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Engineering in vitro microenvironments for translation of cell-based therapies for tendon repair

Deliverables

IDF and patent filings

To protect intellectual property, three patents strengthening European innovation in cell-based therapy development will be filed: i) methods to differentiate dermal fibroblasts (DFs) and stem cells (BMSCs) towards tenogenic lineage; ii) methods to maintain tendon-specific function in vitro; and iii) the final tendon substitute products.

Digital media dissemination

Led by NUI Galway, digital media dissemination will include the Tendon Therapy website and dedicated project accounts on social media including twitter and linked-in. All press releases will also be issued electronically.

Ethics

provide documents linked to the ethics issues

Progress report

progress report

Mid Term review meeting

mid term review meeting

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Publications

Natural Architectures for Tissue Engineering and Regenerative Medicine

Author(s): Floris Honig, Steven Vermeulen, Amir A. Zadpoor, Jan de Boer, Lidy E. Fratila-Apachitei
Published in: Journal of Functional Biomaterials, 11/3, 2020, Page(s) 47, ISSN 2079-4983
Publisher: MDPI
DOI: 10.3390/jfb11030047

Screening as a strategy to drive regenerative medicine research

Author(s): Steven Vermeulen, Jan de Boer
Published in: Methods, 2020, ISSN 1046-2023
Publisher: Academic Press
DOI: 10.1016/j.ymeth.2020.04.004

Mechanotransduction is a context-dependent activator of TGF-β signaling in mesenchymal stem cells

Author(s): Steven Vermeulen, Nadia Roumans, Floris Honig, Aurélie Carlier, Dennie G.A.J. Hebels, Aysegul Dede Eren, Peter ten Dijke, Aliaksei Vasilevich, Jan de Boer
Published in: Biomaterials, 259, 2020, Page(s) 120331, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120331

Advancements and Challenges in Multidomain Multicargo Delivery Vehicles

Author(s): Eugenia Pugliese, João Q. Coentro, Dimitrios I. Zeugolis
Published in: Advanced Materials, 30/13, 2018, Page(s) 1704324, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201704324

Biophysics Rules the Cell Culture but Has Yet to Reach the Clinic

Author(s): Salomé Guillaumin, Ignacio Sallent, Dimitrios I. Zeugolis
Published in: Journal of the American Academy of Orthopaedic Surgeons, 25/7, 2017, Page(s) e144-e147, ISSN 1067-151X
Publisher: American Academy of Orthopaedic Surgeons
DOI: 10.5435/JAAOS-D-17-00324

Micro-Topographies Promote Late Chondrogenic Differentiation Markers in the ATDC5 Cell Line

Author(s): Bach Q. Le, Aliaksei Vasilevich, Steven Vermeulen, Frits Hulshof, Dimitrios F. Stamatialis, Clemens A. van Blitterswijk, Jan de Boer
Published in: Tissue Engineering Part A, 23/9-10, 2017, Page(s) 458-469, ISSN 1937-3341
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.TEA.2016.0421

Identification of topographical architectures supporting the phenotype of rat tenocytes

Author(s): Steven Vermeulen, Aliaksei Vasilevich, Dimitrios Tsiapalis, Nadia Roumans, Pascal Vroemen, Nick R.M. Beijer, Aysegul Dede Eren, Dimitrios Zeugolis, Jan de Boer
Published in: Acta Biomaterialia, 83, 2019, Page(s) 277-290, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2018.10.041

Current and upcoming therapies to modulate skin scarring and fibrosis

Author(s): João Q. Coentro, Eugenia Pugliese, Geoffrey Hanley, Michael Raghunath, Dimitrios I. Zeugolis
Published in: Advanced Drug Delivery Reviews, Theme issue format, 2018, Page(s) digital, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2018.08.009

Wound healing and scar wars

Author(s): Eugenia Pugliese, João Q. Coentro, Michael Raghunath, Dimitrios I. Zeugolis
Published in: Advanced Drug Delivery Reviews, 129, 2018, Page(s) 1-3, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2018.05.010

Shaping Cell Fate: Influence of Topographical Substratum Properties on Embryonic Stem Cells

Author(s): Sarita Kumari, Steven Vermeulen, Ben van der Veer, Aurélie Carlier, Jan de Boer, Deepa Subramanyam
Published in: Tissue Engineering Part B: Reviews, 24/4, 2018, Page(s) 255-266, ISSN 1937-3368
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.teb.2017.0468

Joint academic and industrial efforts towards innovative and efficient solutions for clinical needs

Author(s): Andrea De Pieri, Sofia Ribeiro, Dimitrios Tsiapalis, David Eglin, Marc Bohner, Peter Dubruel, Philip Procter, Dimitrios I. Zeugolis, Yves Bayon
Published in: Journal of Materials Science: Materials in Medicine, 29/8, 2018, ISSN 0957-4530
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10856-018-6136-3

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

Author(s): Anna Sorushanova, Luis M. Delgado, Zhuning Wu, Naledi Shologu, Aniket Kshirsagar, Rufus Raghunath, Anne M. Mullen, Yves Bayon, Abhay Pandit, Michael Raghunath, Dimitrios I. Zeugolis
Published in: Advanced Materials, 31/1, 2019, Page(s) 1801651, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201801651

Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose‐derived stem cells

Author(s): Ana I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes
Published in: Journal of Tissue Engineering and Regenerative Medicine, 13/12, 2019, Page(s) 2204-2217, ISSN 1932-6254
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/term.2967

Decellularized Porcine Achilles tendon induces anti-inflammatory macrophage phenotype in Vitro and tendon repair in vivo

Author(s): Aysegul Dede Eren, Ravi Sinha, Egemen Deniz Eren, Yuan Huipin, Sultan Gulce-Iz, Henriette Valster, Lorenzo Moroni, Jasper Foolen, Jan de Boer
Published in: Journal of Immunology and Regenerative Medicine, 8, 2020, Page(s) 100027, ISSN 2468-4988
Publisher: Elsevier
DOI: 10.1016/j.regen.2020.100027

The synergistic effect of low oxygen tension and macromolecular crowding in the development of extracellular matrix-rich tendon equivalents

Author(s): Dimitrios Tsiapalis, Andrea De Pieri, Kyriakos Spanoudes, Ignacio Sallent, Stephen Kearns, Jack L Kelly, Michael Raghunath, Dimitrios I Zeugolis
Published in: Biofabrication, 12/2, 2020, Page(s) 025018, ISSN 1758-5090
Publisher: IOP Publishing
DOI: 10.1088/1758-5090/ab6412

Hypoxia Preconditioning of Bone Marrow Mesenchymal Stem Cells Before Implantation in Orthopaedics

Author(s): Dimitrios Tsiapalis, Dimitrios I. Zeugolis
Published in: Journal of the American Academy of Orthopaedic Surgeons, 27/23, 2019, Page(s) e1040-e1042, ISSN 1067-151X
Publisher: American Academy of Orthopaedic Surgeons
DOI: 10.5435/jaaos-d-19-00044

The cytokine secretion profile of mesenchymal stromal cells is determined by surface structure of the microenvironment

Author(s): Daniëlle G. Leuning, Nick R. M. Beijer, Nadia A. du Fossé, Steven Vermeulen, Ellen Lievers, Cees van Kooten, Ton J. Rabelink, Jan de Boer
Published in: Scientific Reports, 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-25700-5

Translational Research Symposium—collaborative efforts as driving forces of healthcare innovation

Author(s): João Q. Coentro, Andrea De Pieri, Diana Gaspar, Dimitrios Tsiapalis, Dimitrios I. Zeugolis, Yves Bayon
Published in: Journal of Materials Science: Materials in Medicine, 30/12, 2019, ISSN 0957-4530
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10856-019-6339-2

ISEV2018 abstract book

Author(s): Clotilde Théry, Kenneth Witwer
Published in: Journal of Extracellular Vesicles, 7/sup1, 2018, Page(s) 1461450, ISSN 2001-3078
Publisher: US
DOI: 10.1080/20013078.2018.1461450

Local pharmacological induction of angiogenesis: Drugs for cells and cells as drugs

Author(s): Diana Gaspar, Rita Peixoto, Andrea De Pieri, Britta Striegl, Dimitrios I. Zeugolis, Michael Raghunath
Published in: Advanced Drug Delivery Reviews, 146, 2019, Page(s) 126-154, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2019.06.002

British Society for Matrix Biology Spring 2019 Meeting: “Stroma, Niche, Repair”

Author(s): Gifford. V., et. at.,
Published in: International Journal of Experimental Pathology, 100/4, 2019, ISSN 0959-9673
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/iep.12332

Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation

Author(s): Vassey, Matthew J.; Figueredo, Grazziela P.; Scurr, David; Vasilevich, Aliaksei S.; Vermeulen, Steven; Carlier, Aurélie; Luckett, Jeni; Beijer, Nick R.M.; Williams, Paul; Winkler, Dave; de Boer, Jan; Ghaemmaghami, Amir M.; Alexander, Morgan R.
Published in: Advanced Science, 2020, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.201903392

Seaweed polysaccharides as macromolecular crowding agents

Author(s): Andrea De Pieri, Shubhasmin Rana, Stefanie Korntner, Dimitrios I. Zeugolis
Published in: International Journal of Biological Macromolecules, 164, 2020, Page(s) 434-446, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2020.07.087

Bioreactors for Tendon Tissue Engineering

Author(s): Ana I. Gonçalves
Published in: Bioreactors for Stem Cell Expansion and Differentiation, 2018, Page(s) 269-300, ISBN 9780-429453144
Publisher: CRC Press
DOI: 10.1201/9780429453144-10

Preparation and Characterization of Tissue Surrogates Rich in Extracellular Matrix Using the Principles of Macromolecular Crowding

Author(s): Adrian Djalali-Cuevas, Sergio Garnica-Galvez, Andrea Rampin, Diana Gaspar, Ioannis Skoufos, Athina Tzora, Nikitas Prassinos, Nikolaos Diakakis, Dimitrios I. Zeugolis
Published in: The Extracellular Matrix - Methods and Protocols, 1952, 2019, Page(s) 245-259, ISBN 978-1-4939-9132-7
Publisher: Springer New York
DOI: 10.1007/978-1-4939-9133-4_20

Designing Microenvironments for Optimal Outcomes in Tissue Engineering and Regenerative Medicine: From Biopolymers to Culturing Conditions

Author(s): Dimitrios Tsiapalis, Sofia Ribeiro, Andrea De Pieri, Ignacio Sallent, Salomé Guillaumin, Diana Gaspar, Stefanie Korntner, Yves Bayon, Manuela E. Gomes, Rui L. Reis, Dimitrios I. Zeugolis
Published in: Reference Module in Biomedical Sciences, 2019, ISBN 9780-128012383
Publisher: Elsevier
DOI: 10.1016/b978-0-12-801238-3.11140-7

Scaffolds for tendon tissue engineering

Author(s): Héctor Capella-Monsonís, Salomé Guillaumin, Sofia Ribeiro, Stefanie Korntner, Yves Bayon, Dimitrios I. Zeugolis
Published in: Handbook of Tissue Engineering Scaffolds: Volume One, 2019, Page(s) 259-298, ISBN 9780-081025635
Publisher: Elsevier
DOI: 10.1016/b978-0-08-102563-5.00013-7

The effect of aligned electrospun fibers and macromolecular crowding in tenocyte culture

Author(s): Dimitrios Tsiapalis, Shubhasmin Rana, Meletios Doulgkeroglou, Stephen Kearns, Jack Kelly, Yves Bayon, Dimitrios I. Zeugolis
Published in: Methods in Cell Biology, 2019
Publisher: Elsevier
DOI: 10.1016/bs.mcb.2019.11.003

Production and Characterization of Chemically Cross-Linked Collagen Scaffolds

Author(s): Ignacio Sallent, Héctor Capella-Monsonís, Dimitrios I. Zeugolis
Published in: Collagen - Methods and Protocols, 1944, 2019, Page(s) 23-38, ISBN 978-1-4939-9094-8
Publisher: Springer New York
DOI: 10.1007/978-1-4939-9095-5_3

Concept Design of a New Portable Medical Device for Lymphedema Monitoring: A EIT Health ClinMed Summer School Project

Author(s): Jordi Tisaire, Elena Rodrigo, Sofia Ribeiro, Mariachiara Ricci, Juan Cuellar, Dimitrios Zeugolis, Yves Bayon, Isabel Rocha
Published in: Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies, 2019, Page(s) 611-620, ISBN 978-989-758-353-7
Publisher: SCITEPRESS - Science and Technology Publications
DOI: 10.5220/0007696706110620

Design and Characterization of Synthetic Biodegradable Films for Soft Tissue Engineering

Author(s): Ribeiro, S.; Fernandes, E.; Gomes, M.; Reis, R.; Bayon, Y. and Zeugolis, D.
Published in: Doctoral Consortium - Volume 1: DCBIOSTEC, 2019, Page(s) 28-32
Publisher: DCBIOSTEC

Empowering Translation of New Ideas - A EIT Health ClinMed Summer School Overview

Author(s): Sofia Ribeiro, Mariachiara Ricci, Albert Von Der Lieth, Yves Bayon, Dimitrios Zeugolis, Sylvia Pelayo, Isabelle Marque, Lionel Pazart
Published in: Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies, 2019, Page(s) 603-610, ISBN 978-989-758-353-7
Publisher: SCITEPRESS - Science and Technology Publications
DOI: 10.5220/0007696606030610