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Regulation of red cell life-span, erythropoiesis, survival, senescence and clearance

Objective

Anaemia is the most common pathological condition affecting 1.6 billion individuals worldwide. It thus presents a serious health care problem and an economic burden. Reduction in red blood cell (RBC) number can be caused by blood loss, diet, stress conditions including endurance sport, and pathologies which are caused by primary genetic aberrations or are secondary to the malfunction of other cell types. Transfusion of RBC, which is often the only cure for severe cases of anaemia, is associated with risks such as thrombosis and transfusion reactions due to allo-immunisation. There is an unmet need to improve treatment of anaemia through early and accurate diagnosis, targeted treatment, and increased safety and effectiveness of RBC transfusion. The aim of RELEVANCE is to improve fast and cost-effective diagnosis of the underlying cause of primary anaemia, and to improve treatment options for both general and personalised medicine. We defined five key objectives: (1) to improve diagnostics of anaemia, particularly for hereditary rare forms of anaemia (RA); (2) to find novel treatments for anaemia that target RBC production, ageing and clearance; (3) to reduce premature loss of RBC following transfusion; (4) to produce cultured RBC for transfusion; (5) to monitor and optimise RBC function during sport and exercise. RELEVANCE will train 15 early stage researchers (ESR) at four SMEs and eight academic partners, two of whom are at blood supply centres and two are diagnostic centres for RA. The continuous interactions between the clinic, blood supply centers, basic research, and industry will select for the most relevant unmet medical needs, and will stimulate innovative procedures that are immediately probed for applicability and validity both in a research and a clinical setting. RELEVANCE will organize three open access summer schools, extending training beyond the ESR of the ITN sustaining the critical number of young talented professionals in the field.

Call for proposal

H2020-MSCA-ITN-2015
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Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITAT ZURICH
Address
Ramistrasse 71
8006 Zurich
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 309 431,22

Participants (13)

UNIVERSITAT DES SAARLANDES
Germany
EU contribution
€ 498 432,96
Address
Campus
66123 Saarbrucken
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF BRISTOL
United Kingdom
EU contribution
€ 273 287,88
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI PAVIA
Italy
EU contribution
€ 258 061,32
Address
Strada Nuova 65
27100 Pavia
Activity type
Higher or Secondary Education Establishments
Stichting Sanquin Bloedvoorziening
Netherlands
EU contribution
€ 510 748,56
Address
Plesmanlaan 125
1006 AN Amsterdam
Activity type
Research Organisations
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 255 374,28
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Participation ended

Spain
EU contribution
€ 9 432,94
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 262 875,60
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 262 875,60
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
ARIVIS AG
Germany
EU contribution
€ 249 216,48
Address
Einsteinstrasse 10
85716 Unterschleissheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EPIGEM LIMITED
United Kingdom
EU contribution
€ 273 287,88
Address
Malmo Court Kirkleatham Business
TS10 5SQ Redcar
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NANION TECHNOLOGIES GMBH
Germany
EU contribution
€ 249 216,48
Address
Ganghoferstrasse 70A
80339 Munchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
OPTOROBOTIX APS
Denmark
EU contribution
€ 201 445,75
Address
N Dalhoffs Vej 5
2000 Frederiksberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS
Spain
EU contribution
€ 238 440,02
Address
Carrer Muntaner 383 3/2
08021 Barcelona
Activity type
Research Organisations

Partners (2)

PHAST GmbH
Germany
Address

Homburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
Address
Heinrich-hertz-allee 1
66386 St Ingbert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)