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Targeted small-molecule Stabilisation of Protein-Protein Interactions

Deliverables

Researcher Declaration

Declaration of ESRs

Recruitment

Recruitment of ESRs for TASPPI finalized

Career Development Plan

Career Plan for all ESRs finalized

Businessplan Startup

Businessplan for the spin-off of TASPPI

Open Access Publication(s)

Publications in peer-reviewed journals

Publications

Biophysical and structural insight into the USP8/14-3-3 interaction

Author(s): Federica Centorrino, Alice Ballone, Madita Wolter, Christian Ottmann
Published in: FEBS Letters, Issue 592, 2018, Page(s) 1211-1220, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.1002/1873-3468.13017

14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2)

Author(s): Katarina Psenakova, Olivia Petrvalska, Salome Kylarova, Domenico Lentini Santo, Dana Kalabova, Petr Herman, Veronika Obsilova, Tomas Obsil
Published in: Biochimica et Biophysica Acta (BBA) - General Subjects, Issue 1862, 2018, Page(s) 1612-1625, ISSN 0304-4165
Publisher: Elsevier BV
DOI: 10.1016/j.bbagen.2018.04.006

Structural characterization of 14-3-3ζ in complex with the human Son of sevenless homolog 1 (SOS1)

Author(s): Alice Ballone, Federica Centorrino, Madita Wolter, Christian Ottmann
Published in: Journal of Structural Biology, Issue 202, 2018, Page(s) 210-215, ISSN 1047-8477
Publisher: Academic Press
DOI: 10.1016/j.jsb.2018.01.011

Backbone chemical shift assignments of human 14-3-3σ

Author(s): João Filipe Neves, Isabelle Landrieu, Hamida Merzougui, Emmanuelle Boll, Xavier Hanoulle, François-Xavier Cantrelle
Published in: Biomolecular NMR Assignments, Issue 13/1, 2019, Page(s) 103-107, ISSN 1874-2718
Publisher: Springer Verlag
DOI: 10.1007/s12104-018-9860-1

Protein X-ray crystallography of the 14-3-3ζ/SOS1 complex

Author(s): Alice Ballone, Federica Centorrino, Madita Wolter, Christian Ottmann
Published in: Data in Brief, Issue 19, 2018, Page(s) 1683-1687, ISSN 2352-3409
Publisher: Elsevier BV
DOI: 10.1016/j.dib.2018.06.060

14-3-3: A Case Study in PPI Modulation

Author(s): Alice Ballone, Federica Centorrino, Christian Ottmann
Published in: Molecules, Issue 23/6, 2018, Page(s) 1386, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23061386

Interaction of an IκBα Peptide with 14-3-3

Author(s): Madita Wolter, Domenico Lentini Santo, Petr Herman, Alice Ballone, Federica Centorrino, Tomas Obsil, Christian Ottmann
Published in: ACS Omega, Issue 5/10, 2020, Page(s) 5380-5388, ISSN 2470-1343
Publisher: ACS Publications
DOI: 10.1021/acsomega.9b04413

Allosteric activation of yeast enzyme neutral trehalase by calcium and 14-3-3 protein

Author(s): M. Alblova, A. Smidova, D. Kalabova, D. Lentini Santo, T. Obsil, V Obsilova. Obsilova
Published in: Physiological Research, Issue 68, 2019, Page(s) 147-160, ISSN 0862-8408
Publisher: Akademie Ved Ceske Republiky
DOI: 10.33549/physiolres.933950

Set-up and screening of a fragment library targeting the 14-3-3 protein interface

Author(s): Dario Valenti, João Filipe Neves, François-Xavier Cantrelle, Stanimira Hristeva, Domenico Lentini Santo, Tomáš Obšil, Xavier Hanoulle, Laura M. Levy, Dimitrios Tzalis, Isabelle Landrieu, Christian Ottmann
Published in: MedChemComm, Issue 10/10, 2019, Page(s) 1796-1802, ISSN 2040-2503
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9md00215d

Adoption of a Turn Conformation Drives the Binding Affinity of p53 C-Terminal Domain Peptides to 14-3-3σ

Author(s): Ave Kuusk, João Filipe Neves, Kenny Bravo-Rodriguez, Anders Gunnarsson, Yasser B. Ruiz-Blanco, Michael Ehrmann, Hongming Chen, Isabelle Landrieu, Elsa Sanchez-Garcia, Helen Boyd, Christian Ottmann, Richard G. Doveston
Published in: ACS Chemical Biology, Issue 15/1, 2019, Page(s) 262-271, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.9b00893

Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes

Author(s): Sebastian A. Andrei, Femke A. Meijer, João Filipe Neves, Luc Brunsveld, Isabelle Landrieu, Christian Ottmann, Lech-Gustav Milroy
Published in: ACS Chemical Neuroscience, Issue 9/11, 2018, Page(s) 2639-2654, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.8b00118

Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein–Protein Interaction

Author(s): Leire Iralde-Lorente, Giusy Tassone, Letizia Clementi, Lorenzo Franci, Claire C Munier, Ylenia Cau, Mattia Mori, Mario Chiariello, Adriano Angelucci, Matthew W. D. Perry, Cecilia Pozzi, Stefano Mangani, Maurizio Botta
Published in: ACS Chemical Biology, 2020, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.0c00039

Clinical candidates modulating protein-protein interactions: The fragment-based experience

Author(s): Dario Valenti, Stanimira Hristeva, Dimitrios Tzalis, Christian Ottmann
Published in: European Journal of Medicinal Chemistry, Issue 167, 2019, Page(s) 76-95, ISSN 0223-5234
Publisher: Elsevier BV
DOI: 10.1016/j.ejmech.2019.01.084

AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins

Author(s): Maria Saline, Lukas Badertscher, Madita Wolter, Roxanne Lau, Anders Gunnarsson, Tomas Jacso, Tyrrell Norris, Christian Ottmann, Arjan Snijder
Published in: Journal of Biological Chemistry, Issue 294/35, 2019, Page(s) 13106-13116, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.008649

Design Of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization

Author(s): Francesco Bosica, Sebastian Andrei, João Filipe Neves, Peter Brandt, Anders Gunnarsson, Isabelle Landrieu, Christian Ottmann, Gavin O'Mahony
Published in: Chemistry - A European Journal, 2020, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202001608

Nuclear Magnetic Resonance Spectroscopy Insights into Tau Structure in Solution: Impact of Post-translational Modifications

Author(s): Clément Danis, Elian Dupré, Xavier Hanoulle, Isabelle Landrieu, Alessia Lasorsa, João Filipe Neves, Robert Schneider, Caroline Smet-Nocca
Published in: Tau Biology, Issue 1184, 2019, Page(s) 35-45, ISBN 978-981-32-9357-1
Publisher: Springer Singapore
DOI: 10.1007/978-981-32-9358-8_3

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