Regulation of red cell life-span, erythropoiesis, survival, senescence and clearance

Livrables

Training Schools

Further training schools to be held in M20, M18, M40

Dissemination Toolkit

Templates for presentations, posters, for meeting and internal documents will be provided to all partners.

Outreach activities

Further reports on outreach activities to be submitted in M28, M40

Website

The website will serve as an additional showcase for presenting the project's achievements and activities.

Publications

The potential of erythrocytes as cellular aging models

Auteurs: Lars Kaestner, Giampaolo Minetti
Publié dans: Cell Death and Differentiation, Numéro 24/9, 2017, Page(s) 1475-1477, ISSN 1350-9047
Éditeur: Nature Publishing Group
DOI: 10.1038/cdd.2017.100

The buckling instability of aggregating red blood cells

Auteurs: Daniel Flormann, Othmane Aouane, Lars Kaestner, Christian Ruloff, Chaouqi Misbah, Thomas Podgorski, Christian Wagner
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-017-07634-6

Is Increased Intracellular Calcium in Red Blood Cells a Common Component in the Molecular Mechanism Causing Anemia?

Auteurs: Laura Hertz, Rick Huisjes, Esther Llaudet-Planas, Polina Petkova-Kirova, Asya Makhro, Jens G. Danielczok, Stephane Egee, Maria del Mar Mañú-Pereira, Richard van Wijk, Joan-Lluis Vives Corrons, Anna Bogdanova, Lars Kaestner
Publié dans: Frontiers in Physiology, Numéro 8, 2017, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2017.00673

Membrane Remodelling and Vesicle Formation During Ageing of Human Red Blood Cells

Auteurs: Annarita Ciana, Cesare Achilli, Anjali Gaur, Giampaolo Minetti
Publié dans: Cellular Physiology and Biochemistry, Numéro 42/3, 2017, Page(s) 1127-1138, ISSN 1015-8987
Éditeur: S. Karger AG
DOI: 10.1159/000478768

Does Erythropoietin Regulate TRPC Channels in Red Blood Cells?

Auteurs: Jens Danielczok, Laura Hertz, Sandra Ruppenthal, Elisabeth Kaiser, Polina Petkova-Kirova, Anna Bogdanova, Elmar Krause, Peter Lipp, Marc Freichel, Lars Kaestner, Lutz Birnbaumer
Publié dans: Cellular Physiology and Biochemistry, Numéro 41/3, 2017, Page(s) 1219-1228, ISSN 1015-8987
Éditeur: S. Karger AG
DOI: 10.1159/000464384

DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism

Auteurs: Elina Ovchynnikova, Francesca Aglialoro, Arthur E. H. Bentlage, Gestur Vidarsson, Nichole D. Salinas, Marieke von Lindern, Niraj H. Tolia, Emile van den Akker
Publié dans: Blood, Numéro 130/12, 2017, Page(s) 1441-1444, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2017-03-774364

Gardos Channelopathy: a variant of hereditary Stomatocytosis with complex molecular regulation

Auteurs: Elisa Fermo; Anna Bogdanova; Polina Petkova-Kirova; Anna Zaninoni; Anna Paola Marcello; Asya Makhro; Pascal Hänggi; Laura Hertz; Jens Danielczok; Cristina Vercellati; Nadia Mirra; Alberto Zanella; Agostino Cortelezzi; Wilma Barcellini; Lars Kaestner; Paola Bianchi
Publié dans: Fermo, Elisa; Bogdanova, Anna; Petkova-Kirova, Polina; Zaninoni, Anna; Marcello, Anna Paola; Makhro, Asya; Hänggi, Pascal; Hertz, Laura; Danielczok, Jens; Vercellati, Cristina; Mirra, Nadia; Zanella, Alberto; Cortelezzi, Agostino; Barcellini, Wilma; Kaestner, Lars; Bianchi, Paola (2017). Gardos Channelopathy: a variant of hereditary Stomatocytosis with complex molecular regulation. Scientific Rep, Numéro 1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.5167/uzh-137952

Comparing the impact of an acute exercise bout on plasma amino acid composition, intraerythrocytic Ca2+ handling, and red cell function in athletes and untrained subjects

Auteurs: Asya Makhro, Thomas Haider, Jue Wang, Nikolay Bogdanov, Patrick Steffen, Christian Wagner, Tim Meyer, Max Gassmann, Anne Hecksteden, Lars Kaestner, Anna Bogdanova
Publié dans: Cell Calcium, Numéro 60/4, 2016, Page(s) 235-244, ISSN 0143-4160
Éditeur: Churchill Livingstone
DOI: 10.1016/j.ceca.2016.05.005

The Molecular Structure of Human Red Blood Cell Membranes from Highly Oriented, Solid Supported Multi-Lamellar Membranes

Auteurs: Sebastian Himbert, Richard J. Alsop, Markus Rose, Laura Hertz, Alexander Dhaliwal, Jose M. Moran-Mirabal, Chris P. Verschoor, Dawn M. E. Bowdish, Lars Kaestner, Christian Wagner, Maikel C. Rheinstädter
Publié dans: Scientific Reports, Numéro 7, 2017, Page(s) 39661, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep39661

Spectrin and Other Membrane-Skeletal Components in Human Red Blood Cells of Different Age

Auteurs: Annarita Ciana, Cesare Achilli, Giampaolo Minetti
Publié dans: Cellular Physiology and Biochemistry, Numéro 42/3, 2017, Page(s) 1139-1152, ISSN 1015-8987
Éditeur: S. Karger AG
DOI: 10.1159/000478769

Novel Insights in the Regulation of Phosphatidylserine Exposure in Human Red Blood Cells

Auteurs: Mauro C. Wesseling, Lisa Wagner-Britz, Duc Bach Nguyen, Salome Asanidze, Judy Mutua, Nagla Mohamed, Benjamin Hanf, Mehrdad Ghashghaeinia, Lars Kaestner, Ingolf Bernhardt
Publié dans: Cellular Physiology and Biochemistry, Numéro 39/5, 2016, Page(s) 1941-1954, ISSN 1015-8987
Éditeur: S. Karger AG
DOI: 10.1159/000447891

Impact of hydroxycarbamide and interferon-α on red cell adhesion and membrane protein expression in polycythemia vera

Auteurs: Mégane Brusson, Maria De Grandis, Sylvie Cochet, Sylvain Bigot, Mickaël Marin, Marjorie Leduc, François Guillonneau, Patrick Mayeux, Thierry Peyrard, Christine Chomienne, Caroline Le Van Kim, Bruno Cassinat, Jean-Jacques Kiladjian, Wassim El Nemer
Publié dans: Haematologica, Numéro 103/6, 2018, Page(s) 972-981, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2017.182303

Continuous Change in Membrane and Membrane-Skeleton Organization During Development From Proerythroblast to Senescent Red Blood Cell

Auteurs: Giampaolo Minetti, Cesare Achilli, Cesare Perotti, Annarita Ciana
Publié dans: Frontiers in Physiology, Numéro 9, 2018, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00286

Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis

Auteurs: Rick Huisjes, Asya Makhro, Esther Llaudet-Planas, Laura Hertz, Polina Petkova-Kirova, Liesbeth P Verhagen, Silvia Pignatelli, Minke AE Rab, Raymond M Schiffelers, Elena Seiler, Wouter W van Solinge, Joan-LLuis Vives Corrons, Maria Mañú-Pereira, Lars Kaestner, Anna Bogdanova, Richard van Wijk
Publié dans: Haematologica, 2019, Page(s) haematol.2018.188151, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.188151

Glutaraldehyde – A Subtle Tool in the Investigation of Healthy and Pathologic Red Blood Cells

Auteurs: Asena Abay, Greta Simionato, Revaz Chachanidze, Anna Bogdanova, Laura Hertz, Paola Bianchi, Emile van den Akker, Marieke von Lindern, Marc Leonetti, Giampaolo Minetti, Christian Wagner, Lars Kaestner
Publié dans: Frontiers in Physiology, Numéro 10, 2019, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00514

The Shape Shifting Story of Reticulocyte Maturation

Auteurs: Elina Ovchynnikova, Francesca Aglialoro, Marieke von Lindern, Emile van den Akker
Publié dans: Frontiers in Physiology, Numéro 9, 2018, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00829

Editorial: The Red Cell Life-Cycle From Erythropoiesis to Clearance

Auteurs: Lars Kaestner, Anna Bogdanova
Publié dans: Frontiers in Physiology, Numéro 9, 2018, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.01537

A Previously Unrecognized Ca2+-inhibited Nonselective Cation Channel in Red Blood Cells

Auteurs: Polina Petkova-Kirova, Laura Hertz, Asya Makhro, Jens Danielczok, Rick Huisjes, Esther Llaudet-Planas, Maria del Mar Mañú-Pereira, Joan-Luis Vives Corrons, Richard van Wijk, Anna Bogdanova, Lars Kaestner
Publié dans: HemaSphere, Numéro 2/5, 2018, Page(s) e146, ISSN 2572-9241
Éditeur: Open acccess journal of the European Hematology Association
DOI: 10.1097/HS9.0000000000000146

Voltage-Activated Ion Channels in Non-excitable Cells—A Viewpoint Regarding Their Physiological Justification

Auteurs: Lars Kaestner, Xijia Wang, Laura Hertz, Ingolf Bernhardt
Publié dans: Frontiers in Physiology, Numéro 9, 2018, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00450

Classification of red blood cell shapes in flow using outlier tolerant machine learning

Auteurs: Alexander Kihm, Lars Kaestner, Christian Wagner, Stephan Quint
Publié dans: PLOS Computational Biology, Numéro 14/6, 2018, Page(s) e1006278, ISSN 1553-7358
Éditeur: San Francisco CA: Public Library of Science
DOI: 10.1371/journal.pcbi.1006278

Influence of Equimolar Doses of Beetroot Juice and Sodium Nitrate on Time Trial Performance in Handcycling

Auteurs: Flueck, Joelle Leonie; Gallo, Alessandro; Moelijker, Nynke; Bogdanov, Nikolay; Bogdanova, Anna; Perret, Claudio
Publié dans: Nutrients, Numéro 11(7), 2019, Page(s) 1642, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3929/ethz-b-000360090

Red Blood Cell Passage of Small Capillaries Is Associated with Transient Ca2+-mediated Adaptations

Auteurs: Jens G. Danielczok, Emmanuel Terriac, Laura Hertz, Polina Petkova-Kirova, Franziska Lautenschläger, Matthias W. Laschke, Lars Kaestner
Publié dans: Frontiers in Physiology, Numéro 8, 2017, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2017.00979

Three-dimensional light sculpting using a geometric analysis

Auteurs: Andrew Bañas, Einstom Engay, Ada-Ioana Bunea, Stephen Daedalus Separa, Jesper Glückstad
Publié dans: Optics Communications, Numéro 431, 2019, Page(s) 210-215, ISSN 0030-4018
Éditeur: Elsevier BV
DOI: 10.1016/j.optcom.2018.09.036

Point spread function shaping using geometric analysis

Auteurs: Andrew Bañas, Stephen Daedalus Separa, Einstom Engay, Jesper Glückstad
Publié dans: Optics Communications, Numéro 427, 2018, Page(s) 522-527, ISSN 0030-4018
Éditeur: Elsevier BV
DOI: 10.1016/j.optcom.2018.06.068

The Evolution of Erythrocytes Becoming Red in Respect to Fluorescence

Auteurs: Laura Hertz, Sandra Ruppenthal, Greta Simionato, Stephan Quint, Alexander Kihm, Asena Abay, Polina Petkova-Kirova, Ulrich Boehm, Petra Weissgerber, Christian Wagner, Matthias W. Laschke, Lars Kaestner
Publié dans: Frontiers in Physiology, Numéro 10, 2019, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00753

Commentary: Voltage Gating of Mechanosensitive PIEZO Channels

Auteurs: Lars Kaestner, Stephane Egee
Publié dans: Frontiers in Physiology, Numéro 9, 2018, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.01565

Differential interaction between DARC and SDF-1 on erythrocytes and their precursors

Auteurs: T. R. L. Klei, F. Aglialoro, F. P. J. Mul, S. Tol, P. C. Ligthart, I. M. Seignette, J. Geissler, E. van den Akker, R. van Bruggen
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-52186-6

PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis

Auteurs: Pedro L. Moura, Bethan R. Hawley, Johannes G.G. Dobbe, Geert J. Streekstra, Minke A.E. Rab, Paola Bianchi, Richard van Wijk, Ashley M. Toye, Timothy J. Satchwell
Publié dans: Haematologica, 2019, Page(s) haematol.2019.231159, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.231159

Reticulocyte and red blood cell deformation triggers specific phosphorylation events

Auteurs: Pedro L. Moura, Maria A. Lizarralde Iragorri, Olivier Français, Bruno Le Pioufle, Johannes G. G. Dobbe, Geert J. Streekstra, Wassim El Nemer, Ashley M. Toye, Timothy J. Satchwell
Publié dans: Blood Advances, Numéro 3/17, 2019, Page(s) 2653-2663, ISSN 2473-9529
Éditeur: The American Society of Hematology
DOI: 10.1182/bloodadvances.2019000545

Non-muscle myosin II drives vesicle loss during human reticulocyte maturation

Auteurs: Pedro L. Moura, Bethan R. Hawley, Tosti J. Mankelow, Rebecca E. Griffiths, Johannes G.G. Dobbe, Geert J. Streekstra, David J. Anstee, Timothy J. Satchwell, Ashley M. Toye
Publié dans: Haematologica, Numéro 103/12, 2018, Page(s) 1997-2007, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.199083

Impact of a 10 km running trial on eryptosis, red blood cell rheology, and electrophysiology in endurance trained athletes: a pilot study

Auteurs: Elie Nader, David Monedero, Mélanie Robert, Sarah Skinner, Emeric Stauffer, Agnès Cibiel, Michèle Germain, Jules Hugonnet, Alexander Scheer, Philippe Joly, Céline Renoux, Philippe Connes, Stéphane Égée
Publié dans: European Journal of Applied Physiology, Numéro 120/1, 2020, Page(s) 255-266, ISSN 1439-6319
Éditeur: Springer Verlag
DOI: 10.1007/s00421-019-04271-x

Circular RNA expression in human hematopoietic cells is widespread and cell-type specific

Auteurs: Benoit P Nicolet, Sander Engels, Francesca Aglialoro, Emile van den Akker, Marieke von Lindern, Monika C Wolkers
Publié dans: Nucleic Acids Research, Numéro 46/16, 2018, Page(s) 8168-8180, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gky721

Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors

Auteurs: Nahuel A. Paolini, Kat S. Moore, Franca M. di Summa, Ivo F. A. C. Fokkema, Peter A. C. ‘t Hoen, Marieke von Lindern
Publié dans: PLOS ONE, Numéro 13/4, 2018, Page(s) e0193790, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0193790

Red Blood Cells: Chasing Interactions

Auteurs: Virginia Pretini, Mischa H. Koenen, Lars Kaestner, Marcel H. A. M. Fens, Raymond M. Schiffelers, Marije Bartels, Richard Van Wijk
Publié dans: Frontiers in Physiology, Numéro 10, 2019, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00945

Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements

Auteurs: Timothy J. Satchwell, Katherine E. Wright, Katy L. Haydn-Smith, Fernando Sánchez-Román Terán, Pedro L. Moura, Joseph Hawksworth, Jan Frayne, Ashley M. Toye, Jake Baum
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-11790-w

A novel gain-of-function mutation of Piezo1 is functionally affirmed in red blood cells by high-throughput patch clamp

Auteurs: Giustina M. Rotordam, Elisa Fermo, Nadine Becker, Wilma Barcellini, Andrea Brüggemann, Niels Fertig, Stéphane Egée, Markus Rapedius, Paola Bianchi, Lars Kaestner
Publié dans: Haematologica, Numéro 103/10, 2018, Page(s) haematol.2018.201160, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.201160

NMDA receptor activity in circulating red blood cells: methods of detection

Auteurs: Makhro, Asya; Kaestner, Lars; Bogdanova, Anna
Publié dans: Makhro, Asya; Kaestner, Lars; Bogdanova, Anna (2017). NMDA receptor activity in circulating red blood cells: methods of detection. In: Burnashev, Nail; Szepetowski, Pierre. NMDA Receptors. Hatfield, Hertfordshire, UK: Springer, 265-282., Numéro 1, 2017
Éditeur: Springer
DOI: 10.5167/uzh-140866

Droits de propriété intellectuelle

CLASSIFICATION, SCREENING AND DIAGNOSTIC METHODS AND APPARATUS

Numéro de demande/publication: 20 18072127
Date: 2018-08-15
Demandeur(s): UNIVERSITAT ZURICH

MICROFLUIDIC DEVICE AND APPARATUS

Numéro de demande/publication: 20 18050992
Date: 2018-04-16
Demandeur(s): EPIGEM LIMITED

CLASSIFICATION, SCREENING AND DIAGNOSTIC METHODS AND APPARATUS

Numéro de demande/publication: 20 18072127
Date: 2018-08-15
Demandeur(s): EPIGEM LIMITED

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Publications

Droits de propriété intellectuelle

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