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Exploiting Glycosylation of Colorectal Cancer for the development of improved diagnostics and therapeutics

Objective

Colorectal cancer (CRC) is a major worldwide cancer burden with about 1.4 million cases in 2012 and an annual mortality of approximately 700,000. Early detection is crucial as treatment is most efficient in early stages where population based screenings could substantially reduce incidence and mortality.
Current screening techniques are invasive or lack sensitivity and specificity. Moreover, the molecular mechanisms leading to the formation of different antigens suggested as CRC biomarkers and potential therapeutic targets are poorly understood, especially with regard to carbohydrate-based molecules, such as glycans. Enhancing our understanding of the structure-function relationship of glycosylation in CRC could lead to the discovery of improved diagnostic and prognostic biomarkers and pave the way for nov-el therapeutic targets.
Building on an established network of analysts with many years of experience in (glyco)proteomics and biomarker research, in collaboration with colleagues in the field of glycobiology and glyco-immunology, GlyCoCan will develop new methods, and use current state of the art methods, to investigate the role of glycosylation in many different aspects of CRC.
The GlyCoCan multi-disciplinary network will principally be a training programme with a substantial industrial focus on technology transfer and teaching of internationally adopted biopharma regulations (GMP, ISO9001, ICH guidelines). The underlying specific research objectives will be addressed within individual ESR projects, giving rise to a generation of ESRs whose main focus is investigating and tackling the challenges of the role of glycosylation within CRC and other diseases.
The network will address the currently unmet need for glycosylation researchers with an inter-disciplinary perspective to fully exploit the immense potential of the young scientific field of glyco-oncology and to set them on a path to successful and productive careers in academic and industrial collaborations.

Field of science

  • /social sciences/sociology/demography/mortality
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /social sciences/educational sciences/pedagogy/teaching
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /medical and health sciences/clinical medicine/oncology/cancer/colorectal cancer

Call for proposal

H2020-MSCA-ITN-2015
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

ACADEMISCH ZIEKENHUIS LEIDEN
Address
Albinusdreef 2
2333 ZA Leiden
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 628 470,95

Participants (9)

LUDGER LIMITED
United Kingdom
EU contribution
€ 273 287,88
Address
Culham Science Centre - Building E1
OX14 3EB Abingdon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GENOS DOO ZA VJESTACENJE I ANALIZU
Croatia
EU contribution
€ 371 641,50
Address
Vatrogasna 112
31000 Osijek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 249 216,48
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 525 751,20
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
STICHTING VU
Netherlands
EU contribution
€ 255 374,28
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 258 061,32
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
UNIVERSIDADE NOVA DE LISBOA

Participation ended

Portugal
EU contribution
€ 0
Address
Campus De Campolide
1099 085 Lisboa
Activity type
Higher or Secondary Education Establishments
NOVA ID FCT - ASSOCIACAO PARA A INOVACAO E DESENVOLVIMENTO DA FCT
Portugal
EU contribution
€ 476 712,72
Address
Campus De Caparica Faculdade De Ciencias E Tecnologia Da Universidade Nova De Lisboa
2829 516 Caparica
Activity type
Research Organisations
STICHTING VUMC
Netherlands
EU contribution
€ 255 374,28
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations

Partners (7)

Postdoc Career Development Forum BV
Netherlands
Address
Hooghiemstraplein 144
3508SB Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ROCHE DIAGNOSTICS GMBH
Germany
Address
Sandhofer Strasse 116
68305 Mannheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUTO PORTUGUES DE ONCOLOGIA DO PORTO FRANCISCO GENTIL, EPE
Portugal
Address
Rua Antonio Bernardino Almeida
4200-072 Porto
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA
Portugal
Address
Avenida Da Republica Quinta Do Marques
2781-901 Oeiras
Activity type
Research Organisations
DC4U
Netherlands
Address
De Corridor 21E
3621 ZA Breukelen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITATSKLINIKUM SCHLESWIG-HOLSTEIN
Germany
Address
Ratzeburger Allee 160
23562 Lübeck
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAET WIEN
Austria
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments