Regulation of red cell life-span, erythropoiesis, survival, senescence and clearance

Informazioni relative al progetto

RELEVANCE

ID dell’accordo di sovvenzione: 675115

DOI

10.3030/675115

Progetto chiuso

Data della firma CE 3 Agosto 2015

Data di avvio 1 Settembre 2015

Data di completamento 30 Novembre 2019

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 852 126,97

Contributo UE

€ 3 852 126,97

Coordinato da

UNIVERSITAT ZURICH
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (2)

Training Schools

Further training schools to be held in M20, M18, M40

Dissemination Toolkit

Templates for presentations, posters, for meeting and internal documents will be provided to all partners.

Documents, reports (1)

Outreach activities

Further reports on outreach activities to be submitted in M28, M40

Websites, patent fillings, videos etc. (1)

Website

The website will serve as an additional showcase for presenting the project's achievements and activities.

Pubblicazioni

Peer reviewed articles (35)

The potential of erythrocytes as cellular aging models

Autori: Lars Kaestner, Giampaolo Minetti
Pubblicato in: Cell Death and Differentiation, Numero 24/9, 2017, Pagina/e 1475-1477, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/cdd.2017.100

The buckling instability of aggregating red blood cells

Autori: Daniel Flormann, Othmane Aouane, Lars Kaestner, Christian Ruloff, Chaouqi Misbah, Thomas Podgorski, Christian Wagner
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-07634-6

Is Increased Intracellular Calcium in Red Blood Cells a Common Component in the Molecular Mechanism Causing Anemia?

Autori: Laura Hertz, Rick Huisjes, Esther Llaudet-Planas, Polina Petkova-Kirova, Asya Makhro, Jens G. Danielczok, Stephane Egee, Maria del Mar Mañú-Pereira, Richard van Wijk, Joan-Lluis Vives Corrons, Anna Bogdanova, Lars Kaestner
Pubblicato in: Frontiers in Physiology, Numero 8, 2017, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2017.00673

Membrane Remodelling and Vesicle Formation During Ageing of Human Red Blood Cells

Autori: Annarita Ciana, Cesare Achilli, Anjali Gaur, Giampaolo Minetti
Pubblicato in: Cellular Physiology and Biochemistry, Numero 42/3, 2017, Pagina/e 1127-1138, ISSN 1015-8987
Editore: S. Karger AG
DOI: 10.1159/000478768

Does Erythropoietin Regulate TRPC Channels in Red Blood Cells?

Autori: Jens Danielczok, Laura Hertz, Sandra Ruppenthal, Elisabeth Kaiser, Polina Petkova-Kirova, Anna Bogdanova, Elmar Krause, Peter Lipp, Marc Freichel, Lars Kaestner, Lutz Birnbaumer
Pubblicato in: Cellular Physiology and Biochemistry, Numero 41/3, 2017, Pagina/e 1219-1228, ISSN 1015-8987
Editore: S. Karger AG
DOI: 10.1159/000464384

DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism

Autori: Elina Ovchynnikova, Francesca Aglialoro, Arthur E. H. Bentlage, Gestur Vidarsson, Nichole D. Salinas, Marieke von Lindern, Niraj H. Tolia, Emile van den Akker
Pubblicato in: Blood, Numero 130/12, 2017, Pagina/e 1441-1444, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2017-03-774364

Gardos Channelopathy: a variant of hereditary Stomatocytosis with complex molecular regulation

Autori: Elisa Fermo; Anna Bogdanova; Polina Petkova-Kirova; Anna Zaninoni; Anna Paola Marcello; Asya Makhro; Pascal Hänggi; Laura Hertz; Jens Danielczok; Cristina Vercellati; Nadia Mirra; Alberto Zanella; Agostino Cortelezzi; Wilma Barcellini; Lars Kaestner; Paola Bianchi
Pubblicato in: Fermo, Elisa; Bogdanova, Anna; Petkova-Kirova, Polina; Zaninoni, Anna; Marcello, Anna Paola; Makhro, Asya; Hänggi, Pascal; Hertz, Laura; Danielczok, Jens; Vercellati, Cristina; Mirra, Nadia; Zanella, Alberto; Cortelezzi, Agostino; Barcellini, Wilma; Kaestner, Lars; Bianchi, Paola (2017). Gardos Channelopathy: a variant of hereditary Stomatocytosis with complex molecular regulation. Scientific Rep, Numero 1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.5167/uzh-137952

Comparing the impact of an acute exercise bout on plasma amino acid composition, intraerythrocytic Ca2+ handling, and red cell function in athletes and untrained subjects

Autori: Asya Makhro, Thomas Haider, Jue Wang, Nikolay Bogdanov, Patrick Steffen, Christian Wagner, Tim Meyer, Max Gassmann, Anne Hecksteden, Lars Kaestner, Anna Bogdanova
Pubblicato in: Cell Calcium, Numero 60/4, 2016, Pagina/e 235-244, ISSN 0143-4160
Editore: Churchill Livingstone
DOI: 10.1016/j.ceca.2016.05.005

The Molecular Structure of Human Red Blood Cell Membranes from Highly Oriented, Solid Supported Multi-Lamellar Membranes

Autori: Sebastian Himbert, Richard J. Alsop, Markus Rose, Laura Hertz, Alexander Dhaliwal, Jose M. Moran-Mirabal, Chris P. Verschoor, Dawn M. E. Bowdish, Lars Kaestner, Christian Wagner, Maikel C. Rheinstädter
Pubblicato in: Scientific Reports, Numero 7, 2017, Pagina/e 39661, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep39661

Spectrin and Other Membrane-Skeletal Components in Human Red Blood Cells of Different Age

Autori: Annarita Ciana, Cesare Achilli, Giampaolo Minetti
Pubblicato in: Cellular Physiology and Biochemistry, Numero 42/3, 2017, Pagina/e 1139-1152, ISSN 1015-8987
Editore: S. Karger AG
DOI: 10.1159/000478769

Novel Insights in the Regulation of Phosphatidylserine Exposure in Human Red Blood Cells

Autori: Mauro C. Wesseling, Lisa Wagner-Britz, Duc Bach Nguyen, Salome Asanidze, Judy Mutua, Nagla Mohamed, Benjamin Hanf, Mehrdad Ghashghaeinia, Lars Kaestner, Ingolf Bernhardt
Pubblicato in: Cellular Physiology and Biochemistry, Numero 39/5, 2016, Pagina/e 1941-1954, ISSN 1015-8987
Editore: S. Karger AG
DOI: 10.1159/000447891

Impact of hydroxycarbamide and interferon-α on red cell adhesion and membrane protein expression in polycythemia vera

Autori: Mégane Brusson, Maria De Grandis, Sylvie Cochet, Sylvain Bigot, Mickaël Marin, Marjorie Leduc, François Guillonneau, Patrick Mayeux, Thierry Peyrard, Christine Chomienne, Caroline Le Van Kim, Bruno Cassinat, Jean-Jacques Kiladjian, Wassim El Nemer
Pubblicato in: Haematologica, Numero 103/6, 2018, Pagina/e 972-981, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2017.182303

Continuous Change in Membrane and Membrane-Skeleton Organization During Development From Proerythroblast to Senescent Red Blood Cell

Autori: Giampaolo Minetti, Cesare Achilli, Cesare Perotti, Annarita Ciana
Pubblicato in: Frontiers in Physiology, Numero 9, 2018, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00286

Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis

Autori: Rick Huisjes, Asya Makhro, Esther Llaudet-Planas, Laura Hertz, Polina Petkova-Kirova, Liesbeth P Verhagen, Silvia Pignatelli, Minke AE Rab, Raymond M Schiffelers, Elena Seiler, Wouter W van Solinge, Joan-LLuis Vives Corrons, Maria Mañú-Pereira, Lars Kaestner, Anna Bogdanova, Richard van Wijk
Pubblicato in: Haematologica, 2019, Pagina/e haematol.2018.188151, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.188151

Glutaraldehyde – A Subtle Tool in the Investigation of Healthy and Pathologic Red Blood Cells

Autori: Asena Abay, Greta Simionato, Revaz Chachanidze, Anna Bogdanova, Laura Hertz, Paola Bianchi, Emile van den Akker, Marieke von Lindern, Marc Leonetti, Giampaolo Minetti, Christian Wagner, Lars Kaestner
Pubblicato in: Frontiers in Physiology, Numero 10, 2019, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00514

The Shape Shifting Story of Reticulocyte Maturation

Autori: Elina Ovchynnikova, Francesca Aglialoro, Marieke von Lindern, Emile van den Akker
Pubblicato in: Frontiers in Physiology, Numero 9, 2018, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00829

Editorial: The Red Cell Life-Cycle From Erythropoiesis to Clearance

Autori: Lars Kaestner, Anna Bogdanova
Pubblicato in: Frontiers in Physiology, Numero 9, 2018, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.01537

A Previously Unrecognized Ca2+-inhibited Nonselective Cation Channel in Red Blood Cells

Autori: Polina Petkova-Kirova, Laura Hertz, Asya Makhro, Jens Danielczok, Rick Huisjes, Esther Llaudet-Planas, Maria del Mar Mañú-Pereira, Joan-Luis Vives Corrons, Richard van Wijk, Anna Bogdanova, Lars Kaestner
Pubblicato in: HemaSphere, Numero 2/5, 2018, Pagina/e e146, ISSN 2572-9241
Editore: Open acccess journal of the European Hematology Association
DOI: 10.1097/HS9.0000000000000146

Voltage-Activated Ion Channels in Non-excitable Cells—A Viewpoint Regarding Their Physiological Justification

Autori: Lars Kaestner, Xijia Wang, Laura Hertz, Ingolf Bernhardt
Pubblicato in: Frontiers in Physiology, Numero 9, 2018, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00450

Classification of red blood cell shapes in flow using outlier tolerant machine learning

Autori: Alexander Kihm, Lars Kaestner, Christian Wagner, Stephan Quint
Pubblicato in: PLOS Computational Biology, Numero 14/6, 2018, Pagina/e e1006278, ISSN 1553-7358
Editore: San Francisco CA: Public Library of Science
DOI: 10.1371/journal.pcbi.1006278

Influence of Equimolar Doses of Beetroot Juice and Sodium Nitrate on Time Trial Performance in Handcycling

Autori: Flueck, Joelle Leonie; Gallo, Alessandro; Moelijker, Nynke; Bogdanov, Nikolay; Bogdanova, Anna; Perret, Claudio
Pubblicato in: Nutrients, Numero 11(7), 2019, Pagina/e 1642, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3929/ethz-b-000360090

Red Blood Cell Passage of Small Capillaries Is Associated with Transient Ca2+-mediated Adaptations

Autori: Jens G. Danielczok, Emmanuel Terriac, Laura Hertz, Polina Petkova-Kirova, Franziska Lautenschläger, Matthias W. Laschke, Lars Kaestner
Pubblicato in: Frontiers in Physiology, Numero 8, 2017, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2017.00979

Three-dimensional light sculpting using a geometric analysis

Autori: Andrew Bañas, Einstom Engay, Ada-Ioana Bunea, Stephen Daedalus Separa, Jesper Glückstad
Pubblicato in: Optics Communications, Numero 431, 2019, Pagina/e 210-215, ISSN 0030-4018
Editore: Elsevier BV
DOI: 10.1016/j.optcom.2018.09.036

Point spread function shaping using geometric analysis

Autori: Andrew Bañas, Stephen Daedalus Separa, Einstom Engay, Jesper Glückstad
Pubblicato in: Optics Communications, Numero 427, 2018, Pagina/e 522-527, ISSN 0030-4018
Editore: Elsevier BV
DOI: 10.1016/j.optcom.2018.06.068

The Evolution of Erythrocytes Becoming Red in Respect to Fluorescence

Autori: Laura Hertz, Sandra Ruppenthal, Greta Simionato, Stephan Quint, Alexander Kihm, Asena Abay, Polina Petkova-Kirova, Ulrich Boehm, Petra Weissgerber, Christian Wagner, Matthias W. Laschke, Lars Kaestner
Pubblicato in: Frontiers in Physiology, Numero 10, 2019, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00753

Commentary: Voltage Gating of Mechanosensitive PIEZO Channels

Autori: Lars Kaestner, Stephane Egee
Pubblicato in: Frontiers in Physiology, Numero 9, 2018, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.01565

Differential interaction between DARC and SDF-1 on erythrocytes and their precursors

Autori: T. R. L. Klei, F. Aglialoro, F. P. J. Mul, S. Tol, P. C. Ligthart, I. M. Seignette, J. Geissler, E. van den Akker, R. van Bruggen
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-52186-6

PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis

Autori: Pedro L. Moura, Bethan R. Hawley, Johannes G.G. Dobbe, Geert J. Streekstra, Minke A.E. Rab, Paola Bianchi, Richard van Wijk, Ashley M. Toye, Timothy J. Satchwell
Pubblicato in: Haematologica, 2019, Pagina/e haematol.2019.231159, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.231159

Reticulocyte and red blood cell deformation triggers specific phosphorylation events

Autori: Pedro L. Moura, Maria A. Lizarralde Iragorri, Olivier Français, Bruno Le Pioufle, Johannes G. G. Dobbe, Geert J. Streekstra, Wassim El Nemer, Ashley M. Toye, Timothy J. Satchwell
Pubblicato in: Blood Advances, Numero 3/17, 2019, Pagina/e 2653-2663, ISSN 2473-9529
Editore: The American Society of Hematology
DOI: 10.1182/bloodadvances.2019000545

Non-muscle myosin II drives vesicle loss during human reticulocyte maturation

Autori: Pedro L. Moura, Bethan R. Hawley, Tosti J. Mankelow, Rebecca E. Griffiths, Johannes G.G. Dobbe, Geert J. Streekstra, David J. Anstee, Timothy J. Satchwell, Ashley M. Toye
Pubblicato in: Haematologica, Numero 103/12, 2018, Pagina/e 1997-2007, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.199083

Impact of a 10 km running trial on eryptosis, red blood cell rheology, and electrophysiology in endurance trained athletes: a pilot study

Autori: Elie Nader, David Monedero, Mélanie Robert, Sarah Skinner, Emeric Stauffer, Agnès Cibiel, Michèle Germain, Jules Hugonnet, Alexander Scheer, Philippe Joly, Céline Renoux, Philippe Connes, Stéphane Égée
Pubblicato in: European Journal of Applied Physiology, Numero 120/1, 2020, Pagina/e 255-266, ISSN 1439-6319
Editore: Springer Verlag
DOI: 10.1007/s00421-019-04271-x

Circular RNA expression in human hematopoietic cells is widespread and cell-type specific

Autori: Benoit P Nicolet, Sander Engels, Francesca Aglialoro, Emile van den Akker, Marieke von Lindern, Monika C Wolkers
Pubblicato in: Nucleic Acids Research, Numero 46/16, 2018, Pagina/e 8168-8180, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gky721

Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors

Autori: Nahuel A. Paolini, Kat S. Moore, Franca M. di Summa, Ivo F. A. C. Fokkema, Peter A. C. ‘t Hoen, Marieke von Lindern
Pubblicato in: PLOS ONE, Numero 13/4, 2018, Pagina/e e0193790, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0193790

Red Blood Cells: Chasing Interactions

Autori: Virginia Pretini, Mischa H. Koenen, Lars Kaestner, Marcel H. A. M. Fens, Raymond M. Schiffelers, Marije Bartels, Richard Van Wijk
Pubblicato in: Frontiers in Physiology, Numero 10, 2019, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00945

Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements

Autori: Timothy J. Satchwell, Katherine E. Wright, Katy L. Haydn-Smith, Fernando Sánchez-Román Terán, Pedro L. Moura, Joseph Hawksworth, Jan Frayne, Ashley M. Toye, Jake Baum
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-11790-w

Other (1)

A novel gain-of-function mutation of Piezo1 is functionally affirmed in red blood cells by high-throughput patch clamp

Autori: Giustina M. Rotordam, Elisa Fermo, Nadine Becker, Wilma Barcellini, Andrea Brüggemann, Niels Fertig, Stéphane Egée, Markus Rapedius, Paola Bianchi, Lars Kaestner
Pubblicato in: Haematologica, Numero 103/10, 2018, Pagina/e haematol.2018.201160, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.201160

Book chapters (1)

NMDA receptor activity in circulating red blood cells: methods of detection

Autori: Makhro, Asya; Kaestner, Lars; Bogdanova, Anna
Pubblicato in: Makhro, Asya; Kaestner, Lars; Bogdanova, Anna (2017). NMDA receptor activity in circulating red blood cells: methods of detection. In: Burnashev, Nail; Szepetowski, Pierre. NMDA Receptors. Hatfield, Hertfordshire, UK: Springer, 265-282., Numero 1, 2017
Editore: Springer
DOI: 10.5167/uzh-140866

Diritti di proprietà intellettuale

Patent (3)

CLASSIFICATION, SCREENING AND DIAGNOSTIC METHODS AND APPARATUS

Numero candidatura/pubblicazione: 20 18072127
Data: 2018-08-15
Candidato/i: EPIGEM LIMITED

MICROFLUIDIC DEVICE AND APPARATUS

Numero candidatura/pubblicazione: 20 18050992
Data: 2018-04-16
Candidato/i: EPIGEM LIMITED

CLASSIFICATION, SCREENING AND DIAGNOSTIC METHODS AND APPARATUS

Numero candidatura/pubblicazione: 20 18072127
Data: 2018-08-15
Candidato/i: UNIVERSITAT ZURICH