Unraveling Principles of PDZ-mediated Cell Signaling

Resultado final

Functional website

All ESRs will participate in public outreach activities, present at international conferences and submit at least two manuscripts for publication in a scientific journal

Publicaciones

Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners

Autores: Yanlei Zhu, Florent Delhommel, Florence Cordier, Susanne Lüchow, Ariel Mechaly, Baptiste Colcombet-Cazenave, Virginie Girault, Elise Pepermans, Amel Bahloul, Candice Gautier, Sébastien Brûlé, Bertrand Raynal, Sylviane Hoos, Ahmed Haouz, Célia Caillet-Saguy, Ylva Ivarsson, Nicolas Wolff
Publicado en: Journal of Molecular Biology, 2020, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2020.09.012

Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study

Autores: Gergo Gogl, Pau Jane, Célia Caillet-Saguy, Camille Kostmann, Goran Bich, Alexandra Cousido-Siah, Laszlo Nyitray, Renaud Vincentelli, Nicolas Wolff, Yves Nominé, Nikolai Sluchanko, Gilles Travé
Publicado en: Structure, 2020, ISSN 1878-4186
Editor: Cell Press
DOI: 10.1016/j.str.2020.03.010

Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation

Autores: Gergő Gógl, Beáta Biri-Kovács, Fabien Durbesson, Pau Jane, Yves Nomine, Camille Kostmann, Viktória Bilics, Márton Simon, Attila Reményi, Renaud Vincentelli, Gilles Trave, László Nyitray
Publicado en: J Mol Biol., 2020, ISSN 1948-5875
Editor: American Chemical Society
DOI: 10.1016/j.jmb.2019.01.038

Functional interplay between protein domains in a supramodular structure involving the postsynaptic density protein PSD-95

Autores: Louise Laursen, Elin Karlsson, Stefano Gianni, Per Jemth
Publicado en: Journal of Biological Chemistry, Edición 295/7, 2020, Página(s) 1992-2000, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.011050

ELM—the eukaryotic linear motif resource in 2020

Autores: Manjeet Kumar, Marc Gouw, Sushama Michael, Hugo Sámano-Sánchez, Rita Pancsa, Juliana Glavina, Athina Diakogianni, Jesús Alvarado Valverde, Dayana Bukirova, Jelena Čalyševa, Nicolas Palopoli, Norman E Davey, Lucía B Chemes, Toby J Gibson
Publicado en: Nucleic Acids Research, 2019, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkz1030

Divergent evolution of a protein-protein interaction revealed through ancestral sequence reconstruction and resurrection.

Autores: Laursen, L., Calyseva, J., Gibson, T., and Jemth, P.
Publicado en: Molecular Biology and Evolution, 2020, ISSN 1537-1719
Editor: Oxford University Press
DOI: 10.1093/molbev/msaa198

Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95

Autores: Candice Gautier, Lorenzo Visconti, Per Jemth, Stefano Gianni
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-12827-0

The planar cell polarity Vangl2 protein: From genetics to cellular and molecular functions

Autores: Eric Bailly, Alexandra Walton, Jean-Paul Borg
Publicado en: Seminars in Cell & Developmental Biology, 2017, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2017.10.030

Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis

Autores: Amandine Cartier-Michaud, Anne-Laure Bailly, Stéphane Betzi, Xiaoli Shi, Jean-Claude Lissitzky, Ana Zarubica, Arnauld Sergé, Philippe Roche, Adrien Lugari, Véronique Hamon, Florence Bardin, Carine Derviaux, Frédérique Lembo, Stéphane Audebert, Sylvie Marchetto, Bénédicte Durand, Jean-Paul Borg, Ning Shi, Xavier Morelli, Michel Aurrand-Lions
Publicado en: PLOS Genetics, Edición 13/6, 2017, Página(s) e1006803, ISSN 1549-1277
Editor: Public Library of Science
DOI: 10.1371/journal.pgen.1006803

A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib

Autores: Tianliang Sun, Lida Yang, Harmandeep Kaur, Jenny Pestel, Mario Looso, Hendrik Nolte, Cornelius Krasel, Daniel Heil, Ramesh K. Krishnan, Marie-Josée Santoni, Jean-Paul Borg, Moritz Bünemann, Stefan Offermanns, Jakub M. Swiercz, Thomas Worzfeld
Publicado en: The Journal of Cell Biology, Edición 216/1, 2017, Página(s) 199-215, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.201602002

Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma

Autores: Madeline N. Hayes, Karin McCarthy, Alexander Jin, Mariana L. Oliveira, Sowmya Iyer, Sara P. Garcia, Sivasish Sindiri, Berkley Gryder, Zainab Motala, G. Petur Nielsen, Jean-Paul Borg, Matt van de Rijn, David Malkin, Javed Khan, Myron S. Ignatius, David M. Langenau
Publicado en: Cell Stem Cell, Edición 22/3, 2018, Página(s) 414-427.e6, ISSN 1934-5909
Editor: Cell Press
DOI: 10.1016/j.stem.2018.02.002

Wnt/Planar Cell Polarity Signaling: New Opportunities for Cancer Treatment

Autores: Avais M. Daulat, Jean-Paul Borg
Publicado en: Trends in Cancer, Edición 3/2, 2017, Página(s) 113-125, ISSN 2405-8033
Editor: Cell Press
DOI: 10.1016/j.trecan.2017.01.001

Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse

Autores: Muna L Hilal, Maité M Moreau, Claudia Racca, Vera L Pinheiro, Nicolas H Piguel, Marie-Josée Santoni, Steve Dos Santos Carvalho, Jean-Michel Blanc, Yah-Se K Abada, Ronan Peyroutou, Chantal Medina, Hélène Doat, Thomas Papouin, Laurent Vuillard, Jean-Paul Borg, Rivka Rachel, Aude Panatier, Mireille Montcouquiol, Stéphane H R Oliet, Nathalie Sans
Publicado en: Cerebral Cortex, Edición 27/12, 2016, Página(s) 5635-5651, ISSN 1047-3211
Editor: Oxford University Press
DOI: 10.1093/cercor/bhw333

Epithelial barrier dysfunction in desmoglein-1 deficiency

Autores: Laura Polivka, Smail Hadj-Rabia, Elodie Bal, Stéphanie Leclerc-Mercier, Marine Madrange, Yamina Hamel, Damien Bonnet, Stéphanie Mallet, Hubert Lepidi, Caroline Ovaert, Patrick Barbet, Christophe Dupont, Bénédicte Neven, Arnold Munnich, Lisa M. Godsel, Florence Campeotto, Robert Weil, Emmanuel Laplantine, Sylvie Marchetto, Jean-Paul Borg, William I. Weis, Jean-Laurent Casanova, Anne Puel, Kathl
Publicado en: Journal of Allergy and Clinical Immunology, 2018, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2018.04.007

β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy

Autores: Concetta Saponaro, Sara Sergio, Antonio Coluccia, Maria De Luca, Giuseppe La Regina, Luca Mologni, Valeria Famiglini, Valentina Naccarato, Daniela Bonetti, Candice Gautier, Stefano Gianni, Daniele Vergara, Michel Salzet, Isabelle Fournier, Cecilia Bucci, Romano Silvestri, Carlo Gambacorti Passerini, Michele Maffia, Addolorata Maria Luce Coluccia
Publicado en: Oncogene, Edición 37/24, 2018, Página(s) 3301-3316, ISSN 0950-9232
Editor: Nature Publishing Group
DOI: 10.1038/s41388-018-0170-y

Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation

Autores: Jia Yuan, Wenbo Deng, Jeeyeon Cha, Xiaofei Sun, Jean-Paul Borg, Sudhansu. K. Dey
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-03092-4

Seeking allosteric networks in PDZ domains

Autores: Candice Gautier, Louise Laursen, Per Jemth, Stefano Gianni
Publicado en: Protein Engineering, Design and Selection, 2018, ISSN 1741-0126
Editor: Oxford University Press
DOI: 10.1093/protein/gzy033

Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents

Autores: Antonio Coluccia, Giuseppe La Regina, Valentina Naccarato, Marianna Nalli, Viviana Orlando, Stefano Biagioni, Maria Laura De Angelis, Marta Baiocchi, Candice Gautier, Stefano Gianni, Fiorella Di Pastena, Laura Di Magno, Gianluca Canettieri, Addolorata Maria Luce Coluccia, Romano Silvestri
Publicado en: ACS Medicinal Chemistry Letters, 2019, ISSN 1948-5875
Editor: American Chemical Society
DOI: 10.1021/acsmedchemlett.8b00532

Supertertiary protein structure affects an allosteric network

Autores: Louise Laursen, Johanna Kliche, Stefano Gianni, Per Jemth
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/39, 2020, Página(s) 24294-24304, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2007201117

High-Throughput Production of a New Library of Human Single and Tandem PDZ Domains Allows Quantitative PDZ-Peptide Interaction Screening Through High-Throughput Holdup Assay.

Autores: Yoan Duhoo, Virginie Girault, Jeremy Turchetto, Laurie Ramond, Fabien Durbesson, Patrick Fourquet, Yves Nominé, Vânia Cardoso, Ana Filipa Sequeira, Joana L A Brás, Carlos M G A Fontes, Gilles Travé, Nicolas Wolff, Renaud Vincentelli
Publicado en: Methods Mol Biol, 2020, ISSN 1741-0126
Editor: Oxford University Press
DOI: 10.1007/978-1-4939-9624-7_21

How to Annotate and Submit a Short Linear Motif to the Eukaryotic Linear Motif Resource

Autores: Marc Gouw, Jesús Alvarado-Valverde, Jelena Čalyševa, Francesca Diella, Manjeet Kumar, Sushama Michael, Kim Van Roey, Holger Dinkel, Toby J. Gibson
Publicado en: Intrinsically Disordered Proteins - Methods and Protocols, Edición 2141, 2020, Página(s) 73-102, ISBN 978-1-0716-0523-3
Editor: Springer US
DOI: 10.1007/978-1-0716-0524-0_4

Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications

Autores: Mészáros, Bálint; Sámano-Sánchez, Hugo; Alvarado-Valverde, Jesús; Čalyševa, Jelena; Martínez-Pérez, Elizabeth; Alves, Renato; Kumar, Manjeet; Rippmann, Friedrich; Chemes, Lucía B.; Gibson, Toby J.; .
Publicado en: arxiv preprint server, Edición 4, 2020, ISSN 2331-8422
Editor: ArXiv.org

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