Training network providing cutting-EDGE knowlEDGE on Herpes Virology and Immunology

Resultado final

Communication of subject to high school students

Communication of subject to high school students. Due date: M21 - 32. Lead beneficiary: ALL

Characterization of two identified mutant proteins
Antiviral treatment potential evaluated in the SLE model
Evaluation of the potential of miRNA inhibition for tumor therapy

Evaluation of the potential of miRNA inhibition for tumor therapy .

Employment of CRISPR/Cas to block viral genes: immune evasion and oncogenic transformation
Development of specific and effective inhibitors of EBV microRNAs
Use of DNA sensors as biomarker to improve management of kidney transplant recipients

Use of DNA sensors as biomarker to improve management of kidney transplant recipients .

Description of the mechanism underlying phenotypes in mice
Characterization of newly identified VZV restriction factors
Recruitment Manager

Recruitment of Project manager completed .

Communication of ideas/results to stakeholders in the private and public sectors

Communication of ideas/results to stakeholders in the private and public sectors. Due date: M27-28. Lead beneficiary: all

Recruitment ESRs

Recruitment of ESRs completed.

Characterization of SLE phenotypes in mice – and impact on CMV infection
Demonstration of the function of two proteins on viral replication in vitro and in vivo

Demonstration of the function of two proteins on viral replication in vitro and in vivo.

Completion of development of lentiviral vectors for CRISPR-mediated editing of herpes genomes
PhD Tesis

ESR training finalised, Submission of PhD theses. Lead beneficiary: All

Draft Periodic Report

compulsory deliverable

CRISPR/Cas KO cell lines generated
Mid-term review meeting

compulsory deliverable

Identification of a cytosolic protease that detects and degrades incoming HSV1 capsids
Functional characterization of two host proteins interacting with HSV-1 capsids

Functional characterization of two host proteins interacting with HSV-1 capsids.

Participation in Science events for the public

Participation in Science events for the public. Due date:M27 -38, Lead beneficiary:all

Completion of characterization of ORF21/31 interactions with cellular proteins
Identification of viral molecules responsible for DNA sensor activation and their use to predict graft success or failure
Patent and publications in int. journals starting

Patent and publications in int. journals starting. Lead beneficiary: all. WP1-4,6

Characterization of two identified mutant proteins in the patients

Publicaciones

RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death

Autores: Mirjam Schilling, Anne Bridgeman, Nicki Gray, Jonny Hertzog, Philip Hublitz, Alain Kohl, Jan Rehwinkel
Publicado en: Cells, Edición 9/6, 2020, Página(s) 1476, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells9061476

Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins

Autores: Maibritt Mardahl; Franck Rapaport; Mette Christiansen
Publicado en: https://nn.neurology.org, Edición 2, 2018, Página(s) e500, ISSN 2332-7812
Editor: neurology.org
DOI: 10.1101/244848

Catch me if you can: the arms race between human cytomegalovirus and the innate immune system

Autores: Ganna Galitska, Matteo Biolatti, Gloria Griffante, Francesca Gugliesi, Selina Pasquero, Valentina Dell'Oste, Santo Landolfo
Publicado en: Future Virology, Edición 14/4, 2019, Página(s) 247-263, ISSN 1746-0794
Editor: Future Medicine Ltd.
DOI: 10.2217/fvl-2018-0189

Biological relevance of Cytomegalovirus genetic variability in congenitally and postnatally infected children

Autores: Ganna Galitska, Matteo Biolatti, Marco De Andrea, Agata Leone, Alessandra Coscia, Luigi Bertolotti, Ugo Ala, Enrico Bertino, Valentina Dell’Oste, Santo Landolfo
Publicado en: Journal of Clinical Virology, Edición 108, 2018, Página(s) 132-140, ISSN 1386-6532
Editor: Elsevier BV
DOI: 10.1016/j.jcv.2018.09.019

A Conserved Mechanism of APOBEC3 Relocalization by Herpesviral Ribonucleotide Reductase Large Subunits

Autores: Adam Z. Cheng, Sofia N. Moraes, Claire Attarian, Jaime Yockteng-Melgar, Matthew C. Jarvis, Matteo Biolatti, Ganna Galitska, Valentina Dell’Oste, Lori Frappier, Craig J. Bierle, Stephen A. Rice, Reuben S. Harris
Publicado en: Journal of Virology, Edición 93/23, 2019, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/jvi.01539-19

HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0

Autores: Niko Hensel, Verena Raker, Benjamin Förthmann, Nora Tula Detering, Sabrina Kubinski, Anna Buch, Georgios Katzilieris-Petras, Julia Spanier, Viktoria Gudi, Sylvia Wagenknecht, Verena Kopfnagel, Thomas Andreas Werfel, Martin Stangel, Andreas Beineke, Ulrich Kalinke, Søren Riis Paludan, Beate Sodeik, Peter Claus
Publicado en: Journal of Neuroinflammation, Edición 16/1, 2019, ISSN 1742-2094
Editor: BioMed Central
DOI: 10.1186/s12974-019-1647-5

RNA accessibility impacts potency of Tough Decoy microRNA inhibitors

Autores: Marjolein J. G. Hooykaas, Jasper A. Soppe, Hendrik M. De Buhr, Elisabeth Kruse, Emmanuel J. H. J. Wiertz, Robert J. Lebbink
Publicado en: RNA Biology, Edición 15/11, 2018, Página(s) 1410-1419, ISSN 1547-6286
Editor: Landes Bioscience
DOI: 10.1080/15476286.2018.1537746

A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope

Autores: Rutger D. Luteijn, Patrique Praest, Frank Thiele, Saravanan Manikam Sadasivam, Katrin Singethan, Jan W. Drijfhout, Christian Bach, Steffen Matthijn de Boer, Robert J. Lebbink, Sha Tao, Markus Helfer, Nina C. Bach, Ulrike Protzer, Ana I. Costa, J. Antoinette Killian, Ingo Drexler, Emmanuel J. H. J. Wiertz
Publicado en: Cells, Edición 9/9, 2020, Página(s) 1989, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells9091989

Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins

Autores: Madalina E. Carter-Timofte, Anders F. Hansen, Maibritt Mardahl, Sébastien Fribourg, Franck Rapaport, Shen-Ying Zhang, Jean-Laurent Casanova, Søren R. Paludan, Mette Christiansen, Carsten S. Larsen, Trine H. Mogensen
Publicado en: Neurology - Neuroimmunology Neuroinflammation, Edición 5/6, 2018, Página(s) e500, ISSN 2332-7812
Editor: neurology.org
DOI: 10.1212/nxi.0000000000000500

The Viral Tegument Protein pp65 Impairs Transcriptional Upregulation of IL-1β by Human Cytomegalovirus through Inhibition of NF-kB Activity

Autores: Matteo Biolatti, Valentina Dell’Oste, Sara Scutera, Francesca Gugliesi, Gloria Griffante, Marco De Andrea, Tiziana Musso, Santo Landolfo
Publicado en: Viruses, Edición 10/10, 2018, Página(s) 567, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v10100567

Harnessing CRISPR to combat human viral infections

Autores: Hendrik de Buhr, Robert Jan Lebbink
Publicado en: Current Opinion in Immunology, Edición 54, 2018, Página(s) 123-129, ISSN 0952-7915
Editor: Elsevier BV
DOI: 10.1016/j.coi.2018.06.002

Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

Autores: Judith Lang, Patrick Bohn, Hilal Bhat, Holger Jastrow, Bernd Walkenfort, Feyza Cansiz, Julian Fink, Michael Bauer, Dominik Olszewski, Ana Ramos-Nascimento, Vikas Duhan, Sarah-Kim Friedrich, Katrin Anne Becker, Adalbert Krawczyk, Michael J. Edwards, Andreas Burchert, Magdalena Huber, Justa Friebus-Kardash, Joachim R. Göthert, Cornelia Hardt, Hans Christian Probst, Fabian Schumacher, Karl Köhrer,
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-15072-8

Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling

Autores: Jonny Hertzog, Antonio Gregorio Dias Junior, Rachel E. Rigby, Claire L. Donald, Alice Mayer, Erdinc Sezgin, Chaojun Song, Boquan Jin, Philip Hublitz, Christian Eggeling, Alain Kohl, Jan Rehwinkel
Publicado en: European Journal of Immunology, 2018, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201847483

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons

Autores: Katinka Döhner, Ana Ramos-Nascimento, Dagmara Bialy, Fenja Anderson, Ana Hickford-Martinez, Franziska Rother, Thalea Koithan, Kathrin Rudolph, Anna Buch, Ute Prank, Anne Binz, Stefanie Hügel, Robert Jan Lebbink, Rob C. Hoeben, Enno Hartmann, Michael Bader, Rudolf Bauerfeind, Beate Sodeik
Publicado en: PLOS Pathogens, Edición 14/1, 2018, Página(s) e1006823, ISSN 1553-7374
Editor: PLOS Pathogens
DOI: 10.1371/journal.ppat.1006823

New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins

Autores: Patrique Praest, A. Manuel Liaci, Friedrich Förster, Emmanuel J.H.J. Wiertz
Publicado en: Molecular Immunology, 2018, ISSN 0161-5890
Editor: Pergamon Press
DOI: 10.1016/j.molimm.2018.03.020

The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins

Autores: P. Praest, R.D. Luteijn, I.G.J. Brak-Boer, J. Lanfermeijer, H. Hoelen, L. Ijgosse, A.I. Costa, R.D. Gorham, R.J. Lebbink, E.J.H.J. Wiertz
Publicado en: Molecular Immunology, Edición 101, 2018, Página(s) 55-64, ISSN 0161-5890
Editor: Pergamon Press
DOI: 10.1016/j.molimm.2018.05.025

Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections

Autores: Benson Ogunjimi, Shen-Ying Zhang, Katrine B. Sørensen, Kristian A. Skipper, Madalina Carter-Timofte, Gaspard Kerner, Stefanie Luecke, Thaneas Prabakaran, Yujia Cai, Josephina Meester, Esther Bartholomeus, Nikhita Ajit Bolar, Geert Vandeweyer, Charlotte Claes, Yasmine Sillis, Lazaro Lorenzo, Raffaele A. Fiorenza, Soraya Boucherit, Charlotte Dielman, Steven Heynderickx, George Elias, Andrea Kurotov
Publicado en: Journal of Clinical Investigation, Edición 127/9, 2017, Página(s) 3543-3556, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/JCI92280

One Step Ahead: Herpesviruses Light the Way to Understanding Interferon-Stimulated Genes (ISGs)

Autores: A. Cristina Gonzalez-Perez, Markus Stempel, Baca Chan, Melanie M. Brinkmann
Publicado en: Frontiers in Microbiology, Edición 11, 2020, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2020.00124

Fluorescent TAP as a Platform for Virus-Induced Degradation of the Antigenic Peptide Transporter

Autores: Magda Wąchalska, Małgorzata Graul, Patrique Praest, Rutger D. Luteijn, Aleksandra W. Babnis, Emmanuel J. H. J. Wiertz, Krystyna Bieńkowska-Szewczyk, Andrea D. Lipińska
Publicado en: Cells, Edición 8/12, 2019, Página(s) 1590, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells8121590

Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding

Autores: Andrea Iannucci, Valeria Caneparo, Stefano Raviola, Isacco Debernardi, Donato Colangelo, Riccardo Miggiano, Gloria Griffante, Santo Landolfo, Marisa Gariglio, Marco De Andrea
Publicado en: PLOS Pathogens, Edición 16/9, 2020, Página(s) e1008811, ISSN 1553-7374
Editor: PloS Pathogens
DOI: 10.1371/journal.ppat.1008811

Varicella-Zoster Virus ORF9 Is an Antagonist of the DNA Sensor cGAS

Autores: Hertzog, Jonny; Rigby, Rachel E.; Roll, Sonja; Cursi, Chiara; Chauveau, Lise; Davenne, Tamara; Rehwinkel, Jan
Publicado en: 2020
Editor: bioRxiv
DOI: 10.1101/2020.02.11.943415

A Flow Cytometry-Based Approach to Unravel Viral Interference with the MHC Class I Antigen Processing and Presentation Pathway

Autores: Patrique Praest, Hendrik de Buhr, Emmanuel J. H. J. Wiertz
Publicado en: Antigen Processing - Methods and Protocols, Edición 1988, 2019, Página(s) 187-198, ISBN 978-1-4939-9449-6
Editor: Springer New York
DOI: 10.1007/978-1-4939-9450-2_14

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