Modulation of glycolytic flux as a new approach for treatment of atherosclerosis and plaque stabilization: a multidisciplinary study

Livrables

At least 12 papers acknowledging the project published

At least 12 papers acknowledging the project published on peer reviewed journals

Statement on individual training, local courses, technical and transferable skills acquired (at each network meeting)

A statement will be delivered to each PhD related to individual training, local courses, technical and transferable skills acquired (M12,18, 24,30, 36)

Network Meetings Organized (including virtual meeting)

Organization of seven interdisciplinary meetings (comprising workshops, virtual meetings and summer schools; 6,12,18,24,30,36, 42) inviting distinguished scientists and experts from industry

At least 6 papers acknowledging the project published

At least 6 papers acknowledging the project published on peer reviewed journals

2 Summer schools organized

Implementation of interdisciplinary knowledge by the way of two Summer Schools (Imaging and Radiopharmaceutical development Summer school M18 and Pharma-Skills Summer School M30)

2 Workshops on Scientific training

Implementation of interdisciplinary knowledge by the way of two workshops on specific topics of interest for PhD students (M6,42)

EThics - delivery of documents

compulsory delievrable

Sueprvisory Board meeting

compulsort delievrable

Recruitment advertising publication

Preparation of Flyer (M1) and Consortium webportal/partners webpages (M1-2); Call for applicants (M2); d) Media newsletters; Selected applicants and reserve list (M5)

Consortium web-site creation and scientific blog

portal Web-site as essential tool for communication between MoGlyNet members, the scientific community and the general public will be set up

Publications

Rescoring Virtual Screening Results with the MM-PBSA Methods: Beware of Internal Dielectric Constants

Auteurs: Hu, Xiao; Contini, Alessandro
Publié dans: JOURNAL OF CHEMICAL INFORMATION AND MODELING, Numéro 18, 2019, ISSN 1549-9596
Éditeur: American Chemical Society
DOI: 10.1021/acs.jcim.9b00095

Protein network analyses of pulmonary endothelial cells in chronic thromboembolic pulmonary hypertension

Auteurs: Sarath Babu Nukala, Olga Tura-Ceide, Giancarlo Aldini, Valérie Smolders, Isabel Blanco, Victor I. Peinado, Manuel Castellà, Joan Albert Barberà, Alessandra Altomare, Giovanna Baron, Marina Carini, Marta Cascante and Alfonsina D’Amato
Publié dans: Sci Rep, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-85004-z

In vitro angiogenesis inhibition with selective compounds targeting the key glycolytic enzyme PFKFB3

Auteurs: Abdali A, Baci D, Damiani I, Belloni F, De Dominicis C, Gelmi ML, Corsini A, Bellosta S.
Publié dans: Pharmacol Res, 2021, ISSN 1043-6618
Éditeur: Academic Press
DOI: 10.1016/j.phrs.2021.105592

Endothelial Dysfunction in Pulmonary Hypertension: Cause or Consequence?

Auteurs: Kondababu Kurakula, Valérie F.E.D Smolders, Olga Tura-Ceide, J. Wouter Jukema, Paul H. A. Quax, Marie-José Goumans
Publié dans: Biomedicines, 2021, ISSN 2227-9059
Éditeur: MDPI
DOI: 10.3390/biomedicines9010057

Prolonged Hyperoxygenation Treatment Improves Vein Graft Patency and Decreases Macrophage Content in Atherosclerotic Lesions in ApoE3*Leiden Mice.

Auteurs: Parma, Laura; Peters, Hendrika A. B.; Baganha, Fabiana; Sluimer, Judith C.; de Vries, Margreet R.; Quax, Paul H.A.
Publié dans: Cells, 9(2):336. Multidisciplinary Digital Publishing Institute (MDPI), Numéro 2, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.3390/cells9020336

Mass Spectrometry-based Label-free Quantitative Proteomics To Study the Effect of 3PO Drug at Cellular Level

Auteurs: Nukala, S.B.; Baron, G.; Aldini, G.; Carini, M.; D' Amato, A.
Publié dans: ACS Med chem lett, Numéro 5, 2019, ISSN 1948-5875
Éditeur: American Chemical Society
DOI: 10.1021/acsmedchemlett.8b00593

Bis(maltolato)oxovanadium(IV) Induces Angiogenesis via Phosphorylation of VEGFR2.

Auteurs: Parma L, Peters HAB, Johansson ME, Gutiérrez S, Meijerink H, de Kimpe S, de Vries MR, Quax PHA
Publié dans: Int J Mol Sci., 2020, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21134643

PFKFB3 gene deletion in endothelial cells inhibits intraplaque angiogenesis and lesion formation in a murine model of venous bypass grafting

Auteurs: Perrotta P, de Vries MR, Peeters B, Guns P-J, De Meyer GRY, Quax PHA, Martinet W.
Publié dans: Angiogenesis, 2021, ISSN 0969-6970
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10456-021-09816-3

Metabolic profile in endothelial cells of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension

Auteurs: V.F.E.D. Smolders Rodríguez C, I. Blanco, R. Szulcek, Wim Timens, L. Piccari, Y. Roger, X. Hu, Constanza Morén, C. Bonjoch, L. Sebastián, M. Castellà, J. Osorio, V. I. Peinado, Harm Jan Bogaard, P. H. A. Quax, M. Cascante, J.A. Barberà, O. Tura-Ceide
Publié dans: Sci Rep, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.21203/rs.3.rs-1008061/v1

Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia

Auteurs: van der Kwast RVCT, Parma L, van der Bent ML, van Ingen E, Baganha F, Peters HAB, Goossens EAC, Simons KH, Palmen M, de Vries MR, Quax PHA, Nossent AY
Publié dans: Mol Ther Nucleic Acids, 2020, ISSN 2162-2531
Éditeur: Nature Publishing Group
DOI: 10.1016/j.omtn.2020.07.020

The Inflammatory Profile of CTEPH Derived Endothelial Cells is a Possible Driver of Disease Progression

Auteurs: Valérie F.E.D. Smolders, Kirsten Lodder, Cristina Rodriguez, Olga Tura-Ceide, Joan Albert Barberà, J. Wouter Jukema, Paul H.A. Quax, Marie José T.H. Goumans, Kondababu Kurakula
Publié dans: Cells, 2021, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells10040737

Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension

Auteurs: Olga Tura-Ceide, Valérie F.E.D. Smolders, Núria Aventin, Constanza Morén, Mariona Guitart-Mampel, Isabel Blanco, Lucilla Piccari, Jeisson Osorio, Cristina Rodríguez, Montserrat Rigol, Núria Solanes, Andrea Malandrino, Kondababu Kurakula, Marie Jose Goumans, Paul H.A. Quax, Victor I. Peinado, Manuel Castellà, Joan Albert Barberà
Publié dans: Sci Rep, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-98320-1

Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis.

Auteurs: Welten SMJ, de Jong RCM, Wezel A, de Vries MR, Boonstra MC, Parma L, Jukema JW, van der Sluis TC, Arens R, Bot I, Agrawal S, Quax PHA, Nossent AY
Publié dans: Atherosclerosis, 2017, ISSN 0021-9150
Éditeur: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2017.04.011

Partial inhibition of glycolysis reduces atherogenesis independent of intraplaque neovascularization in mice

Auteurs: Perrotta P, Van der Veken B, Van der Veken P, Pintelon I, Adrianssens E, Timmerman V, De Meyer GRY, Martinet W.
Publié dans: Arterioscler Thromb Vasc Biol., 2020, ISSN 1079-5642
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.119.313692

bFGF blockade reduces intraplaque angiogenesis and macrophage infiltration in atherosclerotic vein graft lesions in ApoE3*Leiden mice.

Auteurs: Parma L, Peters HAB, Sluiter TJ, Simons KH, Lazzari P, de Vries MR, Quax PHA
Publié dans: Sci Rep., 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-72992-7

Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization

Auteurs: Fabiana Baganha; Fabiana Baganha; Rob C.M. de Jong; Erna Peters; Wietske Voorham; J. Wouter Jukema; Mirela Delibegovic; Margreet R. de Vries; Paul H.A. Quax
Publié dans: Angiogenesis, Numéro 5, 2021, ISSN 1573-7209
Éditeur: springer
DOI: 10.1007/s10456-021-09767-9

The PFKFB3 inhibitor AZ67 inhibits angiogenesis independently of glycolysis inhibition

Auteurs: Emini Veseli B, Van Wielendaele P, Delibegovic M, Martinet W, De Meyer GRY
Publié dans: Int J Mol Sci., 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22115970

Decreased glycolysis as metabolic fingerprint of endothelial cells in chronic thromboembolic pulmonary hypertensio

Auteurs: Valérie F. Smolders, Cristina Rodríguez, Isabel Blanco, Jeisson Osorio, Lucilla Piccari, Cristina Bonjoch, Paul H.A. Quax, Victor I. Peinado, Manel Castellà, Joan Albert Barberà, Marta Cascante, Olga Tura-Ceide
Publié dans: American Journal of Respiratory Cell and Molecular Biology, 2020, ISSN 1044-1549
Éditeur: American Lung Association
DOI: 10.1165/rcmb.2019-0409le

Inflammation in Vein Graft Disease

Auteurs: Margreet R. de Vries, Paul H. A. Quax
Publié dans: Frontiers in Cardiovascular Medicine, Numéro 5, 2018, ISSN 2297-055X
Éditeur: Masanori Aikawa, Harvard Medical School, United States
DOI: 10.3389/fcvm.2018.00003

Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis

Auteurs: Laura Parma, Fabiana Baganha, Paul H.A. Quax, Margreet R. de Vries
Publié dans: European Journal of Pharmacology, Numéro 816, 2017, Page(s) 107-115, ISSN 0014-2999
Éditeur: Elsevier BV
DOI: 10.1016/j.ejphar.2017.04.028

An Efficient Implementation of the Nwat-MMGBSA Method to Rescore Docking Results in Medium-Throughput Virtual Screenings

Auteurs: Irene Maffucci, Xiao Hu, Valentina Fumagalli, Alessandro Contini
Publié dans: Frontiers in Chemistry, Numéro 6, 2018, ISSN 2296-2646
Éditeur: EDITED BY Daniela Schuster Paracelsus Medizinische Privatuniversität, Salzburg, Austria
DOI: 10.3389/fchem.2018.00043

Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization

Auteurs: Margreet R. de Vries, Paul H.A. Quax
Publié dans: Current Opinion in Lipidology, Numéro 27/5, 2016, Page(s) 499-506, ISSN 0957-9672
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOL.0000000000000339

Novel MMP-inhibiting peptides for stabilizing atherosclerotic plaques

Auteurs: Anahita Abdali, Helena Macut, Xiao Hu, Sara Pellegrino, Alberto Corsini, Maria Luisa Gelmi, Stefano Bellosta
Publié dans: Atherosclerosis, Numéro 263, 2017, Page(s) e47-e48, ISSN 0021-9150
Éditeur: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2017.06.162

Animal models of atherosclerosis

Auteurs: Besa Emini Veseli, Paola Perrotta, Gregory R.A. De Meyer, Lynn Roth, Carole Van der Donckt, Wim Martinet, Guido R.Y. De Meyer
Publié dans: European Journal of Pharmacology, Numéro 816, 2017, Page(s) 3-13, ISSN 0014-2999
Éditeur: Elsevier BV
DOI: 10.1016/J.EJPHAR.2017.05.010

The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development

Auteurs: Rob C. M. de Jong, Mark M. Ewing, Margreet R. de Vries, Jacco C. Karper, Antonius J. N. M. Bastiaansen, Hendrika A. B. Peters, Fabiana Baghana, Peter J. van den Elsen, Céline Gongora, J. Wouter Jukema, Paul H. A. Quax
Publié dans: PLOS ONE, Numéro 12/10, 2017, Page(s) e0185820, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0185820

Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels

Auteurs: M. R. de Vries, L. Parma, H. A. B. Peters, A. Schepers, J. F. Hamming, J. W. Jukema, M. J. T. H. Goumans, L. Guo, A. V. Finn, R. Virmani, C. K. Ozaki, P. H. A. Quax
Publié dans: Journal of Internal Medicine, 2018, ISSN 0954-6820
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/joim.12821

Advances in the treatment of explicit water molecules in docking and binding free energy calculations

Auteurs: Xiao Hu, Irene Maffucci, Alessandro Contini
Publié dans: Current Medicinal Chemistry, Numéro 25, 2018, ISSN 0929-8673
Éditeur: Bentham Science Publishers
DOI: 10.2174/0929867325666180514110824

Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis

Auteurs: Paola Perrotta, Besa Emini Veseli, Bieke Van der Veken, Lynn Roth, Wim Martinet, Guido R.Y. De Meyer
Publié dans: Vascular Pharmacology, 2018, ISSN 1537-1891
Éditeur: Elsevier BV
DOI: 10.1016/j.vph.2018.06.014

Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels

Auteurs: M. R. de Vries, L. Parma, H. A. B. Peters, A. Schepers, J. F. Hamming, J. W. Jukema, M. J. T. H. Goumans, L. Guo, A. V. Finn, R. Virmani, C. K. Ozaki, P. H. A. Quax
Publié dans: Journal of Internal Medicine, Numéro 285/1, 2019, Page(s) 59-74, ISSN 0954-6820
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/joim.12821

Pharmacokinetic drug interactions of the non-vitamin K antagonist oral anticoagulants (NOACs)

Auteurs: Paolo Gelosa, Laura Castiglioni, Marco Tenconi, Ludovico Baldessin, Giorgio Racagni, Alberto Corsini, Stefano Bellosta
Publié dans: Pharmacological Research, Numéro 135, 2018, Page(s) 60-79, ISSN 1043-6618
Éditeur: Academic Press
DOI: 10.1016/j.phrs.2018.07.016

Proprotein Convertase Subtilisin-Kexin type-9 (PCSK9) and triglyceride-rich lipoprotein metabolism: Facts and gaps

Auteurs: Andrea Baragetti, Daniela Grejtakova, Manuela Casula, Elena Olmastroni, Gloria Saccani Jotti, Giuseppe Danilo Norata, Alberico L. Catapano, Stefano Bellosta
Publié dans: Pharmacological Research, Numéro 130, 2018, Page(s) 1-11, ISSN 1043-6618
Éditeur: Academic Press
DOI: 10.1016/j.phrs.2018.01.025

Adenosine-to-Inosine Editing of MicroRNA-487b Alters Target Gene Selection After Ischemia and Promotes Neovascularization

Auteurs: Reginald V.C.T. van der Kwast, Eva van Ingen, Laura Parma, Hendrika A.B. Peters, Paul H.A. Quax, A. Yaël Nossent
Publié dans: Circulation Research, Numéro 122/3, 2018, Page(s) 444-456, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.117.312345

Metabolic Alterations in Cardiopulmonary Vascular Dysfunction

Auteurs: Valérie Françoise Smolders, Erika Zodda, Paul H. A. Quax, Marina Carini, Joan Albert Barberà, Timothy M. Thomson, Olga Tura-Ceide, Marta Cascante
Publié dans: Frontiers in Molecular Biosciences, Numéro 5, 2019, ISSN 2296-889X
Éditeur: Annalisa Pastore King's College London London, United Kingdom Field Chief Editor
DOI: 10.3389/fmolb.2018.00120

Differentially Expressed Proteins in Primary Endothelial Cells Derived From Patients With Acute Myocardial Infarction

Auteurs: Sarath Babu Nukala, Luca Regazzoni, Giancarlo Aldini, Erika Zodda, Olga Tura-Ceide, Nicholas L. Mills, Marta Cascante, Marina Carini, Alfonsina D’Amato
Publié dans: Hypertension, Numéro 74/4, 2019, Page(s) 947-956, ISSN 0194-911X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.119.13472

Tuning PFKFB3 Bisphosphatase Activity Through Allosteric Interference

Auteurs: Helena Macut, Xiao Hu, Delia Tarantino, Ettore Gilardoni, Francesca Clerici, Luca Regazzoni, Alessandro Contini, Sara Pellegrino, Maria Luisa Gelmi
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-56708-0

Assessment of Microvessel Permeability in Murine Atherosclerotic Vein Grafts Using Two-Photon Intravital Microscopy

Auteurs: Baganha F, Ritsma L, Quax PHA, de Vries MR
Publié dans: Int J Mol Sci. 2020, 2020, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21239244

The Role of Immunomodulation in Vein Graft Remodeling and Failure.

Auteurs: Fabiana Baganha; Fabiana Baganha; Alwin de Jong; J. Wouter Jukema; Paul H.A. Quax; Margreet R. de Vries
Publié dans: Journal of Cardiovascular Translational Research, Numéro 24, 2021, ISSN 1937-5387
Éditeur: Springer Pub. Co.,
DOI: 10.1007/s12265-020-10001-y

Small molecule 3PO inhibits glycolysis but does not bind to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3)

Auteurs: Emini Veseli B, Perrotta P, Van Wielendaele P, Lambeir A-M, Abdali A, Bellosta S, Monaco G, Bultynck G, Martinet W, De Meyer GRY
Publié dans: FEBS Lett., 2020, ISSN 0014-5793
Éditeur: Elsevier BV
DOI: 10.1002/1873-3468.13878

[18F]ZCDD083: a PFKFB3-targeted PET tracer for atherosclerotic plaque imaging

Auteurs: Carlo De Dominicis, Paola Perrotta, Sergio Dall’Angelo, Leonie Wyffels, Steven Staelens,* Guido R. Y. De Meyer, Matteo Zanda
Publié dans: ACS Medicinal Chemistry Letters, 2020, ISSN 1948-5875
Éditeur: American Chemical Society
DOI: 10.1021/acsmedchemlett.9b00677

Three-dimensional imaging of intraplaque neovascularization in a mouse model of advanced atherosclerosis

Auteurs: Perrotta P, Pintelon I, De Vries MR, Quax PHA, Timmermans J-P, De Meyer GRY, Martinet W.
Publié dans: J Vasc Res., 2020, ISSN 1018-1172
Éditeur: S. Karger AG
DOI: 10.1159/000508449

DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF PFKFB3 PHOSPHATASE ACTIVITY ALLOSTERIC MODULATORS

Auteurs: "Helena Macut DISFARM - Section of General and Organic Chemistry ""A. Marchesini"", University of Milan, Via Venezian 21, 20133 Milan, Italy. ; Xiao Hu; Delia Tarantino; Luca Giovanni Regazzoni; Ettore Gilardoni; Sara Pellegrino; Maria Luisa Gelmi"
Publié dans: International Symposium on Medicinal Chemistry Lublijana, 2018
Éditeur: International Symposium on Medicinal Chemistry
DOI: 10.5281/zenodo.1415341

Differentially Expressed Proteins in Pulmonary Endothelial Cells in Chronic Thromboembolic Pulmonary Hypertension

Auteurs: S.B. Nukala , O. Tura , L. Regazzoni , C. Marinello , A. Abdali , G. Aldini , V.F. Smolders, I. Blanco , J.A. Barbera , M. Cascante , M. Carini
Publié dans: American Journal of Respiratory and Critical Care Medicine 2018; 197:A3738 ATS International conference,, 2018
Éditeur: ATS International conference
DOI: 2434/590474

Virtual screening approach in drug discovery targeting the PFKFB3 kinase binding site

Auteurs: Cristofori, Virginia; Contini, Alessandro
Publié dans: eCheminfo workshop in Drug Design, 18-22 July 2016 University of Milan, 2016
Éditeur: University of Milan
DOI: 10.5281/zenodo.826382

Structure-based design and synthesis of new PFKFB3 kinase inhibitors as candidate therapeutics for treating atherosclerosis

Auteurs: Cristofori, Virginia; Stanzione, Francesca; Zanda, Matteo; Contini, Alessandro
Publié dans: Medicinal Chemistry Residential Summer School, 2017
Éditeur: Medicinal Chemistry Residential Summer School Loughborough
DOI: 10.5281/zenodo.826380

Structure-based design and synthesis of new PFKFB3 kinase inhibitors as candidate therapeutics for treating atherosclerosis

Auteurs: Cristofori, Virginia
Publié dans: Winter Symposium 16th and 17th of February, Aberdeen University, 2017
Éditeur: Aberdeen University
DOI: 10.5281/zenodo.827178

Dysfunctional endothelial cells in patients with chronic thromboembolic pulmonary hypertension

Auteurs: Valérie Françoise Smolders; Joan Albert Barberà; Olga Tura-Ceide
Publié dans: ERS 2017 on September 11th 2017, Milan, Italy., 2017
Éditeur: ERS 2017
DOI: 10.5281/zenodo.1402475

Endothelial cells dysfunctionality associated to acute myocardial infarction: regulation of metabolic pathways as a new therapeutic strategy.

Auteurs: Erika Zodda, Anusha Jayaraman, Pedro de Atauri, Ramón Messeguer, Olga Tura-Ceide, Timothy M. Thomson, & Marta Cascante.
Publié dans: FEBS3+ Barcelona 2017, 2017
Éditeur: FEBS3 Barcelona (Fira de Barcelona)
DOI: 10.5281/zenodo.1342535

Derivation and characterization of endothelial cells from patients with chronic thromboembolic pulmonary hypertension

Auteurs: Valérie Françoise Smolders; Joan Albert Barberà; Olga Tura-Ceide
Publié dans: ATS 2018 2018, San Diego (CA), USA., 2018
Éditeur: ATS 2018
DOI: 10.5281/zenodo.1402522

Metabolic characterization of endothelial cells dysfunctionality associated to acute myocardial infarction

Auteurs: Erika Zodda; Anusha Jayaraman; Pedro de Atauri; Ramon Messeguer; Olga Tura-Ceide; Timothy M. Thomson; Marta Cascante
Publié dans: ENABLE Conference - The 1st European PhD and Postdoc, 15-17 Noviembre 2017, Palau Casades , Barcelona (Spain), 2017
Éditeur: ENABLE Conference -
DOI: 10.5281/zenodo.1342612

Mass Spectrometry-Based Label Free Quantitative Proteomics to study the effect of 3-PO in endothelial cells

Auteurs: NUKALA, SARATH BABU D'AMATO, ALFONSINA REGAZZONI, LUCA GIOVANNI ALDINI, GIANCARLO CARINI, MARINA
Publié dans: Joint Meeting in Medicinal Chemistry MedChemSicily Palermo nel 2018., 2018
Éditeur: Meeting in Medicinal Chemistry MedChemSicily
DOI: 2434/590476

Vascular Discovery: From Genes to Medicine Scientific

Auteurs: A. Abdali, A. Corsini, D. Baci, C. De Dominicis, M. Zanda, M.L. Gelmi, S. Bellosta
Publié dans: Vascular Discovery: From Genes to Medicine Scientific Conference S. Francisco, 2018
Éditeur: Vascular Discovery: From Genes to Medicine Scientific Conference
DOI: 2434/585140

Angiogenesis inhibition with novel compounds targeting the key glycolytic enzyme PFKFB3

Auteurs: Abdali, A; A. Corsini, D. Baci, C. De Dominicis, M. Zanda, M. L. Gelmi, S. Bellosta.
Publié dans: 86th Congress of the European Atherosclerosis Society EAS, Lisbon (Portugal), 2018
Éditeur: 86th Congress of the European Atherosclerosis Society EAS, Lisbon (Portugal)
DOI: 2434/585142

Novel compounds targeting PFKFB3, the key glycolytic enzyme, as a way to inhibit angiogenesis

Auteurs: Anahita Abdali, Bellosta Stefano, Corsini Alberto, Carlo De Dominicis, Matteo Zanda, Gelmi Maria Luisa
Publié dans: SISA Palermo, 19-21 November 2017, 2017
Éditeur: SISA Palermo
DOI: 2434/585138

“In vitro study on the effects of inhibitors of angiogenesis in atherosclerosis”

Auteurs: L. Parma, C. De Dominicis, H. A. B. Peters, M. R. De Vries and P. H. A. Quax
Publié dans: ESVS spring meeting in Leiden, May 19-20, 2017., 2017
Éditeur: ESVS spring meeting in Leiden
DOI: 10.5281/zenodo.826048

In vivo evaluation by optical and PET imaging of IP angiogenesis and validation of PFKFB3 inhibitors in a murine vein graft model

Auteurs: Baganha F., De Vries M. and Quax P.
Publié dans: Dutch Heart Foundation, 2016
Éditeur: Dutch Heart Foundation
DOI: 10.5281/zenodo.832534

Humanized IgG monoclonal anti-phosphorylcholine reduces vein graft failure

Auteurs: Fabiana Baganha; Erna Peters; Margreet de Vries; Knut Pettersson; Paul H.A. Quax
Publié dans: ESVS spring meeting 2017, 2017
Éditeur: ESVS
DOI: 10.5281/zenodo.832549

VEGFR2 blockade reduces intraplaque haemorrhage and enhances plaque stability by augmentation of plaque neovessel maturation

Auteurs: Margreet de Vries; Laura Parma; Erna Peters; Jaap Hamming; Marie-José Goumans; Paul Quax
Publié dans: International Vascular Biology Meeting (IVBM), Boston, Massachusetts, USA, 30 Oct – 03 Nov, 2016, 2016
Éditeur: International Vascular Biology Meeting (IVBM),
DOI: 10.5281/zenodo.831473

Dysfunctional endothelial cells in patients with chronic thromboembolic pulmonary hypertension

Auteurs: Valérie Françoise Smolders; Joan Albert Barberà; Olga Tura-Ceide
Publié dans: ERS 2017, 2017
Éditeur: ERS 2017
DOI: 10.5281/zenodo.1402475

“P-140 VEGFR2 blockade in murine atherosclerotic vein grafts enhances plaque stability and reduces intraplaque haemorrhage by enhancement of plaque neovessel maturation”

Auteurs: M. de Vries, L. Parma, E. Peters, J. Hamming, M.- J. Goumans, P. Quax
Publié dans: Perspectives in Vascular Biology meeting , Frankfurt,, 2016
Éditeur: Perspectives in Vascular Biology meeting , Frankfurt,
DOI: 10.5281/zenodo.1478810

“In vitro and in vivo study on the effects of inhibitors of angiogenesis in atherosclerosis”

Auteurs: Parma L, M. R. De Vries, P. H. A. Quax
Publié dans: PhD course Dutch Heart Foundation,, 2016
Éditeur: Dutch Heart Foundation,
DOI: 10.5281/zenodo.1478817

“Design, synthesis and in vitro evaluation of modulators of PFKFB3 phosphatase activity”

Auteurs: H. Macut, X. Hu, D. Tarantino, L. Parma, S. Pellegrino, M. L. Gelmi
Publié dans: Marie Curie Alumni Association General Assembly and Annual Conference,, 2018
Éditeur: Marie Curie Alumni Association General Assembly and Annual Conference,
DOI: 10.5281/zenodo.1478786

“Derivation and characterization of endothelial cells from patients with chronic thromboembolic pulmonary hypertension”

Auteurs: V. Smolders, Olga Tura-Ceide, Jéssica Garcia-Lucio, Lucilla Piccari, Victor I. Peinado, Manel Castella, Joan Albert Barberà .
Publié dans: spring meeting in Leiden, 2017
Éditeur: University of Leiden
DOI: 10.5281/zenodo.826143

“Study of central carbon metabolism of Endothelial Cells in normal and pathological conditions”

Auteurs: E. Zodda, A. Jayaraman, P. de Atauri, S. Marin, R. Messeguer, O. Tura-Ceide, T. M Thomson, M. Cascante
Publié dans: EMBO conference, 2016
Éditeur: EMBO conference
DOI: 10.5281/zenodo.826394

"""Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension"" "

Auteurs: V. Smolders, O. Tura-Ceide, J. Garcia-Lucio, L. Piccari, V. I. Peinado, M. Castella, J. A. Barberà.
Publié dans: Jornadas Docencia CIBERES/CIBER-BBN 2016., 2016
Éditeur: CIBERES/CIBER-BBN 2016, Madrid, Spain,
DOI: 10.5281/zenodo.826133

“Small molecule mediated inhibition of bFGF reduces in vivo angiogenesis and is a promising candidate to combat intraplaque angiogenesis in atherosclerosis”

Auteurs: L. Parma, M.R. De Vries, H.A.B. Peters and P.H.A. Quax
Publié dans: ESM-EVBO summer school, 2018
Éditeur: ESM-EVBO
DOI: 10.5281/zenodo.1478821

Quantitative Proteomics: Strategies and tools to Probe Biology

Auteurs: Nukala SB, , MM Idris, Marina Carini
Publié dans: European Molecular Biology Laboratory (EMBL),, 2016
Éditeur: European Molecular Biology Laboratory (EMBL)
DOI: 2434/517613

Targeting glycolysis to inhibit intra-plaque angiogenesis.

Auteurs: Perrotta P., M.de Vries, W. Martinet , P. Quax
Publié dans: ESVS Meeting_Basic and Translation Research in vascular biology., 2017
Éditeur: ESVS Meeting_Basic and Translation Research in vascular biology

Target glycolysis to promote stabilization of advanced atherosclerotic plaques ORAL

Auteurs: Paola Perrotta
Publié dans: Spring Meeting of the Belgian Society of Physiology and Pharmacology 27/04/2018, 2018
Éditeur: Belgian Society of Physiology and Pharmacology

“Flexible Water Docking and Virtual Screening Using PLANTS Combined with Tuned Water Selection criteria”

Auteurs: X. Hu, A. Contini
Publié dans: 11th Triennial Congress of the World Association of Theoretical and Computational Chemists,, 2017
Éditeur: World Association of Theoretical and Computational Chemists
DOI: 2434/599488

“Docking and Virtual Screening with Flexible Hydration and Potentials in MM-PBSA rescoring”

Auteurs: X. Hu, A. Contini,
Publié dans: 13th German Conference on Chemoinformatics, 2017
Éditeur: German Conference on Chemoinformatics

Automatization of the Nwat-MMGBSA method to rescore docking results in medium-throughput virtual screening applications

Auteurs: Hu X.; Contini, A.
Publié dans: Triennial Congress of the World Association of Theoretical and Computational Chemists, 2017
Éditeur: Triennial Congress of the World Association of Theoretical and Computational Chemists

“Difference in Virtual Screening Enrichment Using polar and non-polar interactions of MM-PB/GBSA methods”

Auteurs: X. Hu, A. Contini
Publié dans: echeminfo Oxford 2018 workshop, 2018
Éditeur: echeminfo Oxford 2018 workshop, Didcot, UK, 2018 Training and Innovation Course in Drug Design

“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Auteurs: Baganha F., M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Publié dans: International Vascular Biology Meeting, 2018
Éditeur: International Vascular Biology Meeting
DOI: 10.5281/zenodo.1489036

“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Auteurs: F. Baganha, M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Publié dans: Frontiers in Cardiovascular, 2018
Éditeur: Frontiers in Cardiovascular
DOI: 10.5281/zenodo.1488964

“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Auteurs: Baganha F., M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Publié dans: RVMM Meeting, 2018
Éditeur: Rembrandt Vascular cardiovascular Institute
DOI: 10.5281/zenodo.1489044

F“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Auteurs: F. Baganha, M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Publié dans: Rembrandt Symposium, 2017
Éditeur: Rembrandt Symposium
DOI: 10.5281/zenodo.1489038

“Humanized IgG monoclonal anti-phosphorylcholine reduces vein graft failure”

Auteurs: Baganha F. , M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Publié dans: AIO research meeting, 2018
Éditeur: AIO research meeting
DOI: 10.5281/zenodo.1489028

Drug discovery and Computation Biology

Auteurs: Cristofori V.
Publié dans: PechaKucha Night, 2017
Éditeur: PechaKucha Night The Belmont Filmhouse Aberdeen,
DOI: 10.5281/zenodo.1486103

Dysfunctional endothelial cells in patients with chronic thromboembolic pulmonary hypertension

Auteurs: Valerie smolders
Publié dans: 2 Reunión de Investigación en Hipertensión Pulmonar., 2018
Éditeur: CIBERES
DOI: 10.5281/zenodo.1557576

Synthesis and characterization of the autoregulatory domain of PFKFB3

Auteurs: H. Macut, S. Pellegrino, M.L. Gelmi
Publié dans: International Symposium on Medicinal Chemistry : book of abstracts, 2016, Page(s) 137
Éditeur: EFCM
DOI: 2434/489548

Design, synthesis and in vitro evaluation of modulators of PFKFB3 autoregulatory domain

Auteurs: MACUT, HELENA; HU, XIAO; GELMI, MARIA LUISA; PELLEGRINO, SARA; TARANTINO, DELIA
Publié dans: 10th Joint Meeting on medicinal chemistry, 25.-28.6.2017 Dubrovnik, Croatia., 2017
Éditeur: http://www.jmmc2017.hr/
DOI: 2434/516356

Combining 3D-RISM with hydropathic charateristic water evaluation: first step preparation for further PLANTS virtual screening with flexible explicit water molecules

Auteurs: HU, XIAO CONTINI, ALESSANDRO
Publié dans: eCheminfo workshop in Drug Design, 2016
Éditeur: http://www.echeminfo.com/events/drug-design-euro
DOI: 2434/516738

Combining 3D-RISM with hydrophatic characteristic water evaluation: first step preparation for further PLANTS virtual screening with flexible explicit water molecules

Auteurs: HU, XIAO CONTINI, ALESSANDRO
Publié dans: 12th German Conference on Chemoinformatics, 2016
Éditeur: https://www.gdch.de/index.php?id=3089
DOI: 2434/517787

Novel MMP-inhibiting peptides for stabilizing atherosclerotic plaques

Auteurs: ABDALI, ANAHITA MACUT, HELENA PELLEGRINO, SARA GELMI, MARIA LUISA BELLOSTA, STEFANO
Publié dans: 85th European Atherosclerosis Society (EAS) Congress in Prague: Science at a Glance, 2017
Éditeur: http://eas2017.com/
DOI: 2434/508315

Annual Research Day: Project summary for Elevator Pitch

Auteurs: Smolders, Valérie F.
Publié dans: 'Kaag dag : Annual Research meeting Leiden,, Numéro 1, 2018
Éditeur: University of Leiden
DOI: 10.5281/zenodo.1402470

Synthesis of PFKFB3 inhibitors for Positron Emission Tomography imaging of atherosclerotic plaque

Auteurs: Carlo, De Dominicis
Publié dans: Graduate School 2017 Winter Symposium at the University of Aberdeen, Numéro 2, 2017
Éditeur: University of Aberdeen
DOI: 10.5281/zenodo.827185

[18F]AZ68: a PFKFB3 targeted PET tracer for imaging atherosclerotic plaque

Auteurs: De Dominicis, C. Dall'Angelo Sergio; Perrotta Paola; Zanda Matteo; Staelens Steven; De Meyer Guido; Wyffels Leonie
Publié dans: 2018
Éditeur: Scottish Molecular Imaging Meeting Glasgow
DOI: 10.5281/zenodo.1422742

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