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EU Training Network on Novel Targets and Methods in Atrial Fibrillation

Objective

The AFib-TrainNet consortium will enable promising young scientists to become excellent research leaders of the future, capable of fighting the challenges that Atrial Fibrillation (AF) presents to the European population. AF is the most common sustained cardiac arrhythmia, occurring in between 1-2% of the general population. More than 6 million Europeans suffer from this arrhythmia and its prevalence is expected to increase by more than two-fold during the next 40 years due to increased life expectancy. Thus, AF is said to assume epidemic proportions. Current options for pharmacological therapy are limited by both low efficacy and side effects, including life‐threatening ventricular arrhythmias and severe extra-cardiac toxicities.
A very limited number of novel AF drug therapies have been introduced in the last 20 years. This imbalance reflects a gap in understanding in both how AF develops and how it can be treated, which thereby limits the development of new medicines. Our ambition with the AFib-TrainNet is to fill this gap by producing new knowledge, leading to critical insight into origins and mechanisms of sustenance of atrial fibrillation. We will accomplish this by developing novel experimental and computational models recapitulating human AF, and employing these models on two very promising atrial biological targets. Experimental models will be instrumental in improving the understanding AF’s underlying mechanisms, and will, along with clinical data, inform state-of-the-art computational models of human atrial electrophysiology. These new tools will permit fresh insight into the molecular, cellular and electrical mechanisms involved in the progression of healthy atria into an AF state. Our endeavor will deliver results which can be leveraged by the pharmaceutical industry to target AF drug development, and the work accomplished in AFib-TrainNet will thus constitute a beacon in the search for new AF medicine.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /medical and health sciences/clinical medicine/cardiology/cardiac arrhythmia

Call for proposal

H2020-MSCA-ITN-2015
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

KOBENHAVNS UNIVERSITET
Address
Norregade 10
1165 Kobenhavn
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 870 245,64

Participants (6)

SIMULA RESEARCH LABORATORY AS
Norway
EU contribution
€ 572 550,48
Address
Martin Linges Vei 17
1364 Fornebu
Activity type
Research Organisations
UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 546 575,76
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 510 748,56
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 747 649,44
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments
ACESION PHARMA APS
Denmark
EU contribution
€ 580 163,76
Address
Ole Maaloes Vej 3
2200 Kobenhavn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CLYDE BIOSCIENCES LIMITED
United Kingdom
EU contribution
€ 273 287,88
Address
Biocity Scotland Bo'ness Road
ML1 5UH Motherwell Lanarkshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (4)

XENTION LTD
United Kingdom
Address
Iconix Park, London Road, Pampisford
CB22 3EG Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BEN-GURION UNIVERSITY OF THE NEGEV
Israel
Address
.
84105 Beer Sheva
Activity type
Higher or Secondary Education Establishments
OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN
Austria
Address
Dr. Ignaz Seipel-platz 2
1010 Wien
Activity type
Research Organisations
FONDAZIONE CARDIOCENTRO TICINO
Switzerland
Address
Via Tesserete 48
6900 Lugano
Activity type
Research Organisations