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World-wide E-infrastructure for structural biology

Objective

The focus of structural biology is shifting from single macromolecules produced by simpler prokaryotic organisms, to the macromolecular machinery of higher organisms, including systems of central relevance for human health. Structural biologists are expert in one or more techniques. They now often need to use complementary techniques in which they are less expert. Instruct supports them in using multiple experimental techniques, and visiting multiple experimental facilities, within a single project.
The Protein Data Bank is a public repository for the final structure. Journals require deposition as a precondition of publication. However, metadata is often incomplete.
This project will pilot an infrastructure for storing and processing data that supports the growing use of combined techniques. There are some technique-specific pipelines for data analysis and structure determination. Little is available in terms of automated pipelines to handle integrated datasets. Integrated management of structural biology data from different techniques is lacking altogether.
The proposed activity will integrate the data management facilities that already exist, and enable the provision of new ones. The resulting integration will provide users with an overview of the experiments performed at the different research infrastructures visited, and links to the different data stores. It will extend existing facilities for processing this data. As processing is performed, it will automatically capture metadata reflecting the history of the project. The effort will use existing metadata standards, and integrate with them new domain-specific metadata terms.
This proposal will develop application level service specific to uses cases in structural biology, enabling structural biologists to get the benefit of the generic services developed by EUDAT and the EGI.

Fields of science (EuroSciVoc)

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

RIA - Research and Innovation action

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-EINFRA-2014-2015

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Coordinator

UNITED KINGDOM RESEARCH AND INNOVATION
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 780 750,00
Address
POLARIS HOUSE NORTH STAR AVENUE
SN2 1FL Swindon
United Kingdom

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Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Swindon
Activity type
Research Organisations
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 780 750,00

Participants (9)

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