Training network providing cutting-EDGE knowlEDGE on Herpes Virology and Immunology

Livrables

Communication of subject to high school students

Communication of subject to high school students. Due date: M21 - 32. Lead beneficiary: ALL

Characterization of two identified mutant proteins
Antiviral treatment potential evaluated in the SLE model
Evaluation of the potential of miRNA inhibition for tumor therapy

Evaluation of the potential of miRNA inhibition for tumor therapy .

Employment of CRISPR/Cas to block viral genes: immune evasion and oncogenic transformation
Development of specific and effective inhibitors of EBV microRNAs
Use of DNA sensors as biomarker to improve management of kidney transplant recipients

Use of DNA sensors as biomarker to improve management of kidney transplant recipients .

Description of the mechanism underlying phenotypes in mice
Characterization of newly identified VZV restriction factors
Recruitment Manager

Recruitment of Project manager completed .

Communication of ideas/results to stakeholders in the private and public sectors

Communication of ideas/results to stakeholders in the private and public sectors. Due date: M27-28. Lead beneficiary: all

Recruitment ESRs

Recruitment of ESRs completed.

Characterization of SLE phenotypes in mice – and impact on CMV infection
Demonstration of the function of two proteins on viral replication in vitro and in vivo

Demonstration of the function of two proteins on viral replication in vitro and in vivo.

Completion of development of lentiviral vectors for CRISPR-mediated editing of herpes genomes
PhD Tesis

ESR training finalised, Submission of PhD theses. Lead beneficiary: All

Draft Periodic Report

compulsory deliverable

CRISPR/Cas KO cell lines generated
Mid-term review meeting

compulsory deliverable

Identification of a cytosolic protease that detects and degrades incoming HSV1 capsids
Functional characterization of two host proteins interacting with HSV-1 capsids

Functional characterization of two host proteins interacting with HSV-1 capsids.

Participation in Science events for the public

Participation in Science events for the public. Due date:M27 -38, Lead beneficiary:all

Completion of characterization of ORF21/31 interactions with cellular proteins
Identification of viral molecules responsible for DNA sensor activation and their use to predict graft success or failure
Patent and publications in int. journals starting

Patent and publications in int. journals starting. Lead beneficiary: all. WP1-4,6

Characterization of two identified mutant proteins in the patients

Publications

RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death

Auteurs: Mirjam Schilling, Anne Bridgeman, Nicki Gray, Jonny Hertzog, Philip Hublitz, Alain Kohl, Jan Rehwinkel
Publié dans: Cells, Numéro 9/6, 2020, Page(s) 1476, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells9061476

Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins

Auteurs: Maibritt Mardahl; Franck Rapaport; Mette Christiansen
Publié dans: https://nn.neurology.org, Numéro 2, 2018, Page(s) e500, ISSN 2332-7812
Éditeur: neurology.org
DOI: 10.1101/244848

Catch me if you can: the arms race between human cytomegalovirus and the innate immune system

Auteurs: Ganna Galitska, Matteo Biolatti, Gloria Griffante, Francesca Gugliesi, Selina Pasquero, Valentina Dell'Oste, Santo Landolfo
Publié dans: Future Virology, Numéro 14/4, 2019, Page(s) 247-263, ISSN 1746-0794
Éditeur: Future Medicine Ltd.
DOI: 10.2217/fvl-2018-0189

Biological relevance of Cytomegalovirus genetic variability in congenitally and postnatally infected children

Auteurs: Ganna Galitska, Matteo Biolatti, Marco De Andrea, Agata Leone, Alessandra Coscia, Luigi Bertolotti, Ugo Ala, Enrico Bertino, Valentina Dell’Oste, Santo Landolfo
Publié dans: Journal of Clinical Virology, Numéro 108, 2018, Page(s) 132-140, ISSN 1386-6532
Éditeur: Elsevier BV
DOI: 10.1016/j.jcv.2018.09.019

A Conserved Mechanism of APOBEC3 Relocalization by Herpesviral Ribonucleotide Reductase Large Subunits

Auteurs: Adam Z. Cheng, Sofia N. Moraes, Claire Attarian, Jaime Yockteng-Melgar, Matthew C. Jarvis, Matteo Biolatti, Ganna Galitska, Valentina Dell’Oste, Lori Frappier, Craig J. Bierle, Stephen A. Rice, Reuben S. Harris
Publié dans: Journal of Virology, Numéro 93/23, 2019, ISSN 0022-538X
Éditeur: American Society for Microbiology
DOI: 10.1128/jvi.01539-19

HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0

Auteurs: Niko Hensel, Verena Raker, Benjamin Förthmann, Nora Tula Detering, Sabrina Kubinski, Anna Buch, Georgios Katzilieris-Petras, Julia Spanier, Viktoria Gudi, Sylvia Wagenknecht, Verena Kopfnagel, Thomas Andreas Werfel, Martin Stangel, Andreas Beineke, Ulrich Kalinke, Søren Riis Paludan, Beate Sodeik, Peter Claus
Publié dans: Journal of Neuroinflammation, Numéro 16/1, 2019, ISSN 1742-2094
Éditeur: BioMed Central
DOI: 10.1186/s12974-019-1647-5

RNA accessibility impacts potency of Tough Decoy microRNA inhibitors

Auteurs: Marjolein J. G. Hooykaas, Jasper A. Soppe, Hendrik M. De Buhr, Elisabeth Kruse, Emmanuel J. H. J. Wiertz, Robert J. Lebbink
Publié dans: RNA Biology, Numéro 15/11, 2018, Page(s) 1410-1419, ISSN 1547-6286
Éditeur: Landes Bioscience
DOI: 10.1080/15476286.2018.1537746

A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope

Auteurs: Rutger D. Luteijn, Patrique Praest, Frank Thiele, Saravanan Manikam Sadasivam, Katrin Singethan, Jan W. Drijfhout, Christian Bach, Steffen Matthijn de Boer, Robert J. Lebbink, Sha Tao, Markus Helfer, Nina C. Bach, Ulrike Protzer, Ana I. Costa, J. Antoinette Killian, Ingo Drexler, Emmanuel J. H. J. Wiertz
Publié dans: Cells, Numéro 9/9, 2020, Page(s) 1989, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells9091989

Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins

Auteurs: Madalina E. Carter-Timofte, Anders F. Hansen, Maibritt Mardahl, Sébastien Fribourg, Franck Rapaport, Shen-Ying Zhang, Jean-Laurent Casanova, Søren R. Paludan, Mette Christiansen, Carsten S. Larsen, Trine H. Mogensen
Publié dans: Neurology - Neuroimmunology Neuroinflammation, Numéro 5/6, 2018, Page(s) e500, ISSN 2332-7812
Éditeur: neurology.org
DOI: 10.1212/nxi.0000000000000500

The Viral Tegument Protein pp65 Impairs Transcriptional Upregulation of IL-1β by Human Cytomegalovirus through Inhibition of NF-kB Activity

Auteurs: Matteo Biolatti, Valentina Dell’Oste, Sara Scutera, Francesca Gugliesi, Gloria Griffante, Marco De Andrea, Tiziana Musso, Santo Landolfo
Publié dans: Viruses, Numéro 10/10, 2018, Page(s) 567, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v10100567

Harnessing CRISPR to combat human viral infections

Auteurs: Hendrik de Buhr, Robert Jan Lebbink
Publié dans: Current Opinion in Immunology, Numéro 54, 2018, Page(s) 123-129, ISSN 0952-7915
Éditeur: Elsevier BV
DOI: 10.1016/j.coi.2018.06.002

Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

Auteurs: Judith Lang, Patrick Bohn, Hilal Bhat, Holger Jastrow, Bernd Walkenfort, Feyza Cansiz, Julian Fink, Michael Bauer, Dominik Olszewski, Ana Ramos-Nascimento, Vikas Duhan, Sarah-Kim Friedrich, Katrin Anne Becker, Adalbert Krawczyk, Michael J. Edwards, Andreas Burchert, Magdalena Huber, Justa Friebus-Kardash, Joachim R. Göthert, Cornelia Hardt, Hans Christian Probst, Fabian Schumacher, Karl Köhrer,
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-15072-8

Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling

Auteurs: Jonny Hertzog, Antonio Gregorio Dias Junior, Rachel E. Rigby, Claire L. Donald, Alice Mayer, Erdinc Sezgin, Chaojun Song, Boquan Jin, Philip Hublitz, Christian Eggeling, Alain Kohl, Jan Rehwinkel
Publié dans: European Journal of Immunology, 2018, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201847483

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons

Auteurs: Katinka Döhner, Ana Ramos-Nascimento, Dagmara Bialy, Fenja Anderson, Ana Hickford-Martinez, Franziska Rother, Thalea Koithan, Kathrin Rudolph, Anna Buch, Ute Prank, Anne Binz, Stefanie Hügel, Robert Jan Lebbink, Rob C. Hoeben, Enno Hartmann, Michael Bader, Rudolf Bauerfeind, Beate Sodeik
Publié dans: PLOS Pathogens, Numéro 14/1, 2018, Page(s) e1006823, ISSN 1553-7374
Éditeur: PLOS Pathogens
DOI: 10.1371/journal.ppat.1006823

New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins

Auteurs: Patrique Praest, A. Manuel Liaci, Friedrich Förster, Emmanuel J.H.J. Wiertz
Publié dans: Molecular Immunology, 2018, ISSN 0161-5890
Éditeur: Pergamon Press
DOI: 10.1016/j.molimm.2018.03.020

The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins

Auteurs: P. Praest, R.D. Luteijn, I.G.J. Brak-Boer, J. Lanfermeijer, H. Hoelen, L. Ijgosse, A.I. Costa, R.D. Gorham, R.J. Lebbink, E.J.H.J. Wiertz
Publié dans: Molecular Immunology, Numéro 101, 2018, Page(s) 55-64, ISSN 0161-5890
Éditeur: Pergamon Press
DOI: 10.1016/j.molimm.2018.05.025

Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections

Auteurs: Benson Ogunjimi, Shen-Ying Zhang, Katrine B. Sørensen, Kristian A. Skipper, Madalina Carter-Timofte, Gaspard Kerner, Stefanie Luecke, Thaneas Prabakaran, Yujia Cai, Josephina Meester, Esther Bartholomeus, Nikhita Ajit Bolar, Geert Vandeweyer, Charlotte Claes, Yasmine Sillis, Lazaro Lorenzo, Raffaele A. Fiorenza, Soraya Boucherit, Charlotte Dielman, Steven Heynderickx, George Elias, Andrea Kurotov
Publié dans: Journal of Clinical Investigation, Numéro 127/9, 2017, Page(s) 3543-3556, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/JCI92280

One Step Ahead: Herpesviruses Light the Way to Understanding Interferon-Stimulated Genes (ISGs)

Auteurs: A. Cristina Gonzalez-Perez, Markus Stempel, Baca Chan, Melanie M. Brinkmann
Publié dans: Frontiers in Microbiology, Numéro 11, 2020, ISSN 1664-302X
Éditeur: Frontiers Media
DOI: 10.3389/fmicb.2020.00124

Fluorescent TAP as a Platform for Virus-Induced Degradation of the Antigenic Peptide Transporter

Auteurs: Magda Wąchalska, Małgorzata Graul, Patrique Praest, Rutger D. Luteijn, Aleksandra W. Babnis, Emmanuel J. H. J. Wiertz, Krystyna Bieńkowska-Szewczyk, Andrea D. Lipińska
Publié dans: Cells, Numéro 8/12, 2019, Page(s) 1590, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells8121590

Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding

Auteurs: Andrea Iannucci, Valeria Caneparo, Stefano Raviola, Isacco Debernardi, Donato Colangelo, Riccardo Miggiano, Gloria Griffante, Santo Landolfo, Marisa Gariglio, Marco De Andrea
Publié dans: PLOS Pathogens, Numéro 16/9, 2020, Page(s) e1008811, ISSN 1553-7374
Éditeur: PloS Pathogens
DOI: 10.1371/journal.ppat.1008811

Varicella-Zoster Virus ORF9 Is an Antagonist of the DNA Sensor cGAS

Auteurs: Hertzog, Jonny; Rigby, Rachel E.; Roll, Sonja; Cursi, Chiara; Chauveau, Lise; Davenne, Tamara; Rehwinkel, Jan
Publié dans: 2020
Éditeur: bioRxiv
DOI: 10.1101/2020.02.11.943415

A Flow Cytometry-Based Approach to Unravel Viral Interference with the MHC Class I Antigen Processing and Presentation Pathway

Auteurs: Patrique Praest, Hendrik de Buhr, Emmanuel J. H. J. Wiertz
Publié dans: Antigen Processing - Methods and Protocols, Numéro 1988, 2019, Page(s) 187-198, ISBN 978-1-4939-9449-6
Éditeur: Springer New York
DOI: 10.1007/978-1-4939-9450-2_14

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