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World-wide E-infrastructure for structural biology

Objective

The focus of structural biology is shifting from single macromolecules produced by simpler prokaryotic organisms, to the macromolecular machinery of higher organisms, including systems of central relevance for human health. Structural biologists are expert in one or more techniques. They now often need to use complementary techniques in which they are less expert. Instruct supports them in using multiple experimental techniques, and visiting multiple experimental facilities, within a single project.
The Protein Data Bank is a public repository for the final structure. Journals require deposition as a precondition of publication. However, metadata is often incomplete.
This project will pilot an infrastructure for storing and processing data that supports the growing use of combined techniques. There are some technique-specific pipelines for data analysis and structure determination. Little is available in terms of automated pipelines to handle integrated datasets. Integrated management of structural biology data from different techniques is lacking altogether.
The proposed activity will integrate the data management facilities that already exist, and enable the provision of new ones. The resulting integration will provide users with an overview of the experiments performed at the different research infrastructures visited, and links to the different data stores. It will extend existing facilities for processing this data. As processing is performed, it will automatically capture metadata reflecting the history of the project. The effort will use existing metadata standards, and integrate with them new domain-specific metadata terms.
This proposal will develop application level service specific to uses cases in structural biology, enabling structural biologists to get the benefit of the generic services developed by EUDAT and the EGI.

Field of science

  • /natural sciences/biological sciences/molecular biology/structural biology
  • /social sciences/sociology/governance/public services
  • /humanities/history and archaeology/history
  • /natural sciences/computer and information sciences/data science/data analysis

Call for proposal

H2020-EINFRA-2015-1
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNITED KINGDOM RESEARCH AND INNOVATION
Address
Polaris House North Star Avenue
SN2 1FL Swindon
United Kingdom
Activity type
Research Organisations
EU contribution
€ 780 750

Participants (9)

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands
EU contribution
€ 194 625
Address
Plesmanlaan 121
1066 CX Amsterdam
Activity type
Research Organisations
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 641 750
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Masarykova univerzita
Czechia
EU contribution
€ 393 250
Address
Zerotinovo Namesti 9
60177 Brno Stred
Activity type
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 402 500
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE
Italy
EU contribution
€ 421 250
Address
Piazza San Marco 4
50121 Firenze
Activity type
Higher or Secondary Education Establishments
INSTRUCT ACADEMIC SERVICES LIMITED
United Kingdom
EU contribution
€ 152 750
Address
University Of Oxford Offices Wellington Square
OX1 2JD Oxford
Activity type
Other
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 392 250
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
LUNA SAS
France
EU contribution
€ 258 000
Address
26 Bis Rue De La Fontaine Au Roi
75011 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ISTITUTO NAZIONALE DI FISICA NUCLEARE
Italy
EU contribution
€ 344 000
Address
Via Enrico Fermi 54
00044 Frascati
Activity type
Research Organisations