Deliverables Websites, patent fillings, videos etc. (1) PDZnet website Functional website Documents, reports (1) CDE plan All ESRs will participate in public outreach activities, present at international conferences and submit at least two manuscripts for publication in a scientific journal Publications Peer reviewed articles (20) Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners Author(s): Yanlei Zhu, Florent Delhommel, Florence Cordier, Susanne Lüchow, Ariel Mechaly, Baptiste Colcombet-Cazenave, Virginie Girault, Elise Pepermans, Amel Bahloul, Candice Gautier, Sébastien Brûlé, Bertrand Raynal, Sylviane Hoos, Ahmed Haouz, Célia Caillet-Saguy, Ylva Ivarsson, Nicolas Wolff Published in: Journal of Molecular Biology, 2020, ISSN 0022-2836 Publisher: Academic Press DOI: 10.1016/j.jmb.2020.09.012 Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study Author(s): Gergo Gogl, Pau Jane, Célia Caillet-Saguy, Camille Kostmann, Goran Bich, Alexandra Cousido-Siah, Laszlo Nyitray, Renaud Vincentelli, Nicolas Wolff, Yves Nominé, Nikolai Sluchanko, Gilles Travé Published in: Structure, 2020, ISSN 1878-4186 Publisher: Cell Press DOI: 10.1016/j.str.2020.03.010 Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation Author(s): Gergő Gógl, Beáta Biri-Kovács, Fabien Durbesson, Pau Jane, Yves Nomine, Camille Kostmann, Viktória Bilics, Márton Simon, Attila Reményi, Renaud Vincentelli, Gilles Trave, László Nyitray Published in: J Mol Biol., 2020, ISSN 1948-5875 Publisher: American Chemical Society DOI: 10.1016/j.jmb.2019.01.038 Functional interplay between protein domains in a supramodular structure involving the postsynaptic density protein PSD-95 Author(s): Louise Laursen, Elin Karlsson, Stefano Gianni, Per Jemth Published in: Journal of Biological Chemistry, Issue 295/7, 2020, Page(s) 1992-2000, ISSN 0021-9258 Publisher: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/jbc.ra119.011050 ELM—the eukaryotic linear motif resource in 2020 Author(s): Manjeet Kumar, Marc Gouw, Sushama Michael, Hugo Sámano-Sánchez, Rita Pancsa, Juliana Glavina, Athina Diakogianni, Jesús Alvarado Valverde, Dayana Bukirova, Jelena Čalyševa, Nicolas Palopoli, Norman E Davey, Lucía B Chemes, Toby J Gibson Published in: Nucleic Acids Research, 2019, ISSN 0305-1048 Publisher: Oxford University Press DOI: 10.1093/nar/gkz1030 Divergent evolution of a protein-protein interaction revealed through ancestral sequence reconstruction and resurrection. Author(s): Laursen, L., Calyseva, J., Gibson, T., and Jemth, P. Published in: Molecular Biology and Evolution, 2020, ISSN 1537-1719 Publisher: Oxford University Press DOI: 10.1093/molbev/msaa198 Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95 Author(s): Candice Gautier, Lorenzo Visconti, Per Jemth, Stefano Gianni Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-017-12827-0 The planar cell polarity Vangl2 protein: From genetics to cellular and molecular functions Author(s): Eric Bailly, Alexandra Walton, Jean-Paul Borg Published in: Seminars in Cell & Developmental Biology, 2017, ISSN 1084-9521 Publisher: Academic Press DOI: 10.1016/j.semcdb.2017.10.030 Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis Author(s): Amandine Cartier-Michaud, Anne-Laure Bailly, Stéphane Betzi, Xiaoli Shi, Jean-Claude Lissitzky, Ana Zarubica, Arnauld Sergé, Philippe Roche, Adrien Lugari, Véronique Hamon, Florence Bardin, Carine Derviaux, Frédérique Lembo, Stéphane Audebert, Sylvie Marchetto, Bénédicte Durand, Jean-Paul Borg, Ning Shi, Xavier Morelli, Michel Aurrand-Lions Published in: PLOS Genetics, Issue 13/6, 2017, Page(s) e1006803, ISSN 1549-1277 Publisher: Public Library of Science DOI: 10.1371/journal.pgen.1006803 A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib Author(s): Tianliang Sun, Lida Yang, Harmandeep Kaur, Jenny Pestel, Mario Looso, Hendrik Nolte, Cornelius Krasel, Daniel Heil, Ramesh K. Krishnan, Marie-Josée Santoni, Jean-Paul Borg, Moritz Bünemann, Stefan Offermanns, Jakub M. Swiercz, Thomas Worzfeld Published in: The Journal of Cell Biology, Issue 216/1, 2017, Page(s) 199-215, ISSN 0021-9525 Publisher: Rockefeller University Press DOI: 10.1083/jcb.201602002 Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma Author(s): Madeline N. Hayes, Karin McCarthy, Alexander Jin, Mariana L. Oliveira, Sowmya Iyer, Sara P. Garcia, Sivasish Sindiri, Berkley Gryder, Zainab Motala, G. Petur Nielsen, Jean-Paul Borg, Matt van de Rijn, David Malkin, Javed Khan, Myron S. Ignatius, David M. Langenau Published in: Cell Stem Cell, Issue 22/3, 2018, Page(s) 414-427.e6, ISSN 1934-5909 Publisher: Cell Press DOI: 10.1016/j.stem.2018.02.002 Wnt/Planar Cell Polarity Signaling: New Opportunities for Cancer Treatment Author(s): Avais M. Daulat, Jean-Paul Borg Published in: Trends in Cancer, Issue 3/2, 2017, Page(s) 113-125, ISSN 2405-8033 Publisher: Cell Press DOI: 10.1016/j.trecan.2017.01.001 Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse Author(s): Muna L Hilal, Maité M Moreau, Claudia Racca, Vera L Pinheiro, Nicolas H Piguel, Marie-Josée Santoni, Steve Dos Santos Carvalho, Jean-Michel Blanc, Yah-Se K Abada, Ronan Peyroutou, Chantal Medina, Hélène Doat, Thomas Papouin, Laurent Vuillard, Jean-Paul Borg, Rivka Rachel, Aude Panatier, Mireille Montcouquiol, Stéphane H R Oliet, Nathalie Sans Published in: Cerebral Cortex, Issue 27/12, 2016, Page(s) 5635-5651, ISSN 1047-3211 Publisher: Oxford University Press DOI: 10.1093/cercor/bhw333 Epithelial barrier dysfunction in desmoglein-1 deficiency Author(s): Laura Polivka, Smail Hadj-Rabia, Elodie Bal, Stéphanie Leclerc-Mercier, Marine Madrange, Yamina Hamel, Damien Bonnet, Stéphanie Mallet, Hubert Lepidi, Caroline Ovaert, Patrick Barbet, Christophe Dupont, Bénédicte Neven, Arnold Munnich, Lisa M. Godsel, Florence Campeotto, Robert Weil, Emmanuel Laplantine, Sylvie Marchetto, Jean-Paul Borg, William I. Weis, Jean-Laurent Casanova, Anne Puel, Kathl Published in: Journal of Allergy and Clinical Immunology, 2018, ISSN 0091-6749 Publisher: Mosby Inc. DOI: 10.1016/j.jaci.2018.04.007 β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy Author(s): Concetta Saponaro, Sara Sergio, Antonio Coluccia, Maria De Luca, Giuseppe La Regina, Luca Mologni, Valeria Famiglini, Valentina Naccarato, Daniela Bonetti, Candice Gautier, Stefano Gianni, Daniele Vergara, Michel Salzet, Isabelle Fournier, Cecilia Bucci, Romano Silvestri, Carlo Gambacorti Passerini, Michele Maffia, Addolorata Maria Luce Coluccia Published in: Oncogene, Issue 37/24, 2018, Page(s) 3301-3316, ISSN 0950-9232 Publisher: Nature Publishing Group DOI: 10.1038/s41388-018-0170-y Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation Author(s): Jia Yuan, Wenbo Deng, Jeeyeon Cha, Xiaofei Sun, Jean-Paul Borg, Sudhansu. K. Dey Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-018-03092-4 Seeking allosteric networks in PDZ domains Author(s): Candice Gautier, Louise Laursen, Per Jemth, Stefano Gianni Published in: Protein Engineering, Design and Selection, 2018, ISSN 1741-0126 Publisher: Oxford University Press DOI: 10.1093/protein/gzy033 Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents Author(s): Antonio Coluccia, Giuseppe La Regina, Valentina Naccarato, Marianna Nalli, Viviana Orlando, Stefano Biagioni, Maria Laura De Angelis, Marta Baiocchi, Candice Gautier, Stefano Gianni, Fiorella Di Pastena, Laura Di Magno, Gianluca Canettieri, Addolorata Maria Luce Coluccia, Romano Silvestri Published in: ACS Medicinal Chemistry Letters, 2019, ISSN 1948-5875 Publisher: American Chemical Society DOI: 10.1021/acsmedchemlett.8b00532 Supertertiary protein structure affects an allosteric network Author(s): Louise Laursen, Johanna Kliche, Stefano Gianni, Per Jemth Published in: Proceedings of the National Academy of Sciences, Issue 117/39, 2020, Page(s) 24294-24304, ISSN 0027-8424 Publisher: National Academy of Sciences DOI: 10.1073/pnas.2007201117 High-Throughput Production of a New Library of Human Single and Tandem PDZ Domains Allows Quantitative PDZ-Peptide Interaction Screening Through High-Throughput Holdup Assay. Author(s): Yoan Duhoo, Virginie Girault, Jeremy Turchetto, Laurie Ramond, Fabien Durbesson, Patrick Fourquet, Yves Nominé, Vânia Cardoso, Ana Filipa Sequeira, Joana L A Brás, Carlos M G A Fontes, Gilles Travé, Nicolas Wolff, Renaud Vincentelli Published in: Methods Mol Biol, 2020, ISSN 1741-0126 Publisher: Oxford University Press DOI: 10.1007/978-1-4939-9624-7_21 Book chapters (1) How to Annotate and Submit a Short Linear Motif to the Eukaryotic Linear Motif Resource Author(s): Marc Gouw, Jesús Alvarado-Valverde, Jelena Čalyševa, Francesca Diella, Manjeet Kumar, Sushama Michael, Kim Van Roey, Holger Dinkel, Toby J. Gibson Published in: Intrinsically Disordered Proteins - Methods and Protocols, Issue 2141, 2020, Page(s) 73-102, ISBN 978-1-0716-0523-3 Publisher: Springer US DOI: 10.1007/978-1-0716-0524-0_4 Non-peer reviewed articles (1) Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications Author(s): Mészáros, Bálint; Sámano-Sánchez, Hugo; Alvarado-Valverde, Jesús; Čalyševa, Jelena; Martínez-Pérez, Elizabeth; Alves, Renato; Kumar, Manjeet; Rippmann, Friedrich; Chemes, Lucía B.; Gibson, Toby J.; . Published in: arxiv preprint server, Issue 4, 2020, ISSN 2331-8422 Publisher: ArXiv.org Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
