Deliverables
Communication of subject to high school students. Due date: M21 - 32. Lead beneficiary: ALL
Characterization of two identified mutant proteinsAntiviral treatment potential evaluated in the SLE model
Evaluation of the potential of miRNA inhibition for tumor therapy
Evaluation of the potential of miRNA inhibition for tumor therapy .
Employment of CRISPR/Cas to block viral genes: immune evasion and oncogenic transformationDevelopment of specific and effective inhibitors of EBV microRNAs
Use of DNA sensors as biomarker to improve management of kidney transplant recipients
Use of DNA sensors as biomarker to improve management of kidney transplant recipients .
Description of the mechanism underlying phenotypes in miceCharacterization of newly identified VZV restriction factors
Recruitment Manager
Recruitment of Project manager completed .
Communication of ideas/results to stakeholders in the private and public sectorsCommunication of ideas/results to stakeholders in the private and public sectors. Due date: M27-28. Lead beneficiary: all
Recruitment ESRsRecruitment of ESRs completed.
Characterization of SLE phenotypes in mice – and impact on CMV infectionDemonstration of the function of two proteins on viral replication in vitro and in vivo
Demonstration of the function of two proteins on viral replication in vitro and in vivo.
Completion of development of lentiviral vectors for CRISPR-mediated editing of herpes genomesPhD Tesis
ESR training finalised, Submission of PhD theses. Lead beneficiary: All
Draft Periodic Reportcompulsory deliverable
CRISPR/Cas KO cell lines generatedMid-term review meeting
compulsory deliverable
Identification of a cytosolic protease that detects and degrades incoming HSV1 capsidsFunctional characterization of two host proteins interacting with HSV-1 capsids
Functional characterization of two host proteins interacting with HSV-1 capsids.
Participation in Science events for the publicParticipation in Science events for the public. Due date:M27 -38, Lead beneficiary:all
Completion of characterization of ORF21/31 interactions with cellular proteinsIdentification of viral molecules responsible for DNA sensor activation and their use to predict graft success or failure
Patent and publications in int. journals starting
Patent and publications in int. journals starting. Lead beneficiary: all. WP1-4,6
Characterization of two identified mutant proteins in the patientsPublications
Author(s):
Mirjam Schilling, Anne Bridgeman, Nicki Gray, Jonny Hertzog, Philip Hublitz, Alain Kohl, Jan Rehwinkel
Published in:
Cells, Issue 9/6, 2020, Page(s) 1476, ISSN 2073-4409
Publisher:
MDPI
DOI:
10.3390/cells9061476
Author(s):
Maibritt Mardahl; Franck Rapaport; Mette Christiansen
Published in:
https://nn.neurology.org, Issue 2, 2018, Page(s) e500, ISSN 2332-7812
Publisher:
neurology.org
DOI:
10.1101/244848
Author(s):
Ganna Galitska, Matteo Biolatti, Gloria Griffante, Francesca Gugliesi, Selina Pasquero, Valentina Dell'Oste, Santo Landolfo
Published in:
Future Virology, Issue 14/4, 2019, Page(s) 247-263, ISSN 1746-0794
Publisher:
Future Medicine Ltd.
DOI:
10.2217/fvl-2018-0189
Author(s):
Ganna Galitska, Matteo Biolatti, Marco De Andrea, Agata Leone, Alessandra Coscia, Luigi Bertolotti, Ugo Ala, Enrico Bertino, Valentina Dell’Oste, Santo Landolfo
Published in:
Journal of Clinical Virology, Issue 108, 2018, Page(s) 132-140, ISSN 1386-6532
Publisher:
Elsevier BV
DOI:
10.1016/j.jcv.2018.09.019
Author(s):
Adam Z. Cheng, Sofia N. Moraes, Claire Attarian, Jaime Yockteng-Melgar, Matthew C. Jarvis, Matteo Biolatti, Ganna Galitska, Valentina Dell’Oste, Lori Frappier, Craig J. Bierle, Stephen A. Rice, Reuben S. Harris
Published in:
Journal of Virology, Issue 93/23, 2019, ISSN 0022-538X
Publisher:
American Society for Microbiology
DOI:
10.1128/jvi.01539-19
Author(s):
Niko Hensel, Verena Raker, Benjamin Förthmann, Nora Tula Detering, Sabrina Kubinski, Anna Buch, Georgios Katzilieris-Petras, Julia Spanier, Viktoria Gudi, Sylvia Wagenknecht, Verena Kopfnagel, Thomas Andreas Werfel, Martin Stangel, Andreas Beineke, Ulrich Kalinke, Søren Riis Paludan, Beate Sodeik, Peter Claus
Published in:
Journal of Neuroinflammation, Issue 16/1, 2019, ISSN 1742-2094
Publisher:
BioMed Central
DOI:
10.1186/s12974-019-1647-5
Author(s):
Marjolein J. G. Hooykaas, Jasper A. Soppe, Hendrik M. De Buhr, Elisabeth Kruse, Emmanuel J. H. J. Wiertz, Robert J. Lebbink
Published in:
RNA Biology, Issue 15/11, 2018, Page(s) 1410-1419, ISSN 1547-6286
Publisher:
Landes Bioscience
DOI:
10.1080/15476286.2018.1537746
Author(s):
Rutger D. Luteijn, Patrique Praest, Frank Thiele, Saravanan Manikam Sadasivam, Katrin Singethan, Jan W. Drijfhout, Christian Bach, Steffen Matthijn de Boer, Robert J. Lebbink, Sha Tao, Markus Helfer, Nina C. Bach, Ulrike Protzer, Ana I. Costa, J. Antoinette Killian, Ingo Drexler, Emmanuel J. H. J. Wiertz
Published in:
Cells, Issue 9/9, 2020, Page(s) 1989, ISSN 2073-4409
Publisher:
MDPI
DOI:
10.3390/cells9091989
Author(s):
Madalina E. Carter-Timofte, Anders F. Hansen, Maibritt Mardahl, Sébastien Fribourg, Franck Rapaport, Shen-Ying Zhang, Jean-Laurent Casanova, Søren R. Paludan, Mette Christiansen, Carsten S. Larsen, Trine H. Mogensen
Published in:
Neurology - Neuroimmunology Neuroinflammation, Issue 5/6, 2018, Page(s) e500, ISSN 2332-7812
Publisher:
neurology.org
DOI:
10.1212/nxi.0000000000000500
Author(s):
Matteo Biolatti, Valentina Dell’Oste, Sara Scutera, Francesca Gugliesi, Gloria Griffante, Marco De Andrea, Tiziana Musso, Santo Landolfo
Published in:
Viruses, Issue 10/10, 2018, Page(s) 567, ISSN 1999-4915
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/v10100567
Author(s):
Hendrik de Buhr, Robert Jan Lebbink
Published in:
Current Opinion in Immunology, Issue 54, 2018, Page(s) 123-129, ISSN 0952-7915
Publisher:
Elsevier BV
DOI:
10.1016/j.coi.2018.06.002
Author(s):
Judith Lang, Patrick Bohn, Hilal Bhat, Holger Jastrow, Bernd Walkenfort, Feyza Cansiz, Julian Fink, Michael Bauer, Dominik Olszewski, Ana Ramos-Nascimento, Vikas Duhan, Sarah-Kim Friedrich, Katrin Anne Becker, Adalbert Krawczyk, Michael J. Edwards, Andreas Burchert, Magdalena Huber, Justa Friebus-Kardash, Joachim R. Göthert, Cornelia Hardt, Hans Christian Probst, Fabian Schumacher, Karl Köhrer,
Published in:
Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher:
Nature Publishing Group
DOI:
10.1038/s41467-020-15072-8
Author(s):
Jonny Hertzog, Antonio Gregorio Dias Junior, Rachel E. Rigby, Claire L. Donald, Alice Mayer, Erdinc Sezgin, Chaojun Song, Boquan Jin, Philip Hublitz, Christian Eggeling, Alain Kohl, Jan Rehwinkel
Published in:
European Journal of Immunology, 2018, ISSN 0014-2980
Publisher:
John Wiley & Sons Ltd.
DOI:
10.1002/eji.201847483
Author(s):
Katinka Döhner, Ana Ramos-Nascimento, Dagmara Bialy, Fenja Anderson, Ana Hickford-Martinez, Franziska Rother, Thalea Koithan, Kathrin Rudolph, Anna Buch, Ute Prank, Anne Binz, Stefanie Hügel, Robert Jan Lebbink, Rob C. Hoeben, Enno Hartmann, Michael Bader, Rudolf Bauerfeind, Beate Sodeik
Published in:
PLOS Pathogens, Issue 14/1, 2018, Page(s) e1006823, ISSN 1553-7374
Publisher:
PLOS Pathogens
DOI:
10.1371/journal.ppat.1006823
Author(s):
Patrique Praest, A. Manuel Liaci, Friedrich Förster, Emmanuel J.H.J. Wiertz
Published in:
Molecular Immunology, 2018, ISSN 0161-5890
Publisher:
Pergamon Press
DOI:
10.1016/j.molimm.2018.03.020
Author(s):
P. Praest, R.D. Luteijn, I.G.J. Brak-Boer, J. Lanfermeijer, H. Hoelen, L. Ijgosse, A.I. Costa, R.D. Gorham, R.J. Lebbink, E.J.H.J. Wiertz
Published in:
Molecular Immunology, Issue 101, 2018, Page(s) 55-64, ISSN 0161-5890
Publisher:
Pergamon Press
DOI:
10.1016/j.molimm.2018.05.025
Author(s):
Benson Ogunjimi, Shen-Ying Zhang, Katrine B. Sørensen, Kristian A. Skipper, Madalina Carter-Timofte, Gaspard Kerner, Stefanie Luecke, Thaneas Prabakaran, Yujia Cai, Josephina Meester, Esther Bartholomeus, Nikhita Ajit Bolar, Geert Vandeweyer, Charlotte Claes, Yasmine Sillis, Lazaro Lorenzo, Raffaele A. Fiorenza, Soraya Boucherit, Charlotte Dielman, Steven Heynderickx, George Elias, Andrea Kurotov
Published in:
Journal of Clinical Investigation, Issue 127/9, 2017, Page(s) 3543-3556, ISSN 0021-9738
Publisher:
American Society for Clinical Investigation
DOI:
10.1172/JCI92280
Author(s):
A. Cristina Gonzalez-Perez, Markus Stempel, Baca Chan, Melanie M. Brinkmann
Published in:
Frontiers in Microbiology, Issue 11, 2020, ISSN 1664-302X
Publisher:
Frontiers Media
DOI:
10.3389/fmicb.2020.00124
Author(s):
Magda Wąchalska, Małgorzata Graul, Patrique Praest, Rutger D. Luteijn, Aleksandra W. Babnis, Emmanuel J. H. J. Wiertz, Krystyna Bieńkowska-Szewczyk, Andrea D. Lipińska
Published in:
Cells, Issue 8/12, 2019, Page(s) 1590, ISSN 2073-4409
Publisher:
MDPI
DOI:
10.3390/cells8121590
Author(s):
Andrea Iannucci, Valeria Caneparo, Stefano Raviola, Isacco Debernardi, Donato Colangelo, Riccardo Miggiano, Gloria Griffante, Santo Landolfo, Marisa Gariglio, Marco De Andrea
Published in:
PLOS Pathogens, Issue 16/9, 2020, Page(s) e1008811, ISSN 1553-7374
Publisher:
PloS Pathogens
DOI:
10.1371/journal.ppat.1008811
Author(s):
Hertzog, Jonny; Rigby, Rachel E.; Roll, Sonja; Cursi, Chiara; Chauveau, Lise; Davenne, Tamara; Rehwinkel, Jan
Published in:
2020
Publisher:
bioRxiv
DOI:
10.1101/2020.02.11.943415
Author(s):
Patrique Praest, Hendrik de Buhr, Emmanuel J. H. J. Wiertz
Published in:
Antigen Processing - Methods and Protocols, Issue 1988, 2019, Page(s) 187-198, ISBN 978-1-4939-9449-6
Publisher:
Springer New York
DOI:
10.1007/978-1-4939-9450-2_14
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