Modulation of glycolytic flux as a new approach for treatment of atherosclerosis and plaque stabilization: a multidisciplinary study

Risultati finali

At least 12 papers acknowledging the project published

At least 12 papers acknowledging the project published on peer reviewed journals

Statement on individual training, local courses, technical and transferable skills acquired (at each network meeting)

A statement will be delivered to each PhD related to individual training, local courses, technical and transferable skills acquired (M12,18, 24,30, 36)

Network Meetings Organized (including virtual meeting)

Organization of seven interdisciplinary meetings (comprising workshops, virtual meetings and summer schools; 6,12,18,24,30,36, 42) inviting distinguished scientists and experts from industry

At least 6 papers acknowledging the project published

At least 6 papers acknowledging the project published on peer reviewed journals

2 Summer schools organized

Implementation of interdisciplinary knowledge by the way of two Summer Schools (Imaging and Radiopharmaceutical development Summer school M18 and Pharma-Skills Summer School M30)

2 Workshops on Scientific training

Implementation of interdisciplinary knowledge by the way of two workshops on specific topics of interest for PhD students (M6,42)

EThics - delivery of documents

compulsory delievrable

Sueprvisory Board meeting

compulsort delievrable

Recruitment advertising publication

Preparation of Flyer (M1) and Consortium webportal/partners webpages (M1-2); Call for applicants (M2); d) Media newsletters; Selected applicants and reserve list (M5)

Consortium web-site creation and scientific blog

portal Web-site as essential tool for communication between MoGlyNet members, the scientific community and the general public will be set up

Pubblicazioni

Rescoring Virtual Screening Results with the MM-PBSA Methods: Beware of Internal Dielectric Constants

Autori: Hu, Xiao; Contini, Alessandro
Pubblicato in: JOURNAL OF CHEMICAL INFORMATION AND MODELING, Numero 18, 2019, ISSN 1549-9596
Editore: American Chemical Society
DOI: 10.1021/acs.jcim.9b00095

Protein network analyses of pulmonary endothelial cells in chronic thromboembolic pulmonary hypertension

Autori: Sarath Babu Nukala, Olga Tura-Ceide, Giancarlo Aldini, Valérie Smolders, Isabel Blanco, Victor I. Peinado, Manuel Castellà, Joan Albert Barberà, Alessandra Altomare, Giovanna Baron, Marina Carini, Marta Cascante and Alfonsina D’Amato
Pubblicato in: Sci Rep, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-85004-z

In vitro angiogenesis inhibition with selective compounds targeting the key glycolytic enzyme PFKFB3

Autori: Abdali A, Baci D, Damiani I, Belloni F, De Dominicis C, Gelmi ML, Corsini A, Bellosta S.
Pubblicato in: Pharmacol Res, 2021, ISSN 1043-6618
Editore: Academic Press
DOI: 10.1016/j.phrs.2021.105592

Endothelial Dysfunction in Pulmonary Hypertension: Cause or Consequence?

Autori: Kondababu Kurakula, Valérie F.E.D Smolders, Olga Tura-Ceide, J. Wouter Jukema, Paul H. A. Quax, Marie-José Goumans
Pubblicato in: Biomedicines, 2021, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines9010057

Prolonged Hyperoxygenation Treatment Improves Vein Graft Patency and Decreases Macrophage Content in Atherosclerotic Lesions in ApoE3*Leiden Mice.

Autori: Parma, Laura; Peters, Hendrika A. B.; Baganha, Fabiana; Sluimer, Judith C.; de Vries, Margreet R.; Quax, Paul H.A.
Pubblicato in: Cells, 9(2):336. Multidisciplinary Digital Publishing Institute (MDPI), Numero 2, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.3390/cells9020336

Mass Spectrometry-based Label-free Quantitative Proteomics To Study the Effect of 3PO Drug at Cellular Level

Autori: Nukala, S.B.; Baron, G.; Aldini, G.; Carini, M.; D' Amato, A.
Pubblicato in: ACS Med chem lett, Numero 5, 2019, ISSN 1948-5875
Editore: American Chemical Society
DOI: 10.1021/acsmedchemlett.8b00593

Bis(maltolato)oxovanadium(IV) Induces Angiogenesis via Phosphorylation of VEGFR2.

Autori: Parma L, Peters HAB, Johansson ME, Gutiérrez S, Meijerink H, de Kimpe S, de Vries MR, Quax PHA
Pubblicato in: Int J Mol Sci., 2020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21134643

PFKFB3 gene deletion in endothelial cells inhibits intraplaque angiogenesis and lesion formation in a murine model of venous bypass grafting

Autori: Perrotta P, de Vries MR, Peeters B, Guns P-J, De Meyer GRY, Quax PHA, Martinet W.
Pubblicato in: Angiogenesis, 2021, ISSN 0969-6970
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10456-021-09816-3

Metabolic profile in endothelial cells of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension

Autori: V.F.E.D. Smolders Rodríguez C, I. Blanco, R. Szulcek, Wim Timens, L. Piccari, Y. Roger, X. Hu, Constanza Morén, C. Bonjoch, L. Sebastián, M. Castellà, J. Osorio, V. I. Peinado, Harm Jan Bogaard, P. H. A. Quax, M. Cascante, J.A. Barberà, O. Tura-Ceide
Pubblicato in: Sci Rep, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.21203/rs.3.rs-1008061/v1

Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia

Autori: van der Kwast RVCT, Parma L, van der Bent ML, van Ingen E, Baganha F, Peters HAB, Goossens EAC, Simons KH, Palmen M, de Vries MR, Quax PHA, Nossent AY
Pubblicato in: Mol Ther Nucleic Acids, 2020, ISSN 2162-2531
Editore: Nature Publishing Group
DOI: 10.1016/j.omtn.2020.07.020

The Inflammatory Profile of CTEPH Derived Endothelial Cells is a Possible Driver of Disease Progression

Autori: Valérie F.E.D. Smolders, Kirsten Lodder, Cristina Rodriguez, Olga Tura-Ceide, Joan Albert Barberà, J. Wouter Jukema, Paul H.A. Quax, Marie José T.H. Goumans, Kondababu Kurakula
Pubblicato in: Cells, 2021, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10040737

Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension

Autori: Olga Tura-Ceide, Valérie F.E.D. Smolders, Núria Aventin, Constanza Morén, Mariona Guitart-Mampel, Isabel Blanco, Lucilla Piccari, Jeisson Osorio, Cristina Rodríguez, Montserrat Rigol, Núria Solanes, Andrea Malandrino, Kondababu Kurakula, Marie Jose Goumans, Paul H.A. Quax, Victor I. Peinado, Manuel Castellà, Joan Albert Barberà
Pubblicato in: Sci Rep, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-98320-1

Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis.

Autori: Welten SMJ, de Jong RCM, Wezel A, de Vries MR, Boonstra MC, Parma L, Jukema JW, van der Sluis TC, Arens R, Bot I, Agrawal S, Quax PHA, Nossent AY
Pubblicato in: Atherosclerosis, 2017, ISSN 0021-9150
Editore: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2017.04.011

Partial inhibition of glycolysis reduces atherogenesis independent of intraplaque neovascularization in mice

Autori: Perrotta P, Van der Veken B, Van der Veken P, Pintelon I, Adrianssens E, Timmerman V, De Meyer GRY, Martinet W.
Pubblicato in: Arterioscler Thromb Vasc Biol., 2020, ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.119.313692

bFGF blockade reduces intraplaque angiogenesis and macrophage infiltration in atherosclerotic vein graft lesions in ApoE3*Leiden mice.

Autori: Parma L, Peters HAB, Sluiter TJ, Simons KH, Lazzari P, de Vries MR, Quax PHA
Pubblicato in: Sci Rep., 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-72992-7

Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization

Autori: Fabiana Baganha; Fabiana Baganha; Rob C.M. de Jong; Erna Peters; Wietske Voorham; J. Wouter Jukema; Mirela Delibegovic; Margreet R. de Vries; Paul H.A. Quax
Pubblicato in: Angiogenesis, Numero 5, 2021, ISSN 1573-7209
Editore: springer
DOI: 10.1007/s10456-021-09767-9

The PFKFB3 inhibitor AZ67 inhibits angiogenesis independently of glycolysis inhibition

Autori: Emini Veseli B, Van Wielendaele P, Delibegovic M, Martinet W, De Meyer GRY
Pubblicato in: Int J Mol Sci., 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22115970

Decreased glycolysis as metabolic fingerprint of endothelial cells in chronic thromboembolic pulmonary hypertensio

Autori: Valérie F. Smolders, Cristina Rodríguez, Isabel Blanco, Jeisson Osorio, Lucilla Piccari, Cristina Bonjoch, Paul H.A. Quax, Victor I. Peinado, Manel Castellà, Joan Albert Barberà, Marta Cascante, Olga Tura-Ceide
Pubblicato in: American Journal of Respiratory Cell and Molecular Biology, 2020, ISSN 1044-1549
Editore: American Lung Association
DOI: 10.1165/rcmb.2019-0409le

Inflammation in Vein Graft Disease

Autori: Margreet R. de Vries, Paul H. A. Quax
Pubblicato in: Frontiers in Cardiovascular Medicine, Numero 5, 2018, ISSN 2297-055X
Editore: Masanori Aikawa, Harvard Medical School, United States
DOI: 10.3389/fcvm.2018.00003

Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis

Autori: Laura Parma, Fabiana Baganha, Paul H.A. Quax, Margreet R. de Vries
Pubblicato in: European Journal of Pharmacology, Numero 816, 2017, Pagina/e 107-115, ISSN 0014-2999
Editore: Elsevier BV
DOI: 10.1016/j.ejphar.2017.04.028

An Efficient Implementation of the Nwat-MMGBSA Method to Rescore Docking Results in Medium-Throughput Virtual Screenings

Autori: Irene Maffucci, Xiao Hu, Valentina Fumagalli, Alessandro Contini
Pubblicato in: Frontiers in Chemistry, Numero 6, 2018, ISSN 2296-2646
Editore: EDITED BY Daniela Schuster Paracelsus Medizinische Privatuniversität, Salzburg, Austria
DOI: 10.3389/fchem.2018.00043

Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization

Autori: Margreet R. de Vries, Paul H.A. Quax
Pubblicato in: Current Opinion in Lipidology, Numero 27/5, 2016, Pagina/e 499-506, ISSN 0957-9672
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOL.0000000000000339

Novel MMP-inhibiting peptides for stabilizing atherosclerotic plaques

Autori: Anahita Abdali, Helena Macut, Xiao Hu, Sara Pellegrino, Alberto Corsini, Maria Luisa Gelmi, Stefano Bellosta
Pubblicato in: Atherosclerosis, Numero 263, 2017, Pagina/e e47-e48, ISSN 0021-9150
Editore: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2017.06.162

Animal models of atherosclerosis

Autori: Besa Emini Veseli, Paola Perrotta, Gregory R.A. De Meyer, Lynn Roth, Carole Van der Donckt, Wim Martinet, Guido R.Y. De Meyer
Pubblicato in: European Journal of Pharmacology, Numero 816, 2017, Pagina/e 3-13, ISSN 0014-2999
Editore: Elsevier BV
DOI: 10.1016/J.EJPHAR.2017.05.010

The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development

Autori: Rob C. M. de Jong, Mark M. Ewing, Margreet R. de Vries, Jacco C. Karper, Antonius J. N. M. Bastiaansen, Hendrika A. B. Peters, Fabiana Baghana, Peter J. van den Elsen, Céline Gongora, J. Wouter Jukema, Paul H. A. Quax
Pubblicato in: PLOS ONE, Numero 12/10, 2017, Pagina/e e0185820, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0185820

Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels

Autori: M. R. de Vries, L. Parma, H. A. B. Peters, A. Schepers, J. F. Hamming, J. W. Jukema, M. J. T. H. Goumans, L. Guo, A. V. Finn, R. Virmani, C. K. Ozaki, P. H. A. Quax
Pubblicato in: Journal of Internal Medicine, 2018, ISSN 0954-6820
Editore: Blackwell Publishing Inc.
DOI: 10.1111/joim.12821

Advances in the treatment of explicit water molecules in docking and binding free energy calculations

Autori: Xiao Hu, Irene Maffucci, Alessandro Contini
Pubblicato in: Current Medicinal Chemistry, Numero 25, 2018, ISSN 0929-8673
Editore: Bentham Science Publishers
DOI: 10.2174/0929867325666180514110824

Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis

Autori: Paola Perrotta, Besa Emini Veseli, Bieke Van der Veken, Lynn Roth, Wim Martinet, Guido R.Y. De Meyer
Pubblicato in: Vascular Pharmacology, 2018, ISSN 1537-1891
Editore: Elsevier BV
DOI: 10.1016/j.vph.2018.06.014

Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels

Autori: M. R. de Vries, L. Parma, H. A. B. Peters, A. Schepers, J. F. Hamming, J. W. Jukema, M. J. T. H. Goumans, L. Guo, A. V. Finn, R. Virmani, C. K. Ozaki, P. H. A. Quax
Pubblicato in: Journal of Internal Medicine, Numero 285/1, 2019, Pagina/e 59-74, ISSN 0954-6820
Editore: Blackwell Publishing Inc.
DOI: 10.1111/joim.12821

Pharmacokinetic drug interactions of the non-vitamin K antagonist oral anticoagulants (NOACs)

Autori: Paolo Gelosa, Laura Castiglioni, Marco Tenconi, Ludovico Baldessin, Giorgio Racagni, Alberto Corsini, Stefano Bellosta
Pubblicato in: Pharmacological Research, Numero 135, 2018, Pagina/e 60-79, ISSN 1043-6618
Editore: Academic Press
DOI: 10.1016/j.phrs.2018.07.016

Proprotein Convertase Subtilisin-Kexin type-9 (PCSK9) and triglyceride-rich lipoprotein metabolism: Facts and gaps

Autori: Andrea Baragetti, Daniela Grejtakova, Manuela Casula, Elena Olmastroni, Gloria Saccani Jotti, Giuseppe Danilo Norata, Alberico L. Catapano, Stefano Bellosta
Pubblicato in: Pharmacological Research, Numero 130, 2018, Pagina/e 1-11, ISSN 1043-6618
Editore: Academic Press
DOI: 10.1016/j.phrs.2018.01.025

Adenosine-to-Inosine Editing of MicroRNA-487b Alters Target Gene Selection After Ischemia and Promotes Neovascularization

Autori: Reginald V.C.T. van der Kwast, Eva van Ingen, Laura Parma, Hendrika A.B. Peters, Paul H.A. Quax, A. Yaël Nossent
Pubblicato in: Circulation Research, Numero 122/3, 2018, Pagina/e 444-456, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.117.312345

Metabolic Alterations in Cardiopulmonary Vascular Dysfunction

Autori: Valérie Françoise Smolders, Erika Zodda, Paul H. A. Quax, Marina Carini, Joan Albert Barberà, Timothy M. Thomson, Olga Tura-Ceide, Marta Cascante
Pubblicato in: Frontiers in Molecular Biosciences, Numero 5, 2019, ISSN 2296-889X
Editore: Annalisa Pastore King's College London London, United Kingdom Field Chief Editor
DOI: 10.3389/fmolb.2018.00120

Differentially Expressed Proteins in Primary Endothelial Cells Derived From Patients With Acute Myocardial Infarction

Autori: Sarath Babu Nukala, Luca Regazzoni, Giancarlo Aldini, Erika Zodda, Olga Tura-Ceide, Nicholas L. Mills, Marta Cascante, Marina Carini, Alfonsina D’Amato
Pubblicato in: Hypertension, Numero 74/4, 2019, Pagina/e 947-956, ISSN 0194-911X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.119.13472

Tuning PFKFB3 Bisphosphatase Activity Through Allosteric Interference

Autori: Helena Macut, Xiao Hu, Delia Tarantino, Ettore Gilardoni, Francesca Clerici, Luca Regazzoni, Alessandro Contini, Sara Pellegrino, Maria Luisa Gelmi
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-56708-0

Assessment of Microvessel Permeability in Murine Atherosclerotic Vein Grafts Using Two-Photon Intravital Microscopy

Autori: Baganha F, Ritsma L, Quax PHA, de Vries MR
Pubblicato in: Int J Mol Sci. 2020, 2020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21239244

The Role of Immunomodulation in Vein Graft Remodeling and Failure.

Autori: Fabiana Baganha; Fabiana Baganha; Alwin de Jong; J. Wouter Jukema; Paul H.A. Quax; Margreet R. de Vries
Pubblicato in: Journal of Cardiovascular Translational Research, Numero 24, 2021, ISSN 1937-5387
Editore: Springer Pub. Co.,
DOI: 10.1007/s12265-020-10001-y

Small molecule 3PO inhibits glycolysis but does not bind to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3)

Autori: Emini Veseli B, Perrotta P, Van Wielendaele P, Lambeir A-M, Abdali A, Bellosta S, Monaco G, Bultynck G, Martinet W, De Meyer GRY
Pubblicato in: FEBS Lett., 2020, ISSN 0014-5793
Editore: Elsevier BV
DOI: 10.1002/1873-3468.13878

[18F]ZCDD083: a PFKFB3-targeted PET tracer for atherosclerotic plaque imaging

Autori: Carlo De Dominicis, Paola Perrotta, Sergio Dall’Angelo, Leonie Wyffels, Steven Staelens,* Guido R. Y. De Meyer, Matteo Zanda
Pubblicato in: ACS Medicinal Chemistry Letters, 2020, ISSN 1948-5875
Editore: American Chemical Society
DOI: 10.1021/acsmedchemlett.9b00677

Three-dimensional imaging of intraplaque neovascularization in a mouse model of advanced atherosclerosis

Autori: Perrotta P, Pintelon I, De Vries MR, Quax PHA, Timmermans J-P, De Meyer GRY, Martinet W.
Pubblicato in: J Vasc Res., 2020, ISSN 1018-1172
Editore: S. Karger AG
DOI: 10.1159/000508449

DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF PFKFB3 PHOSPHATASE ACTIVITY ALLOSTERIC MODULATORS

Autori: "Helena Macut DISFARM - Section of General and Organic Chemistry ""A. Marchesini"", University of Milan, Via Venezian 21, 20133 Milan, Italy. ; Xiao Hu; Delia Tarantino; Luca Giovanni Regazzoni; Ettore Gilardoni; Sara Pellegrino; Maria Luisa Gelmi"
Pubblicato in: International Symposium on Medicinal Chemistry Lublijana, 2018
Editore: International Symposium on Medicinal Chemistry
DOI: 10.5281/zenodo.1415341

Differentially Expressed Proteins in Pulmonary Endothelial Cells in Chronic Thromboembolic Pulmonary Hypertension

Autori: S.B. Nukala , O. Tura , L. Regazzoni , C. Marinello , A. Abdali , G. Aldini , V.F. Smolders, I. Blanco , J.A. Barbera , M. Cascante , M. Carini
Pubblicato in: American Journal of Respiratory and Critical Care Medicine 2018; 197:A3738 ATS International conference,, 2018
Editore: ATS International conference
DOI: 2434/590474

Virtual screening approach in drug discovery targeting the PFKFB3 kinase binding site

Autori: Cristofori, Virginia; Contini, Alessandro
Pubblicato in: eCheminfo workshop in Drug Design, 18-22 July 2016 University of Milan, 2016
Editore: University of Milan
DOI: 10.5281/zenodo.826382

Structure-based design and synthesis of new PFKFB3 kinase inhibitors as candidate therapeutics for treating atherosclerosis

Autori: Cristofori, Virginia; Stanzione, Francesca; Zanda, Matteo; Contini, Alessandro
Pubblicato in: Medicinal Chemistry Residential Summer School, 2017
Editore: Medicinal Chemistry Residential Summer School Loughborough
DOI: 10.5281/zenodo.826380

Structure-based design and synthesis of new PFKFB3 kinase inhibitors as candidate therapeutics for treating atherosclerosis

Autori: Cristofori, Virginia
Pubblicato in: Winter Symposium 16th and 17th of February, Aberdeen University, 2017
Editore: Aberdeen University
DOI: 10.5281/zenodo.827178

Dysfunctional endothelial cells in patients with chronic thromboembolic pulmonary hypertension

Autori: Valérie Françoise Smolders; Joan Albert Barberà; Olga Tura-Ceide
Pubblicato in: ERS 2017 on September 11th 2017, Milan, Italy., 2017
Editore: ERS 2017
DOI: 10.5281/zenodo.1402475

Endothelial cells dysfunctionality associated to acute myocardial infarction: regulation of metabolic pathways as a new therapeutic strategy.

Autori: Erika Zodda, Anusha Jayaraman, Pedro de Atauri, Ramón Messeguer, Olga Tura-Ceide, Timothy M. Thomson, & Marta Cascante.
Pubblicato in: FEBS3+ Barcelona 2017, 2017
Editore: FEBS3 Barcelona (Fira de Barcelona)
DOI: 10.5281/zenodo.1342535

Derivation and characterization of endothelial cells from patients with chronic thromboembolic pulmonary hypertension

Autori: Valérie Françoise Smolders; Joan Albert Barberà; Olga Tura-Ceide
Pubblicato in: ATS 2018 2018, San Diego (CA), USA., 2018
Editore: ATS 2018
DOI: 10.5281/zenodo.1402522

Metabolic characterization of endothelial cells dysfunctionality associated to acute myocardial infarction

Autori: Erika Zodda; Anusha Jayaraman; Pedro de Atauri; Ramon Messeguer; Olga Tura-Ceide; Timothy M. Thomson; Marta Cascante
Pubblicato in: ENABLE Conference - The 1st European PhD and Postdoc, 15-17 Noviembre 2017, Palau Casades , Barcelona (Spain), 2017
Editore: ENABLE Conference -
DOI: 10.5281/zenodo.1342612

Mass Spectrometry-Based Label Free Quantitative Proteomics to study the effect of 3-PO in endothelial cells

Autori: NUKALA, SARATH BABU D'AMATO, ALFONSINA REGAZZONI, LUCA GIOVANNI ALDINI, GIANCARLO CARINI, MARINA
Pubblicato in: Joint Meeting in Medicinal Chemistry MedChemSicily Palermo nel 2018., 2018
Editore: Meeting in Medicinal Chemistry MedChemSicily
DOI: 2434/590476

Vascular Discovery: From Genes to Medicine Scientific

Autori: A. Abdali, A. Corsini, D. Baci, C. De Dominicis, M. Zanda, M.L. Gelmi, S. Bellosta
Pubblicato in: Vascular Discovery: From Genes to Medicine Scientific Conference S. Francisco, 2018
Editore: Vascular Discovery: From Genes to Medicine Scientific Conference
DOI: 2434/585140

Angiogenesis inhibition with novel compounds targeting the key glycolytic enzyme PFKFB3

Autori: Abdali, A; A. Corsini, D. Baci, C. De Dominicis, M. Zanda, M. L. Gelmi, S. Bellosta.
Pubblicato in: 86th Congress of the European Atherosclerosis Society EAS, Lisbon (Portugal), 2018
Editore: 86th Congress of the European Atherosclerosis Society EAS, Lisbon (Portugal)
DOI: 2434/585142

Novel compounds targeting PFKFB3, the key glycolytic enzyme, as a way to inhibit angiogenesis

Autori: Anahita Abdali, Bellosta Stefano, Corsini Alberto, Carlo De Dominicis, Matteo Zanda, Gelmi Maria Luisa
Pubblicato in: SISA Palermo, 19-21 November 2017, 2017
Editore: SISA Palermo
DOI: 2434/585138

“In vitro study on the effects of inhibitors of angiogenesis in atherosclerosis”

Autori: L. Parma, C. De Dominicis, H. A. B. Peters, M. R. De Vries and P. H. A. Quax
Pubblicato in: ESVS spring meeting in Leiden, May 19-20, 2017., 2017
Editore: ESVS spring meeting in Leiden
DOI: 10.5281/zenodo.826048

In vivo evaluation by optical and PET imaging of IP angiogenesis and validation of PFKFB3 inhibitors in a murine vein graft model

Autori: Baganha F., De Vries M. and Quax P.
Pubblicato in: Dutch Heart Foundation, 2016
Editore: Dutch Heart Foundation
DOI: 10.5281/zenodo.832534

Humanized IgG monoclonal anti-phosphorylcholine reduces vein graft failure

Autori: Fabiana Baganha; Erna Peters; Margreet de Vries; Knut Pettersson; Paul H.A. Quax
Pubblicato in: ESVS spring meeting 2017, 2017
Editore: ESVS
DOI: 10.5281/zenodo.832549

VEGFR2 blockade reduces intraplaque haemorrhage and enhances plaque stability by augmentation of plaque neovessel maturation

Autori: Margreet de Vries; Laura Parma; Erna Peters; Jaap Hamming; Marie-José Goumans; Paul Quax
Pubblicato in: International Vascular Biology Meeting (IVBM), Boston, Massachusetts, USA, 30 Oct – 03 Nov, 2016, 2016
Editore: International Vascular Biology Meeting (IVBM),
DOI: 10.5281/zenodo.831473

Dysfunctional endothelial cells in patients with chronic thromboembolic pulmonary hypertension

Autori: Valérie Françoise Smolders; Joan Albert Barberà; Olga Tura-Ceide
Pubblicato in: ERS 2017, 2017
Editore: ERS 2017
DOI: 10.5281/zenodo.1402475

“P-140 VEGFR2 blockade in murine atherosclerotic vein grafts enhances plaque stability and reduces intraplaque haemorrhage by enhancement of plaque neovessel maturation”

Autori: M. de Vries, L. Parma, E. Peters, J. Hamming, M.- J. Goumans, P. Quax
Pubblicato in: Perspectives in Vascular Biology meeting , Frankfurt,, 2016
Editore: Perspectives in Vascular Biology meeting , Frankfurt,
DOI: 10.5281/zenodo.1478810

“In vitro and in vivo study on the effects of inhibitors of angiogenesis in atherosclerosis”

Autori: Parma L, M. R. De Vries, P. H. A. Quax
Pubblicato in: PhD course Dutch Heart Foundation,, 2016
Editore: Dutch Heart Foundation,
DOI: 10.5281/zenodo.1478817

“Design, synthesis and in vitro evaluation of modulators of PFKFB3 phosphatase activity”

Autori: H. Macut, X. Hu, D. Tarantino, L. Parma, S. Pellegrino, M. L. Gelmi
Pubblicato in: Marie Curie Alumni Association General Assembly and Annual Conference,, 2018
Editore: Marie Curie Alumni Association General Assembly and Annual Conference,
DOI: 10.5281/zenodo.1478786

“Derivation and characterization of endothelial cells from patients with chronic thromboembolic pulmonary hypertension”

Autori: V. Smolders, Olga Tura-Ceide, Jéssica Garcia-Lucio, Lucilla Piccari, Victor I. Peinado, Manel Castella, Joan Albert Barberà .
Pubblicato in: spring meeting in Leiden, 2017
Editore: University of Leiden
DOI: 10.5281/zenodo.826143

“Study of central carbon metabolism of Endothelial Cells in normal and pathological conditions”

Autori: E. Zodda, A. Jayaraman, P. de Atauri, S. Marin, R. Messeguer, O. Tura-Ceide, T. M Thomson, M. Cascante
Pubblicato in: EMBO conference, 2016
Editore: EMBO conference
DOI: 10.5281/zenodo.826394

"""Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension"" "

Autori: V. Smolders, O. Tura-Ceide, J. Garcia-Lucio, L. Piccari, V. I. Peinado, M. Castella, J. A. Barberà.
Pubblicato in: Jornadas Docencia CIBERES/CIBER-BBN 2016., 2016
Editore: CIBERES/CIBER-BBN 2016, Madrid, Spain,
DOI: 10.5281/zenodo.826133

“Small molecule mediated inhibition of bFGF reduces in vivo angiogenesis and is a promising candidate to combat intraplaque angiogenesis in atherosclerosis”

Autori: L. Parma, M.R. De Vries, H.A.B. Peters and P.H.A. Quax
Pubblicato in: ESM-EVBO summer school, 2018
Editore: ESM-EVBO
DOI: 10.5281/zenodo.1478821

Quantitative Proteomics: Strategies and tools to Probe Biology

Autori: Nukala SB, , MM Idris, Marina Carini
Pubblicato in: European Molecular Biology Laboratory (EMBL),, 2016
Editore: European Molecular Biology Laboratory (EMBL)
DOI: 2434/517613

Targeting glycolysis to inhibit intra-plaque angiogenesis.

Autori: Perrotta P., M.de Vries, W. Martinet , P. Quax
Pubblicato in: ESVS Meeting_Basic and Translation Research in vascular biology., 2017
Editore: ESVS Meeting_Basic and Translation Research in vascular biology

Target glycolysis to promote stabilization of advanced atherosclerotic plaques ORAL

Autori: Paola Perrotta
Pubblicato in: Spring Meeting of the Belgian Society of Physiology and Pharmacology 27/04/2018, 2018
Editore: Belgian Society of Physiology and Pharmacology

“Flexible Water Docking and Virtual Screening Using PLANTS Combined with Tuned Water Selection criteria”

Autori: X. Hu, A. Contini
Pubblicato in: 11th Triennial Congress of the World Association of Theoretical and Computational Chemists,, 2017
Editore: World Association of Theoretical and Computational Chemists
DOI: 2434/599488

“Docking and Virtual Screening with Flexible Hydration and Potentials in MM-PBSA rescoring”

Autori: X. Hu, A. Contini,
Pubblicato in: 13th German Conference on Chemoinformatics, 2017
Editore: German Conference on Chemoinformatics

Automatization of the Nwat-MMGBSA method to rescore docking results in medium-throughput virtual screening applications

Autori: Hu X.; Contini, A.
Pubblicato in: Triennial Congress of the World Association of Theoretical and Computational Chemists, 2017
Editore: Triennial Congress of the World Association of Theoretical and Computational Chemists

“Difference in Virtual Screening Enrichment Using polar and non-polar interactions of MM-PB/GBSA methods”

Autori: X. Hu, A. Contini
Pubblicato in: echeminfo Oxford 2018 workshop, 2018
Editore: echeminfo Oxford 2018 workshop, Didcot, UK, 2018 Training and Innovation Course in Drug Design

“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Autori: Baganha F., M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Pubblicato in: International Vascular Biology Meeting, 2018
Editore: International Vascular Biology Meeting
DOI: 10.5281/zenodo.1489036

“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Autori: F. Baganha, M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Pubblicato in: Frontiers in Cardiovascular, 2018
Editore: Frontiers in Cardiovascular
DOI: 10.5281/zenodo.1488964

“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Autori: Baganha F., M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Pubblicato in: RVMM Meeting, 2018
Editore: Rembrandt Vascular cardiovascular Institute
DOI: 10.5281/zenodo.1489044

F“A monoclonal human IgG1 phosphorylcholine antibody reduces vein graft remodelling, angiogenesis and intraplaque haemorrhage”

Autori: F. Baganha, M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Pubblicato in: Rembrandt Symposium, 2017
Editore: Rembrandt Symposium
DOI: 10.5281/zenodo.1489038

“Humanized IgG monoclonal anti-phosphorylcholine reduces vein graft failure”

Autori: Baganha F. , M.R. De Vries, Erna Peters, Knut Pettersson and P.H.A. Quax
Pubblicato in: AIO research meeting, 2018
Editore: AIO research meeting
DOI: 10.5281/zenodo.1489028

Drug discovery and Computation Biology

Autori: Cristofori V.
Pubblicato in: PechaKucha Night, 2017
Editore: PechaKucha Night The Belmont Filmhouse Aberdeen,
DOI: 10.5281/zenodo.1486103

Dysfunctional endothelial cells in patients with chronic thromboembolic pulmonary hypertension

Autori: Valerie smolders
Pubblicato in: 2 Reunión de Investigación en Hipertensión Pulmonar., 2018
Editore: CIBERES
DOI: 10.5281/zenodo.1557576

Synthesis and characterization of the autoregulatory domain of PFKFB3

Autori: H. Macut, S. Pellegrino, M.L. Gelmi
Pubblicato in: International Symposium on Medicinal Chemistry : book of abstracts, 2016, Pagina/e 137
Editore: EFCM
DOI: 2434/489548

Design, synthesis and in vitro evaluation of modulators of PFKFB3 autoregulatory domain

Autori: MACUT, HELENA; HU, XIAO; GELMI, MARIA LUISA; PELLEGRINO, SARA; TARANTINO, DELIA
Pubblicato in: 10th Joint Meeting on medicinal chemistry, 25.-28.6.2017 Dubrovnik, Croatia., 2017
Editore: http://www.jmmc2017.hr/
DOI: 2434/516356

Combining 3D-RISM with hydropathic charateristic water evaluation: first step preparation for further PLANTS virtual screening with flexible explicit water molecules

Autori: HU, XIAO CONTINI, ALESSANDRO
Pubblicato in: eCheminfo workshop in Drug Design, 2016
Editore: http://www.echeminfo.com/events/drug-design-euro
DOI: 2434/516738

Combining 3D-RISM with hydrophatic characteristic water evaluation: first step preparation for further PLANTS virtual screening with flexible explicit water molecules

Autori: HU, XIAO CONTINI, ALESSANDRO
Pubblicato in: 12th German Conference on Chemoinformatics, 2016
Editore: https://www.gdch.de/index.php?id=3089
DOI: 2434/517787

Novel MMP-inhibiting peptides for stabilizing atherosclerotic plaques

Autori: ABDALI, ANAHITA MACUT, HELENA PELLEGRINO, SARA GELMI, MARIA LUISA BELLOSTA, STEFANO
Pubblicato in: 85th European Atherosclerosis Society (EAS) Congress in Prague: Science at a Glance, 2017
Editore: http://eas2017.com/
DOI: 2434/508315

Annual Research Day: Project summary for Elevator Pitch

Autori: Smolders, Valérie F.
Pubblicato in: 'Kaag dag : Annual Research meeting Leiden,, Numero 1, 2018
Editore: University of Leiden
DOI: 10.5281/zenodo.1402470

Synthesis of PFKFB3 inhibitors for Positron Emission Tomography imaging of atherosclerotic plaque

Autori: Carlo, De Dominicis
Pubblicato in: Graduate School 2017 Winter Symposium at the University of Aberdeen, Numero 2, 2017
Editore: University of Aberdeen
DOI: 10.5281/zenodo.827185

[18F]AZ68: a PFKFB3 targeted PET tracer for imaging atherosclerotic plaque

Autori: De Dominicis, C. Dall'Angelo Sergio; Perrotta Paola; Zanda Matteo; Staelens Steven; De Meyer Guido; Wyffels Leonie
Pubblicato in: 2018
Editore: Scottish Molecular Imaging Meeting Glasgow
DOI: 10.5281/zenodo.1422742

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