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Engineering in vitro microenvironments for translation of cell-based therapies for tendon repair

Objective

Tendon Therapy Train is a research, training and innovation programme for human and equine tendon repair and regeneration that will exploit recent advancements in tissue engineering by self-assembly (TESA) technologies which have led to the clinical translation and commercialisation of advanced therapy medicinal products (ATMPs). Although TESA therapies have the potential to revolutionise healthcare for numerous clinical targets, a lack of researchers with the necessary interdisciplinary skillset to advance the field is limiting clinical translation. Tendon therapy train, a network of 8 beneficiaries and 8 partners (7 universities, 7 companies and 2 hospitals) from six countries across Europe, will train a cohort of 15 researchers to doctoral level in the interdisciplinary area of ATMPs. The innovative credentials of the research and training programme involve engineering suitable ex vivo culture environments that, by mimicking the native tendon tissue milieu (human and equine), will maintain the tenogenic phenotype of tendon derived cells and differentiate non-tendon derived cells (stem cells and dermal fibroblasts) towards the tenogenic lineage, subsequently enabling development of three-dimensional cell-assembled tissue equivalents, the clinical potential of which will be assessed in suitable preclinical models. The comprehensive Tendon Therapy Train programme will equip researchers with transferable inter- and multidisciplinary skills that will further European-based knowledge, innovation, competitiveness and leadership in the field of TESA / ATMP and ultimately enable clinical translation and commercialisation of the developed technologies.

Coordinator

NATIONAL UNIVERSITY OF IRELAND GALWAY
Net EU contribution
€ 1 062 698,40
Address
University Road
H91 Galway
Ireland

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (8)

UNIVERSIDADE DO MINHO
Portugal
Net EU contribution
€ 238 356,36
Address
Largo Do Paco
4704 553 Braga

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Region
Continente Norte Cávado
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE ROYAL VETERINARY COLLEGE
United Kingdom
Net EU contribution
€ 546 575,76
Address
Royal College Street
NW1 OTU London

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Region
London Outer London — West and North West Barnet
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITEIT MAASTRICHT
Netherlands
Net EU contribution
€ 510 748,56
Address
Minderbroedersberg 4
6200 MD Maastricht

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Region
Limburg (NL) Zuid-Limburg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SOFRADIM PRODUCTION SASU
France
Net EU contribution
€ 262 875,60
Address
Avenue De Formans 116
01600 Trevoux

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Ain
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
PANEPISTIMIO IOANNINON
Greece
Net EU contribution
€ 727 160,76
Address
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina

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Region
Ιωάννινα Ήπειρος Βόρεια Ελλάδα
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
STEMCELL TECHNOLOGIES SARL

Participation ended

France
Net EU contribution
€ 0,00
Address
Minipar Polytec Rue Des Berges 40
38000 Grenoble

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Auvergne-Rhône-Alpes Rhône-Alpes Isère
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
PROXY BIOMEDICAL LIMITED
Ireland
Net EU contribution
€ 265 674,60
Address
Coilleach Spiddal
H91 Galway

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ireland Eastern and Midland Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
STEMCELL TECHNOLOGIES UK LTD
United Kingdom
Net EU contribution
€ 262 875,60
Address
Building 7100 Cambridgde Research Park Beach Drive Waterbeach
CB25 9TL Cambridge

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
East of England East Anglia Cambridgeshire CC
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,01

Partners (7)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Galway Clinic
Ireland
Net EU contribution
€ 0,00
Address

Galway

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Aristotle University
Greece
Net EU contribution
€ 0,00
Address

Thessaloniki

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

PANEPISTIMIO THESSALIAS
Greece
Net EU contribution
€ 0,00
Address
Argonafton Filellinon
38221 Volos

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Region
Μαγνησία Θεσσαλία Κεντρική Ελλάδα
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Bose Ltd.
United Kingdom
Net EU contribution
€ 0,00
Address
Bose House, Quayside, Chatham Maritime
ME4 4QZ Chatham

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Region
South East (England) Kent Medway
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

NAMSA
France
Net EU contribution
€ 0,00
Address
Chemin De L Islon 115
38670 Chasse Sur Rhone

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Isère
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 0,00
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Cell Scale
Canada
Net EU contribution
€ 0,00
Address

Waterloo

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00