Image-Guided Surgery (IGS) and Personalised Postoperative Immunotherapy To Improving Cancer Outcome

Livrables

Training by research and network-wide training completed
Dissemination plan (M7) and Project publications including review articles written by ESRs (M48)
Public engagement activities completed
Conference M30 (Gantt Chart)
Progress reports and periodic reports to EC

Progress reports and periodic reports to EC (months 1-48)

Rotations and SECs completed

Project website live

Publications

Optimization of the Extraction from Spent Coffee Grounds Using the Desirability Approach

Auteurs: Maria Rosa Gigliobianco, Barbara Campisi, Dolores Vargas Peregrina, Roberta Censi, Gulzhan Khamitova, Simone Angeloni, Giovanni Caprioli, Marco Zannotti, Stefano Ferraro, Rita Giovannetti, Cristina Angeloni, Giulio Lupidi, Letizia Pruccoli, Andrea Tarozzi, Dario Voinovich, Piera Di Martino
Publié dans: Antioxidants, Numéro 9/5, 2020, Page(s) 370, ISSN 2076-3921
Éditeur: x
DOI: 10.3390/antiox9050370

Evaluating Brightness and Spectral Properties of Click Beetle and Firefly Luciferases Using Luciferin Analogues: Identification of Preferred Pairings of Luciferase and Substrate for In Vivo Bioluminescence Imaging

Auteurs: Giorgia Zambito, Natasa Gaspar, Yanto Ridwan, Mary P. Hall, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Clemens Löwik, Laura Mezzanotte
Publié dans: Molecular Imaging and Biology, 2020, ISSN 1536-1632
Éditeur: Elsevier BV
DOI: 10.1007/s11307-020-01523-7

The Effects of Crosslinking on the Rheology and Cellular Behavior of Polymer-Based 3D-Multilayered Scaffolds for Restoring Articular Cartilage

Auteurs: Yaima Campos, Francisco J. Sola, Gastón Fuentes, Luis Quintanilla, Amisel Almirall, Luis J. Cruz, José C. Rodríguez-Cabello, Yasuhiko Tabata
Publié dans: Polymers, Numéro 13/6, 2021, Page(s) 907, ISSN 2073-4360
Éditeur: MDPI
DOI: 10.3390/polym13060907

Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins

Auteurs: Raimundo De Araï¿½jo Jr, Jonas Pessoa, Luis Cruz, Alan Chan, Emï¿½lio De Castro Miguel, Rï¿½mulo Cavalcante, Gerly Anne Brito, Heloiza Fernada Silva, Luiz Gasparotto, Paulo Guedes, Aurigena Araï¿½jo
Publié dans: International Journal of Oncology, 2017, ISSN 1019-6439
Éditeur: Demetrios A. Spandidos Ed. & Pub.
DOI: 10.3892/ijo.2017.4179

Spherical neutral Gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats

Auteurs: Thaís Gomes de Carvalho, Vinícius Barreto Garcia, Aurigena Antunes de Araújo, Luiz Henrique da Silva Gasparotto, Heloiza Silva, Gerlane Coelho Bernardo Guerra, Emilio de Castro Miguel, Renata Ferreira de Carvalho Leitão, Deiziane Viana da Silva Costa, Luis J Cruz, Alan B. Chan, Raimundo Fernandes de Araújo Júnior
Publié dans: International Journal of Pharmaceutics, 2018, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2018.06.008

Molecular Adjuvants Based on Plasmids Encoding Protein Aggregation Domains Affect Bone Marrow Niche Homeostasis

Auteurs: Maria Giovanna Sabbieti, Giovanna Lacava, Andrea Amaroli, Luigi Marchetti, Roberta Censi, Piera Di Martino, Dimitrios Agas
Publié dans: Current Gene Therapy, Numéro 17/5, 2018, ISSN 1566-5232
Éditeur: Bentham Science Publishers
DOI: 10.2174/1566523218666180105122626

Diverse Functions of Macrophages in Different Tumor Microenvironments

Auteurs: Ming Yang, Daniel McKay, Jeffrey W. Pollard, Claire E. Lewis
Publié dans: Cancer Research, Numéro 78/19, 2018, Page(s) 5492-5503, ISSN 0008-5472
Éditeur: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-18-1367

Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences

Auteurs: Chih Kit Chung, C.G. Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Publié dans: Journal of Controlled Release, Numéro 285, 2018, Page(s) 56-66, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2018.07.011

Memory CD4+ T cells are generated in the human fetal intestine

Auteurs: Na Li, Vincent van Unen, Tamim Abdelaal, Nannan Guo, Sofya A. Kasatskaya, Kristin Ladell, James E. McLaren, Evgeny S. Egorov, Mark Izraelson, Susana M. Chuva de Sousa Lopes, Thomas Höllt, Olga V Britanova, Jeroen Eggermont, Noel F. C. C. de Miranda, Dmitriy M. Chudakov, David A. Price, Boudewijn P. F. Lelieveldt, Frits Koning
Publié dans: Nature Immunology, 2019, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/s41590-018-0294-9

Opportunities of bacterial cellulose to treat epithelial tissues

Auteurs: Irene Anton-Sales, Uwe Beekmann, Anna Laromaine, Anna Roig, Dana Kralisch
Publié dans: Current Drug Targets, Numéro 20, 2018, Page(s) 808-822, ISSN 1389-4501
Éditeur: Bentham Science Publishers
DOI: 10.2174/1389450120666181129092144

Quantification of phenolic compounds in different types of crafts beers, worts, starting and spent ingredients by liquid chromatography-tandem mass spectrometry

Auteurs: Manuela Cortese, Maria Rosa Gigliobianco, Dolores Vargas Peregrina, Gianni Sagratini, Roberta Censi, Piera Di Martino
Publié dans: Journal of Chromatography A, 2019, Page(s) 460622, ISSN 0021-9673
Éditeur: Elsevier BV
DOI: 10.1016/j.chroma.2019.460622

Environmentally compatible bioconjugated gold nanoparticles as efficient contrast agents for inflammation-induced cancer imaging

Auteurs: Vinícius Barreto Garcia, Thaís Gomes de Carvalho, Luiz Henrique da Silva Gasparotto, Heloiza Fernanda Oliveira da Silva, Aurigena Antunes de Araújo, Gerlane Coelho Bernardo Guerra, Timo Schomann, Luis J. Cruz, Alan B. Chan, Raimundo Fernandes de Araújo Júnior
Publié dans: Nanoscale Research Letters, Numéro 14/1, 2019, ISSN 1931-7573
Éditeur: Springer Verlag
DOI: 10.1186/s11671-019-2986-y

Tissue classification by rapid evaporative ionization mass spectrometry (REIMS): comparison between a diathermic knife and CO2 laser sampling on classification performance

Auteurs: Michele Genangeli, Ron M. A. Heeren, Tiffany Porta Siegel
Publié dans: Analytical and Bioanalytical Chemistry, 2019, ISSN 1618-2642
Éditeur: Springer Verlag
DOI: 10.1007/s00216-019-02148-8

MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment

Auteurs: Michele Genangeli, Annemarie M. M. Heijens, Alice Rustichelli, Noortje Dien Schuit, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Sauro Vittori, Tiffany Porta Siegel, Ron M.A. Heeren
Publié dans: Journal of The American Society for Mass Spectrometry, Numéro 30/10, 2019, Page(s) 2041-2050, ISSN 1044-0305
Éditeur: Elsevier BV
DOI: 10.1007/s13361-019-02265-9

PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors

Auteurs: Guillaume Beyrend, Esmé van der Gracht, Ayse Yilmaz, Suzanne van Duikeren, Marcel Camps, Thomas Höllt, Anna Vilanova, Vincent van Unen, Frits Koning, Noel F. C. C. de Miranda, Ramon Arens, Ferry Ossendorp
Publié dans: Journal for ImmunoTherapy of Cancer, Numéro 7/1, 2019, ISSN 2051-1426
Éditeur: J Immunother Cancer
DOI: 10.1186/s40425-019-0700-3

Cytofast: A workflow for visual and quantitative analysis of flow and mass cytometry data to discover immune signatures and correlations

Auteurs: Guillaume Beyrend, Koen Stam, Thomas Höllt, Ferry Ossendorp, Ramon Arens
Publié dans: Computational and Structural Biotechnology Journal, Numéro 16, 2018, Page(s) 435-442, ISSN 2001-0370
Éditeur: Comput Struct Biotechnol J
DOI: 10.1016/j.csbj.2018.10.004

A comparison of automatic cell identification methods for single-cell RNA sequencing data

Auteurs: Tamim Abdelaal, Lieke Michielsen, Davy Cats, Dylan Hoogduin, Hailiang Mei, Marcel J. T. Reinders, Ahmed Mahfouz
Publié dans: Genome Biology, Numéro 20/1, 2019, ISSN 1474-760X
Éditeur: Genome Biol
DOI: 10.1186/s13059-019-1795-z

Early-Life Compartmentalization of Immune Cells in Human Fetal Tissues Revealed by High-Dimensional Mass Cytometry

Auteurs: Na Li, Vincent van Unen, Nannan Guo, Tamim Abdelaal, Antonios Somarakis, Jeroen Eggermont, Ahmed Mahfouz, Susana M. Chuva de Sousa Lopes, Boudewijn P. F. Lelieveldt, Frits Koning
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: Front Immunol
DOI: 10.3389/fimmu.2019.01932

Cytomegalovirus infection and progressive differentiation of effector-memory T cells

Auteurs: Iris N. Pardieck, Guillaume Beyrend, Anke Redeker, Ramon Arens
Publié dans: F1000Research, Numéro 7, 2018, Page(s) 1554, ISSN 2046-1402
Éditeur: F1000 Research Ltd.
DOI: 10.12688/f1000research.15753.1

High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity

Auteurs: Natasja L de Vries, Vincent van Unen, Marieke E Ijsselsteijn, Tamim Abdelaal, Ruud van der Breggen, Arantza Farina Sarasqueta, Ahmed Mahfouz, Koen C M J Peeters, Thomas Höllt, Boudewijn P F Lelieveldt, Frits Koning, Noel F C C de Miranda
Publié dans: Gut, 2019, Page(s) gutjnl-2019-318672, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-318672

Thermosensitive hybrid hydrogels for the controlled release of bioactive vancomycin in the treatment of orthopaedic implant infections

Auteurs: Roberta Censi, Cristina Casadidio, Alessandra Dubbini, Manuela Cortese, Stefania Scuri, Iolanda Grappasonni, Samuel Golob, Dario Vojnovic, Maria Giovanna Sabbieti, Dimitrios Agas, Piera Di Martino
Publié dans: European Journal of Pharmaceutics and Biopharmaceutics, Numéro 142, 2019, Page(s) 322-333, ISSN 0939-6411
Éditeur: Elsevier BV
DOI: 10.1016/j.ejpb.2019.07.006

Precisely Tailoring Upconversion Dynamics via Energy Migration in Core-Shell Nanostructures

Auteurs: Jing Zuo, Dapeng Sun, Langping Tu, Yanni Wu, Yinghui Cao, Bin Xue, Youlin Zhang, Yulei Chang, Xiaomin Liu, Xianggui Kong, Wybren Jan Buma, Evert Jan Meijer, Hong Zhang
Publié dans: Angewandte Chemie International Edition, Numéro 57/12, 2018, Page(s) 3054-3058, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201711606

Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability

Auteurs: Di Martino, Piera; Gigliobianco, Maria; Casadidio, Cristina; Censi, Roberta
Publié dans: Pharmaceutics, Vol 10, Iss 3, p 134 (2018), Numéro 4, 2018, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.20944/PREPRINTS201807.0233.V1

Cosmetic Formulation Based on an Açai Extract

Auteurs: Roberta Censi, Dolores Vargas Peregrina, Giovanna Lacava, Dimitrios Agas, Giulio Lupidi, Maria Sabbieti, Piera Di Martino
Publié dans: Cosmetics, Numéro 5/3, 2018, Page(s) 48, ISSN 2079-9284
Éditeur: Cosmetics 2018
DOI: 10.3390/cosmetics5030048

Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase

Auteurs: Maxime D. Slooter, Henricus J.M. Handgraaf, Martin C. Boonstra, Lily-Ann van der Velden, Shadhvi S. Bhairosingh, Ivo Que, Lorraine M. de Haan, Stijn Keereweer, Pieter B.A.A. van Driel, Alan Chan, Hisataka Kobayashi, Alexander L. Vahrmeijer, Clemens W.G.M. Löwik
Publié dans: Oral Oncology, Numéro 78, 2018, Page(s) 1-7, ISSN 1368-8375
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.oraloncology.2017.12.006

Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging

Auteurs: Mary P. Hall, Carolyn C. Woodroofe, Monika G. Wood, Ivo Que, Moniek van’t Root, Yanto Ridwan, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Keith V. Wood, Clemens Löwik, Laura Mezzanotte
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-017-02542-9

Chitin and Chitosans: Characteristics, Eco-Friendly Processes, and Applications in Cosmetic Science

Auteurs: Cristina Casadidio, Dolores Vargas Peregrina, Maria Rosa Gigliobianco, Siyuan Deng, Roberta Censi, Piera Di Martino
Publié dans: Marine Drugs, Numéro 17/6, 2019, Page(s) 369, ISSN 1660-3397
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md17060369

A Dual-Color Bioluminescence Reporter Mouse for Simultaneous in vivo Imaging of T Cell Localization and Function

Auteurs: Jan Willem Kleinovink, Laura Mezzanotte, Giorgia Zambito, Marieke F. Fransen, Luis J. Cruz, J. Sjef Verbeek, Alan Chan, Ferry Ossendorp, Clemens Löwik
Publié dans: Frontiers in Immunology, Numéro 9, 2019, ISSN 1664-3224
Éditeur: Front. Immunol
DOI: 10.3389/fimmu.2018.03097

CyTOFmerge: integrating mass cytometry data across multiple panels

Auteurs: Tamim Abdelaal, Thomas Höllt, Vincent van Unen, Boudewijn P F Lelieveldt, Frits Koning, Marcel J T Reinders, Ahmed Mahfouz
Publié dans: Bioinformatics, Numéro 35/20, 2019, Page(s) 4063-4071, ISSN 1367-4803
Éditeur: Oxford University Press
DOI: 10.1093/bioinformatics/btz180

Predicting Cell Populations in Single Cell Mass Cytometry Data

Auteurs: Tamim Abdelaal, Vincent van Unen, Thomas Höllt, Frits Koning, Marcel J.T. Reinders, Ahmed Mahfouz
Publié dans: Cytometry Part A, Numéro 95/7, 2019, Page(s) 769-781, ISSN 1552-4922
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.23738

Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles

Auteurs: Candido G. Da Silva, Marcel G.M. Camps, Tracy M.W.Y. Li, Luana Zerrillo, Clemens W. Löwik, Ferry Ossendorp, Luis J. Cruz
Publié dans: Theranostics, Numéro 9/22, 2019, Page(s) 6485-6500, ISSN 1838-7640
Éditeur: Ivyspring International Publisher
DOI: 10.7150/thno.34429

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Auteurs: Siyuan Deng, Maria Rosa Gigliobianco, Roberta Censi, Piera Di Martino
Publié dans: Nanomaterials, Numéro 10/5, 2020, Page(s) 847, ISSN 2079-4991
Éditeur: MDPI
DOI: 10.3390/nano10050847

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Auteurs: Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Publié dans: Molecules, Numéro 25/9, 2020, Page(s) 2219, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092219

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Auteurs: Zhenfeng Yu, Christina Eich, Luis J. Cruz
Publié dans: Frontiers in Chemistry, Numéro 8, 2020, ISSN 2296-2646
Éditeur: Frontiers in Chemistry
DOI: 10.3389/fchem.2020.00496

Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers

Auteurs: Yulei Chang, Xiaodan Li, Li Zhang, Lu Xia, Xiaomin Liu, Cuixia Li, Youlin Zhang, Langping Tu, Bin Xue, Huiying Zhao, Hong Zhang, Xianggui Kong
Publié dans: Scientific Reports, Numéro 7, 2017, Page(s) 45633, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep45633

One-step in situ solid-substrate-based whole blood immunoassay based on FRET between upconversion and gold nanoparticles

Auteurs: Cuixia Li, Jing Zuo, Qiqing Li, Yulei Chang, Youlin Zhang, Langping Tu, Xiaomin Liu, Bin Xue, Huiying Zhao, Hong Zhang, Xianggui Kong
Publié dans: Biosensors and Bioelectronics, Numéro 92, 2017, Page(s) 335-341, ISSN 0956-5663
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2016.11.003

Accurate Quantitative Sensing of Intracellular pH based on Self-ratiometric Upconversion Luminescent Nanoprobe

Auteurs: Cuixia Li, Jing Zuo, Li Zhang, Yulei Chang, Youlin Zhang, Langping Tu, Xiaomin Liu, Bin Xue, Qiqing Li, Huiying Zhao, Hong Zhang, Xianggui Kong
Publié dans: Scientific Reports, Numéro 6/1, 2016, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep38617

In Vivo Molecular Bioluminescence Imaging: New Tools and Applications

Auteurs: Laura Mezzanotte, Moniek van ‘t Root, Hacer Karatas, Elena A. Goun, Clemens W.G.M. Löwik
Publié dans: Trends in Biotechnology, Numéro 35/7, 2017, Page(s) 640-652, ISSN 0167-7799
Éditeur: Elsevier BV
DOI: 10.1016/j.tibtech.2017.03.012

SpaGE: Spatial Gene Enhancement using scRNA-seq

Auteurs: Tamim Abdelaal, Soufiane Mourragui, Ahmed Mahfouz, Marcel J T Reinders
Publié dans: Nucleic Acids Research, Numéro 48/18, 2020, Page(s) e107-e107, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkaa740

Po-260 deep phenotyping of colorectal cancers by high-dimensional mass cytometry reveals tumor-specific immune landscapes

Auteurs: N De Vries, V Van Unen, T Abdelaal, M Van Herk, R Van der Breggen, A Farina Sarasqueta, T Höllt, B Lelieveldt, F Koning, N De Miranda
Publié dans: Tumour Microenvironment, 2018, Page(s) A328.2-A329
Éditeur: BMJ Publishing Group Ltd
DOI: 10.1136/esmoopen-2018-EACR25.775

Perivascular macrophages in health and disease

Auteurs: Antonio Lapenna, Michele De Palma, Claire E. Lewis
Publié dans: Nature Reviews Immunology, 2018, ISSN 1474-1733
Éditeur: Nature Publishing Group
DOI: 10.1038/s41577-018-0056-9

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