Leistungen
Compulsory deliverable.
15 PhD thesesESR 1: “The role of SK channels in healthy and fibrillating atria: in silico modeling of drug binding, calcium dynamics and biophysical properties” ESR 2: “Establishing an AF pig model for electrophysiological and pharmacological investigations” ESR 3: “SK channel inhibition by different mechanisms of action” ESR 4: “Regulation and quantification of atrial ISK“ ESR 5: “Regulation and importance of human atrial SK channels in health and disease” ESR 6: “Atrial action potential frequency dependence and intracellular Ca2+ transients in normal and failing hearts” ESR 7: “Dynamic-clamping of human atrial cells: contribution of ISK to action potential changes in AF” ESR 8: “Multicellular in silico model of AF: Atrial calcium dynamics and electrophysiology from cell to organ at different stages of atrial fibrillation” ESR 9: “From paroxysmal to permanent AF – exploitation of an AF goat model” ESR 10: “Development and exploitation of AF in horses” ESR 11: “Studying atrial and ventricular remodeling in the dish in human iPSC-derived engineered heart tissues” ESR 12: “Cardiotoxicology and therapeutic profiles of novel drugs using human ES-derived cardiomyocytes” ESR 13: “Regulation of IK,Ach in the atria” ESR 14: “Importance of IK,Ach for action potential adaptation and atrial fibrillation” ESR 15: “Treatment of AF by IK,Ach Blockers“
Report on CDE activities (2)The overall objectives of the communication, dissemination, and exploitation (CDE) strategy are grounded in the project’s core values, which are to improve research and development in AF, thereby increase attention on AF research and eventually improve AF treatment in Europe, as well as to train a new generation of innovative researchers in cardiology who feel at home in both industry and academia. The strategy will be described in the CDE plan, prepared by the Coordinator together with SB within the specifically designed WP and implemented with the help of all partners. The activities will bear in mind the project’s political, societal, scientific, and economical impacts, and build throughout the project to ensure that stakeholder communities are fully aware of the project’s progress and innovative capacity, and are engaged in the transfer and integration of the final results to the market product.
Periodical training activities report (1)Compulsory deliverable.
Report on CDE activities (1)The overall objectives of the communication, dissemination, and exploitation (CDE) strategy are grounded in the project’s core values, which are to improve research and development in AF, thereby increase attention on AF research and eventually improve AF treatment in Europe, as well as to train a new generation of innovative researchers in cardiology who feel at home in both industry and academia. The strategy will be described in the CDE plan, prepared by the Coordinator together with SB within the specifically designed WP and implemented with the help of all partners. The activities will bear in mind the project’s political, societal, scientific, and economical impacts, and build throughout the project to ensure that stakeholder communities are fully aware of the project’s progress and innovative capacity, and are engaged in the transfer and integration of the final results to the market product.
Final report on training activitiesCompulsory deliverable.
CDE plan (1)The overall objectives of the communication, dissemination, and exploitation (CDE) strategy are grounded in the project’s core values, which are to improve research and development in AF, thereby increase attention on AF research and eventually improve AF treatment in Europe, as well as to train a new generation of innovative researchers in cardiology who feel at home in both industry and academia. The strategy will be described in the CDE plan, prepared by the Coordinator together with SB within the specifically designed WP and implemented with the help of all partners. The activities will bear in mind the project’s political, societal, scientific, and economical impacts, and build throughout the project to ensure that stakeholder communities are fully aware of the project’s progress and innovative capacity, and are engaged in the transfer and integration of the final results to the market product.
Progress reportCompulsory deliverable.
Periodical training activities report (3)Compulsory deliverable.
CDE plan (2)The overall objectives of the communication, dissemination, and exploitation (CDE) strategy are grounded in the project’s core values, which are to improve research and development in AF, thereby increase attention on AF research and eventually improve AF treatment in Europe, as well as to train a new generation of innovative researchers in cardiology who feel at home in both industry and academia. The strategy will be described in the CDE plan, prepared by the Coordinator together with SB within the specifically designed WP and implemented with the help of all partners. The activities will bear in mind the project’s political, societal, scientific, and economical impacts, and build throughout the project to ensure that stakeholder communities are fully aware of the project’s progress and innovative capacity, and are engaged in the transfer and integration of the final results to the market product.
Periodical Scientific Reports (2)Compulsory deliverable.
Periodical training activities report (2)Compulsory deliverable.
Periodic reportCompulsory deliverable.
List of recruited ESRsCompulsory deliverable.
CDE plan (3)The overall objectives of the communication, dissemination, and exploitation (CDE) strategy are grounded in the project’s core values, which are to improve research and development in AF, thereby increase attention on AF research and eventually improve AF treatment in Europe, as well as to train a new generation of innovative researchers in cardiology who feel at home in both industry and academia. The strategy will be described in the CDE plan, prepared by the Coordinator together with SB within the specifically designed WP and implemented with the help of all partners. The activities will bear in mind the project’s political, societal, scientific, and economical impacts, and build throughout the project to ensure that stakeholder communities are fully aware of the project’s progress and innovative capacity, and are engaged in the transfer and integration of the final results to the market product.
Periodical Scientific Reports (3)Compulsory deliverable.
In the consortium, we will fill the need and communicate new important knowledge concerning AF to a large audience as well as to specified domain-specific stakeholders. The following strategic access points will be used: An online presence that, in layman’s terms, treats the subject of AF, offers significant information, as well as additional, alternate resources for consideration (website, twitter, upload of videos to YouTube).
Career & Industry Day. The idea of this unique short event is to make the fellows aware of and prepared for specific job opportunities in Europe, both in industry and academia. Best practices of successful job fairs, such as Talents in Germany (www.talents.de), will be taken into account for Career Day organisation. Hosted by the industry partner Acesion, this day will bring together a selection of potential employers from the pharmaceutical industry, applied research institutes, SMEs in e.g. numerical simulation together with the graduating AFib-TrainNet fellows. ESRs will get a clearer picture of career opportunities and challenges, direct contact to both small and large industrial actors and research institutes, and learn more about the different expectations and requirements associated with each. National Public-Private Partnerships (for instance, the European ScreeningPort in Germany, Association of the Pharmaceutical Industry in Norway, among many others) will be actively involved in the preparation of the event and its advertisement.
Synergy meetingA Synergy workshop will be organised to present collective results of the entire project and extensively review the scientific and technological contributions made. The most important stakeholders from the global AF community, EU partners from relevant projects, decision makers, and research institutes will all be invited well in advance.
AFib-TrainNet will participate in the Open Research Data Pilot and is fully committed to ensure the open access of relevant project results and data. All publications produced in the framework of the project will be either published in open access journals or self-archived using research data repositories.
Veröffentlichungen
Autoren:
Márcia R. Vagos, Hermenegild Arevalo, Bernardo Lino de Oliveira, Joakim Sundnes, Mary M. Maleckar
Veröffentlicht in:
Chaos: An Interdisciplinary Journal of Nonlinear Science, Ausgabe 27/9, 2017, Seite(n) 093941, ISSN 1054-1500
Herausgeber:
American Institute of Physics
DOI:
10.1063/1.4999476
Autoren:
Rafel Simó-Vicens, Jeppe E Kirchhoff, Bernardo Dolce, Lea Abildgaard, Tobias Speerschneider, Ulrik S Sørensen, Morten Grunnet, Jonas G Diness, Bo H Bentzen
Veröffentlicht in:
British Journal of Pharmacology, 2017, ISSN 0007-1188
Herausgeber:
Wiley-Blackwell
DOI:
10.1111/bph.14043
Autoren:
Jonas Goldin Diness, Lasse Skibsbye, Rafel Simó-Vicens, Joana Larupa Santos, Pia Lundegaard, Carlotta Citerni, Daniel Rafael Peter Sauter, Sofia Hammami Bomholtz, Jesper Hastrup Svendsen, Søren-Peter Olesen, Ulrik S. Sørensen, Thomas Jespersen, Morten Grunnet, Bo Hjorth Bentzen
Veröffentlicht in:
Circulation: Arrhythmia and Electrophysiology, Ausgabe 10/10, 2017, Seite(n) e005125, ISSN 1941-3149
Herausgeber:
Lippincott Williams & Wilkins Ltd.
DOI:
10.1161/CIRCEP.117.005125
Autoren:
Rafel Simó-Vicens, Daniel R.P. Sauter, Morten Grunnet, Jonas G. Diness, Bo H. Bentzen
Veröffentlicht in:
European Journal of Pharmacology, Ausgabe 803, 2017, Seite(n) 118-123, ISSN 0014-2999
Herausgeber:
Elsevier BV
DOI:
10.1016/j.ejphar.2017.03.039
Autoren:
Henri M.H. Spronk, Anne Margreet De Jong, Sander Verheule, Hetty C. De Boer, Alexander H. Maass, Dennis H. Lau, Michiel Rienstra, Arne van Hunnik, Marion Kuiper, Stijn Lumeij, Stef Zeemering, Dominik Linz, Pieter Willem Kamphuisen, Hugo ten Cate, Harry J. Crijns, Isabelle C. Van Gelder, Anton Jan van Zonneveld, Ulrich Schotten
Veröffentlicht in:
European Heart Journal, Ausgabe 38/1, 2017, Seite(n) 38-50, ISSN 0195-668X
Herausgeber:
Oxford University Press
DOI:
10.1093/eurheartj/ehw119
Autoren:
U. Schotten, D. Dobrev, P. G. Platonov, H. Kottkamp, G. Hindricks
Veröffentlicht in:
Journal of Internal Medicine, Ausgabe 279/5, 2016, Seite(n) 428-438, ISSN 0954-6820
Herausgeber:
Blackwell Publishing Inc.
DOI:
10.1111/joim.12492
Autoren:
Ali Gharaviri, Sander Verheule, Jens Eckstein, Mark Potse, Pawel Kuklik, Nico H.L. Kuijpers, Ulrich Schotten
Veröffentlicht in:
Europace, 2017, Seite(n) euv445, ISSN 1099-5129
Herausgeber:
Oxford University Press
DOI:
10.1093/europace/euv445
Autoren:
Stef Zeemering, Theo A.R. Lankveld, Pietro Bonizzi, Ione Limantoro, Sebastiaan C.A.M. Bekkers, Harry J.G.M. Crijns, Ulrich Schotten
Veröffentlicht in:
EP Europace, 2017, ISSN 1099-5129
Herausgeber:
Oxford University Press
DOI:
10.1093/europace/eux234
Autoren:
Arne van Hunnik, Hussein Nasrallah, Dennis H. Lau, Marion Kuiper, Sander Verheule, Ulrich Schotten
Veröffentlicht in:
EP Europace, 2017, ISSN 1099-5129
Herausgeber:
Oxford University Press
DOI:
10.1093/europace/eux025
Autoren:
Rikke Buhl, Helena Carstensen, Eva Zander Hesselkilde, Bjørg Zinkernagel Klein, Karen Margrethe Hougaard, Kirsten Bomberg Ravn, Ameli Victoria Loft-Andersen, Merle Friederike Fenner, Christian Pipper, Thomas Jespersen
Veröffentlicht in:
Journal of Veterinary Internal Medicine, Ausgabe 32/4, 2018, Seite(n) 1410-1419, ISSN 0891-6640
Herausgeber:
American College of Verterinary Internal Medicine
DOI:
10.1111/jvim.15137
Autoren:
Rafel Simó-Vicens, Sofia H. Bomholtz, Ulrik S. Sørensen, Bo H. Bentzen
Veröffentlicht in:
Frontiers in Pharmacology, Ausgabe 9, 2018, ISSN 1663-9812
Herausgeber:
Frontiers Media S.A.
DOI:
10.3389/fphar.2018.01409
Autoren:
Arne van Hunnik, Stef Zeemering, Piotr Podziemski, Jorik Simons, Giulia Gatta, Laura Hannink, Bart Maesen, Marion Kuiper, Sander Verheule, Ulrich Schotten
Veröffentlicht in:
Frontiers in Physiology, Ausgabe 9, 2018, ISSN 1664-042X
Herausgeber:
Frontiers Research Foundation
DOI:
10.3389/fphys.2018.00947
Autoren:
András Horváth, Marc D. Lemoine, Alexandra Löser, Ingra Mannhardt, Frederik Flenner, Ahmet Umur Uzun, Christiane Neuber, Kaja Breckwoldt, Arne Hansen, Evaldas Girdauskas, Hermann Reichenspurner, Stephan Willems, Norbert Jost, Erich Wettwer, Thomas Eschenhagen, Torsten Christ
Veröffentlicht in:
Stem Cell Reports, Ausgabe 10/3, 2018, Seite(n) 822-833, ISSN 2213-6711
Herausgeber:
Cell Press
DOI:
10.1016/j.stemcr.2018.01.012
Autoren:
Marta Lemme, Bärbel M. Ulmer, Marc D. Lemoine, Antonia T.L. Zech, Frederik Flenner, Ursula Ravens, Hermann Reichenspurner, Miriam Rol-Garcia, Godfrey Smith, Arne Hansen, Torsten Christ, Thomas Eschenhagen
Veröffentlicht in:
Stem Cell Reports, Ausgabe 11/6, 2018, Seite(n) 1378-1390, ISSN 2213-6711
Herausgeber:
Cell Press
DOI:
10.1016/j.stemcr.2018.10.008
Autoren:
Márcia Vagos, Ilsbeth G. M. van Herck, Joakim Sundnes, Hermenegild J. Arevalo, Andrew G. Edwards, Jussi T. Koivumäki
Veröffentlicht in:
Frontiers in Physiology, Ausgabe 9, 2018, ISSN 1664-042X
Herausgeber:
Frontiers Research Foundation
DOI:
10.3389/fphys.2018.01221
Autoren:
Helena Carstensen, Eva Z. Hesselkilde, Merle Fenner, Ameli V. Loft-Andersen, Mette Flethøj, Jørgen K. Kanters, Stefan M. Sattler, Jacob Tfelt-Hansen, Steen Pehrson, Thomas Jespersen, Rikke Buhl
Veröffentlicht in:
Journal of Veterinary Internal Medicine, Ausgabe 32/5, 2018, Seite(n) 1708-1717, ISSN 0891-6640
Herausgeber:
American College of Verterinary Internal Medicine
DOI:
10.1111/jvim.15287
Autoren:
Jeppe Egedal Kirchhoff, Mark Alexander Skarsfeldt, Kalai Mangai Muthukumarasamy, Rafel Simó-Vicens, Sofia Hammami Bomholtz, Lea Abildgaard, Thomas Jespersen, Ulrik S. Sørensen, Morten Grunnet, Bo Hjorth Bentzen, Jonas Goldin Diness
Veröffentlicht in:
Frontiers in Pharmacology, Ausgabe 10, 2019, ISSN 1663-9812
Herausgeber:
Frontiers Media S.A.
DOI:
10.3389/fphar.2019.00668
Autoren:
Marta Lemme, Ingke Braren, Maksymilian Prondzynski, Bülent Aksehirlioglu, Bärbel M Ulmer, Mirja L Schulze, Djemail Ismaili, Christian Meyer, Arne Hansen, Torsten Christ, Marc D Lemoine, Thomas Eschenhagen
Veröffentlicht in:
Cardiovascular Research, 2019, ISSN 0008-6363
Herausgeber:
Elsevier BV
DOI:
10.1093/cvr/cvz245
Autoren:
Ilse van Herck, Rafel Simó Vicens, Hermenegild Arevalo, Jussi Koivumäki, Bo H Bentzen, Andrew G Edwards
Veröffentlicht in:
Poster // Cardiac Arrhythmia symposium, 2017
Herausgeber:
Cardiac Arrhythmia symposium
Autoren:
Ilse van Herck, Rafel Simó Vicens, Hermenegild Arevalo, Jussi Koivumäki, Bo H Bentzen, Andrew G Edwards
Veröffentlicht in:
Poster // 41st EWGCCE meeting, 2017
Herausgeber:
41st EWGCCE meeting
Autoren:
Fenner MF, Hesselkilde E, Carstensen H, Nissen S, Lunddahl C, Jensen M, Loft-Andersen a, Milnes J, Sattler S, Jespersen T, Buhl R
Veröffentlicht in:
Abstract // ECEIM '17 Congress, 2017
Herausgeber:
ECEIM '17 Congress
Autoren:
A. Horváth, A. Uzun, I. Mannhardt, K. Breckwoldt, C. Neuber, A. Löser, A. Varró, A. Hansen, T. Eschenhagen, T. Christ
Veröffentlicht in:
Poster // 40th EWGCCE Meeting, Glasgow, 2016, 2016
Herausgeber:
40th EWGCCE Meeting, Glasgow, 2016
Autoren:
András Horváth, Ingra Mannhardt, Alexandra Löser, Marc D. Lemoine, Christiane Neuber, Kaja Breckwoldt, Frederik Flenner, Ahmet Umur Uzun, Arne Hansen,Evaldas Girdauskas, Hermann Reichenspurner, Stephan Willems, Norbert Jost, Erich Wettwer, Thomas Eschenhagen, Torsten Christ
Veröffentlicht in:
Poster // 14th Dutch-German Joint Meeting of the Molecular Cardiology Groups, 2017
Herausgeber:
14th Dutch-German Joint Meeting of the Molecular Cardiology Groups
Autoren:
Giommi A, Gurgel AR, Saxena P, Smith GL, Workman AJ
Veröffentlicht in:
Abstract / Proc Physiol Soc, Ausgabe 43 (2019) PC041, 2019, Seite(n) 299-300
Herausgeber:
The Physiological Society
Autoren:
L. Soattin; A. Lubberding; BH. Bentzen; T. Jespersen
Veröffentlicht in:
Poster session abstract / EHRA EUROPACE - CARDIOSTIM 2017, Ausgabe Abstract supplement June 18-21, 2017 - Vienna, 2017, Seite(n) ii219-ii220
Herausgeber:
EP Europace, Oxford University Press
Autoren:
Eva Zander Hesselkilde, Helena Carstensen, Merle Friederike Fenner
Veröffentlicht in:
Ridehesten, Hippologisk i Avl & Sport, Ausgabe 2, 2017, Seite(n) 62-66, ISSN 1396-0377
Herausgeber:
Wiegaarden Media
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