BLACANDI can improve life quality and cut cost of diagnosing and managing bladder cancer in half

Projektinformationen

BLACANDI

ID Finanzhilfevereinbarung: 673077

DOI

10.3030/673077

Projekt abgeschlossen

EK-Unterschriftsdatum 10 Juni 2015

Startdatum 1 Juli 2015

Enddatum 31 Dezember 2015

Finanziert unter

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Gesamtkosten

€ 71 429,00

EU-Beitrag

€ 50 000,00

Koordiniert durch

GENOMIC EXPRESSION APS
Denmark

Periodic Reporting for period 1 - BLACANDI (BLACANDI can improve life quality and cut cost of diagnosing and managing bladder cancer in half)

Berichtszeitraum: 2015-07-01 bis 2015-12-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

BLACANDI is based on a successfully concluded small fully randomized blinded clinical study of 500 patients presenting with blood in the urine meeting its end-point of a sensitivity of +90%.

The Horizon2020 phase I feasibility study identified no competitors that could match this end-point; however, a number of competing approaches was identified, which will supplement cytology rather than substitute cystoscopy - and as a result increase cost of care.

Implementation into standard of care would require a clinical study of 4000 patients representing with blood in the urine’ which is planned as the phase II of the BLACANDI Horizon2020 project.

The overall objective of the Bladder Cancer Diagnostic “BLACANDI” project (Phase I + II) is to eliminate or dramatically reduce the use of cystoscopy in the diagnosis and follow-up of bladder cancer patients, and thereby reduce the cost of care of bladder cancer.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

The clinical study performed meet the end-point of +90% sensitivity. All task associated with moving the BLACANDI solution to market through regulatory, IP, engagement with Key Opinion Leaders, clinical trail planning and commercialization plan was executed.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

Many academic institutions and commercial companies has identified many different markers for bladder cancers, however so far all single or combination of markers have failed to match the performance of cystoscopy and for that reason implementation of those markers will only increase cost of care.

Bladder cancer is one of the most expensive cancers to manage. Only 1 out of 10 patients presenting with blood in the urine has bladder cancer; however, in the absence of better assays capable of identifying more than 90% of all cancer cases, cystoscopy has remained the standard of care.

In Europe €1.8 billion/year is spend on cytoscopy just for diagnosing the disease. Due to the risk of recurrence all patients undergo routine cystoscopy often several times/year. Managing recurrence is estimated to cost an additional €1.8 billion/year.
Implementing the BLACANDI system instead of cystoscopy could cut the cost of diagnosing and managing bladder cancer in half.

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