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EU Training Network on Novel Targets and Methods in Atrial Fibrillation

Deliverables

Periodical Scientific Reports (1)

Compulsory deliverable.

15 PhD theses

ESR 1: “The role of SK channels in healthy and fibrillating atria: in silico modeling of drug binding, calcium dynamics and biophysical properties” ESR 2: “Establishing an AF pig model for electrophysiological and pharmacological investigations” ESR 3: “SK channel inhibition by different mechanisms of action” ESR 4: “Regulation and quantification of atrial ISK“ ESR 5: “Regulation and importance of human atrial SK channels in health and disease” ESR 6: “Atrial action potential frequency dependence and intracellular Ca2+ transients in normal and failing hearts” ESR 7: “Dynamic-clamping of human atrial cells: contribution of ISK to action potential changes in AF” ESR 8: “Multicellular in silico model of AF: Atrial calcium dynamics and electrophysiology from cell to organ at different stages of atrial fibrillation” ESR 9: “From paroxysmal to permanent AF – exploitation of an AF goat model” ESR 10: “Development and exploitation of AF in horses” ESR 11: “Studying atrial and ventricular remodeling in the dish in human iPSC-derived engineered heart tissues” ESR 12: “Cardiotoxicology and therapeutic profiles of novel drugs using human ES-derived cardiomyocytes” ESR 13: “Regulation of IK,Ach in the atria” ESR 14: “Importance of IK,Ach for action potential adaptation and atrial fibrillation” ESR 15: “Treatment of AF by IK,Ach Blockers“

Report on CDE activities (2)

The overall objectives of the communication, dissemination, and exploitation (CDE) strategy are grounded in the project’s core values, which are to improve research and development in AF, thereby increase attention on AF research and eventually improve AF treatment in Europe, as well as to train a new generation of innovative researchers in cardiology who feel at home in both industry and academia. The strategy will be described in the CDE plan, prepared by the Coordinator together with SB within the specifically designed WP and implemented with the help of all partners. The activities will bear in mind the project’s political, societal, scientific, and economical impacts, and build throughout the project to ensure that stakeholder communities are fully aware of the project’s progress and innovative capacity, and are engaged in the transfer and integration of the final results to the market product.

Report on CDE activities (1)

The overall objectives of the communication, dissemination, and exploitation (CDE) strategy are grounded in the project’s core values, which are to improve research and development in AF, thereby increase attention on AF research and eventually improve AF treatment in Europe, as well as to train a new generation of innovative researchers in cardiology who feel at home in both industry and academia. The strategy will be described in the CDE plan, prepared by the Coordinator together with SB within the specifically designed WP and implemented with the help of all partners. The activities will bear in mind the project’s political, societal, scientific, and economical impacts, and build throughout the project to ensure that stakeholder communities are fully aware of the project’s progress and innovative capacity, and are engaged in the transfer and integration of the final results to the market product.

CDE plan (1)

The overall objectives of the communication, dissemination, and exploitation (CDE) strategy are grounded in the project’s core values, which are to improve research and development in AF, thereby increase attention on AF research and eventually improve AF treatment in Europe, as well as to train a new generation of innovative researchers in cardiology who feel at home in both industry and academia. The strategy will be described in the CDE plan, prepared by the Coordinator together with SB within the specifically designed WP and implemented with the help of all partners. The activities will bear in mind the project’s political, societal, scientific, and economical impacts, and build throughout the project to ensure that stakeholder communities are fully aware of the project’s progress and innovative capacity, and are engaged in the transfer and integration of the final results to the market product.

Progress report

Compulsory deliverable.

CDE plan (2)

The overall objectives of the communication, dissemination, and exploitation (CDE) strategy are grounded in the project’s core values, which are to improve research and development in AF, thereby increase attention on AF research and eventually improve AF treatment in Europe, as well as to train a new generation of innovative researchers in cardiology who feel at home in both industry and academia. The strategy will be described in the CDE plan, prepared by the Coordinator together with SB within the specifically designed WP and implemented with the help of all partners. The activities will bear in mind the project’s political, societal, scientific, and economical impacts, and build throughout the project to ensure that stakeholder communities are fully aware of the project’s progress and innovative capacity, and are engaged in the transfer and integration of the final results to the market product.

Periodical Scientific Reports (2)

Compulsory deliverable.

Periodic report

Compulsory deliverable.

List of recruited ESRs

Compulsory deliverable.

CDE plan (3)

The overall objectives of the communication, dissemination, and exploitation (CDE) strategy are grounded in the project’s core values, which are to improve research and development in AF, thereby increase attention on AF research and eventually improve AF treatment in Europe, as well as to train a new generation of innovative researchers in cardiology who feel at home in both industry and academia. The strategy will be described in the CDE plan, prepared by the Coordinator together with SB within the specifically designed WP and implemented with the help of all partners. The activities will bear in mind the project’s political, societal, scientific, and economical impacts, and build throughout the project to ensure that stakeholder communities are fully aware of the project’s progress and innovative capacity, and are engaged in the transfer and integration of the final results to the market product.

Periodical Scientific Reports (3)

Compulsory deliverable.

Website

In the consortium, we will fill the need and communicate new important knowledge concerning AF to a large audience as well as to specified domain-specific stakeholders. The following strategic access points will be used: An online presence that, in layman’s terms, treats the subject of AF, offers significant information, as well as additional, alternate resources for consideration (website, twitter, upload of videos to YouTube).

Career and Industry Day

Career & Industry Day. The idea of this unique short event is to make the fellows aware of and prepared for specific job opportunities in Europe, both in industry and academia. Best practices of successful job fairs, such as Talents in Germany (www.talents.de), will be taken into account for Career Day organisation. Hosted by the industry partner Acesion, this day will bring together a selection of potential employers from the pharmaceutical industry, applied research institutes, SMEs in e.g. numerical simulation together with the graduating AFib-TrainNet fellows. ESRs will get a clearer picture of career opportunities and challenges, direct contact to both small and large industrial actors and research institutes, and learn more about the different expectations and requirements associated with each. National Public-Private Partnerships (for instance, the European ScreeningPort in Germany, Association of the Pharmaceutical Industry in Norway, among many others) will be actively involved in the preparation of the event and its advertisement.

Synergy meeting

A Synergy workshop will be organised to present collective results of the entire project and extensively review the scientific and technological contributions made. The most important stakeholders from the global AF community, EU partners from relevant projects, decision makers, and research institutes will all be invited well in advance.

Open Research Data Pilot

AFib-TrainNet will participate in the Open Research Data Pilot and is fully committed to ensure the open access of relevant project results and data. All publications produced in the framework of the project will be either published in open access journals or self-archived using research data repositories.

Searching for OpenAIRE data...

Publications

A computational framework for testing arrhythmia marker sensitivities to model parameters in functionally calibrated populations of atrial cells

Author(s): Márcia R. Vagos, Hermenegild Arevalo, Bernardo Lino de Oliveira, Joakim Sundnes, Mary M. Maleckar
Published in: Chaos: An Interdisciplinary Journal of Nonlinear Science, Issue 27/9, 2017, Page(s) 093941, ISSN 1054-1500
DOI: 10.1063/1.4999476

A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (K Ca 2) channels

Author(s): Rafel Simó-Vicens, Jeppe E Kirchhoff, Bernardo Dolce, Lea Abildgaard, Tobias Speerschneider, Ulrik S Sørensen, Morten Grunnet, Jonas G Diness, Bo H Bentzen
Published in: British Journal of Pharmacology, 2017, ISSN 0007-1188
DOI: 10.1111/bph.14043

Effect of antiarrhythmic drugs on small conductance calcium – activated potassium channels

Author(s): Rafel Simó-Vicens, Daniel R.P. Sauter, Morten Grunnet, Jonas G. Diness, Bo H. Bentzen
Published in: European Journal of Pharmacology, Issue 803, 2017, Page(s) 118-123, ISSN 0014-2999
DOI: 10.1016/j.ejphar.2017.03.039

Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation

Author(s): Henri M.H. Spronk, Anne Margreet De Jong, Sander Verheule, Hetty C. De Boer, Alexander H. Maass, Dennis H. Lau, Michiel Rienstra, Arne van Hunnik, Marion Kuiper, Stijn Lumeij, Stef Zeemering, Dominik Linz, Pieter Willem Kamphuisen, Hugo ten Cate, Harry J. Crijns, Isabelle C. Van Gelder, Anton Jan van Zonneveld, Ulrich Schotten
Published in: European Heart Journal, Issue 38/1, 2017, Page(s) 38-50, ISSN 0195-668X
DOI: 10.1093/eurheartj/ehw119

Current controversies in determining the main mechanisms of atrial fibrillation

Author(s): U. Schotten, D. Dobrev, P. G. Platonov, H. Kottkamp, G. Hindricks
Published in: Journal of Internal Medicine, Issue 279/5, 2016, Page(s) 428-438, ISSN 0954-6820
DOI: 10.1111/joim.12492

How disruption of endo-epicardial electrical connections enhances endo-epicardial conduction during atrial fibrillation

Author(s): Ali Gharaviri, Sander Verheule, Jens Eckstein, Mark Potse, Pawel Kuklik, Nico H.L. Kuijpers, Ulrich Schotten
Published in: Europace, 2017, Page(s) euv445, ISSN 1099-5129
DOI: 10.1093/europace/euv445

The electrocardiogram as a predictor of successful pharmacological cardioversion and progression of atrial fibrillation

Author(s): Stef Zeemering, Theo A.R. Lankveld, Pietro Bonizzi, Ione Limantoro, Sebastiaan C.A.M. Bekkers, Harry J.G.M. Crijns, Ulrich Schotten
Published in: EP Europace, 2017, ISSN 1099-5129
DOI: 10.1093/europace/eux234

Vernakalant does not alter early repolarization or contractility in normal and electrically remodelled atria

Author(s): Arne van Hunnik, Hussein Nasrallah, Dennis H. Lau, Marion Kuiper, Sander Verheule, Ulrich Schotten
Published in: EP Europace, 2017, ISSN 1099-5129
DOI: 10.1093/europace/eux025

Effect of induced chronic atrial fibrillation on exercise performance in Standardbred trotters

Author(s): Rikke Buhl, Helena Carstensen, Eva Zander Hesselkilde, Bjørg Zinkernagel Klein, Karen Margrethe Hougaard, Kirsten Bomberg Ravn, Ameli Victoria Loft-Andersen, Merle Friederike Fenner, Christian Pipper, Thomas Jespersen
Published in: Journal of Veterinary Internal Medicine, Issue 32/4, 2018, Page(s) 1410-1419, ISSN 0891-6640
DOI: 10.1111/jvim.15137

2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels

Author(s): Rafel Simó-Vicens, Sofia H. Bomholtz, Ulrik S. Sørensen, Bo H. Bentzen
Published in: Frontiers in Pharmacology, Issue 9, 2018, ISSN 1663-9812
DOI: 10.3389/fphar.2018.01409

Stationary Atrial Fibrillation Properties in the Goat Do Not Entail Stable or Recurrent Conduction Patterns

Author(s): Arne van Hunnik, Stef Zeemering, Piotr Podziemski, Jorik Simons, Giulia Gatta, Laura Hannink, Bart Maesen, Marion Kuiper, Sander Verheule, Ulrich Schotten
Published in: Frontiers in Physiology, Issue 9, 2018, ISSN 1664-042X
DOI: 10.3389/fphys.2018.00947

Low Resting Membrane Potential and Low Inward Rectifier Potassium Currents Are Not Inherent Features of hiPSC-Derived Cardiomyocytes

Author(s): András Horváth, Marc D. Lemoine, Alexandra Löser, Ingra Mannhardt, Frederik Flenner, Ahmet Umur Uzun, Christiane Neuber, Kaja Breckwoldt, Arne Hansen, Evaldas Girdauskas, Hermann Reichenspurner, Stephan Willems, Norbert Jost, Erich Wettwer, Thomas Eschenhagen, Torsten Christ
Published in: Stem Cell Reports, Issue 10/3, 2018, Page(s) 822-833, ISSN 2213-6711
DOI: 10.1016/j.stemcr.2018.01.012

Atrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium

Author(s): Marta Lemme, Bärbel M. Ulmer, Marc D. Lemoine, Antonia T.L. Zech, Frederik Flenner, Ursula Ravens, Hermann Reichenspurner, Miriam Rol-Garcia, Godfrey Smith, Arne Hansen, Torsten Christ, Thomas Eschenhagen
Published in: Stem Cell Reports, Issue 11/6, 2018, Page(s) 1378-1390, ISSN 2213-6711
DOI: 10.1016/j.stemcr.2018.10.008

Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges

Author(s): Márcia Vagos, Ilsbeth G. M. van Herck, Joakim Sundnes, Hermenegild J. Arevalo, Andrew G. Edwards, Jussi T. Koivumäki
Published in: Frontiers in Physiology, Issue 9, 2018, ISSN 1664-042X
DOI: 10.3389/fphys.2018.01221

Time-dependent antiarrhythmic effects of flecainide on induced atrial fibrillation in horses

Author(s): Helena Carstensen, Eva Z. Hesselkilde, Merle Fenner, Ameli V. Loft-Andersen, Mette Flethøj, Jørgen K. Kanters, Stefan M. Sattler, Jacob Tfelt-Hansen, Steen Pehrson, Thomas Jespersen, Rikke Buhl
Published in: Journal of Veterinary Internal Medicine, Issue 32/5, 2018, Page(s) 1708-1717, ISSN 0891-6640
DOI: 10.1111/jvim.15287

The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts

Author(s): Jeppe Egedal Kirchhoff, Mark Alexander Skarsfeldt, Kalai Mangai Muthukumarasamy, Rafel Simó-Vicens, Sofia Hammami Bomholtz, Lea Abildgaard, Thomas Jespersen, Ulrik S. Sørensen, Morten Grunnet, Bo Hjorth Bentzen, Jonas Goldin Diness
Published in: Frontiers in Pharmacology, Issue 10, 2019, ISSN 1663-9812
DOI: 10.3389/fphar.2019.00668

Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue

Author(s): Marta Lemme, Ingke Braren, Maksymilian Prondzynski, Bülent Aksehirlioglu, Bärbel M Ulmer, Mirja L Schulze, Djemail Ismaili, Christian Meyer, Arne Hansen, Torsten Christ, Marc D Lemoine, Thomas Eschenhagen
Published in: Cardiovascular Research, 2019, ISSN 0008-6363
DOI: 10.1093/cvr/cvz245

Small conductance calcium activated potassium channels: developing an in silico model for pharmacological prediction

Author(s): Ilse van Herck, Rafel Simó Vicens, Hermenegild Arevalo, Jussi Koivumäki, Bo H Bentzen, Andrew G Edwards
Published in: Poster // Cardiac Arrhythmia symposium, 2017

Small conductance calcium activated potassium channels: developing an in silico model for pharmacological prediction

Author(s): Ilse van Herck, Rafel Simó Vicens, Hermenegild Arevalo, Jussi Koivumäki, Bo H Bentzen, Andrew G Edwards
Published in: Poster // 41st EWGCCE meeting, 2017

Anti-arrhythmic Properties of a Potent, Selective IKACH Blocker in an Equine Model of Persistent Atrial Fibrillation

Author(s): Fenner MF, Hesselkilde E, Carstensen H, Nissen S, Lunddahl C, Jensen M, Loft-Andersen a, Milnes J, Sattler S, Jespersen T, Buhl R
Published in: Abstract // ECEIM '17 Congress, 2017

Inward rectifier ion currents in human induced pluripotent stem cell-derived cardiomyocytes

Author(s): A. Horváth, A. Uzun, I. Mannhardt, K. Breckwoldt, C. Neuber, A. Löser, A. Varró, A. Hansen, T. Eschenhagen, T. Christ
Published in: Poster // 40th EWGCCE Meeting, Glasgow, 2016, 2016

Inward rectifier potassium currents and resting membrane potential in human induced pluripotent stem cell-derived cardiomyocytes

Author(s): András Horváth, Ingra Mannhardt, Alexandra Löser, Marc D. Lemoine, Christiane Neuber, Kaja Breckwoldt, Frederik Flenner, Ahmet Umur Uzun, Arne Hansen,Evaldas Girdauskas, Hermann Reichenspurner, Stephan Willems, Norbert Jost, Erich Wettwer, Thomas Eschenhagen, Torsten Christ
Published in: Poster // 14th Dutch-German Joint Meeting of the Molecular Cardiology Groups, 2017

An investigation of small conductance Ca2+-activated K+ current (ISK) in rabbit and human atrial cardiomyocytes

Author(s): Giommi A, Gurgel AR, Saxena P, Smith GL, Workman AJ
Published in: Abstract / Proc Physiol Soc, Issue 43 (2019) PC041, 2019, Page(s) 299-300

Adenosine 1 receptor activation plays a proarrhythmic role in rat atrium

Author(s): L. Soattin; A. Lubberding; BH. Bentzen; T. Jespersen
Published in: Poster session abstract / EHRA EUROPACE - CARDIOSTIM 2017, Issue Abstract supplement June 18-21, 2017 - Vienna, 2017, Page(s) ii219-ii220

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Published in: ISSN 1396-0377