Rezultaty
Compulsory deliverable.
15 PhD thesesESR 1: “The role of SK channels in healthy and fibrillating atria: in silico modeling of drug binding, calcium dynamics and biophysical properties” ESR 2: “Establishing an AF pig model for electrophysiological and pharmacological investigations” ESR 3: “SK channel inhibition by different mechanisms of action” ESR 4: “Regulation and quantification of atrial ISK“ ESR 5: “Regulation and importance of human atrial SK channels in health and disease” ESR 6: “Atrial action potential frequency dependence and intracellular Ca2+ transients in normal and failing hearts” ESR 7: “Dynamic-clamping of human atrial cells: contribution of ISK to action potential changes in AF” ESR 8: “Multicellular in silico model of AF: Atrial calcium dynamics and electrophysiology from cell to organ at different stages of atrial fibrillation” ESR 9: “From paroxysmal to permanent AF – exploitation of an AF goat model” ESR 10: “Development and exploitation of AF in horses” ESR 11: “Studying atrial and ventricular remodeling in the dish in human iPSC-derived engineered heart tissues” ESR 12: “Cardiotoxicology and therapeutic profiles of novel drugs using human ES-derived cardiomyocytes” ESR 13: “Regulation of IK,Ach in the atria” ESR 14: “Importance of IK,Ach for action potential adaptation and atrial fibrillation” ESR 15: “Treatment of AF by IK,Ach Blockers“
Report on CDE activities (2)The overall objectives of the communication, dissemination, and exploitation (CDE) strategy are grounded in the project’s core values, which are to improve research and development in AF, thereby increase attention on AF research and eventually improve AF treatment in Europe, as well as to train a new generation of innovative researchers in cardiology who feel at home in both industry and academia. The strategy will be described in the CDE plan, prepared by the Coordinator together with SB within the specifically designed WP and implemented with the help of all partners. The activities will bear in mind the project’s political, societal, scientific, and economical impacts, and build throughout the project to ensure that stakeholder communities are fully aware of the project’s progress and innovative capacity, and are engaged in the transfer and integration of the final results to the market product.
Periodical training activities report (1)Compulsory deliverable.
Report on CDE activities (1)The overall objectives of the communication, dissemination, and exploitation (CDE) strategy are grounded in the project’s core values, which are to improve research and development in AF, thereby increase attention on AF research and eventually improve AF treatment in Europe, as well as to train a new generation of innovative researchers in cardiology who feel at home in both industry and academia. The strategy will be described in the CDE plan, prepared by the Coordinator together with SB within the specifically designed WP and implemented with the help of all partners. The activities will bear in mind the project’s political, societal, scientific, and economical impacts, and build throughout the project to ensure that stakeholder communities are fully aware of the project’s progress and innovative capacity, and are engaged in the transfer and integration of the final results to the market product.
Final report on training activitiesCompulsory deliverable.
CDE plan (1)The overall objectives of the communication, dissemination, and exploitation (CDE) strategy are grounded in the project’s core values, which are to improve research and development in AF, thereby increase attention on AF research and eventually improve AF treatment in Europe, as well as to train a new generation of innovative researchers in cardiology who feel at home in both industry and academia. The strategy will be described in the CDE plan, prepared by the Coordinator together with SB within the specifically designed WP and implemented with the help of all partners. The activities will bear in mind the project’s political, societal, scientific, and economical impacts, and build throughout the project to ensure that stakeholder communities are fully aware of the project’s progress and innovative capacity, and are engaged in the transfer and integration of the final results to the market product.
Progress reportCompulsory deliverable.
Periodical training activities report (3)Compulsory deliverable.
CDE plan (2)The overall objectives of the communication, dissemination, and exploitation (CDE) strategy are grounded in the project’s core values, which are to improve research and development in AF, thereby increase attention on AF research and eventually improve AF treatment in Europe, as well as to train a new generation of innovative researchers in cardiology who feel at home in both industry and academia. The strategy will be described in the CDE plan, prepared by the Coordinator together with SB within the specifically designed WP and implemented with the help of all partners. The activities will bear in mind the project’s political, societal, scientific, and economical impacts, and build throughout the project to ensure that stakeholder communities are fully aware of the project’s progress and innovative capacity, and are engaged in the transfer and integration of the final results to the market product.
Periodical Scientific Reports (2)Compulsory deliverable.
Periodical training activities report (2)Compulsory deliverable.
Periodic reportCompulsory deliverable.
List of recruited ESRsCompulsory deliverable.
CDE plan (3)The overall objectives of the communication, dissemination, and exploitation (CDE) strategy are grounded in the project’s core values, which are to improve research and development in AF, thereby increase attention on AF research and eventually improve AF treatment in Europe, as well as to train a new generation of innovative researchers in cardiology who feel at home in both industry and academia. The strategy will be described in the CDE plan, prepared by the Coordinator together with SB within the specifically designed WP and implemented with the help of all partners. The activities will bear in mind the project’s political, societal, scientific, and economical impacts, and build throughout the project to ensure that stakeholder communities are fully aware of the project’s progress and innovative capacity, and are engaged in the transfer and integration of the final results to the market product.
Periodical Scientific Reports (3)Compulsory deliverable.
In the consortium, we will fill the need and communicate new important knowledge concerning AF to a large audience as well as to specified domain-specific stakeholders. The following strategic access points will be used: An online presence that, in layman’s terms, treats the subject of AF, offers significant information, as well as additional, alternate resources for consideration (website, twitter, upload of videos to YouTube).
Career & Industry Day. The idea of this unique short event is to make the fellows aware of and prepared for specific job opportunities in Europe, both in industry and academia. Best practices of successful job fairs, such as Talents in Germany (www.talents.de), will be taken into account for Career Day organisation. Hosted by the industry partner Acesion, this day will bring together a selection of potential employers from the pharmaceutical industry, applied research institutes, SMEs in e.g. numerical simulation together with the graduating AFib-TrainNet fellows. ESRs will get a clearer picture of career opportunities and challenges, direct contact to both small and large industrial actors and research institutes, and learn more about the different expectations and requirements associated with each. National Public-Private Partnerships (for instance, the European ScreeningPort in Germany, Association of the Pharmaceutical Industry in Norway, among many others) will be actively involved in the preparation of the event and its advertisement.
Synergy meetingA Synergy workshop will be organised to present collective results of the entire project and extensively review the scientific and technological contributions made. The most important stakeholders from the global AF community, EU partners from relevant projects, decision makers, and research institutes will all be invited well in advance.
AFib-TrainNet will participate in the Open Research Data Pilot and is fully committed to ensure the open access of relevant project results and data. All publications produced in the framework of the project will be either published in open access journals or self-archived using research data repositories.
Publikacje
Autorzy:
Márcia R. Vagos, Hermenegild Arevalo, Bernardo Lino de Oliveira, Joakim Sundnes, Mary M. Maleckar
Opublikowane w:
Chaos: An Interdisciplinary Journal of Nonlinear Science, Numer 27/9, 2017, Strona(/y) 093941, ISSN 1054-1500
Wydawca:
American Institute of Physics
DOI:
10.1063/1.4999476
Autorzy:
Rafel Simó-Vicens, Jeppe E Kirchhoff, Bernardo Dolce, Lea Abildgaard, Tobias Speerschneider, Ulrik S Sørensen, Morten Grunnet, Jonas G Diness, Bo H Bentzen
Opublikowane w:
British Journal of Pharmacology, 2017, ISSN 0007-1188
Wydawca:
Wiley-Blackwell
DOI:
10.1111/bph.14043
Autorzy:
Jonas Goldin Diness, Lasse Skibsbye, Rafel Simó-Vicens, Joana Larupa Santos, Pia Lundegaard, Carlotta Citerni, Daniel Rafael Peter Sauter, Sofia Hammami Bomholtz, Jesper Hastrup Svendsen, Søren-Peter Olesen, Ulrik S. Sørensen, Thomas Jespersen, Morten Grunnet, Bo Hjorth Bentzen
Opublikowane w:
Circulation: Arrhythmia and Electrophysiology, Numer 10/10, 2017, Strona(/y) e005125, ISSN 1941-3149
Wydawca:
Lippincott Williams & Wilkins Ltd.
DOI:
10.1161/CIRCEP.117.005125
Autorzy:
Rafel Simó-Vicens, Daniel R.P. Sauter, Morten Grunnet, Jonas G. Diness, Bo H. Bentzen
Opublikowane w:
European Journal of Pharmacology, Numer 803, 2017, Strona(/y) 118-123, ISSN 0014-2999
Wydawca:
Elsevier BV
DOI:
10.1016/j.ejphar.2017.03.039
Autorzy:
Henri M.H. Spronk, Anne Margreet De Jong, Sander Verheule, Hetty C. De Boer, Alexander H. Maass, Dennis H. Lau, Michiel Rienstra, Arne van Hunnik, Marion Kuiper, Stijn Lumeij, Stef Zeemering, Dominik Linz, Pieter Willem Kamphuisen, Hugo ten Cate, Harry J. Crijns, Isabelle C. Van Gelder, Anton Jan van Zonneveld, Ulrich Schotten
Opublikowane w:
European Heart Journal, Numer 38/1, 2017, Strona(/y) 38-50, ISSN 0195-668X
Wydawca:
Oxford University Press
DOI:
10.1093/eurheartj/ehw119
Autorzy:
U. Schotten, D. Dobrev, P. G. Platonov, H. Kottkamp, G. Hindricks
Opublikowane w:
Journal of Internal Medicine, Numer 279/5, 2016, Strona(/y) 428-438, ISSN 0954-6820
Wydawca:
Blackwell Publishing Inc.
DOI:
10.1111/joim.12492
Autorzy:
Ali Gharaviri, Sander Verheule, Jens Eckstein, Mark Potse, Pawel Kuklik, Nico H.L. Kuijpers, Ulrich Schotten
Opublikowane w:
Europace, 2017, Strona(/y) euv445, ISSN 1099-5129
Wydawca:
Oxford University Press
DOI:
10.1093/europace/euv445
Autorzy:
Stef Zeemering, Theo A.R. Lankveld, Pietro Bonizzi, Ione Limantoro, Sebastiaan C.A.M. Bekkers, Harry J.G.M. Crijns, Ulrich Schotten
Opublikowane w:
EP Europace, 2017, ISSN 1099-5129
Wydawca:
Oxford University Press
DOI:
10.1093/europace/eux234
Autorzy:
Arne van Hunnik, Hussein Nasrallah, Dennis H. Lau, Marion Kuiper, Sander Verheule, Ulrich Schotten
Opublikowane w:
EP Europace, 2017, ISSN 1099-5129
Wydawca:
Oxford University Press
DOI:
10.1093/europace/eux025
Autorzy:
Rikke Buhl, Helena Carstensen, Eva Zander Hesselkilde, Bjørg Zinkernagel Klein, Karen Margrethe Hougaard, Kirsten Bomberg Ravn, Ameli Victoria Loft-Andersen, Merle Friederike Fenner, Christian Pipper, Thomas Jespersen
Opublikowane w:
Journal of Veterinary Internal Medicine, Numer 32/4, 2018, Strona(/y) 1410-1419, ISSN 0891-6640
Wydawca:
American College of Verterinary Internal Medicine
DOI:
10.1111/jvim.15137
Autorzy:
Rafel Simó-Vicens, Sofia H. Bomholtz, Ulrik S. Sørensen, Bo H. Bentzen
Opublikowane w:
Frontiers in Pharmacology, Numer 9, 2018, ISSN 1663-9812
Wydawca:
Frontiers Media S.A.
DOI:
10.3389/fphar.2018.01409
Autorzy:
Arne van Hunnik, Stef Zeemering, Piotr Podziemski, Jorik Simons, Giulia Gatta, Laura Hannink, Bart Maesen, Marion Kuiper, Sander Verheule, Ulrich Schotten
Opublikowane w:
Frontiers in Physiology, Numer 9, 2018, ISSN 1664-042X
Wydawca:
Frontiers Research Foundation
DOI:
10.3389/fphys.2018.00947
Autorzy:
András Horváth, Marc D. Lemoine, Alexandra Löser, Ingra Mannhardt, Frederik Flenner, Ahmet Umur Uzun, Christiane Neuber, Kaja Breckwoldt, Arne Hansen, Evaldas Girdauskas, Hermann Reichenspurner, Stephan Willems, Norbert Jost, Erich Wettwer, Thomas Eschenhagen, Torsten Christ
Opublikowane w:
Stem Cell Reports, Numer 10/3, 2018, Strona(/y) 822-833, ISSN 2213-6711
Wydawca:
Cell Press
DOI:
10.1016/j.stemcr.2018.01.012
Autorzy:
Marta Lemme, Bärbel M. Ulmer, Marc D. Lemoine, Antonia T.L. Zech, Frederik Flenner, Ursula Ravens, Hermann Reichenspurner, Miriam Rol-Garcia, Godfrey Smith, Arne Hansen, Torsten Christ, Thomas Eschenhagen
Opublikowane w:
Stem Cell Reports, Numer 11/6, 2018, Strona(/y) 1378-1390, ISSN 2213-6711
Wydawca:
Cell Press
DOI:
10.1016/j.stemcr.2018.10.008
Autorzy:
Márcia Vagos, Ilsbeth G. M. van Herck, Joakim Sundnes, Hermenegild J. Arevalo, Andrew G. Edwards, Jussi T. Koivumäki
Opublikowane w:
Frontiers in Physiology, Numer 9, 2018, ISSN 1664-042X
Wydawca:
Frontiers Research Foundation
DOI:
10.3389/fphys.2018.01221
Autorzy:
Helena Carstensen, Eva Z. Hesselkilde, Merle Fenner, Ameli V. Loft-Andersen, Mette Flethøj, Jørgen K. Kanters, Stefan M. Sattler, Jacob Tfelt-Hansen, Steen Pehrson, Thomas Jespersen, Rikke Buhl
Opublikowane w:
Journal of Veterinary Internal Medicine, Numer 32/5, 2018, Strona(/y) 1708-1717, ISSN 0891-6640
Wydawca:
American College of Verterinary Internal Medicine
DOI:
10.1111/jvim.15287
Autorzy:
Jeppe Egedal Kirchhoff, Mark Alexander Skarsfeldt, Kalai Mangai Muthukumarasamy, Rafel Simó-Vicens, Sofia Hammami Bomholtz, Lea Abildgaard, Thomas Jespersen, Ulrik S. Sørensen, Morten Grunnet, Bo Hjorth Bentzen, Jonas Goldin Diness
Opublikowane w:
Frontiers in Pharmacology, Numer 10, 2019, ISSN 1663-9812
Wydawca:
Frontiers Media S.A.
DOI:
10.3389/fphar.2019.00668
Autorzy:
Marta Lemme, Ingke Braren, Maksymilian Prondzynski, Bülent Aksehirlioglu, Bärbel M Ulmer, Mirja L Schulze, Djemail Ismaili, Christian Meyer, Arne Hansen, Torsten Christ, Marc D Lemoine, Thomas Eschenhagen
Opublikowane w:
Cardiovascular Research, 2019, ISSN 0008-6363
Wydawca:
Elsevier BV
DOI:
10.1093/cvr/cvz245
Autorzy:
Ilse van Herck, Rafel Simó Vicens, Hermenegild Arevalo, Jussi Koivumäki, Bo H Bentzen, Andrew G Edwards
Opublikowane w:
Poster // Cardiac Arrhythmia symposium, 2017
Wydawca:
Cardiac Arrhythmia symposium
Autorzy:
Ilse van Herck, Rafel Simó Vicens, Hermenegild Arevalo, Jussi Koivumäki, Bo H Bentzen, Andrew G Edwards
Opublikowane w:
Poster // 41st EWGCCE meeting, 2017
Wydawca:
41st EWGCCE meeting
Autorzy:
Fenner MF, Hesselkilde E, Carstensen H, Nissen S, Lunddahl C, Jensen M, Loft-Andersen a, Milnes J, Sattler S, Jespersen T, Buhl R
Opublikowane w:
Abstract // ECEIM '17 Congress, 2017
Wydawca:
ECEIM '17 Congress
Autorzy:
A. Horváth, A. Uzun, I. Mannhardt, K. Breckwoldt, C. Neuber, A. Löser, A. Varró, A. Hansen, T. Eschenhagen, T. Christ
Opublikowane w:
Poster // 40th EWGCCE Meeting, Glasgow, 2016, 2016
Wydawca:
40th EWGCCE Meeting, Glasgow, 2016
Autorzy:
András Horváth, Ingra Mannhardt, Alexandra Löser, Marc D. Lemoine, Christiane Neuber, Kaja Breckwoldt, Frederik Flenner, Ahmet Umur Uzun, Arne Hansen,Evaldas Girdauskas, Hermann Reichenspurner, Stephan Willems, Norbert Jost, Erich Wettwer, Thomas Eschenhagen, Torsten Christ
Opublikowane w:
Poster // 14th Dutch-German Joint Meeting of the Molecular Cardiology Groups, 2017
Wydawca:
14th Dutch-German Joint Meeting of the Molecular Cardiology Groups
Autorzy:
Giommi A, Gurgel AR, Saxena P, Smith GL, Workman AJ
Opublikowane w:
Abstract / Proc Physiol Soc, Numer 43 (2019) PC041, 2019, Strona(/y) 299-300
Wydawca:
The Physiological Society
Autorzy:
L. Soattin; A. Lubberding; BH. Bentzen; T. Jespersen
Opublikowane w:
Poster session abstract / EHRA EUROPACE - CARDIOSTIM 2017, Numer Abstract supplement June 18-21, 2017 - Vienna, 2017, Strona(/y) ii219-ii220
Wydawca:
EP Europace, Oxford University Press
Autorzy:
Eva Zander Hesselkilde, Helena Carstensen, Merle Friederike Fenner
Opublikowane w:
Ridehesten, Hippologisk i Avl & Sport, Numer 2, 2017, Strona(/y) 62-66, ISSN 1396-0377
Wydawca:
Wiegaarden Media
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