F. Baumert, Joachim Lupberger
Publicado en: PLOS Pathogens, Edición 14/3, 2018, Página(s) e1006839, ISSN 1553-7374
Editor: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, c2011.
DOI: 10.1371/journal.ppat.1006839

Hepatitis C Virus (HCV)–Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design

Autores: Florian Wrensch, Emilie Crouchet, Gaetan Ligat, Mirjam B. Zeisel, Zhen-Yong Keck, Steven K. H. Foung, Catherine Schuster, Thomas F. Baumert
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2018.01436

Mapping Determinants of Virus Neutralization and Viral Escape for Rational Design of a Hepatitis C Virus Vaccine

Autores: Mei-Le Keck, Florian Wrensch, Brian G. Pierce, Thomas F. Baumert, Steven K. H. Foung
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2018.01194

Hepatitis B virus evasion from cyclic guanosine monophosphate-adenosine monophosphate synthase sensing in human hepatocytes

Autores: Eloi R. Verrier, Seung-Ae Yim, Laura Heydmann, Houssein El Saghire, Charlotte Bach, Vincent Turon-Lagot, Laurent Mailly, Sarah C. Durand, Julie Lucifora, David Durantel, Patrick Pessaux, Nicolas Manel, Ivan Hirsch, Mirjam B. Zeisel, Nathalie Pochet, Catherine Schuster, Thomas F. Baumert
Publicado en: Hepatology, 2018, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.30054

Beyond viral dependence: The pathological consequences of HCV-induced EGF signaling

Autores: Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Publicado en: Journal of Hepatology, Edición S0168-8278(18), 2018, Página(s) 32118-4, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2018.05.033

Host-targeting therapies for hepatitis C virus infection: current developments and future applications

Autores: Emilie Crouchet, Florian Wrensch, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Publicado en: Therapeutic Advances in Gastroenterology, Edición 11, 2018, Página(s) 175628481875948, ISSN 1756-2848
Editor: London : Sage Publications
DOI: 10.1177/1756284818759483

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

Autores: Isabelle Desombere, Ahmed Atef Mesalam, Richard A. Urbanowicz, Freya Van Houtte, Lieven Verhoye, Zhen-Yong Keck, Ali Farhoudi, Koen Vercauteren, Karin E. Weening, Thomas F. Baumert, Arvind H. Patel, Steven K.H. Foung, Jonathan Ball, Geert Leroux-Roels, Philip Meuleman
Publicado en: Antiviral Research, Edición 148, 2017, Página(s) 53-64, ISSN 0166-3542
Editor: Elsevier BV
DOI: 10.1016/j.antiviral.2017.10.015

Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8 + T Cells in Chronic versus Acute Infection

Autores: David Wolski, Peter K. Foote, Diana Y. Chen, Lia L. Lewis-Ximenez, Catherine Fauvelle, Jasneet Aneja, Andreas Walker, Pierre Tonnerre, Almudena Torres-Cornejo, Daniel Kvistad, Sabrina Imam, Michael T. Waring, Damien C. Tully, Todd M. Allen, Raymond T. Chung, Jörg Timm, W. Nicholas Haining, Arthur Y. Kim, Thomas F. Baumert, Georg M. Lauer
Publicado en: Immunity, Edición 47/4, 2017, Página(s) 648-663.e8, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2017.09.006

Zooming in on liver zonation

Autores: Daniel J. Felmlee, Dominic Grün, Thomas F. Baumert
Publicado en: Hepatology, Edición 67/2, 2018, Página(s) 784-787, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.29554

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

Autores: Zhirong Zhang, Gergö Meszaros, Wan-ting He, Yanfang Xu, Helena de Fatima Magliarelli, Laurent Mailly, Michael Mihlan, Yansheng Liu, Marta Puig Gámez, Alexander Goginashvili, Adrien Pasquier, Olga Bielska, Bénédicte Neven, Pierre Quartier, Rudolf Aebersold, Thomas F. Baumert, Philippe Georgel, Jiahuai Han, Romeo Ricci
Publicado en: The Journal of Experimental Medicine, Edición 214/9, 2017, Página(s) 2671-2693, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20162040

Hepatitis C virus–apolipoprotein interactions: molecular mechanisms and clinical impact

Autores: Emilie Crouchet, Thomas F. Baumert, Catherine Schuster
Publicado en: Expert Review of Proteomics, Edición 14/7, 2017, Página(s) 593-606, ISSN 1478-9450
Editor: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1344102

Entry Inhibitors: A Perspective for Prevention of Hepatitis C Virus Infection in Organ Transplantation

Autores: Che C. Colpitts, Raymond T. Chung, Thomas F. Baumert
Publicado en: ACS Infectious Diseases, Edición 3/9, 2017, Página(s) 620-623, ISSN 2373-8227
Editor: Washington, DC : ACS Publications, [2015]-
DOI: 10.1021/acsinfecdis.7b00091

Advancing hepatitis B virus entry inhibitors

Autores: Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Publicado en: Journal of Hepatology, Edición 66/4, 2017, Página(s) 677-679, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2016.11.028

SCARB1 variants and HCV infection: Host susceptibility is lost in translation

Autores: Che C. Colpitts, Thomas F. Baumert
Publicado en: Journal of Hepatology, Edición 67/2, 2017, Página(s) 211-213, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2017.04.013

SMAD About Hepatitis C Virus Cell Entry and Liver Disease

Autores: Che C. Colpitts, Thomas F. Baumert
Publicado en: Gastroenterology, Edición 152/1, 2017, Página(s) 21-23, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2016.11.029

miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis

Autores: Nicolaas Van Renne, Armando Andres Roca Suarez, Francois H T Duong, Claire Gondeau, Diego Calabrese, Nelly Fontaine, Amina Ababsa, Simonetta Bandiera, Tom Croonenborghs, Nathalie Pochet, Vito De Blasi, Patrick Pessaux, Tullio Piardi, Daniele Sommacale, Atsushi Ono, Kazuaki Chayama, Masashi Fujita, Hidewaki Nakagawa, Yujin Hoshida, Mirjam B Zeisel, Markus H Heim, Thomas F Baumert, Joachim Lupberger
Publicado en: Gut, Edición 67/5, 2018, Página(s) 953-962, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-312270

Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes

Autores: Eloi R. Verrier, Che C. Colpitts, Charlotte Bach, Laura Heydmann, Laetitia Zona, Fei Xiao, Christine Thumann, Emilie Crouchet, Raphaël Gaudin, Camille Sureau, François-Loïc Cosset, Jane A. McKeating, Patrick Pessaux, Yujin Hoshida, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
Publicado en: Cell Reports, Edición 17/5, 2016, Página(s) 1357-1368, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2016.09.084

Cell Culture Models for the Investigation of Hepatitis B and D Virus Infection

Autores: Eloi Verrier, Che Colpitts, Catherine Schuster, Mirjam Zeisel, Thomas Baumert
Publicado en: Viruses, Edición 8/9, 2016, Página(s) 261, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v8090261

Claudins in viral infection: from entry to spread

Autores: Che C. Colpitts, Thomas F. Baumert
Publicado en: Pflügers Archiv - European Journal of Physiology, Edición 469/1, 2017, Página(s) 27-34, ISSN 0031-6768
Editor: Springer Verlag
DOI: 10.1007/s00424-016-1908-4

Hepatitis B virus: is a cure possible?

Autores: Mirjam B. Zeisel, Thomas F. Baumert
Publicado en: Expert Review of Clinical Pharmacology, Edición 9/9, 2016, Página(s) 1129-1130, ISSN 1751-2433
Editor: Future Drugs Ltd.
DOI: 10.1080/17512433.2016.1206466

Hepatitis C virus vaccine candidates inducing protective neutralizing antibodies

Autores: Catherine Fauvelle, Che C. Colpitts, Zhen-yong Keck, Brian G. Pierce, Steven K. H. Foung, Thomas F. Baumert
Publicado en: Expert Review of Vaccines, Edición 15/12, 2016, Página(s) 1535-1544, ISSN 1476-0584
Editor: Future Drugs Ltd.
DOI: 10.1080/14760584.2016.1194759

Circulating microRNAs for early detection of hepatitis B-related hepatocellular carcinoma

Autores: Simonetta Bandiera, Thomas F. Baumert, Mirjam B. Zeisel
Publicado en: HepatoBiliary Surgery and Nutrition, Edición 5/3, 2016, Página(s) 198-200, ISSN 2304-3881
Editor: Hong Kong : AME Publishing Company
DOI: 10.21037/hbsn.2016.03.08

Multifaceted role of E-cadherin in hepatitis C virus infection and pathogenesis

Autores: Che C. Colpitts, Joachim Lupberger, Thomas F. Baumert
Publicado en: Proceedings of the National Academy of Sciences, Edición 113/27, 2016, Página(s) 7298-7300, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1607732113

Translation and protein expression of lncRNAs: Impact for liver disease and hepatocellular carcinoma

Autores: Mirjam B. Zeisel, Thomas F. Baumert
Publicado en: Hepatology, Edición 64/2, 2016, Página(s) 671-674, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.28653

Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge

Autores: Isabelle Desombere, Samira Fafi-Kremer, Freya Van Houtte, Patrick Pessaux, Ali Farhoudi, Laura Heydmann, Lieven Verhoye, Sarah Cole, Jane A. McKeating, Geert Leroux-Roels, Thomas F. Baumert, Arvind H. Patel, Philip Meuleman
Publicado en: Hepatology, Edición 63/4, 2016, Página(s) 1120-1134, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.28428

Tailored Algorithms for Hepatocellular Carcinoma Surveillance: Is One-Size-Fits-All Strategy Outdated?

Autores: Nicolas Goossens, C. Billie Bian, Yujin Hoshida
Publicado en: Current Hepatology Reports, Edición 16/1, 2017, Página(s) 64-71, ISSN 2195-9595
Editor: Springer
DOI: 10.1007/s11901-017-0336-z

Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine

Autores: Naoto Fujiwara, Scott L. Friedman, Nicolas Goossens, Yujin Hoshida
Publicado en: Journal of Hepatology, Edición 68/3, 2018, Página(s) 526-549, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2017.09.016

Combination of Gene Expression Signature and Model for End-Stage Liver Disease Score Predicts Survival of Patients With Severe Alcoholic Hepatitis

Autores: Eric Trépo, Nicolas Goossens, Naoto Fujiwara, Won-Min Song, Antonio Colaprico, Astrid Marot, Laurent Spahr, Pieter Demetter, Christine Sempoux, Gene Y. Im, Joan Saldarriaga, Thierry Gustot, Jacques Devière, Swan N. Thung, Charlotte Minsart, Thomas Sersté, Gianluca Bontempi, Karim Abdelrahman, Jean Henrion, Delphine Degré, Valerio Lucidi, Laura Rubbia-Brandt, Venugopalan D. Nair, Christophe Mor
Publicado en: Gastroenterology, Edición 154/4, 2018, Página(s) 965-975, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.10.048

In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment

Autores: Hadassa Hirschfield, C Billie Bian, Takaaki Higashi, Shigeki Nakagawa, Tizita Z Zeleke, Venugopalan D Nair, Bryan C Fuchs, Yujin Hoshida
Publicado en: Experimental & Molecular Medicine, Edición 50/1, 2018, Página(s) e419, ISSN 2092-6413
Editor: Seoul : Korean Society of Medical Biochemistry and Molecular Biology
DOI: 10.1038/emm.2017.164

The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer

Autores: Derek J. Erstad, Andrew M. Tager, Yujin Hoshida, Bryan C. Fuchs
Publicado en: Molecular & Cellular Oncology, Edición 4/3, 2017, Página(s) e1311827, ISSN 2372-3556
Editor: Taylor & Francis
DOI: 10.1080/23723556.2017.1311827

Generic chemoprevention of hepatocellular carcinoma

Autores: Sai Krishna Athuluri-Divakar, Yujin Hoshida
Publicado en: Annals of the New York Academy of Sciences, 2018, ISSN 0077-8923
Editor: New York Academy of Sciences
DOI: 10.1111/nyas.13971

A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer

Autores: Takuma Tsuchida, Youngmin A. Lee, Naoto Fujiwara, Maria Ybanez, Brittany Allen, Sebastiao Martins, M. Isabel Fiel, Nicolas Goossens, Hsin-I. Chou, Yujin Hoshida, Scott L. Friedman
Publicado en: Journal of Hepatology, Edición 69/2, 2018, Página(s) 385-395, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2018.03.011

The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses

Autores: Carla Eller, Laura Heydmann, Che C. Colpitts, Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert
Publicado en: Cellular and Molecular Life Sciences, Edición 75/21, 2018, Página(s) 3895-3905, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-018-2892-y

HBV core variants, liver fibrosis and hepatocellular carcinoma

Autores: Gaetan Ligat, Catherine Schuster, Thomas F Baumert
Publicado en: Hepatology, 2018, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.30231

Status of Direct-acting Antiviral Therapy for HCV Infection and Remaining Challenges

Autores: Thomas F. Baumert, Thomas Berg, Joseph K. Lim, David R. Nelson
Publicado en: Gastroenterology, 2018, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.10.024

Oncogenic Signaling Induced by HCV Infection

Autores: Alessia Virzì, Armando Roca Suarez, Thomas Baumert, Joachim Lupberger
Publicado en: Viruses, Edición 10/10, 2018, Página(s) 538, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v10100538

Molecular heterogeneity in hepatocellular carcinoma

Autores: Shijia Zhu, Yujin Hoshida
Publicado en: Hepatic Oncology, Edición 5/1, 2018, Página(s) HEP10, ISSN 2045-0923
Editor: future medicine
DOI: 10.2217/hep-2018-0005

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

Autores: James S.V. Lally, Sarani Ghoshal, Danielle K. DePeralta, Omeed Moaven, Lan Wei, Ricard Masia, Derek J. Erstad, Naoto Fujiwara, Vivian Leong, Vanessa P. Houde, Alexander E. Anagnostopoulos, Alice Wang, Lindsay A. Broadfield, Rebecca J. Ford, Robert A. Foster, Jamie Bates, Hailing Sun, Ting Wang, Henry Liu, Adrian S. Ray, Asish K. Saha, Jeremy Greenwood, Sathesh Bhat, Geraldine Harriman, Wenyan Miao
Publicado en: Cell Metabolism, 2018, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2018.08.020

Tight junction proteins in gastrointestinal and liver disease

Autores: Mirjam B Zeisel, Punita Dhawan, Thomas F Baumert
Publicado en: Gut, 2018, Página(s) gutjnl-2018-316906, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-316906

Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

Autores: Youngmin A. Lee, Luke A. Noon, Kemal M. Akat, Maria D. Ybanez, Ting-Fang Lee, Marie-Luise Berres, Naoto Fujiwara, Nicolas Goossens, Hsin-I Chou, Fatemeh P. Parvin-Nejad, Bilon Khambu, Elisabeth G. M. Kramer, Ronald Gordon, Cathie Pfleger, Doris Germain, Gareth R. John, Kirk N. Campbell, Zhenyu Yue, Xiao-Ming Yin, Ana Maria Cuervo, Mark J. Czaja, M. Isabel Fiel, Yujin Hoshida, Scott L. Friedman
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-07338-z

Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus–Infected Cells and Liver to Identify Pathways Associated With Disease Development

Autores: Joachim Lupberger, Tom Croonenborghs, Armando Andres Roca Suarez, Nicolaas Van Renne, Frank Jühling, Marine A. Oudot, Alessia Virzì, Simonetta Bandiera, Carole Jamey, Gergö Meszaros, Daniel Brumaru, Atish Mukherji, Sarah C. Durand, Laura Heydmann, Eloi R. Verrier, Hussein El Saghire, Nourdine Hamdane, Ralf Bartenschlager, Shaunt Fereshetian, Evelyn Ramberger, Rileen Sinha, Mohsen Nabian, Celine
Publicado en: Gastroenterology, Edición 157/2, 2019, Página(s) 537-551.e9, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.04.003

A human liver cell atlas reveals heterogeneity and epithelial progenitors

Autores: Nadim Aizarani, Antonio Saviano, Sagar, Laurent Mailly, Sarah Durand, Josip S. Herman, Patrick Pessaux, Thomas F. Baumert, Dominic Grün
Publicado en: Nature, 2019, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1373-2

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

Autores: Nourdine Hamdane, Frank Jühling, Emilie Crouchet, Houssein El Saghire, Christine Thumann, Marine A. Oudot, Simonetta Bandiera, Antonio Saviano, Clara Ponsolles, Armando Andres Roca Suarez, Shen Li, Naoto Fujiwara, Atsushi Ono, Irwin Davidson, Nabeel Bardeesy, Christian Schmidl, Christoph Bock, Catherine Schuster, Joachim Lupberger, François Habersetzer, Michel Doffoël, Tullio Piardi, Daniele So
Publicado en: Gastroenterology, Edición 156/8, 2019, Página(s) 2313-2329.e7, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.02.038

Functional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity

Autores: Katharina Herzog, Simonetta Bandiera, Sophie Pernot, Catherine Fauvelle, Frank Jühling, Amélie Weiss, Anne Bull, Sarah C Durand, Béatrice Chane-Woon-Ming, Sébastien Pfeffer, Marion Mercey, Hervé Lerat, Jean-Christophe Meunier, Wolfgang Raffelsberger, Laurent Brino, Thomas F Baumert, Mirjam B Zeisel
Publicado en: Gut, 2019, Página(s) gutjnl-2018-317423, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317423

Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets

Autores: Eloi R Verrier, Amélie Weiss, Charlotte Bach, Laura Heydmann, Vincent Turon-Lagot, Arnaud Kopp, Houssein El Saghire, Emilie Crouchet, Patrick Pessaux, Thomas Garcia, Patrick Pale, Mirjam B Zeisel, Camille Sureau, Catherine Schuster, Laurent Brino, Thomas F Baumert
Publicado en: Gut, 2019, Página(s) gutjnl-2018-317065, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-317065

IFITM s mediate viral evasion in acute and chronic hepatitis C virus infection

Autores: Florian Wrensch, Gaëtan Ligat, Laura Heydmann, Catherine Schuster, Mirjam B. Zeisel, Patrick Pessaux, François Habersetzer, Barnabas J. King, Alexander W. Tarr, Jonathan K. Ball, Michael Winkler, Stefan Pöhlmann, Zhen‐yong Keck, Steven K.H. Foung, Thomas F. Baumert
Publicado en: Hepatology, 2019, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.30699

Oxidative Stress Triggers Selective tRNA Retrograde Transport in Human Cells during the Integrated Stress Response

Autores: Hagen Schwenzer, Frank Jühling, Alexander Chu, Laura J. Pallett, Thomas F. Baumert, Mala Maini, Ariberto Fassati
Publicado en: Cell Reports, Edición 26/12, 2019, Página(s) 3416-3428.e5, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.02.077

In vivo combination of human anti-envelope glycoprotein E2 and -Claudin-1 monoclonal antibodies for prevention of hepatitis C virus infection

Autores: Laurent Mailly, Florian Wrensch, Laura Heydmann, Catherine Fauvelle, Nicolas Brignon, Mirjam B. Zeisel, Patrick Pessaux, Zhen-yong Keck, Catherine Schuster, Thomas R. Fuerst, Steven K.H. Foung, Thomas F. Baumert
Publicado en: Antiviral Research, Edición 162, 2019, Página(s) 136-141, ISSN 0166-3542
Editor: Elsevier BV
DOI: 10.1016/j.antiviral.2018.12.018

An E. coli-produced single-chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion

Autores: Cheng Li, Yang Wang, Tiantian Liu, Matthias Niklasch, Ke Qiao, Sarah Durand, Li Chen, Mifang Liang, Thomas F. Baumert, Shuping Tong, Michael Nassal, Yu-Mei Wen, Yong-Xiang Wang
Publicado en: Antiviral Research, Edición 162, 2019, Página(s) 118-129, ISSN 0166-3542
Editor: Elsevier BV
DOI: 10.1016/j.antiviral.2018.12.019

Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma: preliminary results

Autores: Bachir Taouli, Yujin Hoshida, Suguru Kakite, Xintong Chen, Poh Seng Tan, Xiaochen Sun, Shingo Kihira, Kensuke Kojima, Sara Toffanin, M. Isabel Fiel, Hadassa Hirschfield, Mathilde Wagner, Josep M. Llovet
Publicado en: European Radiology, Edición 27/11, 2017, Página(s) 4472-4481, ISSN 0938-7994
Editor: Springer Verlag
DOI: 10.1007/s00330-017-4844-6

Ultrasound‐Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma

Autores: Ghina Bou About, Emilie Thiebault, Marie Wattenhofer‐Donzé, Hugues Jacobs, Alain Guimond, Tania Sorg, Eric Robinet, Thomas F. Baumert, Laurent Monassier, Yann Herault
Publicado en: Current Protocols in Mouse Biology, Edición 9/2, 2019, ISSN 2161-2617
Editor: Wiley
DOI: 10.1002/cpmo.62

Learning from a clinical cohort for HCV vaccine development

Autores: Florian Wrensch, Zhen-yong Keck, Steven K.H. Foung, Thomas F. Baumert
Publicado en: Journal of Hepatology, Edición 71/1, 2019, Página(s) 9-11, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2019.03.030

The circadian clock and liver function in health and disease

Autores: Atish Mukherji, Shannon M. Bailey, Bart Staels, Thomas F. Baumert
Publicado en: Journal of Hepatology, Edición 71/1, 2019, Página(s) 200-211, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2019.03.020

Editorial: Current Progress and Challenges in the Development of a B Cell Based Hepatitis C Virus Vaccine

Autores: Steven K. H. Foung, Thomas F. Baumert
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2018.02577

Hepatocellular Carcinoma Risk Stratification by Genetic Profiling in Patients with Cirrhosis

Autores: Naoto Fujiwara, Yujin Hoshida
Publicado en: Seminars in Liver Disease, Edición 39/02, 2019, Página(s) 153-162, ISSN 0272-8087
Editor: Thieme Medical Publishers
DOI: 10.1055/s-0039-1681031

Addressing the Challenges of Hepatitis C Cure and Persistent Risk of Hepatocellular Carcinoma

Autores: Thomas F. Baumert, Yujin Hoshida
Publicado en: Viruses, Edición 11/5, 2019, Página(s) 441, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11050441

Mortality from liver cirrhosis and HCC in the DAA era: success in viral control is darkened by raise of metabolic disease

Autores: Antonio Saviano, Thomas F. Baumert
Publicado en: HepatoBiliary Surgery and Nutrition, Edición 8/3, 2019, Página(s) 307-310, ISSN 2304-3881
Editor: AME Publishing Company
DOI: 10.21037/hbsn.2019.01.21

Use of big data in drug development for precision medicine: an update

Autores: Tongqi Qian, Shijia Zhu, Yujin Hoshida
Publicado en: Expert Review of Precision Medicine and Drug Development, Edición 4/3, 2019, Página(s) 189-200, ISSN 2380-8993
Editor: Taylor & Francis
DOI: 10.1080/23808993.2019.1617632

Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis

Autores: Simonetta Bandiera, Sophie Pernot, Hussein El Saghire, Sarah C. Durand, Christine Thumann, Emilie Crouchet, Tao Ye, Isabel Fofana, Marine A. Oudot, Jochen Barths, Catherine Schuster, Patrick Pessaux, Markus H. Heim, Thomas F. Baumert, Mirjam B. Zeisel
Publicado en: Journal of Virology, Edición 90/14, 2016, Página(s) 6387-6400, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.00619-16

Extracellular lipid-free apolipoprotein E inhibits HCV replication and induces ABCG1-dependent cholesterol efflux

Autores: Emilie Crouchet, Mathieu Lefèvre, Eloi R Verrier, Marine A Oudot, Thomas F Baumert, Catherine Schuster
Publicado en: Gut, Edición 66/5, 2017, Página(s) 896-907, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2015-311289

Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice

Autores: Tao Wu, Emilie Heuillard, Véronique Lindner, Ghina Bou About, Mihaela Ignat, Jean-Philippe Dillenseger, Nicolas Anton, Eugénie Dalimier, Francine Gossé, Gael Fouré, Franck Blindauer, Céline Giraudeau, Hussein El-Saghire, Mourad Bouhadjar, Cynthia Calligaro, Tania Sorg, Philippe Choquet, Thierry Vandamme, Christophe Ferrand, Jacques Marescaux, Thomas F. Baumert, Michele Diana, Patrick Pessaux,
Publicado en: Scientific Reports, Edición 6/1, 2016, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep35230

Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition

Autores: Shigeki Nakagawa, Lan Wei, Won Min Song, Takaaki Higashi, Sarani Ghoshal, Rosa S. Kim, C. Billie Bian, Suguru Yamada, Xiaochen Sun, Anu Venkatesh, Nicolas Goossens, Gretchen Bain, Gregory Y. Lauwers, Anna P. Koh, Mohamed El-Abtah, Noor B. Ahmad, Hiroki Hoshida, Derek J. Erstad, Ganesh Gunasekaran, Youngmin Lee, Ming-Lung Yu, Wan-Long Chuang, Chia-Yen Dai, Masahiro Kobayashi, Hiromitsu Kumada, Toru
Publicado en: Cancer Cell, Edición 30/6, 2016, Página(s) 879-890, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2016.11.004

Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape

Autores: Che C Colpitts, Rajiv G Tawar, Laurent Mailly, Christine Thumann, Laura Heydmann, Sarah C Durand, Fei Xiao, Eric Robinet, Patrick Pessaux, Mirjam B Zeisel, Thomas F Baumert
Publicado en: Gut, 2017, Página(s) gutjnl-2016-312577, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-312577

Plasmodium P36 determines host cell receptor usage during sporozoite invasion

Autores: Giulia Manzoni, Carine Marinach, Selma Topçu, Sylvie Briquet, Morgane Grand, Matthieu Tolle, Marion Gransagne, Julien Lescar, Chiara Andolina, Jean-François Franetich, Mirjam B Zeisel, Thierry Huby, Eric Rubinstein, Georges Snounou, Dominique Mazier, François Nosten, Thomas F Baumert, Olivier Silvie
Publicado en: eLife, Edición 6, 2017, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/eLife.25903

Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy

Autores: Tanvi Khera, Daniel Todt, Koen Vercauteren, C. Patrick McClure, Lieven Verhoye, Ali Farhoudi, Sabin Bhuju, Robert Geffers, Thomas F. Baumert, Eike Steinmann, Philip Meuleman, Thomas Pietschmann, Richard J.P. Brown
Publicado en: Antiviral Research, Edición 139, 2017, Página(s) 129-137, ISSN 0166-3542
Editor: Elsevier BV
DOI: 10.1016/j.antiviral.2017.01.001

Cost-Effectiveness of Risk Score–Stratified Hepatocellular Carcinoma Screening in Patients with Cirrhosis

Autores: Nicolas Goossens, Amit G Singal, Lindsay Y King, Karin L Andersson, Bryan C Fuchs, Cecilia Besa, Bachir Taouli, Raymond T Chung, Yujin Hoshida
Publicado en: Clinical and Translational Gastroenterology, Edición 8/6, 2017, Página(s) e101, ISSN 2155-384X
Editor: Nature Publishing Group
DOI: 10.1038/ctg.2017.26

Hepatic stellate cells as key target in liver fibrosis

Autores: Takaaki Higashi, Scott L. Friedman, Yujin Hoshida
Publicado en: Advanced Drug Delivery Reviews, 2017, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2017.05.007

Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging

Autores: Stefanie J. Hectors, Mathilde Wagner, Octavia Bane, Cecilia Besa, Sara Lewis, Romain Remark, Nelson Chen, M. Isabel Fiel, Hongfa Zhu, Sacha Gnjatic, Miriam Merad, Yujin Hoshida, Bachir Taouli
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-02706-z

Persisting risk of hepatocellular carcinoma after HCV cure monitored by a liver transcriptome signature

Autores: Atsushi Ono, Nicolas Goossens, Richard S Finn, Warren N Schmidt, Swan N Thung, Gene Y Im, Yujin Hoshida
Publicado en: Hepatology, 2017, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.29203

Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases

Autores: Benjamin Wooden, Nicolas Goossens, Yujin Hoshida, Scott L. Friedman
Publicado en: Gastroenterology, Edición 152/1, 2017, Página(s) 53-67.e3, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2016.09.065

Novel substituted aminothiazoles as potent and selective anti-hepatocellular carcinoma agents

Autores: Huagang Lu, John Rogowskyj, Wenquan Yu, Anu Venkatesh, Noshena Khan, Shigeki Nakagawa, Nicolas Goossens, Anna P. Koh, Takaaki Higashi, Ganesh Gunasekaran, Myron E. Schwarz, Spiros P. Hiotis, Xiaodong Xu, William Kinney, Yujin Hoshida, Timothy Block, Andrea Cuconati, Yanming Du
Publicado en: Bioorganic & Medicinal Chemistry Letters, Edición 26/23, 2016, Página(s) 5819-5824, ISSN 0960-894X
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2016.10.015

Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells

Autores: Daniel F. Hicks, Nicolas Goossens, Ana Blas-García, Takuma Tsuchida, Benjamin Wooden, Michael C. Wallace, Natalia Nieto, Abigale Lade, Benjamin Redhead, Arthur I Cederbaum, Joel T. Dudley, Bryan C. Fuchs, Youngmin A. Lee, Yujin Hoshida, Scott L. Friedman
Publicado en: Scientific Reports, Edición 7, 2017, Página(s) 42563, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep42563

New perspectives for preventing hepatitis C virus liver graft infection

Autores: Daniel J Felmlee, Audrey Coilly, Raymond T Chung, Didier Samuel, Thomas F Baumert
Publicado en: The Lancet Infectious Diseases, Edición 16/6, 2016, Página(s) 735-745, ISSN 1473-3099
Editor: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(16)00120-1

Hepatitis B virus receptors and molecular drug targets

Autores: Eloi R. Verrier, Che C. Colpitts, Camille Sureau, Thomas F. Baumert
Publicado en: Hepatology International, Edición 10/4, 2016, Página(s) 567-573, ISSN 1936-0533
Editor: Springer Pub. Co.
DOI: 10.1007/s12072-016-9718-5

Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma

Autores: Simonetta Bandiera, C Billie Bian, Yujin Hoshida, Thomas F Baumert, Mirjam B Zeisel
Publicado en: Current Opinion in Virology, Edición 20, 2016, Página(s) 99-105, ISSN 1879-6257
Editor: Elsevier BV
DOI: 10.1016/j.coviro.2016.09.010

Autores: Thomas F. Baumert, Frank Jühling, Atsushi Ono, Yujin Hoshida
Publicado en: BMC Medicine, Edición 15/1, 2017, ISSN 1741-7015
Editor: BioMed Central
DOI: 10.1186/s12916-017-0815-7

Toward novel immunocompetent animal models for hepatitis B virus infection

Autores: Laurent Mailly, Mirjam B. Zeisel, Thomas F. Baumert
Publicado en: Hepatology, 2017, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.29249

Characterisation of endogenous Claudin‐1 expression, motility and susceptibility to hepatitis C virus in CRISPR knock‐in cells

Autores: Camille M.H. Clément, Maika S. Deffieu, Cristina M. Dorobantu, Thomas F. Baumert, Nilda Vanesa Ayala‐Nunez, Yves Mély, Philippe Ronde, Raphael Gaudin
Publicado en: Biology of the Cell, Edición 112/5, 2020, Página(s) 140-151, ISSN 0248-4900
Editor: Portland Press, Ltd.
DOI: 10.1111/boc.201900085

Addressing the next challenges: A summary of the 22nd international symposium on hepatitis C virus and related viruses

Autores: Thomas F. Baumert, Catherine Schuster, François-Loïc Cosset, Jean Dubuisson, Maike Hofmann, Norbert Tautz, Mirjam B. Zeisel, Robert Thimme
Publicado en: Journal of Hepatology, Edición 64/4, 2016, Página(s) 968-973, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2015.12.021

Hepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals

Autores: Che C. Colpitts, Thomas F. Baumert
Publicado en: Hepatology International, Edición 10/5, 2016, Página(s) 741-748, ISSN 1936-0533
Editor: Springer Pub. Co.
DOI: 10.1007/s12072-016-9724-7

A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

Autores: Carla Eller, Laura Heydmann, Che C. Colpitts, Houssein El Saghire, Federica Piccioni, Frank Jühling, Karim Majzoub, Caroline Pons, Charlotte Bach, Julie Lucifora, Joachim Lupberger, Michael Nassal, Glenn S. Cowley, Naoto Fujiwara, Sen-Yung Hsieh, Yujin Hoshida, Emanuele Felli, Patrick Pessaux, Camille Sureau, Catherine Schuster, David E. Root, Eloi R. Verrier, Thomas F. Baumert
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-16517-w

Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma

Autores: Frank Jühling, Nourdine Hamdane, Emilie Crouchet, Shen Li, Houssein El Saghire, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Christine Thumann, Antonio Saviano, Armando Andres Roca Suarez, Kaku Goto, Ricard Masia, Mozhdeh Sojoodi, Gunisha Arora, Hiroshi Aikata, Atsushi Ono, Parissa Tabrizian, Myron Schwartz, Stephen J Polyak, Irwin Davidson, Christian Schmidl, Christoph Bock, Catherine Schuste
Publicado en: Gut, 2020, Página(s) gutjnl-2019-318918, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-318918

Hepatitis C Virus and Hepatocellular Carcinoma: When the Host Loses Its Grip

Autores: Kaku Goto, Armando Andres Roca Suarez, Florian Wrensch, Thomas F. Baumert, Joachim Lupberger
Publicado en: International Journal of Molecular Sciences, Edición 21/9, 2020, Página(s) 3057, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093057

Signalome-wide assessment of host cell response to hepatitis C virus

Autores: Gholamreza Haqshenas, Jianmin Wu, Kaylene J. Simpson, Roger J. Daly, Hans J. Netter, Thomas F. Baumert, Christian Doerig
Publicado en: Nature Communications, Edición 8/1, 2017, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms15158

Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design

Autores: Zhen-Yong Keck, Brian G. Pierce, Patrick Lau, Janine Lu, Yong Wang, Alexander Underwood, Rowena A. Bull, Jannick Prentoe, Rodrigo Velázquez-Moctezuma, Melanie R. Walker, Fabio Luciani, Johnathan D. Guest, Catherine Fauvelle, Thomas F. Baumert, Jens Bukh, Andrew R. Lloyd, Steven K. H. Foung
Publicado en: PLOS Pathogens, Edición 15/5, 2019, Página(s) e1007772, ISSN 1553-7374
Editor: PLOS
DOI: 10.1371/journal.ppat.1007772

Hepatitis C virus infection and tight junction proteins: The ties that bind

Autores: Laurent Mailly, Thomas F. Baumert
Publicado en: Biochimica et Biophysica Acta (BBA) - Biomembranes, Edición 1862/7, 2020, Página(s) 183296, ISSN 0005-2736
Editor: Elsevier BV
DOI: 10.1016/j.bbamem.2020.183296

The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans

Autores: Karim Majzoub, Florian Wrensch, Thomas F. Baumert
Publicado en: Viruses, Edición 11/8, 2019, Página(s) 758, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11080758

Uncovering the mechanism of action of aspirin in HCC chemoprevention

Autores: Natascha Roehlen, Thomas F. Baumert
Publicado en: EBioMedicine, Edición 46, 2019, Página(s) 21-22, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2019.07.047

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

Autores: Natascha Roehlen, Emilie Crouchet, Thomas F. Baumert
Publicado en: Cells, Edición 9/4, 2020, Página(s) 875, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells9040875

Tight Junction Proteins and the Biology of Hepatobiliary Disease

Autores: Natascha Roehlen, Armando Andres Roca Suarez, Houssein El Saghire, Antonio Saviano, Catherine Schuster, Joachim Lupberger, Thomas F. Baumert
Publicado en: International Journal of Molecular Sciences, Edición 21/3, 2020, Página(s) 825, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21030825

Single-cell genomics and spatial transcriptomics: discovery of novel cell states and cellular interactions in liver physiology and disease biology

Autores: Antonio Saviano, Neil C. Henderson, Thomas F. Baumert
Publicado en: Journal of Hepatology, 2020, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2020.06.004

Follicular T helper cells shape the HCV-specific CD4+ T cell repertoire after virus elimination

Autores: Maike Smits, Katharina Zoldan, Naveed Ishaque, Zuguang Gu, Katharina Jechow, Dominik Wieland, Christian Conrad, Roland Eils, Catherine Fauvelle, Thomas F. Baumert, Florian Emmerich, Bertram Bengsch, Christoph Neumann-Haefelin, Maike Hofmann, Robert Thimme, Tobias Boettler
Publicado en: Journal of Clinical Investigation, Edición 130/2, 2019, Página(s) 998-1009, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci129642

Hepatitis B Virus–Hepatocyte Interactions and Innate Immune Responses: Experimental Models and Molecular Mechanisms

Autores: Emmanuel Thomas, Thomas F. Baumert
Publicado en: Seminars in Liver Disease, Edición 39/03, 2019, Página(s) 301-314, ISSN 0272-8087
Editor: Thieme Medical Publishers
DOI: 10.1055/s-0039-1685518

Radiomics in hepatocellular carcinoma: a quantitative review

Autores: Taiga Wakabayashi, Farid Ouhmich, Cristians Gonzalez-Cabrera, Emanuele Felli, Antonio Saviano, Vincent Agnus, Peter Savadjiev, Thomas F. Baumert, Patrick Pessaux, Jacques Marescaux, Benoit Gallix
Publicado en: Hepatology International, Edición 13/5, 2019, Página(s) 546-559, ISSN 1936-0533
Editor: Springer Pub. Co.
DOI: 10.1007/s12072-019-09973-0

Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis

Autores: Alessia Virzì, Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Publicado en: Cold Spring Harbor Perspectives in Medicine, Edición 10/1, 2020, Página(s) a037366, ISSN 2157-1422
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a037366

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

Autores: Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai, Abhinav Kumar, Srinivasa Bhargav Rambhatla, Claire L. Donald, Andrea F. Lopez-Clavijo, Simon Rudge, Katherine Pinnick, Wai Hoong Chang, Peter A. C. Wing, Ryan Brown, Ximing Qin, Peter Simmonds, Thomas F. Baumert, David Ray, Andrew Loudon, Peter Balfe, Michael Wakelam, Sam Butterworth, Alain Kohl, Catherine L. Jopling, Nicole Zitzmann, Ja
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-08299-7

MPIC: Molecular Prognostic Indicators in Cirrhosis Database for Clinical Context-Specific in Silico Prognostic Biomarker Validation

Autores: Shun H. Yip, Naoto Fujiwara, Jason Burke, Anand Shetler, Celina Peralta, Tongqi Qian, Hiroki Hoshida, Shijia Zhu, Yujin Hoshida
Publicado en: Frontiers in Genetics, Edición 10, 2019, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2019.00830

Gene signature-MELD score and alcohol relapse determine long-term prognosis of patients with severe alcoholic hepatitis

Autores: Pierre Deltenre 1 2, Eric Trépo 1 3, Naoto Fujiwara, Nicolas Goossens 4 5, Astrid Marot 6, Margaux Dubois 7, Laurent Spahr 5, Jean Henrion 8, Christophe Moreno 1 3, Yujin Hoshida
Publicado en: Liver Int, 2020, ISSN 1478-3231
Editor: John Wiley & Sons, Inc.
DOI: 10.1111/liv.14265

FIB-4 score and hepatocellular carcinoma risk after hepatitis C virus cure: time to revise surveillance?

Autores: Antonio Saviano, Simona Tripon, Thomas F Baumert
Publicado en: Hepatobiliary Surgery and Nutrition, 2020, Página(s) 661-664, ISSN 2304-3881
Editor: AME Publishing Company
DOI: 10.21037/hbsn.2020.01.05

Steatohepatitic Variant of Hepatocellular Carcinoma Is Associated With Both Alcoholic Steatohepatitis and Nonalcoholic Steatohepatitis: A Study of 2 Cohorts With Molecular Insights.

Autores: Jia Qin, MD, PhD,1 Takaaki Higashi, MD, PhD,2 Shigeki Nakagawa, MD, PhD,2 Yo-ichi Yamashita, MD, PhD,2 Toru Beppu, MD, PhD,2 Hideo Baba, MD, PhD,2 Masahiro Kobayashi, MD,3 Hiromitsu Kumada, MD,3 Ganesh Gunasekaran, MD,4 Thomas D. Schiano, MD,5 Swan N. Thung, MD,6 M. Isabel Fiel, MD, Yujin Hoshida, and Stephen C. Ward, MD, PhD6
Publicado en: Am J Surg Pathol, 2021, ISSN 0147-5185
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/pas.0000000000001533

Composite vector formulation for multiple siRNA delivery as a host targeting antiviral in a cell culture model of hepatitis C virus (HCV) infection

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Editor: Wiley
DOI: 10.1002/hep.28767

Cell type-specific pharmacological kinase inhibition for cancer chemoprevention.

Autores: Manjeet Deshmukh; Shigeki Nakagawa; Shigeki Nakagawa; Takaaki Higashi; Takaaki Higashi; Adam Vincek; Anu Venkatesh; Marina Ruiz de Galarreta; Anna P. Koh; Nicolas Goossens; Nicolas Goossens; Hadassa Hirschfield; C Billie Bian; Naoto Fujiwara; Naoto Fujiwara; Atsushi Ono; Atsushi Ono; Hiroki Hoshida; Mohamed El-Abtah; Noor B. Ahmad; Amaia Lujambio; Roberto Sanchez; Bryan C. Fuchs; Klaas Poelstra; J
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Un criblage gain-de-fonction identifie CDKN2C comme facteur d'hôte impliqué dans le cycle viral du virus de l'hépatite B

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