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Training network providing cutting-EDGE knowlEDGE on Herpes Virology and Immunology

Deliverables

Communication of subject to high school students

Communication of subject to high school students. Due date: M21 - 32. Lead beneficiary: ALL

Recruitment Manager

Recruitment of Project manager completed .

Recruitment ESRs

Recruitment of ESRs completed.

Characterization of SLE phenotypes in mice – and impact on CMV infection

Characterization of SLE phenotypes in mice – and impact on CMV infection

Draft Periodic Report

compulsory deliverable

Mid-term review meeting

compulsory deliverable

Patent and publications in int. journals starting

Patent and publications in int. journals starting. Lead beneficiary: all. WP1-4,6

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Publications

Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling

Author(s): Jonny Hertzog, Antonio Gregorio Dias Junior, Rachel E. Rigby, Claire L. Donald, Alice Mayer, Erdinc Sezgin, Chaojun Song, Boquan Jin, Philip Hublitz, Christian Eggeling, Alain Kohl, Jan Rehwinkel
Published in: European Journal of Immunology, 2018, ISSN 0014-2980
DOI: 10.1002/eji.201847483

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons

Author(s): Katinka Döhner, Ana Ramos-Nascimento, Dagmara Bialy, Fenja Anderson, Ana Hickford-Martinez, Franziska Rother, Thalea Koithan, Kathrin Rudolph, Anna Buch, Ute Prank, Anne Binz, Stefanie Hügel, Robert Jan Lebbink, Rob C. Hoeben, Enno Hartmann, Michael Bader, Rudolf Bauerfeind, Beate Sodeik
Published in: PLOS Pathogens, Issue 14/1, 2018, Page(s) e1006823, ISSN 1553-7374
DOI: 10.1371/journal.ppat.1006823

New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins

Author(s): Patrique Praest, A. Manuel Liaci, Friedrich Förster, Emmanuel J.H.J. Wiertz
Published in: Molecular Immunology, 2018, ISSN 0161-5890
DOI: 10.1016/j.molimm.2018.03.020

The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins

Author(s): P. Praest, R.D. Luteijn, I.G.J. Brak-Boer, J. Lanfermeijer, H. Hoelen, L. Ijgosse, A.I. Costa, R.D. Gorham, R.J. Lebbink, E.J.H.J. Wiertz
Published in: Molecular Immunology, Issue 101, 2018, Page(s) 55-64, ISSN 0161-5890
DOI: 10.1016/j.molimm.2018.05.025

Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections

Author(s): Benson Ogunjimi, Shen-Ying Zhang, Katrine B. Sørensen, Kristian A. Skipper, Madalina Carter-Timofte, Gaspard Kerner, Stefanie Luecke, Thaneas Prabakaran, Yujia Cai, Josephina Meester, Esther Bartholomeus, Nikhita Ajit Bolar, Geert Vandeweyer, Charlotte Claes, Yasmine Sillis, Lazaro Lorenzo, Raffaele A. Fiorenza, Soraya Boucherit, Charlotte Dielman, Steven Heynderickx, George Elias, Andrea Kurotov
Published in: Journal of Clinical Investigation, Issue 127/9, 2017, Page(s) 3543-3556, ISSN 0021-9738
DOI: 10.1172/JCI92280