Project description
Overcoming complex fluid challenges
In an era increasingly reliant on complex (bio-)chemical measurements, current analytical capabilities fall short. The proteomics field, for instance, requires the separation of tens of thousands of components, surpassing existing tools’ limits. Liquid chromatography, the primary technique for molecule separation, faces obstacles in transporting molecules between support structures at sufficient speeds. To address this critical challenge, the EVODIS project seeks to accelerate mass transport laterally, surpassing diffusion alone. Through the creation of microstructure arrays and local electrodes in a pressure-driven column, EVODIS will generate anisotropic vortex flows to enhance local mass transfer. This approach holds wider implications for diverse flow systems. Anisotropic vortex flows will offer benefits in mixing, anti-fouling, enhanced mass transfer, and emulsification applications.
Objective
The 21st century is expected to develop towards a society depending ever and ever more on (bio-)chemical measurements of fluids and matrices that are so complex they are well beyond the current analytical capabilities. Incremental improvements can no longer satisfy the current needs of e.g. the proteomics field, requiring the separation of tens of thousands of components. The pace of progress in these fields is therefore predominantly determined by that of analytical tools, whereby liquid chromatography is the most prominent technique to separate small molecules as well as macromolecules, based on differential interaction of each analyte with support structures giving it a unique migration velocity. To improve its performance, a faster transport between these structures needs to be generated. Unfortunately the commonly pursued strategy, relying on diffusion and reducing the structure size, has come to its limits due to practical limitations related to packing and fabrication of sub-micron support structures, pressure tolerance and viscous heating.
A ground-breaking step to advance chromatographic performance to another level would be to accelerate mass transport in the lateral direction, beyond the rate of diffusion only. To meet this requirement, an array of microstructures and local electrodes can be defined to create lateral electroosmotic vortices in a pressure-driven column, aiming to accelerate the local mass transfer in an anisotropic fashion. The achievement of ordered arrays of vortices is intimately linked to this requirement, which is also of broader importance for mixing, anti-fouling of membrane and reactor surfaces, enhanced mass transfer in reactor channels, emulsification, etc. Understanding and implementing anisotropic vortex flows will therefore not only revolutionize analytical and preparative separation procedures, but will also be highly relevant in all flow systems that benefit from enhanced mass transfer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences physical sciences acoustics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-STG - Starting Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2015-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1050 BRUSSEL
Belgium
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