Modulation of glycolytic flux as a new approach for treatment of atherosclerosis and plaque stabilization: a multidisciplinary study

Project Information

MOGLYNET

Grant agreement ID: 675527

DOI 10.3030/675527

Project closed

EC signature date 28 July 2015

Start date 1 September 2015

End date 30 November 2019

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 086 435,52

EU contribution € 3 086 435,52

Coordinated by

UNIVERSITA DEGLI STUDI DI MILANO
Italy

Deliverables

Other (6)

At least 12 papers acknowledging the project published

At least 12 papers acknowledging the project published on peer reviewed journals

Statement on individual training, local courses, technical and transferable skills acquired (at each network meeting)

A statement will be delivered to each PhD related to individual training, local courses, technical and transferable skills acquired (M12,18, 24,30, 36)

Network Meetings Organized (including virtual meeting)

Organization of seven interdisciplinary meetings (comprising workshops, virtual meetings and summer schools; 6,12,18,24,30,36, 42) inviting distinguished scientists and experts from industry

At least 6 papers acknowledging the project published

At least 6 papers acknowledging the project published on peer reviewed journals

2 Summer schools organized

Implementation of interdisciplinary knowledge by the way of two Summer Schools (Imaging and Radiopharmaceutical development Summer school M18 and Pharma-Skills Summer School M30)

2 Workshops on Scientific training

Implementation of interdisciplinary knowledge by the way of two workshops on specific topics of interest for PhD students (M6,42)

Documents, reports (2)

EThics - delivery of documents

compulsory delievrable

Sueprvisory Board meeting

compulsort delievrable

Websites, patent fillings, videos etc. (2)

Recruitment advertising publication

Preparation of Flyer (M1) and Consortium webportal/partners webpages (M1-2); Call for applicants (M2); d) Media newsletters; Selected applicants and reserve list (M5)

Consortium web-site creation and scientific blog

portal Web-site as essential tool for communication between MoGlyNet members, the scientific community and the general public will be set up

Publications

Peer reviewed articles (40)

Rescoring Virtual Screening Results with the MM-PBSA Methods: Beware of Internal Dielectric Constants

Author(s): Hu, Xiao; Contini, Alessandro
Published in: JOURNAL OF CHEMICAL INFORMATION AND MODELING, Issue 18, 2019, ISSN 1549-9596
Publisher: American Chemical Society
DOI: 10.1021/acs.jcim.9b00095

Protein network analyses of pulmonary endothelial cells in chronic thromboembolic pulmonary hypertension

Author(s): Sarath Babu Nukala, Olga Tura-Ceide, Giancarlo Aldini, Valérie Smolders, Isabel Blanco, Victor I. Peinado, Manuel Castellà, Joan Albert Barberà, Alessandra Altomare, Giovanna Baron, Marina Carini, Marta Cascante and Alfonsina D’Amato
Published in: Sci Rep, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-85004-z

In vitro angiogenesis inhibition with selective compounds targeting the key glycolytic enzyme PFKFB3

Author(s): Abdali A, Baci D, Damiani I, Belloni F, De Dominicis C, Gelmi ML, Corsini A, Bellosta S.
Published in: Pharmacol Res, 2021, ISSN 1043-6618
Publisher: Academic Press
DOI: 10.1016/j.phrs.2021.105592

Endothelial Dysfunction in Pulmonary Hypertension: Cause or Consequence?

Author(s): Kondababu Kurakula, Valérie F.E.D Smolders, Olga Tura-Ceide, J. Wouter Jukema, Paul H. A. Quax, Marie-José Goumans
Published in: Biomedicines, 2021, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines9010057

Prolonged Hyperoxygenation Treatment Improves Vein Graft Patency and Decreases Macrophage Content in Atherosclerotic Lesions in ApoE3*Leiden Mice.

Author(s): Parma, Laura; Peters, Hendrika A. B.; Baganha, Fabiana; Sluimer, Judith C.; de Vries, Margreet R.; Quax, Paul H.A.
Published in: Cells, 9(2):336. Multidisciplinary Digital Publishing Institute (MDPI), Issue 2, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.3390/cells9020336

Mass Spectrometry-based Label-free Quantitative Proteomics To Study the Effect of 3PO Drug at Cellular Level

Author(s): Nukala, S.B.; Baron, G.; Aldini, G.; Carini, M.; D' Amato, A.
Published in: ACS Med chem lett, Issue 5, 2019, ISSN 1948-5875
Publisher: American Chemical Society
DOI: 10.1021/acsmedchemlett.8b00593

Bis(maltolato)oxovanadium(IV) Induces Angiogenesis via Phosphorylation of VEGFR2.

Author(s): Parma L, Peters HAB, Johansson ME, Gutiérrez S, Meijerink H, de Kimpe S, de Vries MR, Quax PHA
Published in: Int J Mol Sci., 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21134643

PFKFB3 gene deletion in endothelial cells inhibits intraplaque angiogenesis and lesion formation in a murine model of venous bypass grafting

Author(s): Perrotta P, de Vries MR, Peeters B, Guns P-J, De Meyer GRY, Quax PHA, Martinet W.
Published in: Angiogenesis, 2021, ISSN 0969-6970
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10456-021-09816-3

Metabolic profile in endothelial cells of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension

Author(s): V.F.E.D. Smolders Rodríguez C, I. Blanco, R. Szulcek, Wim Timens, L. Piccari, Y. Roger, X. Hu, Constanza Morén, C. Bonjoch, L. Sebastián, M. Castellà, J. Osorio, V. I. Peinado, Harm Jan Bogaard, P. H. A. Quax, M. Cascante, J.A. Barberà, O. Tura-Ceide
Published in: Sci Rep, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.21203/rs.3.rs-1008061/v1

Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia

Author(s): van der Kwast RVCT, Parma L, van der Bent ML, van Ingen E, Baganha F, Peters HAB, Goossens EAC, Simons KH, Palmen M, de Vries MR, Quax PHA, Nossent AY
Published in: Mol Ther Nucleic Acids, 2020, ISSN 2162-2531
Publisher: Nature Publishing Group
DOI: 10.1016/j.omtn.2020.07.020

The Inflammatory Profile of CTEPH Derived Endothelial Cells is a Possible Driver of Disease Progression

Author(s): Valérie F.E.D. Smolders, Kirsten Lodder, Cristina Rodriguez, Olga Tura-Ceide, Joan Albert Barberà, J. Wouter Jukema, Paul H.A. Quax, Marie José T.H. Goumans, Kondababu Kurakula
Published in: Cells, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10040737

Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension

Author(s): Olga Tura-Ceide, Valérie F.E.D. Smolders, Núria Aventin, Constanza Morén, Mariona Guitart-Mampel, Isabel Blanco, Lucilla Piccari, Jeisson Osorio, Cristina Rodríguez, Montserrat Rigol, Núria Solanes, Andrea Malandrino, Kondababu Kurakula, Marie Jose Goumans, Paul H.A. Quax, Victor I. Peinado, Manuel Castellà, Joan Albert Barberà
Published in: Sci Rep, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-98320-1

Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis.

Author(s): Welten SMJ, de Jong RCM, Wezel A, de Vries MR, Boonstra MC, Parma L, Jukema JW, van der Sluis TC, Arens R, Bot I, Agrawal S, Quax PHA, Nossent AY
Published in: Atherosclerosis, 2017, ISSN 0021-9150
Publisher: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2017.04.011

Partial inhibition of glycolysis reduces atherogenesis independent of intraplaque neovascularization in mice

Author(s): Perrotta P, Van der Veken B, Van der Veken P, Pintelon I, Adrianssens E, Timmerman V, De Meyer GRY, Martinet W.
Published in: Arterioscler Thromb Vasc Biol., 2020, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.119.313692

bFGF blockade reduces intraplaque angiogenesis and macrophage infiltration in atherosclerotic vein graft lesions in ApoE3*Leiden mice.

Author(s): Parma L, Peters HAB, Sluiter TJ, Simons KH, Lazzari P, de Vries MR, Quax PHA
Published in: Sci Rep., 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-72992-7

Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization

Author(s): Fabiana Baganha; Fabiana Baganha; Rob C.M. de Jong; Erna Peters; Wietske Voorham; J. Wouter Jukema; Mirela Delibegovic; Margreet R. de Vries; Paul H.A. Quax
Published in: Angiogenesis, Issue 5, 2021, ISSN 1573-7209
Publisher: springer
DOI: 10.1007/s10456-021-09767-9

The PFKFB3 inhibitor AZ67 inhibits angiogenesis independently of glycolysis inhibition

Author(s): Emini Veseli B, Van Wielendaele P, Delibegovic M, Martinet W, De Meyer GRY
Published in: Int J Mol Sci., 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22115970

Decreased glycolysis as metabolic fingerprint of endothelial cells in chronic thromboembolic pulmonary hypertensio

Author(s): Valérie F. Smolders, Cristina Rodríguez, Isabel Blanco, Jeisson Osorio, Lucilla Piccari, Cristina Bonjoch, Paul H.A. Quax, Victor I. Peinado, Manel Castellà, Joan Albert Barberà, Marta Cascante, Olga Tura-Ceide
Published in: American Journal of Respiratory Cell and Molecular Biology, 2020, ISSN 1044-1549
Publisher: American Lung Association
DOI: 10.1165/rcmb.2019-0409le

Inflammation in Vein Graft Disease

Author(s): Margreet R. de Vries, Paul H. A. Quax
Published in: Frontiers in Cardiovascular Medicine, Issue 5, 2018, ISSN 2297-055X
Publisher: Masanori Aikawa, Harvard Medical School, United States
DOI: 10.3389/fcvm.2018.00003

Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis

Author(s): Laura Parma, Fabiana Baganha, Paul H.A. Quax, Margreet R. de Vries
Published in: European Journal of Pharmacology, Issue 816, 2017, Page(s) 107-115, ISSN 0014-2999
Publisher: Elsevier BV
DOI: 10.1016/j.ejphar.2017.04.028

An Efficient Implementation of the Nwat-MMGBSA Method to Rescore Docking Results in Medium-Throughput Virtual Screenings

Author(s): Irene Maffucci, Xiao Hu, Valentina Fumagalli, Alessandro Contini
Published in: Frontiers in Chemistry, Issue 6, 2018, ISSN 2296-2646
Publisher: EDITED BY Daniela Schuster Paracelsus Medizinische Privatuniversität, Salzburg, Austria
DOI: 10.3389/fchem.2018.00043

Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization

Author(s): Margreet R. de Vries, Paul H.A. Quax
Published in: Current Opinion in Lipidology, Issue 27/5, 2016, Page(s) 499-506, ISSN 0957-9672
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOL.0000000000000339

Novel MMP-inhibiting peptides for stabilizing atherosclerotic plaques

Author(s): Anahita Abdali, Helena Macut, Xiao Hu, Sara Pellegrino, Alberto Corsini, Maria Luisa Gelmi, Stefano Bellosta
Published in: Atherosclerosis, Issue 263, 2017, Page(s) e47-e48, ISSN 0021-9150
Publisher: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2017.06.162

Animal models of atherosclerosis

Author(s): Besa Emini Veseli, Paola Perrotta, Gregory R.A. De Meyer, Lynn Roth, Carole Van der Donckt, Wim Martinet, Guido R.Y. De Meyer
Published in: European Journal of Pharmacology, Issue 816, 2017, Page(s) 3-13, ISSN 0014-2999
Publisher: Elsevier BV
DOI: 10.1016/J.EJPHAR.2017.05.010

The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development

Author(s): Rob C. M. de Jong, Mark M. Ewing, Margreet R. de Vries, Jacco C. Karper, Antonius J. N. M. Bastiaansen, Hendrika A. B. Peters, Fabiana Baghana, Peter J. van den Elsen, Céline Gongora, J. Wouter Jukema, Paul H. A. Quax
Published in: PLOS ONE, Issue 12/10, 2017, Page(s) e0185820, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0185820

Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels

Author(s): M. R. de Vries, L. Parma, H. A. B. Peters, A. Schepers, J. F. Hamming, J. W. Jukema, M. J. T. H. Goumans, L. Guo, A. V. Finn, R. Virmani, C. K. Ozaki, P. H. A. Quax
Published in: Journal of Internal Medicine, 2018, ISSN 0954-6820
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/joim.12821

Advances in the treatment of explicit water molecules in docking and binding free energy calculations

Author(s): Xiao Hu, Irene Maffucci, Alessandro Contini
Published in: Current Medicinal Chemistry, Issue 25, 2018, ISSN 0929-8673
Publisher: Bentham Science Publishers
DOI: 10.2174/0929867325666180514110824

Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis

Author(s): Paola Perrotta, Besa Emini Veseli, Bieke Van der Veken, Lynn Roth, Wim Martinet, Guido R.Y. De Meyer
Published in: Vascular Pharmacology, 2018, ISSN 1537-1891
Publisher: Elsevier BV
DOI: 10.1016/j.vph.2018.06.014

Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels

Author(s): M. R. de Vries, L. Parma, H. A. B. Peters, A. Schepers, J. F. Hamming, J. W. Jukema, M. J. T. H. Goumans, L. Guo, A. V. Finn, R. Virmani, C. K. Ozaki, P. H. A. Quax
Published in: Journal of Internal Medicine, Issue 285/1, 2019, Page(s) 59-74, ISSN 0954-6820
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/joim.12821

Pharmacokinetic drug interactions of the non-vitamin K antagonist oral anticoagulants (NOACs)

Author(s): Paolo Gelosa, Laura Castiglioni, Marco Tenconi, Ludovico Baldessin, Giorgio Racagni, Alberto Corsini, Stefano Bellosta
Published in: Pharmacological Research, Issue 135, 2018, Page(s) 60-79, ISSN 1043-6618
Publisher: Academic Press
DOI: 10.1016/j.phrs.2018.07.016

Proprotein Convertase Subtilisin-Kexin type-9 (PCSK9) and triglyceride-rich lipoprotein metabolism: Facts and gaps

Author(s): Andrea Baragetti, Daniela Grejtakova, Manuela Casula, Elena Olmastroni, Gloria Saccani Jotti, Giuseppe Danilo Norata, Alberico L. Catapano, Stefano Bellosta
Published in: Pharmacological Research, Issue 130, 2018, Page(s) 1-11, ISSN 1043-6618
Publisher: Academic Press
DOI: 10.1016/j.phrs.2018.01.025

Adenosine-to-Inosine Editing of MicroRNA-487b Alters Target Gene Selection After Ischemia and Promotes Neovascularization

Author(s): Reginald V.C.T. van der Kwast, Eva van Ingen, Laura Parma, Hendrika A.B. Peters, Paul H.A. Quax, A. Yaël Nossent
Published in: Circulation Research, Issue 122/3, 2018, Page(s) 444-456, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.117.312345

Metabolic Alterations in Cardiopulmonary Vascular Dysfunction

Author(s): Valérie Françoise Smolders, Erika Zodda, Paul H. A. Quax, Marina Carini, Joan Albert Barberà, Timothy M. Thomson, Olga Tura-Ceide, Marta Cascante
Published in: Frontiers in Molecular Biosciences, Issue 5, 2019, ISSN 2296-889X
Publisher: Annalisa Pastore King's College London London, United Kingdom Field Chief Editor
DOI: 10.3389/fmolb.2018.00120

Differentially Expressed Proteins in Primary Endothelial Cells Derived From Patients With Acute Myocardial Infarction

Author(s): Sarath Babu Nukala, Luca Regazzoni, Giancarlo Aldini, Erika Zodda, Olga Tura-Ceide, Nicholas L. Mills, Marta Cascante, Marina Carini, Alfonsina D’Amato
Published in: Hypertension, Issue 74/4, 2019, Page(s) 947-956, ISSN 0194-911X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.119.13472

Tuning PFKFB3 Bisphosphatase Activity Through Allosteric Interference

Author(s): Helena Macut, Xiao Hu, Delia Tarantino, Ettore Gilardoni, Francesca Clerici, Luca Regazzoni, Alessandro Contini, Sara Pellegrino, Maria Luisa Gelmi
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-56708-0

Assessment of Microvessel Permeability in Murine Atherosclerotic Vein Grafts Using Two-Photon Intravital Microscopy

Author(s): Baganha F, Ritsma L, Quax PHA, de Vries MR
Published in: Int J Mol Sci. 2020, 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21239244

The Role of Immunomodulation in Vein Graft Remodeling and Failure.

Author(s): Fabiana Baganha; Fabiana Baganha; Alwin de Jong; J. Wouter Jukema; Paul H.A. Quax; Margreet R. de Vries
Published in: Journal of Cardiovascular Translational Research, Issue 24, 2021, ISSN 1937-5387
Publisher: Springer Pub. Co.,
DOI: 10.1007/s12265-020-10001-y

Small molecule 3PO inhibits glycolysis but does not bind to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3)

Author(s): Emini Veseli B, Perrotta P, Van Wielendaele P, Lambeir A-M, Abdali A, Bellosta S, Monaco G, Bultynck G, Martinet W, De Meyer GRY
Published in: FEBS Lett., 2020, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.1002/1873-3468.13878

[18F]ZCDD083: a PFKFB3-targeted PET tracer for atherosclerotic plaque imaging

Author(s): Carlo De Dominicis, Paola Perrotta, Sergio Dall’Angelo, Leonie Wyffels, Steven Staelens,* Guido R. Y. De Meyer, Matteo Zanda
Published in: ACS Medicinal Chemistry Letters, 2020, ISSN 1948-5875
Publisher: American Chemical Society
DOI: 10.1021/acsmedchemlett.9b00677

Three-dimensional imaging of intraplaque neovascularization in a mouse model of advanced atherosclerosis

Author(s): Perrotta P, Pintelon I, De Vries MR, Quax PHA, Timmermans J-P, De Meyer GRY, Martinet W.
Published in: J Vasc Res., 2020, ISSN 1018-1172
Publisher: S. Karger AG
DOI: 10.1159/000508449

Conference proceedings (44)

DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF PFKFB3 PHOSPHATASE ACTIVITY ALLOSTERIC MODULATORS

Author(s): "Helena Macut DISFARM - Section of General and Organic Chemistry ""A. Marchesini"", University of Milan, Via Venezian 21, 20133 Milan, Italy. ; Xiao Hu; Delia Tarantino; Luca Giovanni Regazzoni; Ettore Gilardoni; Sara Pellegrino; Maria Luisa Gelmi"
Published in: International Symposium on Medicinal Chemistry Lublijana, 2018
Publisher: International Symposium on Medicinal Chemistry
DOI: 10.5281/zenodo.1415341

Differentially Expressed Proteins in Pulmonary Endothelial Cells in Chronic Thromboembolic Pulmonary Hypertension

Author(s): S.B. Nukala , O. Tura , L. Regazzoni , C. Marinello , A. Abdali , G. Aldini , V.F. Smolders, I. Blanco , J.A. Barbera , M. Cascante , M. Carini
Published in: American Journal of Respiratory and Critical Care Medicine 2018; 197:A3738 ATS International conference,, 2018
Publisher: ATS International conference
DOI: 2434/590474

Virtual screening approach in drug discovery targeting the PFKFB3 kinase binding site

Author(s): Cristofori, Virginia; Contini, Alessandro
Published in: eCheminfo workshop in Drug Design, 18-22 July 2016 University of Milan, 2016
Publisher: University of Milan
DOI: 10.5281/zenodo.826382

Structure-based design and synthesis of new PFKFB3 kinase inhibitors as candidate therapeutics for treating atherosclerosis

Author(s): Cristofori, Virginia; Stanzione, Francesca; Zanda, Matteo; Contini, Alessandro
Published in: Medicinal Chemistry Residential Summer School, 2017
Publisher: Medicinal Chemistry Residential Summer School Loughborough
DOI: 10.5281/zenodo.826380

Structure-based design and synthesis of new PFKFB3 kinase inhibitors as candidate therapeutics for treating atherosclerosis

Author(s): Cristofori, Virginia
Published in: Winter Symposium 16th and 17th of February, Aberdeen University, 2017
Publisher: Aberdeen University
DOI: 10.5281/zenodo.827178

Dysfunctional endothelial cells in patients with chronic thromboembolic pulmonary hypertension

Author(s): Valérie Françoise Smolders; Joan Albert Barberà; Olga Tura-Ceide
Published in: ERS 2017 on September 11th 2017, Milan, Italy., 2017
Publisher: ERS 2017
DOI: 10.5281/zenodo.1402475

Endothelial cells dysfunctionality associated to acute myocardial infarction: regulation of metabolic pathways as a new therapeutic strategy.

Author(s): Erika Zodda, Anusha Jayaraman, Pedro de Atauri, Ramón Messeguer, Olga Tura-Ceide, Timothy M. Thomson, & Marta Cascante.
Published in: FEBS3+ Barcelona 2017, 2017
Publisher: FEBS3 Barcelona (Fira de Barcelona)
DOI: 10.5281/zenodo.1342535

Derivation and characterization of endothelial cells from patients with chronic thromboembolic pulmonary hypertension

Author(s): Valérie Françoise Smolders; Joan Albert Barberà; Olga Tura-Ceide
Published in: ATS 2018 2018, San Diego (CA), USA., 2018
Publisher: ATS 2018
DOI: 10.5281/zenodo.1402522

Metabolic characterization of endothelial cells dysfunctionality associated to acute myocardial infarction

Author(s): Erika Zodda; Anusha Jayaraman; Pedro de Atauri; Ramon Messeguer; Olga Tura-Ceide; Timothy M. Thomson; Marta Cascante
Published in: ENABLE Conference - The 1st European PhD and Postdoc, 15-17 Noviembre 2017, Palau Casades , Barcelona (Spain), 2017
Publisher: ENABLE Conference -
DOI: 10.5281/zenodo.1342612

Mass Spectrometry-Based Label Free Quantitative Proteomics to study the effect of 3-PO in endothelial cells

Author(s): NUKALA, SARATH BABU D'AMATO, ALFONSINA REGAZZONI, LUCA GIOVANNI ALDINI, GIANCARLO CARINI, MARINA
Published in: Joint Meeting in Medicinal Chemistry MedChemSicily Palermo nel 2018., 2018
Publisher: Meeting in Medicinal Chemistry MedChemSicily
DOI: 2434/590476

Vascular Discovery: From Genes to Medicine Scientific

Author(s): A. Abdali, A. Corsini, D. Baci, C. De Dominicis, M. Zanda, M.L. Gelmi, S. Bellosta
Published in: Vascular Discovery: From Genes to Medicine Scientific Conference S. Francisco, 2018
Publisher: Vascular Discovery: From Genes to Medicine Scientific Conference
DOI: 2434/585140

Angiogenesis inhibition with novel compounds targeting the key glycolytic enzyme PFKFB3

Author(s): Abdali, A; A. Corsini, D. Baci, C. De Dominicis, M. Zanda, M. L. Gelmi, S. Bellosta.
Published in: 86th Congress of the European Atherosclerosis Society EAS, Lisbon (Portugal), 2018
Publisher: 86th Congress of the European Atherosclerosis Society EAS, Lisbon (Portugal)
DOI: 2434/585142

Novel compounds targeting PFKFB3, the key glycolytic enzyme, as a way to inhibit angiogenesis

Author(s): Anahita Abdali, Bellosta Stefano, Corsini Alberto, Carlo De Dominicis, Matteo Zanda, Gelmi Maria Luisa
Published in: SISA Palermo, 19-21 November 2017, 2017
Publisher: SISA Palermo
DOI: 2434/585138

“In vitro study on the effects of inhibitors of angiogenesis in atherosclerosis”

Author(s): L. Parma, C. De Dominicis, H. A. B. Peters, M. R. De Vries and P. H. A. Quax
Published in: ESVS spring meeting in Leiden, May 19-20, 2017., 2017
Publisher: ESVS spring meeting in Leiden
DOI: 10.5281/zenodo.826048

In vivo evaluation by optical and PET imaging of IP angiogenesis and validation of PFKFB3 inhibitors in a murine vein graft model

Author(s): Baganha F., De Vries M. and Quax P.
Published in: Dutch Heart Foundation, 2016
Publisher: Dutch Heart Foundation
DOI: 10.5281/zenodo.832534

Humanized IgG monoclonal anti-phosphorylcholine reduces vein graft failure

Author(s): Fabiana Baganha; Erna Peters; Margreet de Vries; Knut Pettersson; Paul H.A. Quax
Published in: ESVS spring meeting 2017, 2017
Publisher: ESVS
DOI: 10.5281/zenodo.832549

VEGFR2 blockade reduces intraplaque haemorrhage and enhances plaque stability by augmentation of plaque neovessel maturation

Author(s): Margreet de Vries; Laura Parma; Erna Peters; Jaap Hamming; Marie-José Goumans; Paul Quax
Published in: International Vascular Biology Meeting (IVBM), Boston, Massachusetts, USA, 30 Oct – 03 Nov, 2016, 2016
Publisher: International Vascular Biology Meeting (IVBM),
DOI: 10.5281/zenodo.831473

Dysfunctional endothelial cells in patients with chronic thromboembolic pulmonary hypertension

Author(s): Valérie Françoise Smolders; Joan Albert Barberà; Olga Tura-Ceide
Published in: ERS 2017, 2017
Publisher: ERS 2017
DOI: 10.5281/zenodo.1402475

“P-140 VEGFR2 blockade in murine atherosclerotic vein grafts enhances plaque stability and reduces intraplaque haemorrhage by enhancement of plaque neovessel maturation”

Author(s): M. de Vries, L. Parma, E. Peters, J. Hamming, M.- J. Goumans, P. Quax
Published in: Perspectives in Vascular Biology meeting , Frankfurt,, 2016
Publisher: Perspectives in Vascular Biology meeting , Frankfurt,
DOI: 10.5281/zenodo.1478810

“In vitro and in vivo study on the effects of inhibitors of angiogenesis in atherosclerosis”

Author(s): Parma L, M. R. De Vries, P. H. A. Quax
Published in: PhD course Dutch Heart Foundation,, 2016
Publisher: Dutch Heart Foundation,
DOI: 10.5281/zenodo.1478817

“Design, synthesis and in vitro evaluation of modulators of PFKFB3 phosphatase activity”

Author(s): H. Macut, X. Hu, D. Tarantino, L. Parma, S. Pellegrino, M. L. Gelmi
Published in: Marie Curie Alumni Association General Assembly and Annual Conference,, 2018
Publisher: Marie Curie Alumni Association General Assembly and Annual Conference,
DOI: 10.5281/zenodo.1478786

“Derivation and characterization of endothelial cells from patients with chronic thromboembolic pulmonary hypertension”

Author(s): V. Smolders, Olga Tura-Ceide, Jéssica Garcia-Lucio, Lucilla Piccari, Victor I. Peinado, Manel Castella, Joan Albert Barberà .
Published in: spring meeting in Leiden, 2017
Publisher: University of Leiden
DOI: 10.5281/zenodo.826143

“Study of central carbon metabolism of Endothelial Cells in normal and pathological conditions”

Author(s): E. Zodda, A. Jayaraman, P. de Atauri, S. Marin, R. Messeguer, O. Tura-Ceide, T. M Thomson, M. Cascante
Published in: EMBO conference, 2016
Publisher: EMBO conference
DOI: 10.5281/zenodo.826394

"""Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension"" "

Author(s): V. Smolders, O. Tura-Ceide, J. Garcia-Lucio, L. Piccari, V. I. Peinado, M. Castella, J. A. Barberà.
Published in: Jornadas Docencia CIBERES/CIBER-BBN 2016., 2016
Publisher: CIBERES/CIBER-BBN 2016, Madrid, Spain,
DOI: 10.5281/zenodo.826133

“Small molecule mediated inhibition of bFGF reduces in vivo angiogenesis and is a promising candidate to combat intraplaque angiogenesis in atherosclerosis”

Author(s): L. Parma, M.R. De Vries, H.A.B. Peters and P.H.A. Quax
Published in: ESM-EVBO summer school, 2018
Publisher: ESM-EVBO
DOI: 10.5281/zenodo.1478821

Quantitative Proteomics: Strategies and tools to Probe Biology

Author(s): Nukala SB, , MM Idris, Marina Carini
Published in: European Molecular Biology Laboratory (EMBL),, 2016
Publisher: European Molecular Biology Laboratory (EMBL)
DOI: 2434/517613

Targeting glycolysis to inhibit intra-plaque angiogenesis.

Author(s): Perrotta P., M.de Vries, W. Martinet , P. Quax
Published in: ESVS Meeting_Basic and Translation Research in vascular biology., 2017
Publisher: ESVS Meeting_Basic and Translation Research in vascular biology

Target glycolysis to promote stabilization of advanced atherosclerotic plaques ORAL

Author(s): Paola Perrotta
Published in: Spring Meeting of the Belgian Society of Physiology and Pharmacology 27/04/2018, 2018
Publisher: Belgian Society of Physiology and Pharmacology

“Flexible Water Docking and Virtual Screening Using PLANTS Combined with Tuned Water Selection criteria”

Author(s): X. Hu, A. Contini
Published in: 11th Triennial Congress of the World Association of Theoretical and Computational Chemists,, 2017
Publisher: World Association of Theoretical and Computational Chemists
DOI: 2434/599488

“Docking and Virtual Screening with Flexible Hydration and Potentials in MM-PBSA rescoring”

Author(s): X. Hu, A. Contini,
Published in: 13th German Conference on Chemoinformatics, 2017
Publisher: German Conference on Chemoinformatics

Automatization of the Nwat-MMGBSA method to rescore docking results in medium-throughput virtual screening applications

Author(s): Hu X.; Contini, A.
Published in: Triennial Congress of the World Association of Theoretical and Computational Chemists, 2017
Publisher: Triennial Congress of the World Association of Theoretical and Computational Chemists

“Difference in Virtual Screening Enrichment Using polar and non-polar interactions of MM-PB/GBSA methods”

Author(s): X. Hu, A. Contini
Published in: echeminfo Oxford 2018 workshop, 2018
Publisher: echeminfo Oxford 2018 workshop, Didcot, UK, 2018 Training and Innovation Course in Drug Design

“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Author(s): Baganha F., M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Published in: International Vascular Biology Meeting, 2018
Publisher: International Vascular Biology Meeting
DOI: 10.5281/zenodo.1489036

“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Author(s): F. Baganha, M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Published in: Frontiers in Cardiovascular, 2018
Publisher: Frontiers in Cardiovascular
DOI: 10.5281/zenodo.1488964

“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Author(s): Baganha F., M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Published in: RVMM Meeting, 2018
Publisher: Rembrandt Vascular cardiovascular Institute
DOI: 10.5281/zenodo.1489044

F“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Author(s): F. Baganha, M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Published in: Rembrandt Symposium, 2017
Publisher: Rembrandt Symposium
DOI: 10.5281/zenodo.1489038

“Humanized IgG monoclonal anti-phosphorylcholine reduces vein graft failure”

Author(s): Baganha F. , M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Published in: AIO research meeting, 2018
Publisher: AIO research meeting
DOI: 10.5281/zenodo.1489028

Drug discovery and Computation Biology

Author(s): Cristofori V.
Published in: PechaKucha Night, 2017
Publisher: PechaKucha Night The Belmont Filmhouse Aberdeen,
DOI: 10.5281/zenodo.1486103

Dysfunctional endothelial cells in patients with chronic thromboembolic pulmonary hypertension

Author(s): Valerie smolders
Published in: 2 Reunión de Investigación en Hipertensión Pulmonar., 2018
Publisher: CIBERES
DOI: 10.5281/zenodo.1557576

Synthesis and characterization of the autoregulatory domain of PFKFB3

Author(s): H. Macut, S. Pellegrino, M.L. Gelmi
Published in: International Symposium on Medicinal Chemistry : book of abstracts, 2016, Page(s) 137
Publisher: EFCM
DOI: 2434/489548

Design, synthesis and in vitro evaluation of modulators of PFKFB3 autoregulatory domain

Author(s): MACUT, HELENA; HU, XIAO; GELMI, MARIA LUISA; PELLEGRINO, SARA; TARANTINO, DELIA
Published in: 10th Joint Meeting on medicinal chemistry, 25.-28.6.2017 Dubrovnik, Croatia., 2017
Publisher: http://www.jmmc2017.hr/
DOI: 2434/516356

Combining 3D-RISM with hydropathic charateristic water evaluation: first step preparation for further PLANTS virtual screening with flexible explicit water molecules

Author(s): HU, XIAO CONTINI, ALESSANDRO
Published in: eCheminfo workshop in Drug Design, 2016
Publisher: http://www.echeminfo.com/events/drug-design-euro
DOI: 2434/516738

Combining 3D-RISM with hydrophatic characteristic water evaluation: first step preparation for further PLANTS virtual screening with flexible explicit water molecules

Author(s): HU, XIAO CONTINI, ALESSANDRO
Published in: 12th German Conference on Chemoinformatics, 2016
Publisher: https://www.gdch.de/index.php?id=3089
DOI: 2434/517787

Novel MMP-inhibiting peptides for stabilizing atherosclerotic plaques

Author(s): ABDALI, ANAHITA MACUT, HELENA PELLEGRINO, SARA GELMI, MARIA LUISA BELLOSTA, STEFANO
Published in: 85th European Atherosclerosis Society (EAS) Congress in Prague: Science at a Glance, 2017
Publisher: http://eas2017.com/
DOI: 2434/508315

Other (3)

Annual Research Day: Project summary for Elevator Pitch

Author(s): Smolders, Valérie F.
Published in: 'Kaag dag : Annual Research meeting Leiden,, Issue 1, 2018
Publisher: University of Leiden
DOI: 10.5281/zenodo.1402470

Synthesis of PFKFB3 inhibitors for Positron Emission Tomography imaging of atherosclerotic plaque

Author(s): Carlo, De Dominicis
Published in: Graduate School 2017 Winter Symposium at the University of Aberdeen, Issue 2, 2017
Publisher: University of Aberdeen
DOI: 10.5281/zenodo.827185

[18F]AZ68: a PFKFB3 targeted PET tracer for imaging atherosclerotic plaque

Author(s): De Dominicis, C. Dall'Angelo Sergio; Perrotta Paola; Zanda Matteo; Staelens Steven; De Meyer Guido; Wyffels Leonie
Published in: 2018
Publisher: Scottish Molecular Imaging Meeting Glasgow
DOI: 10.5281/zenodo.1422742