Exploiting Glycosylation of Colorectal Cancer for the development of improved diagnostics and therapeutics

Deliverables

Website established
Completion of theses

Completion of doctoral theses of the GlyCoCan ESRs

Publications

Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect Hematopoietic Differentiation

Author(s): Di Wang, Tao Zhang, Katarina Madunić, Antonius A. de Waard, Constantin Blöchl, Oleg A. Mayboroda, Marieke Griffioen, Robbert M. Spaapen, Christian G. Huber, Guinevere S.M. Lageveen-Kammeijer, and Manfred Wuhrer
Published in: Journal of proteome Research, 2022, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.1c00911

Characterization of Macrophage Galactose-type Lectin (MGL) ligands in colorectal cancer cell lines

Author(s): Martina Pirro; Yoann Rombouts; Alexandre Stella; Olivier Neyrolles; Odile Burlet-Schiltz; Sandra J. van Vliet; Arnoud H. de Ru; Yassene Mohammed; Manfred Wuhrer; Peter A. van Veelen; Paul J. Hensbergen
Published in: "Biochimica et Biophysica Acta (BBA) - General Subjects, Elsevier, 2020, 1864 (4), pp.129513. ⟨10.1016/j.bbagen.2020.129513⟩", Issue 7, 2020, ISSN 1872-8006
Publisher: Elsevier
DOI: 10.1016/j.bbagen.2020.129513

Serum protein N-glycosylation changes in multiple myeloma

Author(s): Zejian Zhang, Marita Westhrin, Albert Bondt, Manfred Wuhrer, Therese Standal, Stephanie Holst
Published in: Biochimica et Biophysica Acta, 2019, ISSN 0006-3002
Publisher: Elsevier
DOI: 10.1016/j.bbagen.2019.03.001

A Glycan Array-Based Assay for the Identification and Characterization of Plant Glycosyltransferases.

Author(s): Colin Ruprecht; Colin Ruprecht; Max Peter Bartetzko; Max Peter Bartetzko; Deborah Senf; Deborah Senf; Anna Lakhina; Peter J. Smith; Maria J. Soto; Maria J. Soto; Hyunil Oh; Hyunil Oh; Jeong-Yeh Yang; Digantkumar Chapla; Daniel Varón Silva; Mads Hartvig Clausen; Michael G. Hahn; Kelley W. Moremen; Breeanna R. Urbanowicz; Fabian Pfrengle; Fabian Pfrengle; Fabian Pfrengle
Published in: Angewandte Chemie, Issue 1, 2020, ISSN 0044-8249
Publisher: Weinheim-Wiley-VCH
DOI: 10.1002/ange.202003105

Comprehensive N-glycosylation analysis of immunoglobulin G from dried blood spots

Author(s): Jelena Simunovic, Marija Vilaj, Irena Trbojevic-Akmacic, Ana Momcilovic, Frano Vuckovic, Ivan Gudelj, Julija Juric, Natali Nakic, Gordan Lauc, Marija Pezer
Published in: Glycobiology, 2019, ISSN 1460-2423
Publisher: Oxford Academic
DOI: 10.1093/glycob/cwz061

OGT Controls the Expression and the Glycosylation of E-cadherin, and Affects Glycosphingolipid Structures in Human Colon Cell Lines

Author(s): James Biwi,Charlotte Clarisse,Christophe Biot,Radoslaw Pawel Kozak,Katarina Madunic,Marlène Mortuaire,Manfred Wuhrer,Daniel Ian Richard Spencer,Céline Schulz,Yann Guerardel,Tony Lefebvre,Anne-Sophie Vercoutter-Edouart
Published in: Proteomics, 2019, ISSN 1615-9853
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.201800452

The Role of Glycosphingolipids in Immune Cell Functions.

Author(s): Tao Zhang; Antonius A. de Waard; Antonius A. de Waard; Manfred Wuhrer; Robbert M. Spaapen; Robbert M. Spaapen
Published in: Frontiers in Immunology, Vol 10 (2019), Issue 1, 2019, ISSN 1664-3224
Publisher: Frontiers Editorial Office
DOI: 10.3389/fimmu.2019.00090

Colorectal cancer cell lines show striking diversity of their O- glycome reflecting the cellular differentiation phenotype

Author(s): Katarina Madunić; Tao Zhang; Oleg A. Mayboroda; Stephanie Holst; Kathrin Stavenhagen; Chunsheng Jin; Niclas G. Karlsson; Guinevere S. M. Lageveen-Kammeijer; Manfred Wuhrer
Published in: Cellular and Molecular Life Sciences, Issue 10, 2020, ISSN 0014-4754
Publisher: Spinger-Link
DOI: 10.1007/s00018-020-03504-z

Plasma N-glycome composition associates with chronic low back pain

Author(s): IrenaTrbojević-AkmačićaFranoVučkovićaMarijaVilajaAndreaSkelinakLennart C.KarssenbJasminkaKrištićaJulijaJurićaAnaMomčilovićacJelenaŠimunovićaMassimoManginodeManuelaDe GregorifgMaurizioMarchesinighConcettaDagostinogiJerkoŠtambukaMislavNovokmetaRichardRauckjYurii S.AulchenkobDraganPrimoracklmnoLeonardoKapuraljKlaasBuysepDieterMesottenpFrances M.K.WilliamsdJanvan ZundertpMassimoAllegrigqG
Published in: Biochimica et Biophysica Acta (BBA), 2018, ISSN 0006-3002
Publisher: Science Direct
DOI: 10.1016/j.bbagen.2018.07.003

Site-Specific N-Linked Glycosylation Analysis of Human Carcinoembryonic Antigen by Sheathless Capillary Electrophoresis-Tandem Mass Spectrometry

Author(s): Laura Pont; Valeriia Kuzyk; Valeriia Kuzyk; Fernando Benavente; Victoria Sanz-Nebot; Oleg A. Mayboroda; Manfred Wuhrer; Guinevere S. M. Lageveen-Kammeijer
Published in: VOLUME=20;ISSUE=3;STARTPAGE=1666;ENDPAGE=1675;ISSN=1535-3893;TITLE=Journal of Proteome Research, Issue 1, 2021, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.0c00875

Oxonium Ion Guided Analysis of Quantitative Proteomics Data Reveals Site-Specific O-Glycosylation of Anterior Gradient Protein 2 (AGR2)

Author(s): Martina Pirro, Yassene Mohammed, Arnoud H. de Ru, George M. C. Janssen, Rayman T. N. Tjokrodirijo, Katarina Madunić, Manfred Wuhrer, Peter A. van Veelen, Paul J. Hensbergen
Published in: International Journal of Molecular Sciences, Issue 22/10, 2021, Page(s) 5369, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105369

Colon-specific immune microenvironment regulates cancer progression versus rejection

Author(s): Giulia Trimaglio; Anne-Françoise Tilkin-Mariamé; Virginie Feliu; Françoise Lauzeral-Vizcaino; Marie Tosolini; Carine Valle; Maha Ayyoub; Maha Ayyoub; Olivier Neyrolles; Nathalie Vergnolle; Yoann Rombouts; Christel Devaud
Published in: OncoImmunology, Issue 7, 2020, ISSN 2162-4011
Publisher: Landes Bioscience
DOI: 10.1101/2020.01.02.892711

The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations

Author(s): JN Liu, M Dolikun, J Štambuk, I Trbojević-Akmačić, J Zhang, H Wang, DQ Zheng, XY Zhang, HL Peng, ZY Zhao, D Liu, Y Sun, Q Sun, QH Li, JX Zhang, M Sun, WJ Cao, A Momčilović, G. Razdorov, LJ Wu, A Russell, YX Wang, MS Song, G Lauc & W Wang
Published in: Journal of human hypertention, 2018, ISSN 0950-9240
Publisher: Nature Publishing Group
DOI: 10.1038/s41371-018-0071-0

A computer-aided drug design approach to discover tumour suppressor p53 protein activators for colorectal cancer therapy

Author(s): Rui P.S.Patrício, Paula A.Videira, Florbela Pereira
Published in: BIOORGANIC & MEDICINAL CHEMISTRY, 2022, ISSN 0968-0896
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2021.116530

A Glycan Array‐Based Assay for the Identification and Characterization of Plant Glycosyltransferases

Author(s): Colin Ruprecht, Max P. Bartetzko, Deborah Senf, Anna Lakhina, Peter J. Smith, Maria J. Soto, Hyunil Oh, Jeong‐Yeh Yang, Digantkumar Chapla, Daniel Varon Silva, Mads H. Clausen, Michael G. Hahn, Kelley W. Moremen, Breeanna R. Urbanowicz, Fabian Pfrengle
Published in: Angewandte Chemie, Issue 132/30, 2020, Page(s) 12593-12598, ISSN 0044-8249
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202003105

Glycoproteomic Analysis of MGL-Binding Proteins on Acute T-Cell Leukemia Cells.

Author(s): Pirro, Martina; Schoof, Esmee; van Vliet, Sandra J.; Rombouts, Yoann; Stella, Alexandre; de Ru, Arnoud; Mohammed, Yassene; Wuhrer, Manfred; van Veelen, Peter A.; Hensbergen, Paul J.
Published in: VOLUME=18;ISSUE=3;STARTPAGE=1125;ENDPAGE=1132;ISSN=1535-3893;TITLE=Journal of Proteome Research, Issue 16, 2018, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.8b00796

Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells

Author(s): Joost C van der Horst, Henri J van de Vrugt, Hakan Kalay, Daniel I R Spencer, Rad P Kozak, Sandra J van Vliet
Published in: Glycobiology, 2018, ISSN 0959-6658
Publisher: Oxford University Press
DOI: 10.1093/glycob/cwy096

The Sda Synthase B4GALNT2 Reduces Malignancy and Stemness in Colon Cancer Cell Lines Independently of Sialyl Lewis X Inhibition

Author(s): Michela Pucci; Inês Gomes Ferreira; Nadia Malagolini; Manuela Ferracin; Fabio Dall'Olio
Published in: Issue 18, Issue 1, 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21186558

High Expression of the Sda Synthase B4GALNT2 Associates with Good Prognosis and Attenuates Stemness in Colon Cancer

Author(s): Michela Pucci; Inês Gomes Ferreira; Martina Orlandani; Nadia Malagolini; Manuela Ferracin; Fabio Dall'Olio
Published in: Cells, Vol 9, Iss 948, p 948 (2020), Issue 2, 2020, ISSN 2073-4409
Publisher: Cells
DOI: 10.3390/cells9040948

Method comparison for N-glycan profiling: Towards the standardization of glycoanalytical technologies for cell line analysis.

Author(s): Kotsias, Maximilianos; Blanas, Athanasios; van Vliet, Sandra J.; Pirro, Martina; Spencer, Daniel I. R.; Kozak, Radoslaw P.
Published in: Plos One, Issue 1, 2019, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0223270

Dopant-Enriched Nitrogen Gas for Enhanced Electrospray Ionization of Released Glycans in Negative Ion Mode.

Author(s): Katarina Madunić; Sander Wagt; Tao Zhang; Manfred Wuhrer; Guinevere S. M. Lageveen-Kammeijer
Published in: VOLUME=93;ISSUE=18;STARTPAGE=6919;ENDPAGE=6923;TITLE=Analytical Chemistry, Issue 8, 2021, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.1c00023

O- and N-glycosylation analysis of cell lines by ultrahigh resolution MALDI-FTICR-MS

Author(s): Gerda C M Vreeker; Simone Nicolardi; Katarina Madunić; Maximilianos Kotsias; Yuri E. M. van der Burgt; Manfred Wuhrer
Published in: International Journal of Mass Spectrometry, Issue 1, 2020, ISSN 1873-2798
Publisher: Amsterdam Elsevier B>V>
DOI: 10.1016/j.ijms.2019.116267

MHC Class I Stability is Modulated by Cell Surface Sialylation in Human Dendritic Cells

Author(s): Zélia Silva; Tiago Ferro; Danielle Almeida; Helena Soares; José Alexandre Ferreira; Fanny M. Deschepper; Paul J. Hensbergen; Martina Pirro; Sandra J. van Vliet; Sebastian Springer; Paula A. Videira
Published in: Pharmaceutics, Issue 12, 2020, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12030249

Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apoptosis

Author(s): Lenneke A.M. Cornelissen,Athanasios Blanas,Joost C. van der Horst,Laura Kruijssen,Anouk Zaal,Tom O'Toole,Lieke Wiercx,Yvette van Kooyk,Sandra J. van Vliet
Published in: International journal of cancer, 2018, ISSN 1097-0215
Publisher: Wiley Online Library
DOI: 10.1002/ijc.32084

Development of a 96-well plate sample preparation method for integrated N- and O-glycomics using porous graphitized carbon liquid chromatography-mass spectrometry.

Author(s): Tao Zhang; Katarina Madunić; Stephanie Holst; Jing Zhang; Chunsheng Jin; Peter ten Dijke; Niclas G. Karlsson; Kathrin Stavenhagen; Manfred Wuhrer
Published in: Molecular Omics, Issue 1, 2020, ISSN 2515-4184
Publisher: The Royal Society of Chemistry’s
DOI: 10.1039/c9mo00180h

A semi-automated, high throughput approach for O-glycosylation profiling of in vitro established cancer cell lines by MALDI-FT-ICR MS

Author(s): Maximilianos Kotsias; Katarina Madunić; Simone Nicolardi; Radoslaw P. Kozak; Richard A. Gardner; Bas C. Jansen; Daniel I. R. Spencer; Manfred Wuhrer
Published in: Glycoconjugate Journal, Issue 15, 2021, ISSN 0282-0080
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10719-021-10003-1

Histo-blood group glycans in the context of personalized medicine

Author(s): Viktoria Dotz, Manfred Wuhrer
Published in: Biochimica et Biophysica Acta (BBA) - General Subjects, Issue 1860/8, 2016, Page(s) 1596-1607, ISSN 0304-4165
Publisher: Elsevier BV
DOI: 10.1016/j.bbagen.2015.12.026

IgG Glycome in Colorectal Cancer

Author(s): F. Vuckovic, E. Theodoratou, K. Thaci, M. Timofeeva, A. Vojta, J. Stambuk, M. Pucic-Bakovic, P. M. Rudd, L. erek, D. Servis, A. Wennerstro m, S. M. Farrington, M. Perola, Y. Aulchenko, M. G. Dunlop, H. Campbell, G. Lauc
Published in: Clinical Cancer Research, Issue 22/12, 2016, Page(s) 3078-3086, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-15-1867

Mechanisms of disease: The human N-glycome

Author(s): Gordan Lauc, Marija Pezer, Igor Rudan, Harry Campbell
Published in: Biochimica et Biophysica Acta (BBA) - General Subjects, Issue 1860/8, 2016, Page(s) 1574-1582, ISSN 0304-4165
Publisher: Elsevier BV
DOI: 10.1016/j.bbagen.2015.10.016

Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue

Author(s): Mylène A. Carrascal, Catarina Talina, Paula Borralho, A. Gonçalo Mineiro, Ana Raquel Henriques, Cláudia Pen, Manuela Martins, Sofia Braga, Robert Sackstein, Paula A. Videira
Published in: BMC Cancer, Issue 18/1, 2018, ISSN 1471-2407
Publisher: BioMed Central
DOI: 10.1186/s12885-018-4410-x

Glycosylation as a Main Regulator of Growth and Death Factor Receptors Signaling

Author(s): Inês Gomes Ferreira, Michela Pucci, Giulia Venturi, Nadia Malagolini, Mariella Chiricolo and Fabio Dall’Olio
Published in: International Journal of Molecular Sciences, Issue 19/2, 2018, Page(s) 580, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19020580

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

Author(s): Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto Rodríguez, Yvette van Kooyk, Sandra J. van Vliet
Published in: Frontiers in Oncology, Issue 8, 2018, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00039

Serum sialylation changes in cancer

Author(s): Zejian Zhang, Manfred Wuhrer, Stephanie Holst
Published in: Glycoconjugate Journal, Issue 35/2, 2018, Page(s) 139-160, ISSN 0282-0080
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10719-018-9820-0

Simultaneous Immunoglobulin A and G Glycopeptide Profiling for High-Throughput Applications

Author(s): Ana Momčilović; Noortje de Haan; Agnes L. Hipgrave Ederveen; Albert Bondt; Carolien A. M. Koeleman; David Falck; Louise A. de Neef; Wilma E. Mesker; Rob A. E. M. Tollenaar; Arnoud H. de Ru; Peter A. van Veelen; Manfred Wuhrer; Viktoria Dotz
Published in: Analytical Chemistry, Issue 1, 2020, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.9b05722

FUT9-Driven Programming of Colon Cancer Cells towards a Stem Cell-Like State

Author(s): Athanasios Blanas, Anouk Zaal , Irene van der Haar Àvila , Maxime Kempers , Laura Kruijssen, Mike de Kok , Marko A. Popovic, Joost C. van der Horst and Sandra J. van Vliet
Published in: Cancers, 2020, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092580

N-Glycoproteins Have a Major Role in MGL Binding to Colorectal Cancer Cell Lines: Associations with Overall Proteome Diversity

Author(s): Martina Pirro; Yassene Mohammed; Sandra J. van Vliet; Yoann Rombouts; Agnese Sciacca; Arnoud H. de Ru; George M.C. Janssen; Rayman T. N. Tjokrodirijo; Manfred Wuhrer; Peter A. van Veelen; Paul J. Hensbergen
Published in: VOLUME=21;ISSUE=15;STARTPAGE=1;ENDPAGE=13;ISSN=1661-6596;TITLE=International Journal of Molecular Sciences, Issue 1, 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21155522

Improved and semi-automated reductive β-elimination workflow for higher throughput protein O-glycosylation analysis.

Author(s): Kotsias, Maximilianos; Kozak, Radoslaw P.; Gardner, Richard A.; Wuhrer, Manfred; Spencer, Daniel I. R.
Published in: PLoS ONE, Issue 2, 2019, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0210759

Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer

Author(s): Lenneke A. M. Cornelissen, Athanasios Blanas†, Anouk Zaal†, Joost C. van der Horst, Laura J. W. Kruijssen, Tom O’Toole, Yvette van Kooyk and Sandra J. van Vliet*
Published in: FRONTIERS IN ONCOLOGY, 2020, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.01622

High-throughput immunoaffinity enrichment and N-glycan analysis of human plasma haptoglobin

Author(s): Šimunović, Jelena; Gašperšič, Jernej; Černigoj, Urh; Vidič, Jana; Štrancar, Aleš; Novokmet, Mislav; Razdorov, Genadij; Pezer, Marija; Lauc, Gordan; Trbojević-Akmačić, Irena
Published in: Biotechnology and Bioengineering, 2022, ISSN 0006-3592
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.28280

L1CAM as an E-selectin Ligand in Colon Cancer

Author(s): Fanny M. Deschepper; Roberta Zoppi; Martina Pirro; Paul J. Hensbergen; Fabio Dall'Olio; Maximillianos Kotsias; Richard A. Gardner; Daniel I. R. Spencer; Paula A. Videira
Published in: International Journal of Molecular Sciences, 21(21). MDPI, Issue 11, 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21218286

Dopant-Enriched Nitrogen Gas for Enhanced Electrospray Ionization of Released Glycans in Negative Ion Mode

Author(s): Katarina Madunić, Sander Wagt, Tao Zhang, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer
Published in: Analytical Chemistry, Issue 93/18, 2021, Page(s) 6919-6923, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.1c00023

Impact of sialyltransferase ST6GAL1 overexpression on different colon cancer cell types.

Author(s): Venturi, Giulia; Gomes Ferreira, Inês; Pucci, Michela; Ferracin, Manuela; Malagolini, Nadia; Chiricolo, Mariella; Dall’Olio, Fabio
Published in: Glycobiology, Issue 11, 2019, ISSN 1460-2423
Publisher: Oxford Academic
DOI: 10.1093/glycob/cwz053

The Many Ways by Which O -GlcNAcylation May Orchestrate the Diversity of Complex Glycosylations.

Author(s): Biwi, James; Biot, Christophe; Guerardel, Yann; Vercoutter-Edouart, Anne-Sophie; Lefebvre, Tony
Published in: "Molecules, MDPI, 2018, 23 (11), pp.2858. ⟨10.3390/molecules23112858⟩", Issue 1, 2018, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23112858

UNRAVELING MUCIN TYPE OGLYCOSYLATIONSIGNATURESOF COLORECTAL CANCER

Author(s): Katarina Madunic
Published in: 2022, ISBN 978-94-6458-073-0
Publisher: Ridderprint

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