Unraveling Principles of PDZ-mediated Cell Signaling

Risultati finali

Functional website

All ESRs will participate in public outreach activities, present at international conferences and submit at least two manuscripts for publication in a scientific journal

Pubblicazioni

Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners

Autori: Yanlei Zhu, Florent Delhommel, Florence Cordier, Susanne Lüchow, Ariel Mechaly, Baptiste Colcombet-Cazenave, Virginie Girault, Elise Pepermans, Amel Bahloul, Candice Gautier, Sébastien Brûlé, Bertrand Raynal, Sylviane Hoos, Ahmed Haouz, Célia Caillet-Saguy, Ylva Ivarsson, Nicolas Wolff
Pubblicato in: Journal of Molecular Biology, 2020, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2020.09.012

Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study

Autori: Gergo Gogl, Pau Jane, Célia Caillet-Saguy, Camille Kostmann, Goran Bich, Alexandra Cousido-Siah, Laszlo Nyitray, Renaud Vincentelli, Nicolas Wolff, Yves Nominé, Nikolai Sluchanko, Gilles Travé
Pubblicato in: Structure, 2020, ISSN 1878-4186
Editore: Cell Press
DOI: 10.1016/j.str.2020.03.010

Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation

Autori: Gergő Gógl, Beáta Biri-Kovács, Fabien Durbesson, Pau Jane, Yves Nomine, Camille Kostmann, Viktória Bilics, Márton Simon, Attila Reményi, Renaud Vincentelli, Gilles Trave, László Nyitray
Pubblicato in: J Mol Biol., 2020, ISSN 1948-5875
Editore: American Chemical Society
DOI: 10.1016/j.jmb.2019.01.038

Functional interplay between protein domains in a supramodular structure involving the postsynaptic density protein PSD-95

Autori: Louise Laursen, Elin Karlsson, Stefano Gianni, Per Jemth
Pubblicato in: Journal of Biological Chemistry, Numero 295/7, 2020, Pagina/e 1992-2000, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.011050

ELM—the eukaryotic linear motif resource in 2020

Autori: Manjeet Kumar, Marc Gouw, Sushama Michael, Hugo Sámano-Sánchez, Rita Pancsa, Juliana Glavina, Athina Diakogianni, Jesús Alvarado Valverde, Dayana Bukirova, Jelena Čalyševa, Nicolas Palopoli, Norman E Davey, Lucía B Chemes, Toby J Gibson
Pubblicato in: Nucleic Acids Research, 2019, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkz1030

Divergent evolution of a protein-protein interaction revealed through ancestral sequence reconstruction and resurrection.

Autori: Laursen, L., Calyseva, J., Gibson, T., and Jemth, P.
Pubblicato in: Molecular Biology and Evolution, 2020, ISSN 1537-1719
Editore: Oxford University Press
DOI: 10.1093/molbev/msaa198

Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95

Autori: Candice Gautier, Lorenzo Visconti, Per Jemth, Stefano Gianni
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-12827-0

The planar cell polarity Vangl2 protein: From genetics to cellular and molecular functions

Autori: Eric Bailly, Alexandra Walton, Jean-Paul Borg
Pubblicato in: Seminars in Cell & Developmental Biology, 2017, ISSN 1084-9521
Editore: Academic Press
DOI: 10.1016/j.semcdb.2017.10.030

Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis

Autori: Amandine Cartier-Michaud, Anne-Laure Bailly, Stéphane Betzi, Xiaoli Shi, Jean-Claude Lissitzky, Ana Zarubica, Arnauld Sergé, Philippe Roche, Adrien Lugari, Véronique Hamon, Florence Bardin, Carine Derviaux, Frédérique Lembo, Stéphane Audebert, Sylvie Marchetto, Bénédicte Durand, Jean-Paul Borg, Ning Shi, Xavier Morelli, Michel Aurrand-Lions
Pubblicato in: PLOS Genetics, Numero 13/6, 2017, Pagina/e e1006803, ISSN 1549-1277
Editore: Public Library of Science
DOI: 10.1371/journal.pgen.1006803

A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib

Autori: Tianliang Sun, Lida Yang, Harmandeep Kaur, Jenny Pestel, Mario Looso, Hendrik Nolte, Cornelius Krasel, Daniel Heil, Ramesh K. Krishnan, Marie-Josée Santoni, Jean-Paul Borg, Moritz Bünemann, Stefan Offermanns, Jakub M. Swiercz, Thomas Worzfeld
Pubblicato in: The Journal of Cell Biology, Numero 216/1, 2017, Pagina/e 199-215, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.201602002

Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma

Autori: Madeline N. Hayes, Karin McCarthy, Alexander Jin, Mariana L. Oliveira, Sowmya Iyer, Sara P. Garcia, Sivasish Sindiri, Berkley Gryder, Zainab Motala, G. Petur Nielsen, Jean-Paul Borg, Matt van de Rijn, David Malkin, Javed Khan, Myron S. Ignatius, David M. Langenau
Pubblicato in: Cell Stem Cell, Numero 22/3, 2018, Pagina/e 414-427.e6, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2018.02.002

Wnt/Planar Cell Polarity Signaling: New Opportunities for Cancer Treatment

Autori: Avais M. Daulat, Jean-Paul Borg
Pubblicato in: Trends in Cancer, Numero 3/2, 2017, Pagina/e 113-125, ISSN 2405-8033
Editore: Cell Press
DOI: 10.1016/j.trecan.2017.01.001

Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse

Autori: Muna L Hilal, Maité M Moreau, Claudia Racca, Vera L Pinheiro, Nicolas H Piguel, Marie-Josée Santoni, Steve Dos Santos Carvalho, Jean-Michel Blanc, Yah-Se K Abada, Ronan Peyroutou, Chantal Medina, Hélène Doat, Thomas Papouin, Laurent Vuillard, Jean-Paul Borg, Rivka Rachel, Aude Panatier, Mireille Montcouquiol, Stéphane H R Oliet, Nathalie Sans
Pubblicato in: Cerebral Cortex, Numero 27/12, 2016, Pagina/e 5635-5651, ISSN 1047-3211
Editore: Oxford University Press
DOI: 10.1093/cercor/bhw333

Epithelial barrier dysfunction in desmoglein-1 deficiency

Autori: Laura Polivka, Smail Hadj-Rabia, Elodie Bal, Stéphanie Leclerc-Mercier, Marine Madrange, Yamina Hamel, Damien Bonnet, Stéphanie Mallet, Hubert Lepidi, Caroline Ovaert, Patrick Barbet, Christophe Dupont, Bénédicte Neven, Arnold Munnich, Lisa M. Godsel, Florence Campeotto, Robert Weil, Emmanuel Laplantine, Sylvie Marchetto, Jean-Paul Borg, William I. Weis, Jean-Laurent Casanova, Anne Puel, Kathl
Pubblicato in: Journal of Allergy and Clinical Immunology, 2018, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2018.04.007

β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy

Autori: Concetta Saponaro, Sara Sergio, Antonio Coluccia, Maria De Luca, Giuseppe La Regina, Luca Mologni, Valeria Famiglini, Valentina Naccarato, Daniela Bonetti, Candice Gautier, Stefano Gianni, Daniele Vergara, Michel Salzet, Isabelle Fournier, Cecilia Bucci, Romano Silvestri, Carlo Gambacorti Passerini, Michele Maffia, Addolorata Maria Luce Coluccia
Pubblicato in: Oncogene, Numero 37/24, 2018, Pagina/e 3301-3316, ISSN 0950-9232
Editore: Nature Publishing Group
DOI: 10.1038/s41388-018-0170-y

Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation

Autori: Jia Yuan, Wenbo Deng, Jeeyeon Cha, Xiaofei Sun, Jean-Paul Borg, Sudhansu. K. Dey
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-03092-4

Seeking allosteric networks in PDZ domains

Autori: Candice Gautier, Louise Laursen, Per Jemth, Stefano Gianni
Pubblicato in: Protein Engineering, Design and Selection, 2018, ISSN 1741-0126
Editore: Oxford University Press
DOI: 10.1093/protein/gzy033

Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents

Autori: Antonio Coluccia, Giuseppe La Regina, Valentina Naccarato, Marianna Nalli, Viviana Orlando, Stefano Biagioni, Maria Laura De Angelis, Marta Baiocchi, Candice Gautier, Stefano Gianni, Fiorella Di Pastena, Laura Di Magno, Gianluca Canettieri, Addolorata Maria Luce Coluccia, Romano Silvestri
Pubblicato in: ACS Medicinal Chemistry Letters, 2019, ISSN 1948-5875
Editore: American Chemical Society
DOI: 10.1021/acsmedchemlett.8b00532

Supertertiary protein structure affects an allosteric network

Autori: Louise Laursen, Johanna Kliche, Stefano Gianni, Per Jemth
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 117/39, 2020, Pagina/e 24294-24304, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2007201117

High-Throughput Production of a New Library of Human Single and Tandem PDZ Domains Allows Quantitative PDZ-Peptide Interaction Screening Through High-Throughput Holdup Assay.

Autori: Yoan Duhoo, Virginie Girault, Jeremy Turchetto, Laurie Ramond, Fabien Durbesson, Patrick Fourquet, Yves Nominé, Vânia Cardoso, Ana Filipa Sequeira, Joana L A Brás, Carlos M G A Fontes, Gilles Travé, Nicolas Wolff, Renaud Vincentelli
Pubblicato in: Methods Mol Biol, 2020, ISSN 1741-0126
Editore: Oxford University Press
DOI: 10.1007/978-1-4939-9624-7_21

How to Annotate and Submit a Short Linear Motif to the Eukaryotic Linear Motif Resource

Autori: Marc Gouw, Jesús Alvarado-Valverde, Jelena Čalyševa, Francesca Diella, Manjeet Kumar, Sushama Michael, Kim Van Roey, Holger Dinkel, Toby J. Gibson
Pubblicato in: Intrinsically Disordered Proteins - Methods and Protocols, Numero 2141, 2020, Pagina/e 73-102, ISBN 978-1-0716-0523-3
Editore: Springer US
DOI: 10.1007/978-1-0716-0524-0_4

Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications

Autori: Mészáros, Bálint; Sámano-Sánchez, Hugo; Alvarado-Valverde, Jesús; Čalyševa, Jelena; Martínez-Pérez, Elizabeth; Alves, Renato; Kumar, Manjeet; Rippmann, Friedrich; Chemes, Lucía B.; Gibson, Toby J.; .
Pubblicato in: arxiv preprint server, Numero 4, 2020, ISSN 2331-8422
Editore: ArXiv.org

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