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Training network providing cutting-EDGE knowlEDGE on Herpes Virology and Immunology

Deliverables

Communication of subject to high school students

Communication of subject to high school students. Due date: M21 - 32. Lead beneficiary: ALL

Characterization of two identified mutant proteins

Characterization of two identified mutant proteins

Antiviral treatment potential evaluated in the SLE model

Antiviral treatment potential evaluated in the SLE model

Evaluation of the potential of miRNA inhibition for tumor therapy

Evaluation of the potential of miRNA inhibition for tumor therapy .

Employment of CRISPR/Cas to block viral genes: immune evasion and oncogenic transformation

Employment of CRISPR/Cas to block viral genes: immune evasion and oncogenic transformation

Development of specific and effective inhibitors of EBV microRNAs

Development of specific and effective inhibitors of EBV microRNAs

Use of DNA sensors as biomarker to improve management of kidney transplant recipients

Use of DNA sensors as biomarker to improve management of kidney transplant recipients .

Description of the mechanism underlying phenotypes in mice

Description of the mechanism underlying phenotypes in mice

Characterization of newly identified VZV restriction factors

Characterization of newly identified VZV restriction factors

Recruitment Manager

Recruitment of Project manager completed .

Communication of ideas/results to stakeholders in the private and public sectors

Communication of ideas/results to stakeholders in the private and public sectors. Due date: M27-28. Lead beneficiary: all

Recruitment ESRs

Recruitment of ESRs completed.

Characterization of SLE phenotypes in mice – and impact on CMV infection

Characterization of SLE phenotypes in mice – and impact on CMV infection

Demonstration of the function of two proteins on viral replication in vitro and in vivo

Demonstration of the function of two proteins on viral replication in vitro and in vivo.

Completion of development of lentiviral vectors for CRISPR-mediated editing of herpes genomes

Completion of development of lentiviral vectors for CRISPR-mediated editing of herpes genomes

PhD Tesis

ESR training finalised, Submission of PhD theses. Lead beneficiary: All

Draft Periodic Report

compulsory deliverable

CRISPR/Cas KO cell lines generated

CRISPR/Cas KO cell lines generated

Mid-term review meeting

compulsory deliverable

Identification of a cytosolic protease that detects and degrades incoming HSV1 capsids

Identification of a cytosolic protease that detects and degrades incoming HSV1 capsids

Functional characterization of two host proteins interacting with HSV-1 capsids

Functional characterization of two host proteins interacting with HSV-1 capsids.

Participation in Science events for the public

Participation in Science events for the public. Due date:M27 -38, Lead beneficiary:all

Completion of characterization of ORF21/31 interactions with cellular proteins

Completion of characterization of ORF21/31 interactions with cellular proteins

Identification of viral molecules responsible for DNA sensor activation and their use to predict graft success or failure

Identification of viral molecules responsible for DNA sensor activation and their use to predict graft success or failure

Patent and publications in int. journals starting

Patent and publications in int. journals starting. Lead beneficiary: all. WP1-4,6

Characterization of two identified mutant proteins in the patients

Characterization of two identified mutant proteins in the patients

Searching for OpenAIRE data...

Publications

RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death

Author(s): Mirjam Schilling, Anne Bridgeman, Nicki Gray, Jonny Hertzog, Philip Hublitz, Alain Kohl, Jan Rehwinkel
Published in: Cells, Issue 9/6, 2020, Page(s) 1476, ISSN 2073-4409
DOI: 10.3390/cells9061476

Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins

Author(s): Maibritt Mardahl; Franck Rapaport; Mette Christiansen
Published in: https://nn.neurology.org, Issue 2, 2018, Page(s) e500, ISSN 2332-7812
DOI: 10.1101/244848

Catch me if you can: the arms race between human cytomegalovirus and the innate immune system

Author(s): Ganna Galitska, Matteo Biolatti, Gloria Griffante, Francesca Gugliesi, Selina Pasquero, Valentina Dell'Oste, Santo Landolfo
Published in: Future Virology, Issue 14/4, 2019, Page(s) 247-263, ISSN 1746-0794
DOI: 10.2217/fvl-2018-0189

Biological relevance of Cytomegalovirus genetic variability in congenitally and postnatally infected children

Author(s): Ganna Galitska, Matteo Biolatti, Marco De Andrea, Agata Leone, Alessandra Coscia, Luigi Bertolotti, Ugo Ala, Enrico Bertino, Valentina Dell’Oste, Santo Landolfo
Published in: Journal of Clinical Virology, Issue 108, 2018, Page(s) 132-140, ISSN 1386-6532
DOI: 10.1016/j.jcv.2018.09.019

A Conserved Mechanism of APOBEC3 Relocalization by Herpesviral Ribonucleotide Reductase Large Subunits

Author(s): Adam Z. Cheng, Sofia N. Moraes, Claire Attarian, Jaime Yockteng-Melgar, Matthew C. Jarvis, Matteo Biolatti, Ganna Galitska, Valentina Dell’Oste, Lori Frappier, Craig J. Bierle, Stephen A. Rice, Reuben S. Harris
Published in: Journal of Virology, Issue 93/23, 2019, ISSN 0022-538X
DOI: 10.1128/jvi.01539-19

HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0

Author(s): Niko Hensel, Verena Raker, Benjamin Förthmann, Nora Tula Detering, Sabrina Kubinski, Anna Buch, Georgios Katzilieris-Petras, Julia Spanier, Viktoria Gudi, Sylvia Wagenknecht, Verena Kopfnagel, Thomas Andreas Werfel, Martin Stangel, Andreas Beineke, Ulrich Kalinke, Søren Riis Paludan, Beate Sodeik, Peter Claus
Published in: Journal of Neuroinflammation, Issue 16/1, 2019, ISSN 1742-2094
DOI: 10.1186/s12974-019-1647-5

A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope

Author(s): Rutger D. Luteijn, Patrique Praest, Frank Thiele, Saravanan Manikam Sadasivam, Katrin Singethan, Jan W. Drijfhout, Christian Bach, Steffen Matthijn de Boer, Robert J. Lebbink, Sha Tao, Markus Helfer, Nina C. Bach, Ulrike Protzer, Ana I. Costa, J. Antoinette Killian, Ingo Drexler, Emmanuel J. H. J. Wiertz
Published in: Cells, Issue 9/9, 2020, Page(s) 1989, ISSN 2073-4409
DOI: 10.3390/cells9091989

Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins

Author(s): Madalina E. Carter-Timofte, Anders F. Hansen, Maibritt Mardahl, Sébastien Fribourg, Franck Rapaport, Shen-Ying Zhang, Jean-Laurent Casanova, Søren R. Paludan, Mette Christiansen, Carsten S. Larsen, Trine H. Mogensen
Published in: Neurology - Neuroimmunology Neuroinflammation, Issue 5/6, 2018, Page(s) e500, ISSN 2332-7812
DOI: 10.1212/nxi.0000000000000500

The Viral Tegument Protein pp65 Impairs Transcriptional Upregulation of IL-1β by Human Cytomegalovirus through Inhibition of NF-kB Activity

Author(s): Matteo Biolatti, Valentina Dell’Oste, Sara Scutera, Francesca Gugliesi, Gloria Griffante, Marco De Andrea, Tiziana Musso, Santo Landolfo
Published in: Viruses, Issue 10/10, 2018, Page(s) 567, ISSN 1999-4915
DOI: 10.3390/v10100567

Harnessing CRISPR to combat human viral infections

Author(s): Hendrik de Buhr, Robert Jan Lebbink
Published in: Current Opinion in Immunology, Issue 54, 2018, Page(s) 123-129, ISSN 0952-7915
DOI: 10.1016/j.coi.2018.06.002

Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

Author(s): Judith Lang, Patrick Bohn, Hilal Bhat, Holger Jastrow, Bernd Walkenfort, Feyza Cansiz, Julian Fink, Michael Bauer, Dominik Olszewski, Ana Ramos-Nascimento, Vikas Duhan, Sarah-Kim Friedrich, Katrin Anne Becker, Adalbert Krawczyk, Michael J. Edwards, Andreas Burchert, Magdalena Huber, Justa Friebus-Kardash, Joachim R. Göthert, Cornelia Hardt, Hans Christian Probst, Fabian Schumacher, Karl Köhrer,
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-15072-8

Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling

Author(s): Jonny Hertzog, Antonio Gregorio Dias Junior, Rachel E. Rigby, Claire L. Donald, Alice Mayer, Erdinc Sezgin, Chaojun Song, Boquan Jin, Philip Hublitz, Christian Eggeling, Alain Kohl, Jan Rehwinkel
Published in: European Journal of Immunology, 2018, ISSN 0014-2980
DOI: 10.1002/eji.201847483

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons

Author(s): Katinka Döhner, Ana Ramos-Nascimento, Dagmara Bialy, Fenja Anderson, Ana Hickford-Martinez, Franziska Rother, Thalea Koithan, Kathrin Rudolph, Anna Buch, Ute Prank, Anne Binz, Stefanie Hügel, Robert Jan Lebbink, Rob C. Hoeben, Enno Hartmann, Michael Bader, Rudolf Bauerfeind, Beate Sodeik
Published in: PLOS Pathogens, Issue 14/1, 2018, Page(s) e1006823, ISSN 1553-7374
DOI: 10.1371/journal.ppat.1006823

New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins

Author(s): Patrique Praest, A. Manuel Liaci, Friedrich Förster, Emmanuel J.H.J. Wiertz
Published in: Molecular Immunology, 2018, ISSN 0161-5890
DOI: 10.1016/j.molimm.2018.03.020

The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins

Author(s): P. Praest, R.D. Luteijn, I.G.J. Brak-Boer, J. Lanfermeijer, H. Hoelen, L. Ijgosse, A.I. Costa, R.D. Gorham, R.J. Lebbink, E.J.H.J. Wiertz
Published in: Molecular Immunology, Issue 101, 2018, Page(s) 55-64, ISSN 0161-5890
DOI: 10.1016/j.molimm.2018.05.025

Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections

Author(s): Benson Ogunjimi, Shen-Ying Zhang, Katrine B. Sørensen, Kristian A. Skipper, Madalina Carter-Timofte, Gaspard Kerner, Stefanie Luecke, Thaneas Prabakaran, Yujia Cai, Josephina Meester, Esther Bartholomeus, Nikhita Ajit Bolar, Geert Vandeweyer, Charlotte Claes, Yasmine Sillis, Lazaro Lorenzo, Raffaele A. Fiorenza, Soraya Boucherit, Charlotte Dielman, Steven Heynderickx, George Elias, Andrea Kurotov
Published in: Journal of Clinical Investigation, Issue 127/9, 2017, Page(s) 3543-3556, ISSN 0021-9738
DOI: 10.1172/JCI92280

One Step Ahead: Herpesviruses Light the Way to Understanding Interferon-Stimulated Genes (ISGs)

Author(s): A. Cristina Gonzalez-Perez, Markus Stempel, Baca Chan, Melanie M. Brinkmann
Published in: Frontiers in Microbiology, Issue 11, 2020, ISSN 1664-302X
DOI: 10.3389/fmicb.2020.00124

Fluorescent TAP as a Platform for Virus-Induced Degradation of the Antigenic Peptide Transporter

Author(s): Magda Wąchalska, Małgorzata Graul, Patrique Praest, Rutger D. Luteijn, Aleksandra W. Babnis, Emmanuel J. H. J. Wiertz, Krystyna Bieńkowska-Szewczyk, Andrea D. Lipińska
Published in: Cells, Issue 8/12, 2019, Page(s) 1590, ISSN 2073-4409
DOI: 10.3390/cells8121590

Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding

Author(s): Andrea Iannucci, Valeria Caneparo, Stefano Raviola, Isacco Debernardi, Donato Colangelo, Riccardo Miggiano, Gloria Griffante, Santo Landolfo, Marisa Gariglio, Marco De Andrea
Published in: PLOS Pathogens, Issue 16/9, 2020, Page(s) e1008811, ISSN 1553-7374
DOI: 10.1371/journal.ppat.1008811

A Flow Cytometry-Based Approach to Unravel Viral Interference with the MHC Class I Antigen Processing and Presentation Pathway

Author(s): Patrique Praest, Hendrik de Buhr, Emmanuel J. H. J. Wiertz
Published in: Antigen Processing - Methods and Protocols, Issue 1988, 2019, Page(s) 187-198
DOI: 10.1007/978-1-4939-9450-2_14