Skip to main content

Characterizing Adaptation and Migration Events with Modern and Ancient Genomes

Obiettivo

BACKGROUND Ancient DNA research has recently entered the genomics era. Performing
“ancient population genomics” is now technically possible. Utilizing the temporal aspect of this
new data, we can address fundamental evolutionary questions such as the amount of selection
acting on the genome or the mode and tempo of the colonization of the world. AIMS The overall goal of the proposed research is to (i) generate and analyse data to answer two long standing questions in human evolution: understanding the molecular basis of human adaptation to high altitude and investigating the timing of the Polynesian-South American contact, (ii) develop statistical approaches that combine ancient and modern genetic data to estimate the timing and the intensity of a selective sweep and an admixture event. METHODOLOGY Application: We will collect, date and DNA sequence human remains. Combining the ancient genetic data, 14C dates with existing modern genomic data will allow us to increase the resolution as to the timing of the adaptive and the admixture event, respectively, while generating unique datasets. Theory: We will build on existing methods based on one-locus classical population genetic models to develop tools to analyse whole genome time serial data. RELEVANCE Ecological: The results will address the fundamental question of how much of the human genome is undergoing selection, better characterize one of the textbook examples of adaptation in humans and contribute to our understanding of the peopling of the Americas. Medical: We will gain insights into the fundamental stress physiology experienced at high altitude and therefore into altitude-related illnesses. Methodological: The methods developed in this project will not only benefit the growing field of ancient genomics but also other fields where data is collected in a temporal manner, such as experimental evolution and epidemiology

Invito a presentare proposte

ERC-2015-STG
Vedi altri progetti per questo bando

Meccanismo di finanziamento

ERC-STG - Starting Grant

Istituzione ospitante

UNIVERSITE DE LAUSANNE
Indirizzo
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Svizzera
Tipo di attività
Higher or Secondary Education Establishments
Contributo UE
€ 1 438 018,37

Beneficiari (2)

UNIVERSITE DE LAUSANNE
Svizzera
Contributo UE
€ 1 438 018,37
Indirizzo
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Tipo di attività
Higher or Secondary Education Establishments
UNIVERSITAET BERN

Partecipazione conclusa

Svizzera
Contributo UE
€ 60 459,63
Indirizzo
Hochschulstrasse 6
3012 Bern
Tipo di attività
Higher or Secondary Education Establishments