Targeted small-molecule Stabilisation of Protein-Protein Interactions

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Declaration of ESRs

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Recruitment of ESRs for TASPPI finalized

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Career Plan for all ESRs finalized

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Businessplan for the spin-off of TASPPI

Open Access Publication(s)

Publications in peer-reviewed journals

Publicaciones

Biophysical and structural insight into the USP8/14-3-3 interaction

Autores: Federica Centorrino, Alice Ballone, Madita Wolter, Christian Ottmann
Publicado en: FEBS Letters, Edición 592, 2018, Página(s) 1211-1220, ISSN 0014-5793
Editor: Elsevier BV
DOI: 10.1002/1873-3468.13017

14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2)

Autores: Katarina Psenakova, Olivia Petrvalska, Salome Kylarova, Domenico Lentini Santo, Dana Kalabova, Petr Herman, Veronika Obsilova, Tomas Obsil
Publicado en: Biochimica et Biophysica Acta (BBA) - General Subjects, Edición 1862, 2018, Página(s) 1612-1625, ISSN 0304-4165
Editor: Elsevier BV
DOI: 10.1016/j.bbagen.2018.04.006

Structural characterization of 14-3-3ζ in complex with the human Son of sevenless homolog 1 (SOS1)

Autores: Alice Ballone, Federica Centorrino, Madita Wolter, Christian Ottmann
Publicado en: Journal of Structural Biology, Edición 202, 2018, Página(s) 210-215, ISSN 1047-8477
Editor: Academic Press
DOI: 10.1016/j.jsb.2018.01.011

Backbone chemical shift assignments of human 14-3-3σ

Autores: João Filipe Neves, Isabelle Landrieu, Hamida Merzougui, Emmanuelle Boll, Xavier Hanoulle, François-Xavier Cantrelle
Publicado en: Biomolecular NMR Assignments, Edición 13/1, 2019, Página(s) 103-107, ISSN 1874-2718
Editor: Springer Verlag
DOI: 10.1007/s12104-018-9860-1

Protein X-ray crystallography of the 14-3-3ζ/SOS1 complex

Autores: Alice Ballone, Federica Centorrino, Madita Wolter, Christian Ottmann
Publicado en: Data in Brief, Edición 19, 2018, Página(s) 1683-1687, ISSN 2352-3409
Editor: Elsevier BV
DOI: 10.1016/j.dib.2018.06.060

14-3-3: A Case Study in PPI Modulation

Autores: Alice Ballone, Federica Centorrino, Christian Ottmann
Publicado en: Molecules, Edición 23/6, 2018, Página(s) 1386, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23061386

Interaction of an IκBα Peptide with 14-3-3

Autores: Madita Wolter, Domenico Lentini Santo, Petr Herman, Alice Ballone, Federica Centorrino, Tomas Obsil, Christian Ottmann
Publicado en: ACS Omega, Edición 5/10, 2020, Página(s) 5380-5388, ISSN 2470-1343
Editor: ACS Publications
DOI: 10.1021/acsomega.9b04413

Allosteric activation of yeast enzyme neutral trehalase by calcium and 14-3-3 protein

Autores: M. Alblova, A. Smidova, D. Kalabova, D. Lentini Santo, T. Obsil, V Obsilova. Obsilova
Publicado en: Physiological Research, Edición 68, 2019, Página(s) 147-160, ISSN 0862-8408
Editor: Akademie Ved Ceske Republiky
DOI: 10.33549/physiolres.933950

Set-up and screening of a fragment library targeting the 14-3-3 protein interface

Autores: Dario Valenti, João Filipe Neves, François-Xavier Cantrelle, Stanimira Hristeva, Domenico Lentini Santo, Tomáš Obšil, Xavier Hanoulle, Laura M. Levy, Dimitrios Tzalis, Isabelle Landrieu, Christian Ottmann
Publicado en: MedChemComm, Edición 10/10, 2019, Página(s) 1796-1802, ISSN 2040-2503
Editor: Royal Society of Chemistry
DOI: 10.1039/c9md00215d

Adoption of a Turn Conformation Drives the Binding Affinity of p53 C-Terminal Domain Peptides to 14-3-3σ

Autores: Ave Kuusk, João Filipe Neves, Kenny Bravo-Rodriguez, Anders Gunnarsson, Yasser B. Ruiz-Blanco, Michael Ehrmann, Hongming Chen, Isabelle Landrieu, Elsa Sanchez-Garcia, Helen Boyd, Christian Ottmann, Richard G. Doveston
Publicado en: ACS Chemical Biology, Edición 15/1, 2019, Página(s) 262-271, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.9b00893

Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes

Autores: Sebastian A. Andrei, Femke A. Meijer, João Filipe Neves, Luc Brunsveld, Isabelle Landrieu, Christian Ottmann, Lech-Gustav Milroy
Publicado en: ACS Chemical Neuroscience, Edición 9/11, 2018, Página(s) 2639-2654, ISSN 1948-7193
Editor: American Chemical Society
DOI: 10.1021/acschemneuro.8b00118

Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein–Protein Interaction

Autores: Leire Iralde-Lorente, Giusy Tassone, Letizia Clementi, Lorenzo Franci, Claire C Munier, Ylenia Cau, Mattia Mori, Mario Chiariello, Adriano Angelucci, Matthew W. D. Perry, Cecilia Pozzi, Stefano Mangani, Maurizio Botta
Publicado en: ACS Chemical Biology, 2020, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.0c00039

Clinical candidates modulating protein-protein interactions: The fragment-based experience

Autores: Dario Valenti, Stanimira Hristeva, Dimitrios Tzalis, Christian Ottmann
Publicado en: European Journal of Medicinal Chemistry, Edición 167, 2019, Página(s) 76-95, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2019.01.084

AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins

Autores: Maria Saline, Lukas Badertscher, Madita Wolter, Roxanne Lau, Anders Gunnarsson, Tomas Jacso, Tyrrell Norris, Christian Ottmann, Arjan Snijder
Publicado en: Journal of Biological Chemistry, Edición 294/35, 2019, Página(s) 13106-13116, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.008649

Design Of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization

Autores: Francesco Bosica, Sebastian Andrei, João Filipe Neves, Peter Brandt, Anders Gunnarsson, Isabelle Landrieu, Christian Ottmann, Gavin O'Mahony
Publicado en: Chemistry - A European Journal, 2020, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202001608

Nuclear Magnetic Resonance Spectroscopy Insights into Tau Structure in Solution: Impact of Post-translational Modifications

Autores: Clément Danis, Elian Dupré, Xavier Hanoulle, Isabelle Landrieu, Alessia Lasorsa, João Filipe Neves, Robert Schneider, Caroline Smet-Nocca
Publicado en: Tau Biology, Edición 1184, 2019, Página(s) 35-45, ISBN 978-981-32-9357-1
Editor: Springer Singapore
DOI: 10.1007/978-981-32-9358-8_3

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