Regulation of red cell life-span, erythropoiesis, survival, senescence and clearance

Informacje na temat projektu

RELEVANCE

Identyfikator umowy o grant: 675115

DOI

10.3030/675115

Projekt został zamknięty

Data podpisania przez KE 3 Sierpnia 2015

Data rozpoczęcia 1 Września 2015

Data zakończenia 30 Listopada 2019

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 3 852 126,97

Wkład UE

€ 3 852 126,97

Koordynowany przez

UNIVERSITAT ZURICH
Switzerland

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Other (2)

Training Schools

Further training schools to be held in M20, M18, M40

Dissemination Toolkit

Templates for presentations, posters, for meeting and internal documents will be provided to all partners.

Documents, reports (1)

Outreach activities

Further reports on outreach activities to be submitted in M28, M40

Websites, patent fillings, videos etc. (1)

Website

The website will serve as an additional showcase for presenting the project's achievements and activities.

Publikacje

Peer reviewed articles (35)

The potential of erythrocytes as cellular aging models

Autorzy: Lars Kaestner, Giampaolo Minetti
Opublikowane w: Cell Death and Differentiation, Numer 24/9, 2017, Strona(/y) 1475-1477, ISSN 1350-9047
Wydawca: Nature Publishing Group
DOI: 10.1038/cdd.2017.100

The buckling instability of aggregating red blood cells

Autorzy: Daniel Flormann, Othmane Aouane, Lars Kaestner, Christian Ruloff, Chaouqi Misbah, Thomas Podgorski, Christian Wagner
Opublikowane w: Scientific Reports, Numer 7/1, 2017, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-017-07634-6

Is Increased Intracellular Calcium in Red Blood Cells a Common Component in the Molecular Mechanism Causing Anemia?

Autorzy: Laura Hertz, Rick Huisjes, Esther Llaudet-Planas, Polina Petkova-Kirova, Asya Makhro, Jens G. Danielczok, Stephane Egee, Maria del Mar Mañú-Pereira, Richard van Wijk, Joan-Lluis Vives Corrons, Anna Bogdanova, Lars Kaestner
Opublikowane w: Frontiers in Physiology, Numer 8, 2017, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2017.00673

Membrane Remodelling and Vesicle Formation During Ageing of Human Red Blood Cells

Autorzy: Annarita Ciana, Cesare Achilli, Anjali Gaur, Giampaolo Minetti
Opublikowane w: Cellular Physiology and Biochemistry, Numer 42/3, 2017, Strona(/y) 1127-1138, ISSN 1015-8987
Wydawca: S. Karger AG
DOI: 10.1159/000478768

Does Erythropoietin Regulate TRPC Channels in Red Blood Cells?

Autorzy: Jens Danielczok, Laura Hertz, Sandra Ruppenthal, Elisabeth Kaiser, Polina Petkova-Kirova, Anna Bogdanova, Elmar Krause, Peter Lipp, Marc Freichel, Lars Kaestner, Lutz Birnbaumer
Opublikowane w: Cellular Physiology and Biochemistry, Numer 41/3, 2017, Strona(/y) 1219-1228, ISSN 1015-8987
Wydawca: S. Karger AG
DOI: 10.1159/000464384

DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism

Autorzy: Elina Ovchynnikova, Francesca Aglialoro, Arthur E. H. Bentlage, Gestur Vidarsson, Nichole D. Salinas, Marieke von Lindern, Niraj H. Tolia, Emile van den Akker
Opublikowane w: Blood, Numer 130/12, 2017, Strona(/y) 1441-1444, ISSN 0006-4971
Wydawca: American Society of Hematology
DOI: 10.1182/blood-2017-03-774364

Gardos Channelopathy: a variant of hereditary Stomatocytosis with complex molecular regulation

Autorzy: Elisa Fermo; Anna Bogdanova; Polina Petkova-Kirova; Anna Zaninoni; Anna Paola Marcello; Asya Makhro; Pascal Hänggi; Laura Hertz; Jens Danielczok; Cristina Vercellati; Nadia Mirra; Alberto Zanella; Agostino Cortelezzi; Wilma Barcellini; Lars Kaestner; Paola Bianchi
Opublikowane w: Fermo, Elisa; Bogdanova, Anna; Petkova-Kirova, Polina; Zaninoni, Anna; Marcello, Anna Paola; Makhro, Asya; Hänggi, Pascal; Hertz, Laura; Danielczok, Jens; Vercellati, Cristina; Mirra, Nadia; Zanella, Alberto; Cortelezzi, Agostino; Barcellini, Wilma; Kaestner, Lars; Bianchi, Paola (2017). Gardos Channelopathy: a variant of hereditary Stomatocytosis with complex molecular regulation. Scientific Rep, Numer 1, 2017, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.5167/uzh-137952

Comparing the impact of an acute exercise bout on plasma amino acid composition, intraerythrocytic Ca2+ handling, and red cell function in athletes and untrained subjects

Autorzy: Asya Makhro, Thomas Haider, Jue Wang, Nikolay Bogdanov, Patrick Steffen, Christian Wagner, Tim Meyer, Max Gassmann, Anne Hecksteden, Lars Kaestner, Anna Bogdanova
Opublikowane w: Cell Calcium, Numer 60/4, 2016, Strona(/y) 235-244, ISSN 0143-4160
Wydawca: Churchill Livingstone
DOI: 10.1016/j.ceca.2016.05.005

The Molecular Structure of Human Red Blood Cell Membranes from Highly Oriented, Solid Supported Multi-Lamellar Membranes

Autorzy: Sebastian Himbert, Richard J. Alsop, Markus Rose, Laura Hertz, Alexander Dhaliwal, Jose M. Moran-Mirabal, Chris P. Verschoor, Dawn M. E. Bowdish, Lars Kaestner, Christian Wagner, Maikel C. Rheinstädter
Opublikowane w: Scientific Reports, Numer 7, 2017, Strona(/y) 39661, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/srep39661

Spectrin and Other Membrane-Skeletal Components in Human Red Blood Cells of Different Age

Autorzy: Annarita Ciana, Cesare Achilli, Giampaolo Minetti
Opublikowane w: Cellular Physiology and Biochemistry, Numer 42/3, 2017, Strona(/y) 1139-1152, ISSN 1015-8987
Wydawca: S. Karger AG
DOI: 10.1159/000478769

Novel Insights in the Regulation of Phosphatidylserine Exposure in Human Red Blood Cells

Autorzy: Mauro C. Wesseling, Lisa Wagner-Britz, Duc Bach Nguyen, Salome Asanidze, Judy Mutua, Nagla Mohamed, Benjamin Hanf, Mehrdad Ghashghaeinia, Lars Kaestner, Ingolf Bernhardt
Opublikowane w: Cellular Physiology and Biochemistry, Numer 39/5, 2016, Strona(/y) 1941-1954, ISSN 1015-8987
Wydawca: S. Karger AG
DOI: 10.1159/000447891

Impact of hydroxycarbamide and interferon-α on red cell adhesion and membrane protein expression in polycythemia vera

Autorzy: Mégane Brusson, Maria De Grandis, Sylvie Cochet, Sylvain Bigot, Mickaël Marin, Marjorie Leduc, François Guillonneau, Patrick Mayeux, Thierry Peyrard, Christine Chomienne, Caroline Le Van Kim, Bruno Cassinat, Jean-Jacques Kiladjian, Wassim El Nemer
Opublikowane w: Haematologica, Numer 103/6, 2018, Strona(/y) 972-981, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2017.182303

Continuous Change in Membrane and Membrane-Skeleton Organization During Development From Proerythroblast to Senescent Red Blood Cell

Autorzy: Giampaolo Minetti, Cesare Achilli, Cesare Perotti, Annarita Ciana
Opublikowane w: Frontiers in Physiology, Numer 9, 2018, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00286

Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis

Autorzy: Rick Huisjes, Asya Makhro, Esther Llaudet-Planas, Laura Hertz, Polina Petkova-Kirova, Liesbeth P Verhagen, Silvia Pignatelli, Minke AE Rab, Raymond M Schiffelers, Elena Seiler, Wouter W van Solinge, Joan-LLuis Vives Corrons, Maria Mañú-Pereira, Lars Kaestner, Anna Bogdanova, Richard van Wijk
Opublikowane w: Haematologica, 2019, Strona(/y) haematol.2018.188151, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.188151

Glutaraldehyde – A Subtle Tool in the Investigation of Healthy and Pathologic Red Blood Cells

Autorzy: Asena Abay, Greta Simionato, Revaz Chachanidze, Anna Bogdanova, Laura Hertz, Paola Bianchi, Emile van den Akker, Marieke von Lindern, Marc Leonetti, Giampaolo Minetti, Christian Wagner, Lars Kaestner
Opublikowane w: Frontiers in Physiology, Numer 10, 2019, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00514

The Shape Shifting Story of Reticulocyte Maturation

Autorzy: Elina Ovchynnikova, Francesca Aglialoro, Marieke von Lindern, Emile van den Akker
Opublikowane w: Frontiers in Physiology, Numer 9, 2018, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00829

Editorial: The Red Cell Life-Cycle From Erythropoiesis to Clearance

Autorzy: Lars Kaestner, Anna Bogdanova
Opublikowane w: Frontiers in Physiology, Numer 9, 2018, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.01537

A Previously Unrecognized Ca2+-inhibited Nonselective Cation Channel in Red Blood Cells

Autorzy: Polina Petkova-Kirova, Laura Hertz, Asya Makhro, Jens Danielczok, Rick Huisjes, Esther Llaudet-Planas, Maria del Mar Mañú-Pereira, Joan-Luis Vives Corrons, Richard van Wijk, Anna Bogdanova, Lars Kaestner
Opublikowane w: HemaSphere, Numer 2/5, 2018, Strona(/y) e146, ISSN 2572-9241
Wydawca: Open acccess journal of the European Hematology Association
DOI: 10.1097/HS9.0000000000000146

Voltage-Activated Ion Channels in Non-excitable Cells—A Viewpoint Regarding Their Physiological Justification

Autorzy: Lars Kaestner, Xijia Wang, Laura Hertz, Ingolf Bernhardt
Opublikowane w: Frontiers in Physiology, Numer 9, 2018, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00450

Classification of red blood cell shapes in flow using outlier tolerant machine learning

Autorzy: Alexander Kihm, Lars Kaestner, Christian Wagner, Stephan Quint
Opublikowane w: PLOS Computational Biology, Numer 14/6, 2018, Strona(/y) e1006278, ISSN 1553-7358
Wydawca: San Francisco CA: Public Library of Science
DOI: 10.1371/journal.pcbi.1006278

Influence of Equimolar Doses of Beetroot Juice and Sodium Nitrate on Time Trial Performance in Handcycling

Autorzy: Flueck, Joelle Leonie; Gallo, Alessandro; Moelijker, Nynke; Bogdanov, Nikolay; Bogdanova, Anna; Perret, Claudio
Opublikowane w: Nutrients, Numer 11(7), 2019, Strona(/y) 1642, ISSN 2072-6643
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3929/ethz-b-000360090

Red Blood Cell Passage of Small Capillaries Is Associated with Transient Ca2+-mediated Adaptations

Autorzy: Jens G. Danielczok, Emmanuel Terriac, Laura Hertz, Polina Petkova-Kirova, Franziska Lautenschläger, Matthias W. Laschke, Lars Kaestner
Opublikowane w: Frontiers in Physiology, Numer 8, 2017, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2017.00979

Three-dimensional light sculpting using a geometric analysis

Autorzy: Andrew Bañas, Einstom Engay, Ada-Ioana Bunea, Stephen Daedalus Separa, Jesper Glückstad
Opublikowane w: Optics Communications, Numer 431, 2019, Strona(/y) 210-215, ISSN 0030-4018
Wydawca: Elsevier BV
DOI: 10.1016/j.optcom.2018.09.036

Point spread function shaping using geometric analysis

Autorzy: Andrew Bañas, Stephen Daedalus Separa, Einstom Engay, Jesper Glückstad
Opublikowane w: Optics Communications, Numer 427, 2018, Strona(/y) 522-527, ISSN 0030-4018
Wydawca: Elsevier BV
DOI: 10.1016/j.optcom.2018.06.068

The Evolution of Erythrocytes Becoming Red in Respect to Fluorescence

Autorzy: Laura Hertz, Sandra Ruppenthal, Greta Simionato, Stephan Quint, Alexander Kihm, Asena Abay, Polina Petkova-Kirova, Ulrich Boehm, Petra Weissgerber, Christian Wagner, Matthias W. Laschke, Lars Kaestner
Opublikowane w: Frontiers in Physiology, Numer 10, 2019, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00753

Commentary: Voltage Gating of Mechanosensitive PIEZO Channels

Autorzy: Lars Kaestner, Stephane Egee
Opublikowane w: Frontiers in Physiology, Numer 9, 2018, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.01565

Differential interaction between DARC and SDF-1 on erythrocytes and their precursors

Autorzy: T. R. L. Klei, F. Aglialoro, F. P. J. Mul, S. Tol, P. C. Ligthart, I. M. Seignette, J. Geissler, E. van den Akker, R. van Bruggen
Opublikowane w: Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-52186-6

PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis

Autorzy: Pedro L. Moura, Bethan R. Hawley, Johannes G.G. Dobbe, Geert J. Streekstra, Minke A.E. Rab, Paola Bianchi, Richard van Wijk, Ashley M. Toye, Timothy J. Satchwell
Opublikowane w: Haematologica, 2019, Strona(/y) haematol.2019.231159, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.231159

Reticulocyte and red blood cell deformation triggers specific phosphorylation events

Autorzy: Pedro L. Moura, Maria A. Lizarralde Iragorri, Olivier Français, Bruno Le Pioufle, Johannes G. G. Dobbe, Geert J. Streekstra, Wassim El Nemer, Ashley M. Toye, Timothy J. Satchwell
Opublikowane w: Blood Advances, Numer 3/17, 2019, Strona(/y) 2653-2663, ISSN 2473-9529
Wydawca: The American Society of Hematology
DOI: 10.1182/bloodadvances.2019000545

Non-muscle myosin II drives vesicle loss during human reticulocyte maturation

Autorzy: Pedro L. Moura, Bethan R. Hawley, Tosti J. Mankelow, Rebecca E. Griffiths, Johannes G.G. Dobbe, Geert J. Streekstra, David J. Anstee, Timothy J. Satchwell, Ashley M. Toye
Opublikowane w: Haematologica, Numer 103/12, 2018, Strona(/y) 1997-2007, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.199083

Impact of a 10 km running trial on eryptosis, red blood cell rheology, and electrophysiology in endurance trained athletes: a pilot study

Autorzy: Elie Nader, David Monedero, Mélanie Robert, Sarah Skinner, Emeric Stauffer, Agnès Cibiel, Michèle Germain, Jules Hugonnet, Alexander Scheer, Philippe Joly, Céline Renoux, Philippe Connes, Stéphane Égée
Opublikowane w: European Journal of Applied Physiology, Numer 120/1, 2020, Strona(/y) 255-266, ISSN 1439-6319
Wydawca: Springer Verlag
DOI: 10.1007/s00421-019-04271-x

Circular RNA expression in human hematopoietic cells is widespread and cell-type specific

Autorzy: Benoit P Nicolet, Sander Engels, Francesca Aglialoro, Emile van den Akker, Marieke von Lindern, Monika C Wolkers
Opublikowane w: Nucleic Acids Research, Numer 46/16, 2018, Strona(/y) 8168-8180, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gky721

Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors

Autorzy: Nahuel A. Paolini, Kat S. Moore, Franca M. di Summa, Ivo F. A. C. Fokkema, Peter A. C. ‘t Hoen, Marieke von Lindern
Opublikowane w: PLOS ONE, Numer 13/4, 2018, Strona(/y) e0193790, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0193790

Red Blood Cells: Chasing Interactions

Autorzy: Virginia Pretini, Mischa H. Koenen, Lars Kaestner, Marcel H. A. M. Fens, Raymond M. Schiffelers, Marije Bartels, Richard Van Wijk
Opublikowane w: Frontiers in Physiology, Numer 10, 2019, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00945

Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements

Autorzy: Timothy J. Satchwell, Katherine E. Wright, Katy L. Haydn-Smith, Fernando Sánchez-Román Terán, Pedro L. Moura, Joseph Hawksworth, Jan Frayne, Ashley M. Toye, Jake Baum
Opublikowane w: Nature Communications, Numer 10/1, 2019, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-019-11790-w

Other (1)

A novel gain-of-function mutation of Piezo1 is functionally affirmed in red blood cells by high-throughput patch clamp

Autorzy: Giustina M. Rotordam, Elisa Fermo, Nadine Becker, Wilma Barcellini, Andrea Brüggemann, Niels Fertig, Stéphane Egée, Markus Rapedius, Paola Bianchi, Lars Kaestner
Opublikowane w: Haematologica, Numer 103/10, 2018, Strona(/y) haematol.2018.201160, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.201160

Book chapters (1)

NMDA receptor activity in circulating red blood cells: methods of detection

Autorzy: Makhro, Asya; Kaestner, Lars; Bogdanova, Anna
Opublikowane w: Makhro, Asya; Kaestner, Lars; Bogdanova, Anna (2017). NMDA receptor activity in circulating red blood cells: methods of detection. In: Burnashev, Nail; Szepetowski, Pierre. NMDA Receptors. Hatfield, Hertfordshire, UK: Springer, 265-282., Numer 1, 2017
Wydawca: Springer
DOI: 10.5167/uzh-140866

Prawa własności intelektualnej

Patent (3)

CLASSIFICATION, SCREENING AND DIAGNOSTIC METHODS AND APPARATUS

Numer wniosku/publikacji: 20 18072127
Data: 2018-08-15
Wnioskodawca/wnioskodawcy: EPIGEM LIMITED

MICROFLUIDIC DEVICE AND APPARATUS

Numer wniosku/publikacji: 20 18050992
Data: 2018-04-16
Wnioskodawca/wnioskodawcy: EPIGEM LIMITED

CLASSIFICATION, SCREENING AND DIAGNOSTIC METHODS AND APPARATUS

Numer wniosku/publikacji: 20 18072127
Data: 2018-08-15
Wnioskodawca/wnioskodawcy: UNIVERSITAT ZURICH