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Modulation of glycolytic flux as a new approach for treatment of atherosclerosis and plaque stabilization: a multidisciplinary study

Deliverables

At least 12 papers acknowledging the project published

At least 12 papers acknowledging the project published on peer reviewed journals

Statement on individual training, local courses, technical and transferable skills acquired (at each network meeting)

A statement will be delivered to each PhD related to individual training, local courses, technical and transferable skills acquired (M12,18, 24,30, 36)

Network Meetings Organized (including virtual meeting)

Organization of seven interdisciplinary meetings (comprising workshops, virtual meetings and summer schools; 6,12,18,24,30,36, 42) inviting distinguished scientists and experts from industry

At least 6 papers acknowledging the project published

At least 6 papers acknowledging the project published on peer reviewed journals

2 Summer schools organized

Implementation of interdisciplinary knowledge by the way of two Summer Schools (Imaging and Radiopharmaceutical development Summer school M18 and Pharma-Skills Summer School M30)

2 Workshops on Scientific training

Implementation of interdisciplinary knowledge by the way of two workshops on specific topics of interest for PhD students (M6,42)

Recruitment advertising publication

Preparation of Flyer (M1) and Consortium webportal/partners webpages (M1-2); Call for applicants (M2); d) Media newsletters; Selected applicants and reserve list (M5)

Consortium web-site creation and scientific blog

portal Web-site as essential tool for communication between MoGlyNet members, the scientific community and the general public will be set up

Searching for OpenAIRE data...

Publications

DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF PFKFB3 PHOSPHATASE ACTIVITY ALLOSTERIC MODULATORS

Author(s): "Helena Macut DISFARM - Section of General and Organic Chemistry ""A. Marchesini"", University of Milan, Via Venezian 21, 20133 Milan, Italy. ; Xiao Hu; Delia Tarantino; Luca Giovanni Regazzoni; Ettore Gilardoni; Sara Pellegrino; Maria Luisa Gelmi"
Published in: International Symposium on Medicinal Chemistry Lublijana, 2018
DOI: 10.5281/zenodo.1415341

Differentially Expressed Proteins in Pulmonary Endothelial Cells in Chronic Thromboembolic Pulmonary Hypertension

Author(s): S.B. Nukala , O. Tura , L. Regazzoni , C. Marinello , A. Abdali , G. Aldini , V.F. Smolders, I. Blanco , J.A. Barbera , M. Cascante , M. Carini
Published in: American Journal of Respiratory and Critical Care Medicine 2018; 197:A3738 ATS International conference,, 2018
DOI: 2434/590474

Virtual screening approach in drug discovery targeting the PFKFB3 kinase binding site

Author(s): Cristofori, Virginia; Contini, Alessandro
Published in: eCheminfo workshop in Drug Design, 18-22 July 2016 University of Milan, 2016
DOI: 10.5281/zenodo.826382

Structure-based design and synthesis of new PFKFB3 kinase inhibitors as candidate therapeutics for treating atherosclerosis

Author(s): Cristofori, Virginia; Stanzione, Francesca; Zanda, Matteo; Contini, Alessandro
Published in: Medicinal Chemistry Residential Summer School, 2017
DOI: 10.5281/zenodo.826380

Structure-based design and synthesis of new PFKFB3 kinase inhibitors as candidate therapeutics for treating atherosclerosis

Author(s): Cristofori, Virginia
Published in: Winter Symposium 16th and 17th of February, Aberdeen University, 2017
DOI: 10.5281/zenodo.827178

Dysfunctional endothelial cells in patients with chronic thromboembolic pulmonary hypertension

Author(s): Valérie Françoise Smolders; Joan Albert Barberà; Olga Tura-Ceide
Published in: ERS 2017 on September 11th 2017, Milan, Italy., 2017
DOI: 10.5281/zenodo.1402475

Derivation and characterization of endothelial cells from patients with chronic thromboembolic pulmonary hypertension

Author(s): Valérie Françoise Smolders; Joan Albert Barberà; Olga Tura-Ceide
Published in: ATS 2018 2018, San Diego (CA), USA., 2018
DOI: 10.5281/zenodo.1402522

Metabolic characterization of endothelial cells dysfunctionality associated to acute myocardial infarction

Author(s): Erika Zodda; Anusha Jayaraman; Pedro de Atauri; Ramon Messeguer; Olga Tura-Ceide; Timothy M. Thomson; Marta Cascante
Published in: ENABLE Conference - The 1st European PhD and Postdoc, 15-17 Noviembre 2017, Palau Casades , Barcelona (Spain), 2017
DOI: 10.5281/zenodo.1342612

Mass Spectrometry-Based Label Free Quantitative Proteomics to study the effect of 3-PO in endothelial cells

Author(s): NUKALA, SARATH BABU D'AMATO, ALFONSINA REGAZZONI, LUCA GIOVANNI ALDINI, GIANCARLO CARINI, MARINA
Published in: Joint Meeting in Medicinal Chemistry MedChemSicily Palermo nel 2018., 2018
DOI: 2434/590476

Vascular Discovery: From Genes to Medicine Scientific

Author(s): A. Abdali, A. Corsini, D. Baci, C. De Dominicis, M. Zanda, M.L. Gelmi, S. Bellosta
Published in: Vascular Discovery: From Genes to Medicine Scientific Conference S. Francisco, 2018
DOI: 2434/585140

Angiogenesis inhibition with novel compounds targeting the key glycolytic enzyme PFKFB3

Author(s): Abdali, A; A. Corsini, D. Baci, C. De Dominicis, M. Zanda, M. L. Gelmi, S. Bellosta.
Published in: 86th Congress of the European Atherosclerosis Society EAS, Lisbon (Portugal), 2018
DOI: 2434/585142

Novel compounds targeting PFKFB3, the key glycolytic enzyme, as a way to inhibit angiogenesis

Author(s): Anahita Abdali, Bellosta Stefano, Corsini Alberto, Carlo De Dominicis, Matteo Zanda, Gelmi Maria Luisa
Published in: SISA Palermo, 19-21 November 2017, 2017
DOI: 2434/585138

“In vitro study on the effects of inhibitors of angiogenesis in atherosclerosis”

Author(s): L. Parma, C. De Dominicis, H. A. B. Peters, M. R. De Vries and P. H. A. Quax
Published in: ESVS spring meeting in Leiden, May 19-20, 2017., 2017
DOI: 10.5281/zenodo.826048

In vivo evaluation by optical and PET imaging of IP angiogenesis and validation of PFKFB3 inhibitors in a murine vein graft model

Author(s): Baganha F., De Vries M. and Quax P.
Published in: Dutch Heart Foundation, 2016
DOI: 10.5281/zenodo.832534

Humanized IgG monoclonal anti-phosphorylcholine reduces vein graft failure

Author(s): Fabiana Baganha; Erna Peters; Margreet de Vries; Knut Pettersson; Paul H.A. Quax
Published in: ESVS spring meeting 2017, 2017
DOI: 10.5281/zenodo.832549

VEGFR2 blockade reduces intraplaque haemorrhage and enhances plaque stability by augmentation of plaque neovessel maturation

Author(s): Margreet de Vries; Laura Parma; Erna Peters; Jaap Hamming; Marie-José Goumans; Paul Quax
Published in: International Vascular Biology Meeting (IVBM), Boston, Massachusetts, USA, 30 Oct – 03 Nov, 2016, 2016
DOI: 10.5281/zenodo.831473

Dysfunctional endothelial cells in patients with chronic thromboembolic pulmonary hypertension

Author(s): Valérie Françoise Smolders; Joan Albert Barberà; Olga Tura-Ceide
Published in: ERS 2017, 2017
DOI: 10.5281/zenodo.1402475

“P-140 VEGFR2 blockade in murine atherosclerotic vein grafts enhances plaque stability and reduces intraplaque haemorrhage by enhancement of plaque neovessel maturation”

Author(s): M. de Vries, L. Parma, E. Peters, J. Hamming, M.- J. Goumans, P. Quax
Published in: Perspectives in Vascular Biology meeting , Frankfurt,, 2016
DOI: 10.5281/zenodo.1478810

“In vitro and in vivo study on the effects of inhibitors of angiogenesis in atherosclerosis”

Author(s): Parma L, M. R. De Vries, P. H. A. Quax
Published in: PhD course Dutch Heart Foundation,, 2016
DOI: 10.5281/zenodo.1478817

“Design, synthesis and in vitro evaluation of modulators of PFKFB3 phosphatase activity”

Author(s): H. Macut, X. Hu, D. Tarantino, L. Parma, S. Pellegrino, M. L. Gelmi
Published in: Marie Curie Alumni Association General Assembly and Annual Conference,, 2018
DOI: 10.5281/zenodo.1478786

“Derivation and characterization of endothelial cells from patients with chronic thromboembolic pulmonary hypertension”

Author(s): V. Smolders, Olga Tura-Ceide, Jéssica Garcia-Lucio, Lucilla Piccari, Victor I. Peinado, Manel Castella, Joan Albert Barberà .
Published in: spring meeting in Leiden, 2017
DOI: 10.5281/zenodo.826143

“Study of central carbon metabolism of Endothelial Cells in normal and pathological conditions”

Author(s): E. Zodda, A. Jayaraman, P. de Atauri, S. Marin, R. Messeguer, O. Tura-Ceide, T. M Thomson, M. Cascante
Published in: EMBO conference, 2016
DOI: 10.5281/zenodo.826394

"""Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension"" "

Author(s): V. Smolders, O. Tura-Ceide, J. Garcia-Lucio, L. Piccari, V. I. Peinado, M. Castella, J. A. Barberà.
Published in: Jornadas Docencia CIBERES/CIBER-BBN 2016., 2016
DOI: 10.5281/zenodo.826133

“Small molecule mediated inhibition of bFGF reduces in vivo angiogenesis and is a promising candidate to combat intraplaque angiogenesis in atherosclerosis”

Author(s): L. Parma, M.R. De Vries, H.A.B. Peters and P.H.A. Quax
Published in: ESM-EVBO summer school, 2018
DOI: 10.5281/zenodo.1478821

Quantitative Proteomics: Strategies and tools to Probe Biology

Author(s): Nukala SB, , MM Idris, Marina Carini
Published in: European Molecular Biology Laboratory (EMBL),, 2016
DOI: 2434/517613

Targeting glycolysis to inhibit intra-plaque angiogenesis.

Author(s): Perrotta P., M.de Vries, W. Martinet , P. Quax
Published in: ESVS Meeting_Basic and Translation Research in vascular biology., 2017

Target glycolysis to promote stabilization of advanced atherosclerotic plaques ORAL

Author(s): Paola Perrotta
Published in: Spring Meeting of the Belgian Society of Physiology and Pharmacology 27/04/2018, 2018

“Flexible Water Docking and Virtual Screening Using PLANTS Combined with Tuned Water Selection criteria”

Author(s): X. Hu, A. Contini
Published in: 11th Triennial Congress of the World Association of Theoretical and Computational Chemists,, 2017
DOI: 2434/599488

“Docking and Virtual Screening with Flexible Hydration and Potentials in MM-PBSA rescoring”

Author(s): X. Hu, A. Contini,
Published in: 13th German Conference on Chemoinformatics, 2017

Automatization of the Nwat-MMGBSA method to rescore docking results in medium-throughput virtual screening applications

Author(s): Hu X.; Contini, A.
Published in: Triennial Congress of the World Association of Theoretical and Computational Chemists, 2017

“Difference in Virtual Screening Enrichment Using polar and non-polar interactions of MM-PB/GBSA methods”

Author(s): X. Hu, A. Contini
Published in: echeminfo Oxford 2018 workshop, 2018

“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Author(s): Baganha F., M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Published in: International Vascular Biology Meeting, 2018
DOI: 10.5281/zenodo.1489036

“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Author(s): F. Baganha, M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Published in: Frontiers in Cardiovascular, 2018
DOI: 10.5281/zenodo.1488964

“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Author(s): Baganha F., M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Published in: RVMM Meeting, 2018
DOI: 10.5281/zenodo.1489044

F“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Author(s): F. Baganha, M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Published in: Rembrandt Symposium, 2017
DOI: 10.5281/zenodo.1489038

“Humanized IgG monoclonal anti-phosphorylcholine reduces vein graft failure”

Author(s): Baganha F. , M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Published in: AIO research meeting, 2018
DOI: 10.5281/zenodo.1489028

Drug discovery and Computation Biology

Author(s): Cristofori V.
Published in: PechaKucha Night, 2017
DOI: 10.5281/zenodo.1486103

Dysfunctional endothelial cells in patients with chronic thromboembolic pulmonary hypertension

Author(s): Valerie smolders
Published in: 2 Reunión de Investigación en Hipertensión Pulmonar., 2018
DOI: 10.5281/zenodo.1557576

Synthesis and characterization of the autoregulatory domain of PFKFB3

Author(s): H. Macut, S. Pellegrino, M.L. Gelmi
Published in: International Symposium on Medicinal Chemistry : book of abstracts, 2016, Page(s) 137
DOI: 2434/489548

Design, synthesis and in vitro evaluation of modulators of PFKFB3 autoregulatory domain

Author(s): MACUT, HELENA; HU, XIAO; GELMI, MARIA LUISA; PELLEGRINO, SARA; TARANTINO, DELIA
Published in: 10th Joint Meeting on medicinal chemistry, 25.-28.6.2017 Dubrovnik, Croatia., 2017
DOI: 2434/516356

Combining 3D-RISM with hydropathic charateristic water evaluation: first step preparation for further PLANTS virtual screening with flexible explicit water molecules

Author(s): HU, XIAO CONTINI, ALESSANDRO
Published in: eCheminfo workshop in Drug Design, 2016
DOI: 2434/516738

Combining 3D-RISM with hydrophatic characteristic water evaluation: first step preparation for further PLANTS virtual screening with flexible explicit water molecules

Author(s): HU, XIAO CONTINI, ALESSANDRO
Published in: 12th German Conference on Chemoinformatics, 2016
DOI: 2434/517787

Novel MMP-inhibiting peptides for stabilizing atherosclerotic plaques

Author(s): ABDALI, ANAHITA MACUT, HELENA PELLEGRINO, SARA GELMI, MARIA LUISA BELLOSTA, STEFANO
Published in: 85th European Atherosclerosis Society (EAS) Congress in Prague: Science at a Glance, 2017
DOI: 2434/508315

Annual Research Day: Project summary for Elevator Pitch

Author(s): Smolders, Valérie F.
Published in: 'Kaag dag : Annual Research meeting Leiden,, Issue 1, 2018
DOI: 10.5281/zenodo.1402470

Synthesis of PFKFB3 inhibitors for Positron Emission Tomography imaging of atherosclerotic plaque

Author(s): Carlo, De Dominicis
Published in: Graduate School 2017 Winter Symposium at the University of Aberdeen, Issue 2, 2017
DOI: 10.5281/zenodo.827185

[18F]AZ68: a PFKFB3 targeted PET tracer for imaging atherosclerotic plaque

Author(s): De Dominicis, C. Dall'Angelo Sergio; Perrotta Paola; Zanda Matteo; Staelens Steven; De Meyer Guido; Wyffels Leonie
Published in: 2018
DOI: 10.5281/zenodo.1422742

Inflammation in Vein Graft Disease

Author(s): Margreet R. de Vries, Paul H. A. Quax
Published in: Frontiers in Cardiovascular Medicine, Issue 5, 2018, ISSN 2297-055X
DOI: 10.3389/fcvm.2018.00003

Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis

Author(s): Laura Parma, Fabiana Baganha, Paul H.A. Quax, Margreet R. de Vries
Published in: European Journal of Pharmacology, Issue 816, 2017, Page(s) 107-115, ISSN 0014-2999
DOI: 10.1016/j.ejphar.2017.04.028

An Efficient Implementation of the Nwat-MMGBSA Method to Rescore Docking Results in Medium-Throughput Virtual Screenings

Author(s): Irene Maffucci, Xiao Hu, Valentina Fumagalli, Alessandro Contini
Published in: Frontiers in Chemistry, Issue 6, 2018, ISSN 2296-2646
DOI: 10.3389/fchem.2018.00043

Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization


Published in: ISSN 0957-9672
DOI: 10.1097/MOL.0000000000000339

Novel MMP-inhibiting peptides for stabilizing atherosclerotic plaques

Author(s): Anahita Abdali, Helena Macut, Xiao Hu, Sara Pellegrino, Alberto Corsini, Maria Luisa Gelmi, Stefano Bellosta
Published in: Atherosclerosis, Issue 263, 2017, Page(s) e47-e48, ISSN 0021-9150
DOI: 10.1016/j.atherosclerosis.2017.06.162

Animal models of atherosclerosis

Author(s): Besa Emini Veseli, Paola Perrotta, Gregory R.A. De Meyer, Lynn Roth, Carole Van der Donckt, Wim Martinet, Guido R.Y. De Meyer
Published in: European Journal of Pharmacology, Issue 816, 2017, Page(s) 3-13, ISSN 0014-2999
DOI: 10.1016/J.EJPHAR.2017.05.010

The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development

Author(s): Rob C. M. de Jong, Mark M. Ewing, Margreet R. de Vries, Jacco C. Karper, Antonius J. N. M. Bastiaansen, Hendrika A. B. Peters, Fabiana Baghana, Peter J. van den Elsen, Céline Gongora, J. Wouter Jukema, Paul H. A. Quax
Published in: PLOS ONE, Issue 12/10, 2017, Page(s) e0185820, ISSN 1932-6203
DOI: 10.1371/journal.pone.0185820

Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels

Author(s): M. R. de Vries, L. Parma, H. A. B. Peters, A. Schepers, J. F. Hamming, J. W. Jukema, M. J. T. H. Goumans, L. Guo, A. V. Finn, R. Virmani, C. K. Ozaki, P. H. A. Quax
Published in: Journal of Internal Medicine, 2018, ISSN 0954-6820
DOI: 10.1111/joim.12821

Advances in the treatment of explicit water molecules in docking and binding free energy calculations

Author(s): Xiao Hu, Irene Maffucci, Alessandro Contini
Published in: Current Medicinal Chemistry, Issue 25, 2018, ISSN 0929-8673
DOI: 10.2174/0929867325666180514110824

Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis

Author(s): Paola Perrotta, Besa Emini Veseli, Bieke Van der Veken, Lynn Roth, Wim Martinet, Guido R.Y. De Meyer
Published in: Vascular Pharmacology, 2018, ISSN 1537-1891
DOI: 10.1016/j.vph.2018.06.014

Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels

Author(s): M. R. de Vries, L. Parma, H. A. B. Peters, A. Schepers, J. F. Hamming, J. W. Jukema, M. J. T. H. Goumans, L. Guo, A. V. Finn, R. Virmani, C. K. Ozaki, P. H. A. Quax
Published in: Journal of Internal Medicine, Issue 285/1, 2019, Page(s) 59-74, ISSN 0954-6820
DOI: 10.1111/joim.12821

Pharmacokinetic drug interactions of the non-vitamin K antagonist oral anticoagulants (NOACs)

Author(s): Paolo Gelosa, Laura Castiglioni, Marco Tenconi, Ludovico Baldessin, Giorgio Racagni, Alberto Corsini, Stefano Bellosta
Published in: Pharmacological Research, Issue 135, 2018, Page(s) 60-79, ISSN 1043-6618
DOI: 10.1016/j.phrs.2018.07.016

Proprotein Convertase Subtilisin-Kexin type-9 (PCSK9) and triglyceride-rich lipoprotein metabolism: Facts and gaps

Author(s): Andrea Baragetti, Daniela Grejtakova, Manuela Casula, Elena Olmastroni, Gloria Saccani Jotti, Giuseppe Danilo Norata, Alberico L. Catapano, Stefano Bellosta
Published in: Pharmacological Research, Issue 130, 2018, Page(s) 1-11, ISSN 1043-6618
DOI: 10.1016/j.phrs.2018.01.025

Metabolic Alterations in Cardiopulmonary Vascular Dysfunction

Author(s): Valérie Françoise Smolders, Erika Zodda, Paul H. A. Quax, Marina Carini, Joan Albert Barberà, Timothy M. Thomson, Olga Tura-Ceide, Marta Cascante
Published in: Frontiers in Molecular Biosciences, Issue 5, 2019, ISSN 2296-889X
DOI: 10.3389/fmolb.2018.00120

Tuning PFKFB3 Bisphosphatase Activity Through Allosteric Interference

Author(s): Helena Macut, Xiao Hu, Delia Tarantino, Ettore Gilardoni, Francesca Clerici, Luca Regazzoni, Alessandro Contini, Sara Pellegrino, Maria Luisa Gelmi
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-56708-0