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Engineering in vitro microenvironments for translation of cell-based therapies for tendon repair

Objective

Tendon Therapy Train is a research, training and innovation programme for human and equine tendon repair and regeneration that will exploit recent advancements in tissue engineering by self-assembly (TESA) technologies which have led to the clinical translation and commercialisation of advanced therapy medicinal products (ATMPs). Although TESA therapies have the potential to revolutionise healthcare for numerous clinical targets, a lack of researchers with the necessary interdisciplinary skillset to advance the field is limiting clinical translation. Tendon therapy train, a network of 8 beneficiaries and 8 partners (7 universities, 7 companies and 2 hospitals) from six countries across Europe, will train a cohort of 15 researchers to doctoral level in the interdisciplinary area of ATMPs. The innovative credentials of the research and training programme involve engineering suitable ex vivo culture environments that, by mimicking the native tendon tissue milieu (human and equine), will maintain the tenogenic phenotype of tendon derived cells and differentiate non-tendon derived cells (stem cells and dermal fibroblasts) towards the tenogenic lineage, subsequently enabling development of three-dimensional cell-assembled tissue equivalents, the clinical potential of which will be assessed in suitable preclinical models. The comprehensive Tendon Therapy Train programme will equip researchers with transferable inter- and multidisciplinary skills that will further European-based knowledge, innovation, competitiveness and leadership in the field of TESA / ATMP and ultimately enable clinical translation and commercialisation of the developed technologies.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug
  • /medical and health sciences/medical biotechnology/tissue engineering

Call for proposal

H2020-MSCA-ITN-2015
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

NATIONAL UNIVERSITY OF IRELAND GALWAY
Address
University Road
H91 Galway
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 062 698,40

Participants (8)

UNIVERSIDADE DO MINHO
Portugal
EU contribution
€ 238 356,36
Address
Largo Do Paco
4704 553 Braga
Activity type
Higher or Secondary Education Establishments
THE ROYAL VETERINARY COLLEGE
United Kingdom
EU contribution
€ 546 575,76
Address
Royal College Street
NW1 OTU London
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 510 748,56
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
SOFRADIM PRODUCTION SASU
France
EU contribution
€ 262 875,60
Address
Avenue De Formans 116
01600 Trevoux
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PANEPISTIMIO IOANNINON
Greece
EU contribution
€ 727 160,76
Address
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina
Activity type
Higher or Secondary Education Establishments
STEMCELL TECHNOLOGIES SARL

Participation ended

France
EU contribution
€ 0
Address
Minipar Polytec Rue Des Berges 40
38000 Grenoble
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PROXY BIOMEDICAL LIMITED
Ireland
EU contribution
€ 265 674,60
Address
Coilleach Spiddal
H91 Galway
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STEMCELL TECHNOLOGIES UK LTD
United Kingdom
EU contribution
€ 262 875,60
Address
Building 7100 Cambridgde Research Park Beach Drive Waterbeach
CB25 9TL Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (7)

Galway Clinic
Ireland
Address

Galway
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Aristotle University
Greece
Address

Thessaloniki
Activity type
Higher or Secondary Education Establishments
PANEPISTIMIO THESSALIAS
Greece
Address
Argonafton Filellinon
38221 Volos
Activity type
Higher or Secondary Education Establishments
Bose Ltd.
United Kingdom
Address
Bose House, Quayside, Chatham Maritime
ME4 4QZ Chatham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NAMSA
France
Address
Chemin De L Islon 115
38670 Chasse Sur Rhone
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
Cell Scale
Canada
Address

Waterloo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)