Targeted small-molecule Stabilisation of Protein-Protein Interactions

Risultati finali

Researcher Declaration

Declaration of ESRs

Recruitment

Recruitment of ESRs for TASPPI finalized

Career Development Plan

Career Plan for all ESRs finalized

Businessplan Startup

Businessplan for the spin-off of TASPPI

Open Access Publication(s)

Publications in peer-reviewed journals

Pubblicazioni

Biophysical and structural insight into the USP8/14-3-3 interaction

Autori: Federica Centorrino, Alice Ballone, Madita Wolter, Christian Ottmann
Pubblicato in: FEBS Letters, Numero 592, 2018, Pagina/e 1211-1220, ISSN 0014-5793
Editore: Elsevier BV
DOI: 10.1002/1873-3468.13017

14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2)

Autori: Katarina Psenakova, Olivia Petrvalska, Salome Kylarova, Domenico Lentini Santo, Dana Kalabova, Petr Herman, Veronika Obsilova, Tomas Obsil
Pubblicato in: Biochimica et Biophysica Acta (BBA) - General Subjects, Numero 1862, 2018, Pagina/e 1612-1625, ISSN 0304-4165
Editore: Elsevier BV
DOI: 10.1016/j.bbagen.2018.04.006

Structural characterization of 14-3-3ζ in complex with the human Son of sevenless homolog 1 (SOS1)

Autori: Alice Ballone, Federica Centorrino, Madita Wolter, Christian Ottmann
Pubblicato in: Journal of Structural Biology, Numero 202, 2018, Pagina/e 210-215, ISSN 1047-8477
Editore: Academic Press
DOI: 10.1016/j.jsb.2018.01.011

Backbone chemical shift assignments of human 14-3-3σ

Autori: João Filipe Neves, Isabelle Landrieu, Hamida Merzougui, Emmanuelle Boll, Xavier Hanoulle, François-Xavier Cantrelle
Pubblicato in: Biomolecular NMR Assignments, Numero 13/1, 2019, Pagina/e 103-107, ISSN 1874-2718
Editore: Springer Verlag
DOI: 10.1007/s12104-018-9860-1

Protein X-ray crystallography of the 14-3-3ζ/SOS1 complex

Autori: Alice Ballone, Federica Centorrino, Madita Wolter, Christian Ottmann
Pubblicato in: Data in Brief, Numero 19, 2018, Pagina/e 1683-1687, ISSN 2352-3409
Editore: Elsevier BV
DOI: 10.1016/j.dib.2018.06.060

14-3-3: A Case Study in PPI Modulation

Autori: Alice Ballone, Federica Centorrino, Christian Ottmann
Pubblicato in: Molecules, Numero 23/6, 2018, Pagina/e 1386, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23061386

Interaction of an IκBα Peptide with 14-3-3

Autori: Madita Wolter, Domenico Lentini Santo, Petr Herman, Alice Ballone, Federica Centorrino, Tomas Obsil, Christian Ottmann
Pubblicato in: ACS Omega, Numero 5/10, 2020, Pagina/e 5380-5388, ISSN 2470-1343
Editore: ACS Publications
DOI: 10.1021/acsomega.9b04413

Allosteric activation of yeast enzyme neutral trehalase by calcium and 14-3-3 protein

Autori: M. Alblova, A. Smidova, D. Kalabova, D. Lentini Santo, T. Obsil, V Obsilova. Obsilova
Pubblicato in: Physiological Research, Numero 68, 2019, Pagina/e 147-160, ISSN 0862-8408
Editore: Akademie Ved Ceske Republiky
DOI: 10.33549/physiolres.933950

Set-up and screening of a fragment library targeting the 14-3-3 protein interface

Autori: Dario Valenti, João Filipe Neves, François-Xavier Cantrelle, Stanimira Hristeva, Domenico Lentini Santo, Tomáš Obšil, Xavier Hanoulle, Laura M. Levy, Dimitrios Tzalis, Isabelle Landrieu, Christian Ottmann
Pubblicato in: MedChemComm, Numero 10/10, 2019, Pagina/e 1796-1802, ISSN 2040-2503
Editore: Royal Society of Chemistry
DOI: 10.1039/c9md00215d

Adoption of a Turn Conformation Drives the Binding Affinity of p53 C-Terminal Domain Peptides to 14-3-3σ

Autori: Ave Kuusk, João Filipe Neves, Kenny Bravo-Rodriguez, Anders Gunnarsson, Yasser B. Ruiz-Blanco, Michael Ehrmann, Hongming Chen, Isabelle Landrieu, Elsa Sanchez-Garcia, Helen Boyd, Christian Ottmann, Richard G. Doveston
Pubblicato in: ACS Chemical Biology, Numero 15/1, 2019, Pagina/e 262-271, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.9b00893

Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes

Autori: Sebastian A. Andrei, Femke A. Meijer, João Filipe Neves, Luc Brunsveld, Isabelle Landrieu, Christian Ottmann, Lech-Gustav Milroy
Pubblicato in: ACS Chemical Neuroscience, Numero 9/11, 2018, Pagina/e 2639-2654, ISSN 1948-7193
Editore: American Chemical Society
DOI: 10.1021/acschemneuro.8b00118

Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein–Protein Interaction

Autori: Leire Iralde-Lorente, Giusy Tassone, Letizia Clementi, Lorenzo Franci, Claire C Munier, Ylenia Cau, Mattia Mori, Mario Chiariello, Adriano Angelucci, Matthew W. D. Perry, Cecilia Pozzi, Stefano Mangani, Maurizio Botta
Pubblicato in: ACS Chemical Biology, 2020, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.0c00039

Clinical candidates modulating protein-protein interactions: The fragment-based experience

Autori: Dario Valenti, Stanimira Hristeva, Dimitrios Tzalis, Christian Ottmann
Pubblicato in: European Journal of Medicinal Chemistry, Numero 167, 2019, Pagina/e 76-95, ISSN 0223-5234
Editore: Elsevier BV
DOI: 10.1016/j.ejmech.2019.01.084

AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins

Autori: Maria Saline, Lukas Badertscher, Madita Wolter, Roxanne Lau, Anders Gunnarsson, Tomas Jacso, Tyrrell Norris, Christian Ottmann, Arjan Snijder
Pubblicato in: Journal of Biological Chemistry, Numero 294/35, 2019, Pagina/e 13106-13116, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.008649

Design Of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization

Autori: Francesco Bosica, Sebastian Andrei, João Filipe Neves, Peter Brandt, Anders Gunnarsson, Isabelle Landrieu, Christian Ottmann, Gavin O'Mahony
Pubblicato in: Chemistry - A European Journal, 2020, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202001608

Nuclear Magnetic Resonance Spectroscopy Insights into Tau Structure in Solution: Impact of Post-translational Modifications

Autori: Clément Danis, Elian Dupré, Xavier Hanoulle, Isabelle Landrieu, Alessia Lasorsa, João Filipe Neves, Robert Schneider, Caroline Smet-Nocca
Pubblicato in: Tau Biology, Numero 1184, 2019, Pagina/e 35-45, ISBN 978-981-32-9357-1
Editore: Springer Singapore
DOI: 10.1007/978-981-32-9358-8_3

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