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Engineering in vitro microenvironments for translation of cell-based therapies for tendon repair

Obiettivo

Tendon Therapy Train is a research, training and innovation programme for human and equine tendon repair and regeneration that will exploit recent advancements in tissue engineering by self-assembly (TESA) technologies which have led to the clinical translation and commercialisation of advanced therapy medicinal products (ATMPs). Although TESA therapies have the potential to revolutionise healthcare for numerous clinical targets, a lack of researchers with the necessary interdisciplinary skillset to advance the field is limiting clinical translation. Tendon therapy train, a network of 8 beneficiaries and 8 partners (7 universities, 7 companies and 2 hospitals) from six countries across Europe, will train a cohort of 15 researchers to doctoral level in the interdisciplinary area of ATMPs. The innovative credentials of the research and training programme involve engineering suitable ex vivo culture environments that, by mimicking the native tendon tissue milieu (human and equine), will maintain the tenogenic phenotype of tendon derived cells and differentiate non-tendon derived cells (stem cells and dermal fibroblasts) towards the tenogenic lineage, subsequently enabling development of three-dimensional cell-assembled tissue equivalents, the clinical potential of which will be assessed in suitable preclinical models. The comprehensive Tendon Therapy Train programme will equip researchers with transferable inter- and multidisciplinary skills that will further European-based knowledge, innovation, competitiveness and leadership in the field of TESA / ATMP and ultimately enable clinical translation and commercialisation of the developed technologies.

Invito a presentare proposte

H2020-MSCA-ITN-2015
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Coordinatore

NATIONAL UNIVERSITY OF IRELAND, GALWAY
Indirizzo
University Road
H91 Galway
Irlanda
Tipo di attività
Higher or Secondary Education Establishments
Contributo UE
€ 1 062 698,40

Partecipanti (8)

UNIVERSIDADE DO MINHO
Portogallo
Contributo UE
€ 238 356,36
Indirizzo
Largo Do Paco
4704 553 Braga
Tipo di attività
Higher or Secondary Education Establishments
THE ROYAL VETERINARY COLLEGE
United Kingdom
Contributo UE
€ 546 575,76
Indirizzo
Royal College Street
NW1 OTU London
Tipo di attività
Higher or Secondary Education Establishments
UNIVERSITEIT MAASTRICHT
Paesi Bassi
Contributo UE
€ 510 748,56
Indirizzo
Minderbroedersberg 4
6200 MD Maastricht
Tipo di attività
Higher or Secondary Education Establishments
SOFRADIM PRODUCTION SASU
Francia
Contributo UE
€ 262 875,60
Indirizzo
Avenue De Formans 116
01600 Trevoux
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PANEPISTIMIO IOANNINON
Greece
Contributo UE
€ 727 160,76
Indirizzo
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina
Tipo di attività
Higher or Secondary Education Establishments
STEMCELL TECHNOLOGIES SARL

Partecipazione conclusa

Francia
Contributo UE
€ 0
Indirizzo
Minipar Polytec Rue Des Berges 40
38000 Grenoble
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PROXY BIOMEDICAL LIMITED
Irlanda
Contributo UE
€ 265 674,60
Indirizzo
Coilleach Spiddal
H91 Galway
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STEMCELL TECHNOLOGIES UK LTD
United Kingdom
Contributo UE
€ 262 875,60
Indirizzo
Building 7100 Cambridgde Research Park Beach Drive Waterbeach
CB25 9TL Cambridge
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partner (7)

Galway Clinic
Irlanda
Indirizzo

Galway
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Aristotle University
Greece
Indirizzo

Thessaloniki
Tipo di attività
Higher or Secondary Education Establishments
PANEPISTIMIO THESSALIAS
Greece
Indirizzo
Argonafton Filellinon
38221 Volos
Tipo di attività
Higher or Secondary Education Establishments
Bose Ltd.
United Kingdom
Indirizzo
Bose House, Quayside, Chatham Maritime
ME4 4QZ Chatham
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NAMSA
Francia
Indirizzo
Chemin De L Islon 115
38670 Chasse Sur Rhone
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germania
Indirizzo
Hansastrasse 27C
80686 Munchen
Tipo di attività
Research Organisations
Cell Scale
Canada
Indirizzo

Waterloo
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)