Image-Guided Surgery (IGS) and Personalised Postoperative Immunotherapy To Improving Cancer Outcome

Rezultaty

Training by research and network-wide training completed
Dissemination plan (M7) and Project publications including review articles written by ESRs (M48)
Public engagement activities completed
Conference M30 (Gantt Chart)
Progress reports and periodic reports to EC

Progress reports and periodic reports to EC (months 1-48)

Rotations and SECs completed

Project website live

Publikacje

Optimization of the Extraction from Spent Coffee Grounds Using the Desirability Approach

Autorzy: Maria Rosa Gigliobianco, Barbara Campisi, Dolores Vargas Peregrina, Roberta Censi, Gulzhan Khamitova, Simone Angeloni, Giovanni Caprioli, Marco Zannotti, Stefano Ferraro, Rita Giovannetti, Cristina Angeloni, Giulio Lupidi, Letizia Pruccoli, Andrea Tarozzi, Dario Voinovich, Piera Di Martino
Opublikowane w: Antioxidants, Numer 9/5, 2020, Strona(/y) 370, ISSN 2076-3921
Wydawca: x
DOI: 10.3390/antiox9050370

Evaluating Brightness and Spectral Properties of Click Beetle and Firefly Luciferases Using Luciferin Analogues: Identification of Preferred Pairings of Luciferase and Substrate for In Vivo Bioluminescence Imaging

Autorzy: Giorgia Zambito, Natasa Gaspar, Yanto Ridwan, Mary P. Hall, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Clemens Löwik, Laura Mezzanotte
Opublikowane w: Molecular Imaging and Biology, 2020, ISSN 1536-1632
Wydawca: Elsevier BV
DOI: 10.1007/s11307-020-01523-7

The Effects of Crosslinking on the Rheology and Cellular Behavior of Polymer-Based 3D-Multilayered Scaffolds for Restoring Articular Cartilage

Autorzy: Yaima Campos, Francisco J. Sola, Gastón Fuentes, Luis Quintanilla, Amisel Almirall, Luis J. Cruz, José C. Rodríguez-Cabello, Yasuhiko Tabata
Opublikowane w: Polymers, Numer 13/6, 2021, Strona(/y) 907, ISSN 2073-4360
Wydawca: MDPI
DOI: 10.3390/polym13060907

Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins

Autorzy: Raimundo De Araï¿½jo Jr, Jonas Pessoa, Luis Cruz, Alan Chan, Emï¿½lio De Castro Miguel, Rï¿½mulo Cavalcante, Gerly Anne Brito, Heloiza Fernada Silva, Luiz Gasparotto, Paulo Guedes, Aurigena Araï¿½jo
Opublikowane w: International Journal of Oncology, 2017, ISSN 1019-6439
Wydawca: Demetrios A. Spandidos Ed. & Pub.
DOI: 10.3892/ijo.2017.4179

Spherical neutral Gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats

Autorzy: Thaís Gomes de Carvalho, Vinícius Barreto Garcia, Aurigena Antunes de Araújo, Luiz Henrique da Silva Gasparotto, Heloiza Silva, Gerlane Coelho Bernardo Guerra, Emilio de Castro Miguel, Renata Ferreira de Carvalho Leitão, Deiziane Viana da Silva Costa, Luis J Cruz, Alan B. Chan, Raimundo Fernandes de Araújo Júnior
Opublikowane w: International Journal of Pharmaceutics, 2018, ISSN 0378-5173
Wydawca: Elsevier BV
DOI: 10.1016/j.ijpharm.2018.06.008

Molecular Adjuvants Based on Plasmids Encoding Protein Aggregation Domains Affect Bone Marrow Niche Homeostasis

Autorzy: Maria Giovanna Sabbieti, Giovanna Lacava, Andrea Amaroli, Luigi Marchetti, Roberta Censi, Piera Di Martino, Dimitrios Agas
Opublikowane w: Current Gene Therapy, Numer 17/5, 2018, ISSN 1566-5232
Wydawca: Bentham Science Publishers
DOI: 10.2174/1566523218666180105122626

Diverse Functions of Macrophages in Different Tumor Microenvironments

Autorzy: Ming Yang, Daniel McKay, Jeffrey W. Pollard, Claire E. Lewis
Opublikowane w: Cancer Research, Numer 78/19, 2018, Strona(/y) 5492-5503, ISSN 0008-5472
Wydawca: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-18-1367

Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences

Autorzy: Chih Kit Chung, C.G. Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz
Opublikowane w: Journal of Controlled Release, Numer 285, 2018, Strona(/y) 56-66, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2018.07.011

Memory CD4+ T cells are generated in the human fetal intestine

Autorzy: Na Li, Vincent van Unen, Tamim Abdelaal, Nannan Guo, Sofya A. Kasatskaya, Kristin Ladell, James E. McLaren, Evgeny S. Egorov, Mark Izraelson, Susana M. Chuva de Sousa Lopes, Thomas Höllt, Olga V Britanova, Jeroen Eggermont, Noel F. C. C. de Miranda, Dmitriy M. Chudakov, David A. Price, Boudewijn P. F. Lelieveldt, Frits Koning
Opublikowane w: Nature Immunology, 2019, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/s41590-018-0294-9

Opportunities of bacterial cellulose to treat epithelial tissues

Autorzy: Irene Anton-Sales, Uwe Beekmann, Anna Laromaine, Anna Roig, Dana Kralisch
Opublikowane w: Current Drug Targets, Numer 20, 2018, Strona(/y) 808-822, ISSN 1389-4501
Wydawca: Bentham Science Publishers
DOI: 10.2174/1389450120666181129092144

Quantification of phenolic compounds in different types of crafts beers, worts, starting and spent ingredients by liquid chromatography-tandem mass spectrometry

Autorzy: Manuela Cortese, Maria Rosa Gigliobianco, Dolores Vargas Peregrina, Gianni Sagratini, Roberta Censi, Piera Di Martino
Opublikowane w: Journal of Chromatography A, 2019, Strona(/y) 460622, ISSN 0021-9673
Wydawca: Elsevier BV
DOI: 10.1016/j.chroma.2019.460622

Environmentally compatible bioconjugated gold nanoparticles as efficient contrast agents for inflammation-induced cancer imaging

Autorzy: Vinícius Barreto Garcia, Thaís Gomes de Carvalho, Luiz Henrique da Silva Gasparotto, Heloiza Fernanda Oliveira da Silva, Aurigena Antunes de Araújo, Gerlane Coelho Bernardo Guerra, Timo Schomann, Luis J. Cruz, Alan B. Chan, Raimundo Fernandes de Araújo Júnior
Opublikowane w: Nanoscale Research Letters, Numer 14/1, 2019, ISSN 1931-7573
Wydawca: Springer Verlag
DOI: 10.1186/s11671-019-2986-y

Tissue classification by rapid evaporative ionization mass spectrometry (REIMS): comparison between a diathermic knife and CO2 laser sampling on classification performance

Autorzy: Michele Genangeli, Ron M. A. Heeren, Tiffany Porta Siegel
Opublikowane w: Analytical and Bioanalytical Chemistry, 2019, ISSN 1618-2642
Wydawca: Springer Verlag
DOI: 10.1007/s00216-019-02148-8

MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment

Autorzy: Michele Genangeli, Annemarie M. M. Heijens, Alice Rustichelli, Noortje Dien Schuit, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Sauro Vittori, Tiffany Porta Siegel, Ron M.A. Heeren
Opublikowane w: Journal of The American Society for Mass Spectrometry, Numer 30/10, 2019, Strona(/y) 2041-2050, ISSN 1044-0305
Wydawca: Elsevier BV
DOI: 10.1007/s13361-019-02265-9

PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors

Autorzy: Guillaume Beyrend, Esmé van der Gracht, Ayse Yilmaz, Suzanne van Duikeren, Marcel Camps, Thomas Höllt, Anna Vilanova, Vincent van Unen, Frits Koning, Noel F. C. C. de Miranda, Ramon Arens, Ferry Ossendorp
Opublikowane w: Journal for ImmunoTherapy of Cancer, Numer 7/1, 2019, ISSN 2051-1426
Wydawca: J Immunother Cancer
DOI: 10.1186/s40425-019-0700-3

Cytofast: A workflow for visual and quantitative analysis of flow and mass cytometry data to discover immune signatures and correlations

Autorzy: Guillaume Beyrend, Koen Stam, Thomas Höllt, Ferry Ossendorp, Ramon Arens
Opublikowane w: Computational and Structural Biotechnology Journal, Numer 16, 2018, Strona(/y) 435-442, ISSN 2001-0370
Wydawca: Comput Struct Biotechnol J
DOI: 10.1016/j.csbj.2018.10.004

A comparison of automatic cell identification methods for single-cell RNA sequencing data

Autorzy: Tamim Abdelaal, Lieke Michielsen, Davy Cats, Dylan Hoogduin, Hailiang Mei, Marcel J. T. Reinders, Ahmed Mahfouz
Opublikowane w: Genome Biology, Numer 20/1, 2019, ISSN 1474-760X
Wydawca: Genome Biol
DOI: 10.1186/s13059-019-1795-z

Early-Life Compartmentalization of Immune Cells in Human Fetal Tissues Revealed by High-Dimensional Mass Cytometry

Autorzy: Na Li, Vincent van Unen, Nannan Guo, Tamim Abdelaal, Antonios Somarakis, Jeroen Eggermont, Ahmed Mahfouz, Susana M. Chuva de Sousa Lopes, Boudewijn P. F. Lelieveldt, Frits Koning
Opublikowane w: Frontiers in Immunology, Numer 10, 2019, ISSN 1664-3224
Wydawca: Front Immunol
DOI: 10.3389/fimmu.2019.01932

Cytomegalovirus infection and progressive differentiation of effector-memory T cells

Autorzy: Iris N. Pardieck, Guillaume Beyrend, Anke Redeker, Ramon Arens
Opublikowane w: F1000Research, Numer 7, 2018, Strona(/y) 1554, ISSN 2046-1402
Wydawca: F1000 Research Ltd.
DOI: 10.12688/f1000research.15753.1

High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity

Autorzy: Natasja L de Vries, Vincent van Unen, Marieke E Ijsselsteijn, Tamim Abdelaal, Ruud van der Breggen, Arantza Farina Sarasqueta, Ahmed Mahfouz, Koen C M J Peeters, Thomas Höllt, Boudewijn P F Lelieveldt, Frits Koning, Noel F C C de Miranda
Opublikowane w: Gut, 2019, Strona(/y) gutjnl-2019-318672, ISSN 0017-5749
Wydawca: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-318672

Thermosensitive hybrid hydrogels for the controlled release of bioactive vancomycin in the treatment of orthopaedic implant infections

Autorzy: Roberta Censi, Cristina Casadidio, Alessandra Dubbini, Manuela Cortese, Stefania Scuri, Iolanda Grappasonni, Samuel Golob, Dario Vojnovic, Maria Giovanna Sabbieti, Dimitrios Agas, Piera Di Martino
Opublikowane w: European Journal of Pharmaceutics and Biopharmaceutics, Numer 142, 2019, Strona(/y) 322-333, ISSN 0939-6411
Wydawca: Elsevier BV
DOI: 10.1016/j.ejpb.2019.07.006

Precisely Tailoring Upconversion Dynamics via Energy Migration in Core-Shell Nanostructures

Autorzy: Jing Zuo, Dapeng Sun, Langping Tu, Yanni Wu, Yinghui Cao, Bin Xue, Youlin Zhang, Yulei Chang, Xiaomin Liu, Xianggui Kong, Wybren Jan Buma, Evert Jan Meijer, Hong Zhang
Opublikowane w: Angewandte Chemie International Edition, Numer 57/12, 2018, Strona(/y) 3054-3058, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201711606

Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability

Autorzy: Di Martino, Piera; Gigliobianco, Maria; Casadidio, Cristina; Censi, Roberta
Opublikowane w: Pharmaceutics, Vol 10, Iss 3, p 134 (2018), Numer 4, 2018, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.20944/PREPRINTS201807.0233.V1

Cosmetic Formulation Based on an Açai Extract

Autorzy: Roberta Censi, Dolores Vargas Peregrina, Giovanna Lacava, Dimitrios Agas, Giulio Lupidi, Maria Sabbieti, Piera Di Martino
Opublikowane w: Cosmetics, Numer 5/3, 2018, Strona(/y) 48, ISSN 2079-9284
Wydawca: Cosmetics 2018
DOI: 10.3390/cosmetics5030048

Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase

Autorzy: Maxime D. Slooter, Henricus J.M. Handgraaf, Martin C. Boonstra, Lily-Ann van der Velden, Shadhvi S. Bhairosingh, Ivo Que, Lorraine M. de Haan, Stijn Keereweer, Pieter B.A.A. van Driel, Alan Chan, Hisataka Kobayashi, Alexander L. Vahrmeijer, Clemens W.G.M. Löwik
Opublikowane w: Oral Oncology, Numer 78, 2018, Strona(/y) 1-7, ISSN 1368-8375
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.oraloncology.2017.12.006

Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging

Autorzy: Mary P. Hall, Carolyn C. Woodroofe, Monika G. Wood, Ivo Que, Moniek van’t Root, Yanto Ridwan, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Keith V. Wood, Clemens Löwik, Laura Mezzanotte
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-017-02542-9

Chitin and Chitosans: Characteristics, Eco-Friendly Processes, and Applications in Cosmetic Science

Autorzy: Cristina Casadidio, Dolores Vargas Peregrina, Maria Rosa Gigliobianco, Siyuan Deng, Roberta Censi, Piera Di Martino
Opublikowane w: Marine Drugs, Numer 17/6, 2019, Strona(/y) 369, ISSN 1660-3397
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md17060369

A Dual-Color Bioluminescence Reporter Mouse for Simultaneous in vivo Imaging of T Cell Localization and Function

Autorzy: Jan Willem Kleinovink, Laura Mezzanotte, Giorgia Zambito, Marieke F. Fransen, Luis J. Cruz, J. Sjef Verbeek, Alan Chan, Ferry Ossendorp, Clemens Löwik
Opublikowane w: Frontiers in Immunology, Numer 9, 2019, ISSN 1664-3224
Wydawca: Front. Immunol
DOI: 10.3389/fimmu.2018.03097

CyTOFmerge: integrating mass cytometry data across multiple panels

Autorzy: Tamim Abdelaal, Thomas Höllt, Vincent van Unen, Boudewijn P F Lelieveldt, Frits Koning, Marcel J T Reinders, Ahmed Mahfouz
Opublikowane w: Bioinformatics, Numer 35/20, 2019, Strona(/y) 4063-4071, ISSN 1367-4803
Wydawca: Oxford University Press
DOI: 10.1093/bioinformatics/btz180

Predicting Cell Populations in Single Cell Mass Cytometry Data

Autorzy: Tamim Abdelaal, Vincent van Unen, Thomas Höllt, Frits Koning, Marcel J.T. Reinders, Ahmed Mahfouz
Opublikowane w: Cytometry Part A, Numer 95/7, 2019, Strona(/y) 769-781, ISSN 1552-4922
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.23738

Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles

Autorzy: Candido G. Da Silva, Marcel G.M. Camps, Tracy M.W.Y. Li, Luana Zerrillo, Clemens W. Löwik, Ferry Ossendorp, Luis J. Cruz
Opublikowane w: Theranostics, Numer 9/22, 2019, Strona(/y) 6485-6500, ISSN 1838-7640
Wydawca: Ivyspring International Publisher
DOI: 10.7150/thno.34429

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Autorzy: Siyuan Deng, Maria Rosa Gigliobianco, Roberta Censi, Piera Di Martino
Opublikowane w: Nanomaterials, Numer 10/5, 2020, Strona(/y) 847, ISSN 2079-4991
Wydawca: MDPI
DOI: 10.3390/nano10050847

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Autorzy: Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Opublikowane w: Molecules, Numer 25/9, 2020, Strona(/y) 2219, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092219

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Autorzy: Zhenfeng Yu, Christina Eich, Luis J. Cruz
Opublikowane w: Frontiers in Chemistry, Numer 8, 2020, ISSN 2296-2646
Wydawca: Frontiers in Chemistry
DOI: 10.3389/fchem.2020.00496

Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers

Autorzy: Yulei Chang, Xiaodan Li, Li Zhang, Lu Xia, Xiaomin Liu, Cuixia Li, Youlin Zhang, Langping Tu, Bin Xue, Huiying Zhao, Hong Zhang, Xianggui Kong
Opublikowane w: Scientific Reports, Numer 7, 2017, Strona(/y) 45633, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/srep45633

One-step in situ solid-substrate-based whole blood immunoassay based on FRET between upconversion and gold nanoparticles

Autorzy: Cuixia Li, Jing Zuo, Qiqing Li, Yulei Chang, Youlin Zhang, Langping Tu, Xiaomin Liu, Bin Xue, Huiying Zhao, Hong Zhang, Xianggui Kong
Opublikowane w: Biosensors and Bioelectronics, Numer 92, 2017, Strona(/y) 335-341, ISSN 0956-5663
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2016.11.003

Accurate Quantitative Sensing of Intracellular pH based on Self-ratiometric Upconversion Luminescent Nanoprobe

Autorzy: Cuixia Li, Jing Zuo, Li Zhang, Yulei Chang, Youlin Zhang, Langping Tu, Xiaomin Liu, Bin Xue, Qiqing Li, Huiying Zhao, Hong Zhang, Xianggui Kong
Opublikowane w: Scientific Reports, Numer 6/1, 2016, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/srep38617

In Vivo Molecular Bioluminescence Imaging: New Tools and Applications

Autorzy: Laura Mezzanotte, Moniek van ‘t Root, Hacer Karatas, Elena A. Goun, Clemens W.G.M. Löwik
Opublikowane w: Trends in Biotechnology, Numer 35/7, 2017, Strona(/y) 640-652, ISSN 0167-7799
Wydawca: Elsevier BV
DOI: 10.1016/j.tibtech.2017.03.012

SpaGE: Spatial Gene Enhancement using scRNA-seq

Autorzy: Tamim Abdelaal, Soufiane Mourragui, Ahmed Mahfouz, Marcel J T Reinders
Opublikowane w: Nucleic Acids Research, Numer 48/18, 2020, Strona(/y) e107-e107, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkaa740

Po-260 deep phenotyping of colorectal cancers by high-dimensional mass cytometry reveals tumor-specific immune landscapes

Autorzy: N De Vries, V Van Unen, T Abdelaal, M Van Herk, R Van der Breggen, A Farina Sarasqueta, T Höllt, B Lelieveldt, F Koning, N De Miranda
Opublikowane w: Tumour Microenvironment, 2018, Strona(/y) A328.2-A329
Wydawca: BMJ Publishing Group Ltd
DOI: 10.1136/esmoopen-2018-EACR25.775

Perivascular macrophages in health and disease

Autorzy: Antonio Lapenna, Michele De Palma, Claire E. Lewis
Opublikowane w: Nature Reviews Immunology, 2018, ISSN 1474-1733
Wydawca: Nature Publishing Group
DOI: 10.1038/s41577-018-0056-9

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